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1. 发明授权

US09096635B2 N-alkylthio beta-lactams, alkyl-coenzyme A asymmetric disulfides, and aryl-alkyl disulfides as anti-bacterial agents 有权
标题翻译： N-烷硫基β-内酰胺，烷基辅酶A不对称二硫化物和芳基 - 烷基二硫化物作为抗菌剂
公开(公告)号：US09096635B2
公开(公告)日：2015-08-04
申请号：US14267795
申请日：2014-05-01
申请人： Edward Turos , Kevin D. Revell
发明人： Edward Turos , Kevin D. Revell
IPC分类号： A61K31/105 , A61K31/7076 , A01N41/12 , A01N57/16 , C07H19/16 , C07H19/207 , C07C321/28 , C07D205/08 , C07D213/71
CPC分类号： A01N43/44 , A01N41/12 , A01N57/16 , A61K31/105 , A61K31/397 , A61K31/7076 , C07C321/28 , C07D205/08 , C07D213/71 , C07H19/16 , C07H19/207 , Y02A50/473
摘要： The present invention provides N-alkylthio β-lactams and disulfide compounds (e.g., alkyl-coenzyme A asymmetric disulfides or aryl-alkyl disulfides), compositions containing such compounds, and methods of their use as anti-bacterial agents.
摘要翻译：本发明提供了N-烷硫基 - 内酰胺和二硫化物（例如烷基 - 辅酶A不对称二硫化物或芳基 - 烷基二硫化物），含有这些化合物的组合物及其用作抗细菌剂的方法。

2. 发明申请

US20110160178A1 HETEROSUBSTITUTED N-THIOLATED BETA-LACTAM COMPOUNDS AND METHODS OF USE 有权
标题翻译：异噻唑啉衍生物的酯交酯化合物及其使用方法
公开(公告)号：US20110160178A1
公开(公告)日：2011-06-30
申请号：US12951778
申请日：2010-11-22
申请人： EDWARD TUROS , Praveen Ramaraju
发明人： EDWARD TUROS , Praveen Ramaraju
IPC分类号： A61K31/397 , C07D403/12 , A61K31/4035 , A61P31/04
CPC分类号： C07D403/12 , C07D205/085 , C07D209/48
摘要： The invention relates to heterosubstituted N-thiolated beta-lactams, compositions comprising these compounds, methods for their production, and methods of use as antibiotics to inhibit the growth of bacteria. In one embodiment, the compounds have the structure shown in formula (A) or formula (B) or formula (C): wherein the R groups are as defined in the specification. The antibacterial agents of the invention can be administered to a human or animal to treat or inhibit bacterial infection, such as that of Staphylococcus species, including methicillin-resistant Staphylococcus aureus (MRSA).
摘要翻译：本发明涉及异取代的N-硫醇化β-内酰胺，包含这些化合物的组合物，其生产方法和用作抗生素以抑制细菌生长的方法。在一个实施方案中，化合物具有式（A）或式（B）或式（C）所示的结构：其中R基团如说明书中所定义。本发明的抗菌剂可以施用于人或动物以治疗或抑制细菌感染，例如包括耐甲氧西林金黄色葡萄球菌（MRSA）的葡萄球菌属物种。

3. 发明授权

US06946458B2 N-thiolated beta-lactams: novel antibacterial agents for methicillin-resistant Staphylococcus aureus 有权
标题翻译： N-硫醇化β-内酰胺：耐甲氧西林金黄色葡萄球菌的新型抗菌剂
公开(公告)号：US06946458B2
公开(公告)日：2005-09-20
申请号：US10288897
申请日：2002-11-05
申请人： Edward Turos
发明人： Edward Turos
IPC分类号： A61K31/397 , A61P31/04 , C07D205/08
CPC分类号： C07D205/08
摘要： The invention relates generally to novel N-thiolated β-lactams. More specially, the invention relates to the use of these novel antibacterial agents in the treatment or inhibition of methicillin-resistant Staphylococcus aureaus.
摘要翻译：本发明一般涉及新的N-硫醇化β-内酰胺。更具体地，本发明涉及这些新型抗菌剂在治疗或抑制耐甲氧西林金黄色葡萄球菌中的用途。

4. 发明申请

US20180369163A1 ANTIBACTERIAL S-HETEROSUBSTITUTED DISULFIDES 审中-公开
公开(公告)号：US20180369163A1
公开(公告)日：2018-12-27
申请号：US16105573
申请日：2018-08-20
申请人： Edward Turos , Praveen Ramaraju
发明人： Edward Turos , Praveen Ramaraju
IPC分类号： A61K31/105 , C07C381/00 , C07C321/20 , C07C321/14 , C07H15/00 , A61K31/145
CPC分类号： A61K31/105 , A61K31/145 , C07C321/14 , C07C321/20 , C07C381/00 , C07C2601/14 , C07H15/00
摘要： Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Francisella tularensis. The present invention provides compounds, methods and compositions effective to treat microbial/bacterial infections, and, especially, infections arising from bacteria which have developed resistance to conventional antibiotics.

5. 发明授权

US09670179B1 Antibiotic compositions and methods of use 有权
公开(公告)号：US09670179B1
公开(公告)日：2017-06-06
申请号：US14208330
申请日：2014-03-13
申请人： Edward Turos , Biplob Bhattacharya
发明人： Edward Turos , Biplob Bhattacharya
IPC分类号： A61K31/397 , C07D401/12
CPC分类号： A61K31/496 , C07D401/12
摘要： Embodiments of the present disclosure provide for compositions including an antibiotic containing a N-thiolated beta-lactam moiety, pharmaceutical compositions including the antibiotic, methods of treatment of a condition (e.g., bacterial infection), methods of treatment using compositions or pharmaceutical compositions, and the like.

6. 发明授权

US09533051B2 Menthol-based nanoparticles for drug delivery 有权
标题翻译：用于药物递送的薄荷醇纳米颗粒
公开(公告)号：US09533051B2
公开(公告)日：2017-01-03
申请号：US14958401
申请日：2015-12-03
申请人： Edward Turos , Faeez Sisan Mahzamani , Ashleigh Brooke Bachman , Kristy Lineth Flores
发明人： Edward Turos , Faeez Sisan Mahzamani , Ashleigh Brooke Bachman , Kristy Lineth Flores
IPC分类号： A61K9/50 , A61K47/32 , A61K31/43 , A61K9/107
CPC分类号： A61K47/32 , A61K9/1075 , A61K9/5138 , A61K31/43
摘要： The subject invention pertains to formulations comprising poly(menthyl acrylate) nanoparticles comprising at least one active ingredient contained in a plurality of hydrophobic carriers and dispersed in an aqueous medium. The subject invention further pertains to methods of polymerization of drug loaded nanoparticles made up of methyl acrylate monomers in an aqueous emulsion.
摘要翻译：本发明涉及包含聚（薄荷基丙烯酸酯）纳米颗粒的制剂，其包含至少一种包含在多个疏水载体中并分散在水性介质中的活性成分。本发明进一步涉及由水性乳液中的丙烯酸甲酯单体组成的负载药物的纳米颗粒的聚合方法。

7. 发明授权

US09512160B2 Antibacterial S-heterosubstituted disulfides 有权
标题翻译：抗菌S-杂取代二硫化物
公开(公告)号：US09512160B2
公开(公告)日：2016-12-06
申请号：US12765272
申请日：2010-04-22
申请人： Edward Turos , Praveen Ramaraju
发明人： Edward Turos , Praveen Ramaraju
IPC分类号： C07H15/00 , C07C321/14 , C07C321/20 , C07C381/00
CPC分类号： A61K31/105 , A61K31/145 , C07C321/14 , C07C321/20 , C07C381/00 , C07C2601/14 , C07H15/00
摘要： Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Francisella tularensis. The present invention provides compounds, methods and compositions effective to treat microbial/bacterial infections, and, especially, infections arising from bacteria which have developed resistance to conventional antibiotics.
摘要翻译：对于各种细菌，包括金黄色葡萄球菌，耐甲氧西林金黄色葡萄球菌和土拉弗朗西斯酵母菌显示出有效的体外抗菌活性的合成衍生的S，S-异二取代二硫化物。本发明提供了有效治疗微生物/细菌感染的化合物，方法和组合物，特别是对已经对常规抗生素产生抗性的细菌产生的感染。

8. 发明授权

US09149440B2 Nanoparticles for drug-delivery 有权
标题翻译：用于药物输送的纳米颗粒
公开(公告)号：US09149440B2
公开(公告)日：2015-10-06
申请号：US10570461
申请日：2004-09-02
申请人： Edward Turos , Jeung-Yeop Shim
发明人： Edward Turos , Jeung-Yeop Shim
IPC分类号： A61K9/50 , A61K9/16 , A61K9/51
CPC分类号： A61K9/5138 , A61K9/5192
摘要： This invention relates to polymeric nanoparticles useful for drug delivery with target molecules bonded to the surface of the particles and having sizes of up to 1000 nm, preferably 1 nm to 400 nm, more preferably 1 nm to 200 nm, that are dispersed homogeneously in aqueous solution. The target drug/target substance is covalently bonded to the novel polymeric nanoparticles to secure them from outer intervention in vivo or cell culture in vitro until they are exposed at the target site within the cell. This invention also relates to microemulsion polymerization techniques useful for preparing the novel nanoparticles.
摘要翻译：本发明涉及用于药物递送的聚合物纳米颗粒，其中靶分子键合到颗粒的表面，并且具有高达1000nm，优选1nm至400nm，更优选1nm至200nm的尺寸，其均匀分散在水性解。目标药物/靶物质共价键合到新型聚合物纳米颗粒上以确保它们在体外免受外部干预或体外细胞培养，直到它们暴露于细胞内的靶位点。本发明还涉及可用于制备新型纳米颗粒的微乳液聚合技术。

9. 发明申请

US20120149911A1 DERIVATIVE N-THIOLATED 2-OXAZOLIDINONE ANTIBIOTICS 失效
标题翻译：衍生的N-巯基2-氧杂环丁烷酮抗生素
公开(公告)号：US20120149911A1
公开(公告)日：2012-06-14
申请号：US12028460
申请日：2008-02-08
申请人： Edward Turos , Rajesh Kumar Mishra
发明人： Edward Turos , Rajesh Kumar Mishra
IPC分类号： C07D263/26
CPC分类号： C07D263/26 , C07D263/52
摘要： This invention describes the discovery and synthesis of N-thiolated 2-oxazolidinones as a new class of anti bacterial agents. These compounds can be synthesized from 2-oxazolidinones by Ndeprotection and N-sulfenylation. These new substances were found to exhibit potent anti-bacterial activity, including bacteriostatic properties against Staphylococcus spp., including methicillin resistant Staphylcoccus aureus (MRSA), and Bacillus spp., including Bacillus anthracis.
摘要翻译：本发明描述了N-硫醇化的2-恶唑烷酮作为新类抗细菌剂的发现和合成。这些化合物可以通过Nd保护和N-亚磺酰化由2-恶唑烷酮合成。发现这些新物质显示出有效的抗细菌活性，包括对葡萄球菌属的抑菌性，包括耐甲氧西林金黄色葡萄球菌（MRSA）和芽孢杆菌属（Bacillus spp。），包括炭疽芽孢杆菌。

10. 发明申请

US20090156654A1 DERIVATIVE N-THIOLATED 2-OXAZOLIDINONE ANTIBIOTICS 审中-公开
标题翻译：衍生的N-巯基2-氧杂环丁烷酮抗生素
公开(公告)号：US20090156654A1
公开(公告)日：2009-06-18
申请号：US12339174
申请日：2008-12-19
申请人： Edward Turos , Rajesh Kumar Mishra
发明人： Edward Turos , Rajesh Kumar Mishra
IPC分类号： A61K31/421 , A61P31/04
CPC分类号： C07D263/26 , C07D263/52
摘要： This invention describes the discovery and synthesis of N-thiolated 2-oxazolidinones as a new class of anti bacterial agents. These compounds can be synthesized from 2-oxazolidinones by Ndeprotection and N-sulfenylation. These new substances were found to exhibit potent anti-bacterial activity, including bacteriostatic properties against Staphylococcus spp., including methicillin resistant Staphylococcus aureus (MRSA), and Bacillus spp., including Bacillus anthracis.
摘要翻译：本发明描述了N-硫醇化的2-恶唑烷酮作为新类抗细菌剂的发现和合成。这些化合物可以通过Nd保护和N-亚磺酰化由2-恶唑烷酮合成。发现这些新物质显示出有效的抗细菌活性，包括对葡萄球菌属的抑菌性，包括耐甲氧西林金黄色葡萄球菌（MRSA）和芽孢杆菌属（Bacillus spp。），包括炭疽芽孢杆菌。

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