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1. 发明授权

US4507235A Method for preparing peptides and intermediate products 失效
标题翻译：制备肽和中间产物的方法
公开(公告)号：US4507235A
公开(公告)日：1985-03-26
申请号：US586187
申请日：1984-03-05
申请人： Erich Wunsch
发明人： Erich Wunsch
IPC分类号： A61K38/00 , C07K1/06 , C07K14/595 , C07C103/52
CPC分类号： C07K14/595 , C07K1/065 , A61K38/00
摘要： Peptides having the carboxyl terminated sequence of the pancreozymin-cholstokinin 25-33 modified such that the amino acid group 25 carries a strongly basic group, the amino acid group 28 exhibits a hydrophilic character similar to that of the hydroxyamino acids and the amino acid group 31 exhibits a strongly hydrophobic character similar to that of amino acids with aliphatic side chains, and in particular nonapeptides having the sequence H--X--Asp--Tyr(SO.sub.3 H)--Y--Gly--Trp--Z--Asp--Phe--NH.sub.2 wherein X is arginine, homoarginine, norarginine, N.sub..epsilon.,N.sub..epsilon. -dialkyllysine, N.sub..delta. or N.sub..delta. -dialkyl-ornithine, Y is threonine, serine or hydroxy-proline and Z is norleucine, leucine, norvaline or .alpha.-amino-butyric acid, possess pronounced pancreozymin activity and can be employed in pharmaceutical preparations for controlling the function of the gall bladder and for controlling the enzyme secretion of the pancreas. Tyrosine-O-sulfate-barium salt and its N-acyl derivatives can be used as intermediate products for the preparation of peptides. For introducing the amino acid group 27 an N-acyltyrosine is reacted with an excess of pyridine--SO.sub.3 in a polar organic solvent, the resulting solution is extracted with water, the barium salt of the N-acyl-tyrosine-O-sulfate is precipitated from the aqueous phase by addition of a soluble barium compound, possibly the acyl group is split off in conventional manner, and the resulting tyrosine-O-sulfate-barium salt or its acyl derivative are processed employing the usual methods of peptide synthesis.
摘要翻译：具有胰蛋白酶 - 缩胆囊素25-33羧基末端序列的肽被修饰，使得氨基酸25携带强碱性基团，氨基酸组28表现出与羟基氨基酸和氨基酸组31相似的亲水性表现出类似于具有脂肪族侧链的氨基酸的强疏水性，特别是具有序列HX-Asp-Tyr（SO3H）-Y-Gly-Trp-Z-Asp-Phe-NH2的非肽，其中X是精氨酸，精氨酸，降血清蛋白，Nε，Nε-二烷基赖氨酸，N或N二烷基鸟氨酸，Y是苏氨酸，丝氨酸或羟基脯氨酸，Z是正亮氨酸，亮氨酸，正缬氨酸或α-氨基丁酸，具有显着的胰酶活性，可用于控制胆囊功能和控制胰腺酶分泌的药物制剂中。酪氨酸-O-硫酸盐钡盐及其N-酰基衍生物可用作制备肽的中间产物。为了引入氨基酸组27，使N-酰基酪氨酸与极性有机溶剂中过量的吡啶-SO 3反应，所得溶液用水萃取，N-酰基 - 酪氨酸-O-硫酸盐的钡盐沉淀通过添加可溶性钡化合物从水相中，可能以常规方式分离出酰基，并且使用通常的肽合成方法处理所得的酪氨酸-O-硫酸盐 - 钡盐或其酰基衍生物。

2. 发明授权

US4474428A Rear view mirror adjustable by electric motor 失效
标题翻译：后视镜由电动马达调节
公开(公告)号：US4474428A
公开(公告)日：1984-10-02
申请号：US322339
申请日：1981-11-18
申请人： Erich Wunsch , Udo Wunsch , Eckart Wunsch
发明人： Erich Wunsch , Udo Wunsch , Eckart Wunsch
IPC分类号： B60R1/06 , B60R1/072 , F16D41/20 , G02B5/08
CPC分类号： B60R1/072 , F16D41/206 , Y10T74/20432
摘要： A remote-controlled rear-view mirror assembly having a mirror is movably supported in a housing and can be adjusted by an electric motor from a remote point. An electric motor is mounted in the mirror housing and has an electrically reversible direction of rotation and a stepdown gearing. There is a drive shaft having approximately at its center a driven coaxial cylinder of enlarged diameter with respect to the diameter of the drive shaft and a central annular shoulder dividing the coaxial cylinder into two substantially equal sections. A slipping clutch connects the motor with the drive shaft. Two eccentrics are rotatably mounted on the drive shaft on opposite sides respectively of the equal sections of the coaxial cylinder, each of these eccentrics comprises a cylindrical section and an eccentric disc. There are two wrap springs each of these wrap springs being wound in the same direction partly on one of the two equal sections and partly on one of the two cylindrical section of the eccentrics respectively. A transmission means connects the eccentric discs respectively to the mirror.
摘要翻译：具有反射镜的远程控制的后视镜组件可移动地支撑在壳体中，并且可以通过来自远程点的电动机来调节。电动机安装在镜壳中并具有电可逆的旋转方向和降档装置。驱动轴具有大致在其中心的相对于驱动轴的直径增大直径的驱动同心圆筒和将同轴圆筒分成两个基本相等的部分的中心环形肩部。滑动离合器将电动机与驱动轴连接。两个偏心轮分别可旋转地安装在同轴圆筒的相同部分的相对侧的驱动轴上，这些偏心轮中的每一个包括圆柱形部分和偏心圆盘。有两个卷绕弹簧，这些卷绕弹簧中的每一个分别沿相同的方向缠绕在两个相等的部分中的一个上，并且部分地分别在偏心轮的两个圆柱形部分中的一个上。传动装置将偏心盘分别连接到镜子。

3. 发明授权

US4515730A Compounds for determining the pH value in the interior of a cell 失效
标题翻译：用于测定细胞内部pH值的化合物
公开(公告)号：US4515730A
公开(公告)日：1985-05-07
申请号：US394784
申请日：1982-07-02
申请人： Gunter Valet , Gerhard Ruhenstroth-Bauer , Erich Wunsch , Luis Moroder
发明人： Gunter Valet , Gerhard Ruhenstroth-Bauer , Erich Wunsch , Luis Moroder
IPC分类号： G01N21/75 , C07C255/51 , C07C255/53 , C07C271/06 , C12Q1/00 , C12Q1/02 , C12Q1/37 , C12Q1/44 , G01N21/64 , G01N21/80 , G01N33/84 , C07C121/75
CPC分类号： C07C255/00 , G01N33/84
摘要： A process for determining the pH value in the interior of a cell is described. This is accomplished by measurement of the emission of a fluorescent substance which is absorbed by the cell through incubation in a solution. The solution contains a compound of the said fluorescent substance; the fluorescent substance is separated from this compound in the cell by an enzyme present in the cell. The fluorescent substance selected is one such that the frequency of the emission maximum is dependent on the pH value. The compound of this fluorescent substance which is selected is one which is membrane penetrating. Measurement of the fluorescence is based on the principle of measurement of the frequency at which the emission maximum occurs. A fluorescent substance suitable for this purpose is 2,3-dicyano-1,4-hydroquinone. A suitable membrane penetrating compound is 1,4-diacetoxy-2,3-dicyanobenzene or 1,4-dibutyryloxy-2,3-dicyanobenzene or 1,4-di(-tert-butyloxycarbonyl-1-alanyloxy)-2,3-dicyanobenzene.
摘要翻译：描述了确定细胞内部的pH值的方法。这是通过测量通过在溶液中孵育而被细胞吸收的荧光物质的发射来实现的。该溶液含有所述荧光物质的化合物; 通过存在于细胞中的酶将荧光物质从细胞中的该化合物中分离出来。选择的荧光物质是这样的，使得发射最大值的频率取决于pH值。所选择的荧光物质的化合物是膜渗透的化合物。荧光的测量是基于测量发射最大值的频率的原理。适用于此目的的荧光物质是2,3-二氰基-1,4-对苯二酚。合适的膜渗透化合物是1,4-二乙酰氧基-2,3-二氰基苯或1,4-二丁酰氧基-2,3-二氰基苯或1,4-二（叔丁氧基羰基-1-烷氧基）二氰基苯。

4. 发明授权

US4368192A Peptides 失效
标题翻译：多肽
公开(公告)号：US4368192A
公开(公告)日：1983-01-11
申请号：US145500
申请日：1980-04-29
申请人： Erich Wunsch
发明人： Erich Wunsch
IPC分类号： A61K38/00 , C07K1/06 , C07K14/595 , A61K37/00 , C07C103/52
CPC分类号： C07K14/595 , C07K1/065 , A61K38/00
摘要： Peptides having the carboxyl terminated sequence of the pancreozymin-cholstokinin 25-33 modified such that the amino acid group 25 carries a strongly basic group, the amino acid group 28 exhibits a hydrophilic character similar to that of the hydroxyamino acids and the amino acid group 31 exhibits a strongly hydrophobic character similar to that of amino acids with aliphatic side chains, and in particular nonapeptides having the sequence H--X--Asp--Tyr(SO.sub.3 H)--Y--Gly--Trp--Z--Asp--Phe--NN.sub.2 wherein X is arginine, homoarginine, norarginine, N.sub..epsilon.,N.sub..epsilon. -dialkyllysine, N.sub..delta. or N.sub..delta. -dialkyl-ornithine, Y is threonine, serine or hydroxy-proline and Z is norleucine, leucine, norvaline or .alpha.-amino-butyric acid, possess pronounced pancreozymin activity and can be employed in pharmaceutical preparations for controlling the function of the gall bladder and for controlling the enzyme secretion of the pancreas. Tyrosine-O-sulfate-barium salt and its N-acyl derivatives can be used as intermediate products for the preparation of peptides. For introducing the amino acid group 27 an N-acyl-tyrosine is reacted with an excess of pyridine-SO.sub.3 in a polar organic solvent, the resulting solution is extracted with water, the barium salt of the N-acyl-tyrosine-O-sulfate is precipitated from the aqueous phase by addition of a soluble barium compound, possibly the acyl group is split off in conventional manner, and the resulting tyrosine-O-sulfate-barium salt or its acyl derivative are processed employing the usual methods of peptide synthesis.
摘要翻译：具有胰蛋白酶 - 缩胆囊素25-33羧基末端序列的肽被修饰，使得氨基酸25携带强碱性基团，氨基酸组28表现出与羟基氨基酸和氨基酸组31相似的亲水性表现出类似于具有脂族侧链的氨基酸的强疏水性，特别是具有序列HX-Asp-Tyr（SO3H）-Y-Gly-Trp-Z-Asp-Phe-NN2的非肽，其中X是精氨酸，精氨酸，降血清蛋白，Nε，Nε-二烷基赖氨酸，N或N二烷基鸟氨酸，Y是苏氨酸，丝氨酸或羟基脯氨酸，Z是正亮氨酸，亮氨酸，正缬氨酸或α-氨基丁酸，具有显着的胰酶活性，可用于控制胆囊功能和控制胰腺酶分泌的药物制剂中。酪氨酸-O-硫酸盐钡盐及其N-酰基衍生物可用作制备肽的中间产物。为了引入氨基酸组27，使N-酰基酪氨酸与极性有机溶剂中过量的吡啶-SO 3反应，所得溶液用水萃取，N-酰基 - 酪氨酸-O-硫酸盐的钡盐通过加入可溶性钡化合物从水相中沉淀出来，可能以常规方式将酰基分离出来，所得到的酪氨酸-O-硫酸盐 - 钡盐或其酰基衍生物使用通常的肽合成方法进行处理。

5. 发明授权

US4677060A Process for determining the pH value in the interior of a cell 失效
标题翻译：确定细胞内部pH值的方法
公开(公告)号：US4677060A
公开(公告)日：1987-06-30
申请号：US680078
申请日：1984-12-10
申请人： Gunter Valet , Gerhard Ruhenstroth-Bauer , Erich Wunsch , Luis Moroder
发明人： Gunter Valet , Gerhard Ruhenstroth-Bauer , Erich Wunsch , Luis Moroder
IPC分类号： G01N21/75 , C07C255/51 , C07C255/53 , C07C271/06 , C12Q1/00 , C12Q1/02 , C12Q1/37 , C12Q1/44 , G01N21/64 , G01N21/80 , G01N33/84 , C12Q1/38
CPC分类号： C07C255/00 , G01N33/84
摘要： A process for determining the pH value in the interior of a cell is descrd. This is accomplished by measurement of the emission of a fluorescent substance which is absorbed by the cell through incubation in a solution. The solution contains a compound of the said fluorescent substance; the fluorescent substance is separated from this compound in the cell by an enzyme present in the cell. The fluorescent substance selected is one such that the frequency of the emission maximum is dependent on the pH value. The compound of this fluorescent substance which is selected is one which is membrane penetrating. Measurement of the fluorescence is based on the principle of measurement of the frequency at which the emission maximum occurs. A fluorescent substance suitable for this purpose is 2,3-dicyano-1,4-hydroquinone. A suitable membrane penetrating compound is 1,4-diacetoxy-2,3-dicyanobenzene or 1,4-dibutyryloxy-2,3-dicyanobenzene or 1,4-di(-tert-butyloxycarbonyl-1-alanyloxy)-2,3-dicyanobenzene.
摘要翻译：描述了确定细胞内部的pH值的方法。这是通过测量通过在溶液中孵育而被细胞吸收的荧光物质的发射来实现的。该溶液含有所述荧光物质的化合物; 通过存在于细胞中的酶将荧光物质从细胞中的该化合物中分离出来。选择的荧光物质是这样的，使得发射最大值的频率取决于pH值。所选择的荧光物质的化合物是膜渗透的化合物。荧光的测量是基于测量发射最大值的频率的原理。适用于此目的的荧光物质是2,3-二氰基-1,4-对苯二酚。合适的膜渗透化合物是1,4-二乙酰氧基-2,3-二氰基苯或1,4-二丁酰氧基-2,3-二氰基苯或1,4-二（叔丁氧基羰基-1-烷氧基）二氰基苯。

6. 发明授权

US4640590A Apparatus providing rapid adjustment of a mirror 失效
标题翻译：提供镜子快速调节的装置
公开(公告)号：US4640590A
公开(公告)日：1987-02-03
申请号：US747359
申请日：1985-06-21
申请人： Erich Wunsch
发明人： Erich Wunsch
IPC分类号： B60R1/02 , G02B7/18 , G02B5/08
CPC分类号： B60R1/025
摘要： This invention relates to an apparatus providing rapid adjustment of a mirror which is pivotable about a vertical axis and retained in a housing, especially a vehicle rear view mirror, whereby the mirror is operated by an actuator having movement separated from the axis of rotation of the mirror itself and causing the mirror to rotate beyond its preset adjustment position through a preset angle, the mirror retaining contact which the actuator by means of a spring element. Movement of the actuator is controlled by a rotatable operating disk having a peripheral control curve. As the operating disk rotates, it passes through a movement arc which determines the movement of the actuator and the pivot angle of the mirror; this arc is followed by a rest phase arc which determines the final adjustment position of the actuator and the mirror; this arc is followed by a return arc which controls the return of the mirror and the actuator to their initial adjustment positions; the duration, extent and limits of the pivoting movement are all controlled by the configuration of the operating disk.
摘要翻译：本发明涉及一种能够快速调节反射镜的装置，其可以围绕垂直轴线转动并保持在壳体中，特别是车辆后视镜，由此该反射镜由致动器操作，该致动器具有与旋转轴线镜子本身并使镜子经过预设角度旋转超过其预设调节位置，镜子保持触点是通过弹簧元件的致动器。致动器的移动由具有外围控制曲线的可旋转操作盘控制。当操作盘旋转时，它通过运动弧线，该运动弧确定致动器的运动和镜子的转动角度; 该电弧之后是确定致动器和反射镜的最终调节位置的静止相位弧; 该弧后面是一个返回弧，其控制反射镜和致动器返回到其初始调节位置; 旋转运动的持续时间，范围和限制都由操作盘的配置控制。

7. 发明授权

US5641094A Method and device for taking-out of fluids from containers 失效
标题翻译：从容器中取出流体的方法和装置
公开(公告)号：US5641094A
公开(公告)日：1997-06-24
申请号：US425376
申请日：1995-04-20
申请人： Erich Wunsch
发明人： Erich Wunsch
IPC分类号： B67D1/04 , B67D5/08
CPC分类号： B67D1/0431
摘要： A method for the removal or dispensing of liquids from containers, especially for the tapping of beer, in which pursuant to the quantity of liquid withdrawn, air is introduced into the container for pressure compensation or for the generating of an atmospheric pressure. Furthermore, also disclosed is a device for the dispensing of liquids from containers, especially a beer tapping device which is exchangeably connectable with the containers for effecting the withdrawal of the liquids and which essentially possesses a unitarily or multi-part constructed removal housing including a liquid-withdrawing tap, as well as passageways, bores, conduits or the like for the removal of the liquid and for the infeed of air.
摘要翻译：一种用于从容器中去除或分配液体的方法，特别是用于啤酒开采的方法，其中根据抽出的液体量将空气引入容器中用于压力补偿或产生大气压力。此外，还公开了一种用于从容器中分配液体的装置，特别是可与容器可交换地连接的啤酒抽出装置，用于实现液体的抽出，并且其基本上具有整体或多部件构造的除去壳体，其包括液体 - 抽水龙头，以及通道，孔，管道等，用于去除液体和进入空气。

8. 发明授权

US5041533A Hinge peptide, a process for its manufacture, and its use for the manufacture of synthetic immunogens 失效
标题翻译：铰链肽，其制造方法及其在制造合成免疫原中的应用
公开(公告)号：US5041533A
公开(公告)日：1991-08-20
申请号：US175383
申请日：1988-03-30
申请人： Erich Wunsch , Luis Moroder
发明人： Erich Wunsch , Luis Moroder
IPC分类号： A61K38/00 , A61K39/00 , C07K1/02 , C07K1/113 , C07K7/06 , C07K14/595 , C07K16/06
CPC分类号： C07K16/065 , A61K39/00 , Y10S530/866
摘要： The invention relates to a hinge peptide of the general formula I that maye utilized for the manufacture of synthetic immunogens. The invention also comprises a process for the manufacture of this hinge peptide and a process for the manufacture of synthetic immunogens, where the hinge peptide is employed as a carrier protein.
摘要翻译：本发明涉及可用于制造合成免疫原的通式I的铰链肽。本发明还包括制备该铰链肽的方法和用于制造合成免疫原的方法，其中铰链肽用作载体蛋白。

9. 发明授权

US4234246A Remote controllable rearview mirror 失效
标题翻译：遥控后视镜
公开(公告)号：US4234246A
公开(公告)日：1980-11-18
申请号：US942284
申请日：1978-09-14
申请人： Erich Wunsch , Udo Wunsch , Eckart Wunsch
发明人： Erich Wunsch , Udo Wunsch , Eckart Wunsch
IPC分类号： B60R1/072 , G02B7/18
CPC分类号： B60R1/072
摘要： With a remote controllable rearview mirror for vehicles or the like, the mirror plate is suspended without play by means of pivotally-moveable articulations on at least two, preferably three points, which points are arranged spaced from one another, whereby one suspension point is stationary and connected rigidly with the mirror housing, while one or the other suspension points is fastened respectively on one swingable arm, which arm simultaneously can be formed as a transmission member of the control device, and is constrained for guidance in the plane of pivoting under friction such that there is present a quasi-rigid connection of the mirror plate with the mirror housing.
摘要翻译：利用用于车辆等的可远程控制的后视镜，通过在至少两个，优选三个点上的可枢转地运动的关节来悬挂镜板而不进行游隙，这些点彼此间隔布置，从而一个悬挂点是固定的并且与镜壳体刚性地连接，而一个或另一个悬挂点分别固定在一个可摆动的臂上，该臂同时可以形成为控制装置的传动构件，并且被限制在在摩擦的枢转平面内的引导使得存在镜面板与镜壳体的准刚性连接。

10. 发明授权

US4167508A Phlorethyl-.beta.-alanyl-secretine 失效
标题翻译： Phlorethyl- {62 -alanyl-secretine
公开(公告)号：US4167508A
公开(公告)日：1979-09-11
申请号：US807533
申请日：1977-06-17
申请人： Erich Wunsch
发明人： Erich Wunsch
IPC分类号： G01N33/53 , C07D207/40 , C07D207/404 , C07K1/113 , C07K14/575 , C07K14/645 , C07K14/76 , C07K16/00 , C07C103/52 , A61K37/10 , C07G7/00
CPC分类号： C07D207/404 , C07K14/645 , Y10S436/804 , Y10S436/815
摘要： A radioiodinated phloretyl-.beta.-alanyl-secretin, its salts and its protected derivatives. A process for the manufacture of a radioiodinated phloretyl-.beta.-alanyl-secretin and/or a salt thereof which process involves reacting phloretyl-.beta.-alanyl-secretin and/or a salt thereof with radioactive iodine. Phloretyl-.alpha.-alanyl-secretin, its salts and its protected derivatives. A method for the determination of secretin in a sample, which involves; mixing the sample with a known amount of a radioiodinated phloretyl-.beta.-alanyl-secretin and an antibody specific for secretin; measuring the degree of binding of the labelled radioiodinated phloretyl-.beta.-alanyl-secretin; and determining the amount of secretin present in the sample by comparing the degree of binding with a standard curve which has been obtained by adding known amounts of secretin to a defined mixture of the radioiodinated phloretyl-.beta.-alanyl-secretin and the antibody and determining the degree of binding for this known amount of secretin.
摘要翻译：放射性碘化肉豆蔻酰-β-丙氨酰 - 促胰液素，其盐及其受保护的衍生物。用于制造放射性碘化肉豆蔻酰基-β-丙氨酰 - 促胰液素和/或其盐的方法，该方法包括使肉豆蔻酰基-β-丙氨酰 - 促胰液素和/或其盐与放射性碘反应。肉豆蔻酰-α-丙氨酰 - 促胰液素，其盐及其受保护的衍生物。一种测定样品中促胰液素的方法，涉及：将样品与已知量的放射性碘化肉豆蔻酰-β-丙氨酰 - 促胰液素和特异于促胰液素的抗体混合; 测量标记的放射性碘化肉豆蔻酰-β-丙氨酰 - 胰泌素的结合程度; 以及通过将结合度与通过将已知量的促胰液素添加到放射性碘化肉豆蔻酰-β-丙氨酰 - 胰泌素和所述抗体的限定混合物而获得的标准曲线来确定样品中的分泌素的量，并确定这种已知量的促胰液素的结合程度。

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