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1. 发明申请

US20120149864A1 POLY(ORTHOESTER) POLYMERS, AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译： POLY（ORTHOESTER）聚合物，以及制备和使用它们的方法
公开(公告)号：US20120149864A1
公开(公告)日：2012-06-14
申请号：US13396425
申请日：2012-02-14
申请人： Julie A. Alkatout , Michael Eric Benz , Randall V. Sparer
发明人： Julie A. Alkatout , Michael Eric Benz , Randall V. Sparer
IPC分类号： C08G63/78
CPC分类号： C08G65/34 , C08G63/664 , C08G64/183
摘要： Poly(orthoester) polymers, and methods of making and using such poly(orthoester) polymers are provided. The poly(orthoester) polymers can be useful for applications including, for example, medical devices and pharmaceutical compositions. In a preferred embodiment, the poly(orthoester) polymers are biodegradable.
摘要翻译：提供聚（原酸酯）聚合物，以及制备和使用这种聚（原酸酯）聚合物的方法。聚（原酸酯）聚合物可用于包括例如医疗装置和药物组合物的应用。在优选的实施方案中，聚（原酸酯）聚合物是可生物降解的。

2. 发明申请

US20110082266A1 THERAPEUTIC POLYMERS AND METHODS OF GENERATION 有权
标题翻译：治疗聚合物及其生成方法
公开(公告)号：US20110082266A1
公开(公告)日：2011-04-07
申请号：US12766676
申请日：2010-04-23
申请人： Michael Eric Benz , Erica M. TenBroek , Lian Leon Luo
发明人： Michael Eric Benz , Erica M. TenBroek , Lian Leon Luo
IPC分类号： A61K47/48 , C08G65/00
CPC分类号： A61K9/16 , C08G65/002 , C08G65/38
摘要： The invention describes poly(ortho ester) polymers that include at least one therapeutic compound in the polymer backbone. The therapeutic compound includes at least one phenol residue and an aliphatic alcohol residue or two or more phenolic residues.
摘要翻译：本发明描述了在聚合物主链中包含至少一种治疗化合物的聚（原酸酯）聚合物。治疗化合物包括至少一种苯酚残基和脂族醇残基或两个或多个酚残基。

3. 发明申请

US20110065809A1 Polymerization of Multifunctional Azides, and Polymers Therefrom 审中-公开
标题翻译：多功能叠氮化物和聚合物的聚合
公开(公告)号：US20110065809A1
公开(公告)日：2011-03-17
申请号：US12560240
申请日：2009-09-15
申请人： Michael Eric Benz , Lian Leon Luo , Metasebia T. Munie
发明人： Michael Eric Benz , Lian Leon Luo , Metasebia T. Munie
IPC分类号： A61K47/30 , A61P43/00 , C12P17/16
CPC分类号： A61K9/0024 , A61K47/16 , A61K47/18 , A61K47/34 , A61L27/18 , A61L27/34 , C08L71/02
摘要： Methods for preparing polymers from multifunctional azides and multifunctional azide-reactants are described in the present disclosure. Exemplary multifunctional azide-reactants include multifunctional alkynes and/or multifunctional α-phosphine esters. In certain embodiments, such polymers can be prepared in vivo. Such polymers can be useful in a wide variety of biomedical applications.
摘要翻译：在本公开中描述了从多官能叠氮化物和多官能叠氮化物 - 反应物制备聚合物的方法。示例性多官能叠氮化物反应物包括多官能炔和/或多官能α-膦酯。在某些实施方案中，可以在体内制备这些聚合物。这些聚合物可用于各种各样的生物医学应用。

4. 发明申请

US20100240852A1 HETEROATOM-CONTAINING POLYMERS AND METATHESIS POLYMERIZATION METHODS FOR MAKING SAME 审中-公开
标题翻译：含异构体的聚合物和制备聚合物的异构聚合方法
公开(公告)号：US20100240852A1
公开(公告)日：2010-09-23
申请号：US12728978
申请日：2010-03-22
申请人： Lian Leon Luo , Michael Eric Benz
发明人： Lian Leon Luo , Michael Eric Benz
IPC分类号： C08F24/00 , C08G67/00
CPC分类号： C07D317/12 , A61L27/16 , A61L27/34 , A61L29/041 , A61L29/085 , A61L31/048 , A61L31/10 , C07D493/08 , C08G61/124 , C08G61/125 , C08G61/126 , C08G2261/3342 , C08G2261/418 , C08G2261/419 , C08L29/14
摘要： Heteroatom-containing polymers such as polyketals, and methods of making and using such heteroatom-containing polymers are disclosed herein. The heteroatom-containing polymers can be useful for applications including, for example, medical devices and pharmaceutical compositions. In a preferred embodiment, the heteroatom-containing polymers are polyketals that are biodegradable.
摘要翻译：含有杂原子的聚合物如聚缩酮，以及制备和使用这种含杂原子的聚合物的方法在本文中公开。含杂原子的聚合物可用于包括例如医疗装置和药物组合物的应用。在优选的实施方案中，含杂原子的聚合物是可生物降解的聚缩酮。

5. 发明申请

US20090013517A1 Repair and resurfacing methods for use in remanufacturing a machine system 有权
标题翻译：用于再制造机器系统的修理和重新铺设方法
公开(公告)号：US20090013517A1
公开(公告)日：2009-01-15
申请号：US11827241
申请日：2007-07-11
申请人： Eric Benz , Robert Sharp , Leslie Caviness , Casey Borden , Bobby McDaniel
发明人： Eric Benz , Robert Sharp , Leslie Caviness , Casey Borden , Bobby McDaniel
IPC分类号： B23P6/00
CPC分类号： B23P6/00 , B61C17/00 , Y10T29/49723 , Y10T29/49737
摘要： A method of repairing a housing for a machine system includes returning an inner diameter of at least one bearing bore of the housing to a uniform diameter state. The at least one bearing bore is prepared for resurfacing via removing deeply entrapped grease from within pores in cast surface material of the housing subsequent to returning the inner diameter to a uniform diameter state. Subsequent to preparing the at least one bearing bore for resurfacing, it is resurfaced with a material different from cast material of the housing and bonded therewith, for example via thermal spray coating. Resurfacing a cast metallic component, of iron, steel, or the like with metal spray coating may include removing deeply embedded grease from pores of cast surface material of a cast component, in preparation for spraying the cast component with metal spray resurfacing material.
摘要翻译：修理用于机器系统的壳体的方法包括将壳体的至少一个轴承孔的内径返回到均匀的直径状态。通过在将内径返回到均匀的直径状态之后，通过从壳体的铸造表面材料中的孔隙中的孔隙中去除深度捕获的润滑脂来制备至少一个轴承孔用于表面重铺。在准备用于表面重铺的至少一个轴承孔之后，其用与壳体的铸造材料不同的材料重新表面，并与其结合，例如通过热喷涂。用金属喷涂覆盖铸造金属部件，铁，钢等可以包括从铸造部件的铸造表面材料的孔中去除深嵌入的油脂，以准备用金属喷涂表面表面材料喷涂铸造部件。

6. 发明申请

US20080213349A1 Liposome Complexes Containing Pharmaceutical Agents and Methods 审中-公开
标题翻译：含有药剂和方法的脂质体复合物
公开(公告)号：US20080213349A1
公开(公告)日：2008-09-04
申请号：US12046346
申请日：2008-03-11
申请人： Deepak Ramesh Thakker , Michael Eric Benz
发明人： Deepak Ramesh Thakker , Michael Eric Benz
IPC分类号： A61K9/127 , A61K31/70
CPC分类号： A61K47/6913 , A61K47/6911
摘要： Liposome complexes are provided for site-specific delivery of pharmaceutical agents with improved targeting efficiency. The liposome complexes include a pharmaceutical agent associated with the liposome; a sialic acid-containing molecule associated with the liposome; and optionally a targeting agent attached to the sialic acid-containing molecule. The invention also provides methods of making liposome complexes and their in vivo administration.
摘要翻译：提供脂质体复合物用于具有改善的靶向效率的药剂的位点特异性递送。脂质体复合物包括与脂质体相关的药剂; 与脂质体相关的含唾液酸的分子; 和任选的连接到含唾液酸分子的靶向剂。本发明还提供了制备脂质体复合物及其体内给药的方法。

7. 发明授权

US07101956B2 Compounds containing quaternary carbons, medical devices, and methods 有权
公开(公告)号：US07101956B2
公开(公告)日：2006-09-05
申请号：US10292993
申请日：2002-11-13
申请人： Michael Eric Benz , Edward DiDomenico , Christopher M. Hobot , Randall V. Sparer , Kenneth B. Wagener , John E. Schwendeman
发明人： Michael Eric Benz , Edward DiDomenico , Christopher M. Hobot , Randall V. Sparer , Kenneth B. Wagener , John E. Schwendeman
IPC分类号： C08G18/63
CPC分类号： C08G18/6204 , A61L27/18 , C08F236/20 , C08L101/02 , C08L75/00
摘要： Compounds that include diorgano groups having quaternary carbons and optionally urethane groups, urea groups, or combinations thereof (i.e., polyurethanes, polyureas, or polyurethane-ureas), as well as materials and methods for making such compounds.

8. 发明授权

US07958610B2 Repair and resurfacing methods for use in remanufacturing a machine system 有权
标题翻译：用于再制造机器系统的修理和重新铺设方法
公开(公告)号：US07958610B2
公开(公告)日：2011-06-14
申请号：US11827241
申请日：2007-07-11
申请人： Eric Benz , Robert Sharp , Leslie Caviness , Casey Borden , Bobby McDaniel
发明人： Eric Benz , Robert Sharp , Leslie Caviness , Casey Borden , Bobby McDaniel
IPC分类号： B23P19/04
CPC分类号： B23P6/00 , B61C17/00 , Y10T29/49723 , Y10T29/49737
摘要： A method of repairing a housing for a machine system includes returning an inner diameter of at least one bearing bore of the housing to a uniform diameter state. The at least one bearing bore is prepared for resurfacing via removing deeply entrapped grease from within pores in cast surface material of the housing subsequent to returning the inner diameter to a uniform diameter state. Subsequent to preparing the at least one bearing bore for resurfacing, it is resurfaced with a material different from cast material of the housing and bonded therewith, for example via thermal spray coating. Resurfacing a cast metallic component, of iron, steel, or the like with metal spray coating may include removing deeply embedded grease from pores of cast surface material of a cast component, in preparation for spraying the cast component with metal spray resurfacing material.
摘要翻译：修理用于机器系统的壳体的方法包括将壳体的至少一个轴承孔的内径返回到均匀的直径状态。通过在将内径返回到均匀的直径状态之后，通过从壳体的铸造表面材料中的孔隙中的孔隙中去除深度捕获的润滑脂来制备至少一个轴承孔用于表面重铺。在准备用于表面重铺的至少一个轴承孔之后，其用与壳体的铸造材料不同的材料重新表面，并与其结合，例如通过热喷涂。用金属喷涂覆盖铸造金属部件，铁，钢等可以包括从铸造部件的铸造表面材料的孔中去除深嵌入的油脂，以准备用金属喷涂表面表面材料喷涂铸造部件。

9. 发明申请

US20100255051A1 POLYKETAL POLYMERS, AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：聚合物聚合物，以及制备和使用它们的方法
公开(公告)号：US20100255051A1
公开(公告)日：2010-10-07
申请号：US12818911
申请日：2010-06-18
申请人： Michael Eric Benz , Lian Leon Luo
发明人： Michael Eric Benz , Lian Leon Luo
IPC分类号： A61K31/4168 , C08G2/06 , A61F13/00 , A61P9/12
CPC分类号： A61L31/148 , A61K47/14 , A61L27/54 , A61L27/58 , A61L2300/604 , C08G65/22
摘要： Polyketal polymers, and methods of making and using such polyketal polymers are disclosed herein. The polyketal poylmers can be useful for applications including, for example, medical devices and pharmaceutical compositions. In a preferred embodiment, the polyketal polymers are biodegradable.
摘要翻译：聚缩酮聚合物，以及制备和使用这种聚缩酮聚合物的方法在本文中公开。聚缩酮类聚合物可用于包括例如医疗装置和药物组合物的应用。在优选的实施方案中，聚缩酮聚合物是可生物降解的。

10. 发明申请

US20090269390A1 MEDICAL DEVICES, POLYMERS, COMPOSITIONS, AND METHODS FOR DELIVERING A HALOACETATE 审中-公开
标题翻译：医疗器械，聚合物，组合物和方法，用于输送黑麦草
公开(公告)号：US20090269390A1
公开(公告)日：2009-10-29
申请号：US12429046
申请日：2009-04-23
申请人： Lian Leon Luo , Michael Eric Benz , Christopher M. Hobot , SuPing Lyu
发明人： Lian Leon Luo , Michael Eric Benz , Christopher M. Hobot , SuPing Lyu
IPC分类号： A61L27/54 , A61K31/19 , A61K31/215 , A61P35/00 , C08F283/02
CPC分类号： A61K47/593 , A61K47/58
摘要： Polymers, compositions, and medical devices useful for delivering (e.g., by local and/or sustained delivery) a haloacetate (e.g., dichoroacetate) to a tissue are disclosed herein. Such methods can be useful for treatment of diseases such as cancer.
摘要翻译：本文公开了用于将卤代乙酸酯（例如二氯乙酸酯）递送（例如，通过局部和/或持续递送）到组织的聚合物，组合物和医疗装置。这样的方法可用于治疗诸如癌症的疾病。

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