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1. 发明授权

US08748581B2 Anti-IL-6R polypeptides and pharmaceutical compositions thereof 有权
标题翻译：抗IL-6R多肽及其药物组合物
公开(公告)号：US08748581B2
公开(公告)日：2014-06-10
申请号：US13263179
申请日：2010-04-12
申请人： Els Anna Alice Beirnaert , Cedric Jozef Neotere Ververken , Joost Alexander Kolkman , Maarten Van Roy
发明人： Els Anna Alice Beirnaert , Cedric Jozef Neotere Ververken , Joost Alexander Kolkman , Maarten Van Roy
IPC分类号： C07K16/00 , A61K39/395 , A61K39/00
CPC分类号： C07K16/2866 , A61K39/3955 , A61K2039/505 , C07K16/18 , C07K16/4283 , C07K16/468 , C07K2317/22 , C07K2317/31 , C07K2317/33 , C07K2317/35 , C07K2317/565 , C07K2317/569 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12N15/09
摘要： The present invention relates to amino acid sequences that are directed against/and or that can specifically bind Interleukin-6 Receptor (IL-6R) with improved affinity and/or avidity, and/or that have an improved efficacy and/or potency, and which are capable of (partially, or preferably totally) blocking the IL-6/IL-6R interaction and/or inhibit signalization through IL-6, IL-6R and/or the IL-6/IL-6R complex. The invention further relates to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides, to methods for preparing such amino acid sequences and polypeptides, to host cells expressing or capable of expressing such amino acid sequences or polypeptides, to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells, and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.
摘要翻译：本发明涉及与改善的亲和力和/或亲合力有关的和/或可特异性结合白细胞介素-6受体（IL-6R）的氨基酸序列和/或具有改善的功效和/或效力的氨基酸序列，和其能够（部分或优选全部）阻断IL-6 / IL-6R相互作用和/或通过IL-6，IL-6R和/或IL-6 / IL-6R复合物抑制信号传导。本发明还涉及包含或基本上由一个或多个这样的氨基酸序列组成的化合物或构建体，特别是蛋白质和多肽。本发明还涉及编码这种氨基酸序列和多肽的核酸，制备此类氨基酸序列和多肽的方法，将表达或能够表达该氨基酸序列或多肽的细胞宿主给组合物，特别是药物组合物包括这样的氨基酸序列，多肽，核酸和/或宿主细胞，以及这些氨基酸序列或多肽，核酸，宿主细胞和/或组合物的用途，特别是用于预防，治疗或诊断目的。

2. 发明申请

US20100104568A1 AMINO ACID SEQUENCES DIRECTED AGAINST RANK-L AND POLYPEPTIDES COMPRISING THE SAME FOR THE TREATMENT OF BONE DISEASES AND DISORDERS 有权
标题翻译：针对RANK-L指导的氨基酸序列和包含骨髓疾病和疾病治疗相关的多肽
公开(公告)号：US20100104568A1
公开(公告)日：2010-04-29
申请号：US12558032
申请日：2009-09-11
申请人： Els Anna Alice Beirnaert , Sigrid Cornelis , Hendricus Renerus Jacobus Mattheus Hoogenboom
发明人： Els Anna Alice Beirnaert , Sigrid Cornelis , Hendricus Renerus Jacobus Mattheus Hoogenboom
IPC分类号： A61K39/395 , C07K14/00 , C07K16/00 , C07H21/04 , C12N5/16 , A61K38/16 , C12P21/06
CPC分类号： C07K16/2875 , A61K39/3955 , A61K47/60 , A61K47/6849 , A61K2039/505 , C07K14/765 , C07K16/24 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/76 , C07K2317/94 , C07K2319/31
摘要： The present invention relates to amino acid sequences that are directed against RANK-L, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides; to methods for preparing such amino acid sequences and polypeptides; to host cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.
摘要翻译：本发明涉及针对RANK-L的氨基酸序列，以及包含或基本上由一个或多个这样的氨基酸序列组成的化合物或构建体，特别是蛋白质和多肽。本发明还涉及编码这种氨基酸序列和多肽的核酸; 涉及制备这种氨基酸序列和多肽的方法; 宿主表达或能够表达这种氨基酸序列或多肽的细胞; 包括这样的氨基酸序列，多肽，核酸和/或宿主细胞的组合物，特别是药物组合物; 以及这些氨基酸序列或多肽，核酸，宿主细胞和/或组合物的用途，特别是用于预防，治疗或诊断目的。

3. 发明授权

US08703131B2 Nanobodies against tumor necrosis factor-alpha 有权
标题翻译：抗肿瘤坏死因子-α的纳米抗体
公开(公告)号：US08703131B2
公开(公告)日：2014-04-22
申请号：US11920677
申请日：2006-05-17
申请人： Els Anna Alice Beirnaert
发明人： Els Anna Alice Beirnaert
IPC分类号： A61K39/00 , A61K39/395 , C12P21/04 , C07H21/00 , C07K16/00
CPC分类号： G09F19/20
摘要： The present invention relates to improved Nanobodies™ against Tumor Necrosis Factor-alpha (TNF-alpha), as well as to polypeptides comprising or essentially consisting of one or more of such Nanobodies. The invention also relates to nucleic acids encoding such Nanobodies and polypeptides; to methods for preparing such Nanobodies and polypeptides; to host cells expressing or capable of expressing such Nanobodies or polypeptides; to compositions comprising such Nanobodies, polypeptides, nucleic acids or host cells; and to uses of such Nanobodies, such polypeptides, such nucleic acids, such host cells or such compositions, in particular for prophylactic, therapeutic or diagnostic purposes, such as the prophylactic, therapeutic or diagnostic purposes.
摘要翻译：本发明涉及针对肿瘤坏死因子-α（TNF-α）的改进的纳米抗体TM，以及包含或基本上由一种或多种这样的纳米抗体组成的多肽。本发明还涉及编码这种纳米抗体和多肽的核酸; 制备这种纳米抗体和多肽的方法; 宿主表达或能够表达这种纳米抗体或多肽的细胞; 包含这样的纳米抗体，多肽，核酸或宿主细胞的组合物; 以及这样的纳米抗体，这种多肽，这种核酸，这种宿主细胞或这种组合物的用途，特别是用于预防，治疗或诊断目的，例如预防，治疗或诊断目的。

4. 发明授权

US08623361B2 Amino acid sequences directed against RANK-L and polypeptides comprising the same for the treatment of bone diseases and disorders 有权
标题翻译：针对RANK-L的氨基酸序列和包含其的多肽用于治疗骨骼疾病和病症
公开(公告)号：US08623361B2
公开(公告)日：2014-01-07
申请号：US12599892
申请日：2008-05-23
申请人： Els Anna Alice Beirnaert , Sigrid Cornelis , Hendricus Renerus Jacobus Mattheus Hoogenboom
发明人： Els Anna Alice Beirnaert , Sigrid Cornelis , Hendricus Renerus Jacobus Mattheus Hoogenboom
IPC分类号： A61K39/395
CPC分类号： C07K16/2875 , A61K39/3955 , A61K47/60 , A61K47/6849 , A61K2039/505 , C07K14/765 , C07K16/24 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/76 , C07K2317/94 , C07K2319/31
摘要： The present invention relates to amino acid sequences that are directed against RANK-L, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides; to methods for preparing such amino acid sequences and polypeptides; to host cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.
摘要翻译：本发明涉及针对RANK-L的氨基酸序列，以及包含或基本上由一个或多个这样的氨基酸序列组成的化合物或构建体，特别是蛋白质和多肽。本发明还涉及编码这种氨基酸序列和多肽的核酸; 涉及制备这种氨基酸序列和多肽的方法; 宿主表达或能够表达这种氨基酸序列或多肽的细胞; 包括这样的氨基酸序列，多肽，核酸和/或宿主细胞的组合物，特别是药物组合物; 以及这些氨基酸序列或多肽，核酸，宿主细胞和/或组合物的用途，特别是用于预防，治疗或诊断目的。

5. 发明申请

US20110002929A1 AMINO ACID SEQUENCES DIRECTED AGAINST RANK-L AND POLYPEPTIDES COMPRISING THE SAME FOR THE TREATMENT OF BONE DISEASES AND DISORDERS 有权
标题翻译：针对RANK-L指导的氨基酸序列和包含骨髓疾病和疾病治疗相关的多肽
公开(公告)号：US20110002929A1
公开(公告)日：2011-01-06
申请号：US12599892
申请日：2008-05-23
申请人： Els Anna Alice Beirnaert , Sigrid Cornelis , Hendricus Renerus Jacobus Mattheus Hoogenboom
发明人： Els Anna Alice Beirnaert , Sigrid Cornelis , Hendricus Renerus Jacobus Mattheus Hoogenboom
IPC分类号： A61K39/395 , C07K16/18 , C07H21/04 , C12N5/10 , C12P21/00 , A61P19/08
CPC分类号： C07K16/2875 , A61K39/3955 , A61K47/60 , A61K47/6849 , A61K2039/505 , C07K14/765 , C07K16/24 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/76 , C07K2317/94 , C07K2319/31
摘要： The present invention relates to amino acid sequences that are directed against RANK-L, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides; to methods for preparing such amino acid sequences and polypeptides; to host cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.
摘要翻译：本发明涉及针对RANK-L的氨基酸序列，以及包含或基本上由一个或多个这样的氨基酸序列组成的化合物或构建体，特别是蛋白质和多肽。本发明还涉及编码这种氨基酸序列和多肽的核酸; 涉及制备这种氨基酸序列和多肽的方法; 宿主表达或能够表达这种氨基酸序列或多肽的细胞; 包括这样的氨基酸序列，多肽，核酸和/或宿主细胞的组合物，特别是药物组合物; 以及这些氨基酸序列或多肽，核酸，宿主细胞和/或组合物的用途，特别是用于预防，治疗或诊断目的。

6. 发明授权

US09475877B2 Amino acid sequences directed against RANK-L and polypeptides comprising the same for the treatment of bone diseases and disorders 有权
标题翻译：针对RANK-L的氨基酸序列和包含其的多肽用于治疗骨骼疾病和病症
公开(公告)号：US09475877B2
公开(公告)日：2016-10-25
申请号：US12558032
申请日：2009-09-11
申请人： Els Anna Alice Beirnaert , Sigrid Cornelis , Hendricus Renerus Jacobus Mattheus Hoogenboom
发明人： Els Anna Alice Beirnaert , Sigrid Cornelis , Hendricus Renerus Jacobus Mattheus Hoogenboom
IPC分类号： C07K16/18 , A61K39/395 , C07K16/28 , C07K16/24 , A61K39/00
CPC分类号： C07K16/2875 , A61K39/3955 , A61K47/60 , A61K47/6849 , A61K2039/505 , C07K14/765 , C07K16/24 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/76 , C07K2317/94 , C07K2319/31
摘要： The present invention relates to amino acid sequences that are directed against RANK-L, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides; to methods for preparing such amino acid sequences and polypeptides; to host cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.
摘要翻译：本发明涉及针对RANK-L的氨基酸序列，以及包含或基本上由一个或多个这样的氨基酸序列组成的化合物或构建体，特别是蛋白质和多肽。本发明还涉及编码这种氨基酸序列和多肽的核酸; 涉及制备这种氨基酸序列和多肽的方法; 宿主表达或能够表达这种氨基酸序列或多肽的细胞; 包括这样的氨基酸序列，多肽，核酸和/或宿主细胞的组合物，特别是药物组合物; 以及这些氨基酸序列或多肽，核酸，宿主细胞和/或组合物的用途，特别是用于预防，治疗或诊断目的。

7. 发明申请

US20120077731A1 AMINO ACID SEQUENCES DIRECTED AGAINST IL-6R AND POLYPEPTIDES COMPRISING THE SAME FOR THE TREATMENT OF IL-6R RELATED DISEASES AND DISORDERS 有权
标题翻译：指导针对IL-6R和包含IL-6R相关疾病和疾病的多肽的氨基酸序列
公开(公告)号：US20120077731A1
公开(公告)日：2012-03-29
申请号：US13263179
申请日：2010-04-12
申请人： Els Anna Alice Beirnaert , Cedric Jozef Neotere Ververken , Joost Alexander Kolkman , Maarten Van Roy
发明人： Els Anna Alice Beirnaert , Cedric Jozef Neotere Ververken , Joost Alexander Kolkman , Maarten Van Roy
IPC分类号： A61K38/08 , C07K7/08 , C07K19/00 , C07K14/54 , C12N15/12 , A61P37/00 , A61P35/00 , A61P19/00 , A61P19/10 , A61P3/00 , A61P17/06 , A61P29/00 , A61K38/10 , C12P21/02 , C12N1/21 , C12N1/15 , C12N1/19 , C12N5/10 , C07K7/06
CPC分类号： C07K16/2866 , A61K39/3955 , A61K2039/505 , C07K16/18 , C07K16/4283 , C07K16/468 , C07K2317/22 , C07K2317/31 , C07K2317/33 , C07K2317/35 , C07K2317/565 , C07K2317/569 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12N15/09
摘要： The present invention relates to amino acid sequences that are directed against/and or that can specifically bind Interleukin-6 Receptor (IL-6R) with improved affinity and/or avidity, and/or that have an improved efficacy and/or potency, and which are capable of (partially, or preferably totally) blocking the IL-6/IL-6R interaction and/or inhibit signalization through IL-6, 1L-6R and/or the IL-6/IL-6R complex. The invention further relates to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides, to methods for preparing such amino acid sequences and polypeptides, to host cells expressing or capable of expressing such amino acid sequences or polypeptides, to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells, and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.
摘要翻译：本发明涉及与改善的亲和力和/或亲合力有关的和/或可特异性结合白细胞介素-6受体（IL-6R）的氨基酸序列和/或具有改善的功效和/或效力的氨基酸序列，和其能够（部分或优选完全）阻断IL-6 / IL-6R相互作用和/或通过IL-6,1L-6R和/或IL-6 / IL-6R复合物抑制信号传导。本发明还涉及包含或基本上由一个或多个这样的氨基酸序列组成的化合物或构建体，特别是蛋白质和多肽。本发明还涉及编码这种氨基酸序列和多肽的核酸，制备此类氨基酸序列和多肽的方法，将表达或能够表达该氨基酸序列或多肽的细胞宿主给组合物，特别是药物组合物包括这样的氨基酸序列，多肽，核酸和/或宿主细胞，以及这些氨基酸序列或多肽，核酸，宿主细胞和/或组合物的用途，特别是用于预防，治疗或诊断目的。

8. 发明申请

US20110091462A1 NOVEL ANTIGEN BINDING DIMER-COMPLEXES, METHODS OF MAKING AND USES THEREOF 审中-公开
标题翻译：新型抗原结合二聚体复合物，其制备方法及其用途
公开(公告)号：US20110091462A1
公开(公告)日：2011-04-21
申请号：US12920862
申请日：2009-03-05
申请人： Peter Casteels , Marc Jozef Lauwereys , Patrick Stanssens , Christine Labeur , Carlo Boutton , Ann Brigé , Hendricus Renerus Jacobus M Hoogenboom , Els Anna Alice Beirnaert
发明人： Peter Casteels , Marc Jozef Lauwereys , Patrick Stanssens , Christine Labeur , Carlo Boutton , Ann Brigé , Hendricus Renerus Jacobus M Hoogenboom , Els Anna Alice Beirnaert
IPC分类号： C07K16/00 , A61K39/395
CPC分类号： C07K16/00 , C07K16/18 , C07K16/22 , C07K16/2866 , C07K16/36 , C07K2317/22 , C07K2317/569 , C07K2317/626
摘要： In a broad aspect the present invention generally relates to novel dimer-complexes (herein called “non-fused-dimers” or NFDs) comprising single variable domains, methods of making these complexes and uses thereof. These non-covalently bound dimer-complexes consist of two identical monomers that each comprises of one or more single variable domains (homodimers) or of two different monomers that each comprises on or more single variable domains (heterodimers). The subject NFDs have typically altered e.g. improved binding characteristics over their monomeric counterpart. The NFDs of the invention may further be engineered through linkage by a flexible peptide or cysteines in order to improve the stability. This invention also describes conditions under which such NFDs are formed and conditions under which the formation of such dimers can be avoided.
摘要翻译：在广泛的方面，本发明通常涉及包含单可变结构域的新型二聚体复合物（本文称为“非融合二聚体”或NFD），制备这些复合物的方法及其用途。这些非共价结合的二聚体复合物由两个相同的单体组成，每个单体包含一个或多个单个可变结构域（同源二聚体）或两个不同的单体，其各自包含或多个单个可变结构域（异源二聚体）。受试者NFD通常改变例如改善了其单体对应物的结合特性。本发明的NFD可进一步通过柔性肽或半胱氨酸的连接进行工程改造，以提高稳定性。本发明还描述了形成这种NFD的条件和可以避免形成这种二聚体的条件。

9. 发明申请

US20100215664A1 AMINO ACID SEQUENCES DIRECTED AGAINST IL-6R AND POLYPEPTIDES COMPRISING THE SAME FOR THE TREATMENT OF DISEASES AND DISORDERS ASSOCIATED WITH IL-6 -MEDIATED SIGNALLING 有权
标题翻译：针对IL-6R指导的氨基酸序列和包含与IL-6相关信号相关的疾病和疾病治疗相关的多肽的氨基酸序列
公开(公告)号：US20100215664A1
公开(公告)日：2010-08-26
申请号：US12310223
申请日：2007-08-17
申请人： Joost Alexander Kolkman , Els Anna Alice Beirnaert
发明人： Joost Alexander Kolkman , Els Anna Alice Beirnaert
IPC分类号： A61K39/395 , C07K16/18 , C07H21/04 , A61P31/00 , A61P35/00 , A61P19/10 , A61P17/06 , A61P29/00 , C07K14/00 , C12P21/06
CPC分类号： C07K16/2866 , A61K39/39558 , A61K45/06 , A61K47/6845 , A61K2039/505 , C07K16/18 , C07K16/248 , C07K16/468 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/09 , C12N15/81 , C12N15/86 , C12P21/02
摘要： The invention relates to amino acid sequences that are directed against and/or that can specifically bind to IL-6 receptor, compounds or constructs that comprise said amino acid sequence, nucleic acids that encode said amino acid sequences, compounds or constructs, pharmaceutical compositions comprising said amino acid sequences, compounds or constructs as well as methods for the prevention and/or treatment of diseases and disorders associated with IL-6 receptor.
摘要翻译：本发明涉及针对和/或可以特异性结合IL-6受体的氨基酸序列，包含所述氨基酸序列的化合物或构建体，编码所述氨基酸序列的核酸，化合物或构建体，包含所述氨基酸序列，化合物或构建体以及用于预防和/或治疗与IL-6受体相关的疾病和病症的方法。

10. 发明授权

US08629244B2 Interleukin-6 receptor binding polypeptides 有权
标题翻译：白细胞介素-6受体结合多肽
公开(公告)号：US08629244B2
公开(公告)日：2014-01-14
申请号：US12310223
申请日：2007-08-17
申请人： Joost Alexander Kolkman , Els Anna Alice Beirnaert
发明人： Joost Alexander Kolkman , Els Anna Alice Beirnaert
IPC分类号： C07K16/18 , C07K16/28 , C07K7/00 , C07K14/435 , A61K39/395
CPC分类号： C07K16/2866 , A61K39/39558 , A61K45/06 , A61K47/6845 , A61K2039/505 , C07K16/18 , C07K16/248 , C07K16/468 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/09 , C12N15/81 , C12N15/86 , C12P21/02
摘要： The invention relates to amino acid sequences that are directed against and/or that can specifically bind to IL-6 receptor, compounds or constructs that comprise said amino acid sequence, nucleic acids that encode said amino acid sequences, compounds or constructs, pharmaceutical compositions comprising said amino acid sequences, compounds or constructs as well as methods for the prevention and/or treatment of diseases and disorders associated with IL-6 receptor.
摘要翻译：本发明涉及针对和/或可以特异性结合IL-6受体的氨基酸序列，包含所述氨基酸序列的化合物或构建体，编码所述氨基酸序列的核酸，化合物或构建体，包含所述氨基酸序列，化合物或构建体以及用于预防和/或治疗与IL-6受体相关的疾病和病症的方法。

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