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1. 发明申请

US20120203307A1 METHOD AND DEVICE FOR TREATING ABNORMAL TISSUE GROWTH WITH ELECTRICAL THERAPY 有权
标题翻译：用电疗法治疗异常组织生长的方法和装置
公开(公告)号：US20120203307A1
公开(公告)日：2012-08-09
申请号：US13226319
申请日：2011-09-06
申请人： Edward A. Schroeppel , Mark W. Kroll , Kai Kroll
发明人： Edward A. Schroeppel , Mark W. Kroll , Kai Kroll
IPC分类号： A61N1/08
CPC分类号： A61N1/326 , A61K47/6957 , A61N1/205 , A61N1/30
摘要： This invention relates generally to the electrical treatment of malignant tumors and neoplasms by applying a voltage to affected tissue. Devices and various adaptations therein are described for use in electrical therapy. Additionally, various chemotherapeutic agent and radiation therapies are described which may be advantageously used in conjunction with electrical therapy to ameliorate cancer.
摘要翻译：本发明一般涉及通过向受影响的组织施加电压来恶性肿瘤和肿瘤的电处理。描述了其中的装置和各种适应性用于电疗法。另外，描述了可以有利地与电疗法一起使用以改善癌症的各种化学治疗剂和放射疗法。

2. 发明授权

US07412285B2 Method and device for treating cancer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy 有权
标题翻译：用化学疗法和放射治疗联合电疗治疗癌症的方法和装置
公开(公告)号：US07412285B2
公开(公告)日：2008-08-12
申请号：US10434400
申请日：2003-05-07
申请人： Edward A. Schroeppel , Mark W. Kroll , Kai Kroll
发明人： Edward A. Schroeppel , Mark W. Kroll , Kai Kroll
IPC分类号： A61N1/00
CPC分类号： A61N1/326 , A61K47/6957 , A61N1/205 , A61N1/30
摘要： This invention relates generally to the electrical treatment of malignant tumors and neoplasms by applying a voltage to affected tissue. Devices and various adaptations therein are described for use in electrical therapy. Additionally, various chemotherapeutic agent and radiation therapies are described which may be advantageously used in conjunction with electrical therapy to ameliorate cancer.
摘要翻译：本发明一般涉及通过向受影响的组织施加电压来恶性肿瘤和肿瘤的电处理。描述了其中的装置和各种适应性用于电疗法。另外，描述了可以有利地与电疗法一起使用以改善癌症的各种化学治疗剂和放射疗法。

3. 发明授权

US06738663B2 Implantable device and method for the electrical treatment of cancer 失效
标题翻译：用于电疗治疗癌症的植入装置和方法
公开(公告)号：US06738663B2
公开(公告)日：2004-05-18
申请号：US09974474
申请日：2001-12-14
申请人： Edward A. Schroeppel , Mark W. Kroll
发明人： Edward A. Schroeppel , Mark W. Kroll
IPC分类号： A61N100
CPC分类号： A61N1/326 , A61K47/6957 , A61N1/05 , A61N1/0502 , A61N1/205 , A61N1/30 , A61N1/403
摘要： An implantable electrical method and apparatus for the treatment of cancer tumors based on the usage of various levels of electrical fields and current to assist in specific ways to reduce tumor size. The appropriate voltage, currents, and time duration as well as the usage of adjunctive pharmacological therapy are taught.
摘要翻译：一种用于根据各种水平的电场和电流的使用治疗癌症肿瘤的可植入电气方法和装置，以帮助以具体方式减少肿瘤大小。教授适当的电压，电流和持续时间以及辅助药物治疗的使用。

4. 发明授权

US06571121B2 Implantable medical device responsive to heart rate variability analysis 失效
公开(公告)号：US06571121B2
公开(公告)日：2003-05-27
申请号：US09978848
申请日：2001-10-15
申请人： Edward A. Schroeppel , David Prutchi , André G. Routh
发明人： Edward A. Schroeppel , David Prutchi , André G. Routh
IPC分类号： A61B50402
CPC分类号： A61B5/02405 , A61N1/3622 , A61N1/3627 , A61N1/36585 , A61N1/36592 , A61N1/3962
摘要： A method and apparatus for evaluating heart rate variability of the heart of a person in order to forecast a cardiac event. A cardiac stimulator receives heart beat signals from the heart and determines a measurement of heart rate variability based on statistical data derived from the heart beat signals and sensing data derived from a sensor. This measurement of heart rate variability is compared with previously stored heart rate variability zones defining normal and abnormal heart rate variability. These zones are modifiable after the occurrence of a cardiac event. Once a cardiac event is detected, a pathway is computed which extends from a generally normal heart rate variability condition to an abnormal heart rate variability condition. Subsequent measurements of heart rate variability are compared with this pathway. Selective therapy regimes are initiated depending on the measurement of heart rate variability.

5. 发明授权

US5871532A Epicardial lead for minimally invasive implantation 失效
标题翻译：用于微创植入的心外膜导联
公开(公告)号：US5871532A
公开(公告)日：1999-02-16
申请号：US861643
申请日：1997-05-22
申请人： Edward A. Schroeppel
发明人： Edward A. Schroeppel
IPC分类号： A61N1/05 , A61N1/00
CPC分类号： A61N1/0587 , A61N1/0573 , A61N2001/0578 , A61N2001/058
摘要： A lead assembly for fixation to a human heart via thoracoscopy is provided. The lead assembly includes a lead that has a connector for connection to a cardiac stimulator, such as a pacemaker, a cardioverter/defibrillator, or a sensing instrument. A fixation mechanism is coupled to the lead that includes a tubular housing and a proximally projecting hook that is adapted to engage heart tissue. The hook is pivotable between a retracted position and an extended position. The lead and the hook are manipulated by a stylet. The lead assembly also includes a tubular introducer that is passed through the chest wall of a patient and used to place the lead proximate the epicardium.
摘要翻译：提供了通过胸腔镜检查将人体心脏固定的引导组件。引线组件包括具有用于连接到心脏刺激器的连接器的引线，例如起搏器，心律转复器/除颤器或感测器械。固定机构联接到引线，引线包括管状壳体和适于接合心脏组织的近端突出的钩。钩可在缩回位置和伸出位置之间枢转。导针和钩子由探针管操纵。引导组件还包括穿过患者胸壁的管状引导器，并用于将引线放置在靠近心外膜的位置。

6. 发明授权

US5755764A Implantable cardiac stimulation catheter 失效
标题翻译：可植入心脏刺激导管
公开(公告)号：US5755764A
公开(公告)日：1998-05-26
申请号：US710049
申请日：1996-09-10
申请人： Edward A. Schroeppel
发明人： Edward A. Schroeppel
IPC分类号： A61N1/05
CPC分类号： A61N1/0573 , A61N1/056
摘要： An implantable cardiac stimulation catheter includes a helical electrode segment disposed about a central core of electrically non-conductive material for delivering an electrical pulse to the heart of the patient. The catheter may include a tubular electrode segment disposed on the catheter and electrically connected with the helical electrode. The helical and tubular electrode segments may be defibrillation electrode segments. The catheter may also include a demand pacer electrode for delivering a demand pacing pulse to the heart and/or a fixation mechanism for securing the catheter within the patient's heart.
摘要翻译：可植入心脏刺激导管包括围绕电导体材料的中心芯设置的螺旋电极段，用于将电脉冲传送到患者的心脏。导管可包括设置在导管上并与螺旋电极电连接的管状电极段。螺旋和管状电极段可以是除颤电极段。导管还可以包括用于将需求起搏脉冲递送到心脏的需求起搏器电极和/或用于将导管固定在患者心脏内的固定机构。

7. 发明授权

US5228437A Cardiac pacemaker and method for detecting cardiac signals 失效
标题翻译： CARDIAC PACEMAKER和检测心脏信号的方法
公开(公告)号：US5228437A
公开(公告)日：1993-07-20
申请号：US696160
申请日：1991-05-06
申请人： Edward A. Schroeppel
发明人： Edward A. Schroeppel
IPC分类号： A61N1/362 , A61N1/365 , A61N1/37
CPC分类号： A61N1/365
摘要： An apparatus for detecting an electrical potential in a human body to control the delivery of a therapy. The electrical potential comprises a principal signal and a baseline signal. The apparatus samples the potential through an electrode during a selected interval and stores the value of that potential at the end of the interval. The stored value of the potential will be restored as an initial condition on the electrode at the end of a second interval after delivery of the therapy. In a heart pacemaker, the baseline signal is useful for controlling the output pulses of the pacemaker. The apparatus permits sensing of the baseline signal despite stimulating pulses and charge canceling.
摘要翻译：一种用于检测人体中的电位以控制治疗的递送的装置。电位包括主信号和基线信号。该设备在选定的间隔期间通过电极对电位进行采样，并将该电位的值存储在间隔结束处。存储的电位值将在输送治疗后的第二间隔结束时恢复为电极上的初始状态。在心脏起搏器中，基线信号可用于控制起搏器的输出脉冲。该装置允许感测基线信号，尽管刺激脉冲和电荷消除。

8. 发明授权

US4766902A Automatic sensitivity control for cardiac pacer 失效
标题翻译：心脏起搏器的自动灵敏度控制
公开(公告)号：US4766902A
公开(公告)日：1988-08-30
申请号：US870398
申请日：1986-06-04
申请人： Edward A. Schroeppel
发明人： Edward A. Schroeppel
IPC分类号： A61N1/37 , A61N1/36
CPC分类号： A61N1/3704
摘要： A cardiac pacer is provided which includes a pulse generator for providing pacing pulses and an electrical lead for connection to a chamber of the heart. A pair of separate sensing amplifiers sense selected activity of the heart chamber. One of the sensing amplifiers has a slightly lower threshold and thus a slightly higher sensitivity level than the other sensing amplifier. The thresholds of the respective sensing amplifiers are automatically adjusted so that the first sensing amplifier will sense the selected activity of the heart chamber and the other sensing amplifier will not sense the selected activity.
摘要翻译：提供了一种心搏器，其包括用于提供起搏脉冲的脉冲发生器和用于连接到心脏室的电引线。一对单独的感测放大器感测心室的选定活动。感测放大器中的一个具有稍低的阈值，因此比另一个感测放大器稍高的灵敏度水平。自动调整各个感测放大器的阈值，使得第一感测放大器将感测心室的所选择的活动，而另一感测放大器将不会感测所选择的活动。

9. 发明申请

US20080147134A1 METHODS AND APPARATUS FOR TREATING FIBRILLATION AND CREATING DEFIBRILLATION WAVEFORMS 有权
标题翻译：用于治疗畸形和创建畸形波的方法和装置
公开(公告)号：US20080147134A1
公开(公告)日：2008-06-19
申请号：US12035369
申请日：2008-02-21
申请人： Leo Rubin , Christopher A. Bonnerup , Edward A. Schroeppel
发明人： Leo Rubin , Christopher A. Bonnerup , Edward A. Schroeppel
IPC分类号： A61N1/39
CPC分类号： A61N1/3906 , A61N1/3956
摘要： Methods and apparatus for treating fibrillation utilize biphasic waveforms. A cardiac stimulator includes a defibrillation circuit that uses a pulse width modulated capacitive discharge to generate various biphasic waveforms, one or more of which may be delivered to the heart to treat the fibrillation.
摘要翻译：用于治疗纤维性颤动的方法和装置利用双相波形。心脏刺激器包括使用脉冲宽度调制的电容放电产生各种双相波形的除颤电路，其中的一个或多个可被传送到心脏以治疗纤维性颤动。

10. 发明授权

US06571122B2 Implantable medical device responsive to heart rate variability analysis 失效
公开(公告)号：US06571122B2
公开(公告)日：2003-05-27
申请号：US09978855
申请日：2001-10-15
申请人： Edward A. Schroeppel , David Prutchi , André G. Routh
发明人： Edward A. Schroeppel , David Prutchi , André G. Routh
IPC分类号： A61N1365
CPC分类号： A61B5/02405 , A61N1/3622 , A61N1/3627 , A61N1/36585 , A61N1/36592 , A61N1/3962
摘要： A method and apparatus for evaluating heart rate variability of the heart of a person in order to forecast a cardiac event. A cardiac stimulator receives heart beat signals from the heart and determines a measurement of heart rate variability based on statistical data derived from the heart beat signals and sensing data derived from a sensor. This measurement of heart rate variability is compared with previously stored heart rate variability zones defining normal and abnormal heart rate variability. These zones are modifiable after the occurrence of a cardiac event. Once a cardiac event is detected, a pathway is computed which extends from a generally normal heart rate variability condition to an abnormal heart rate variability condition. Subsequent measurements of heart rate variability are compared with this pathway. Selective therapy regimes are initiated depending on the measurement of heart rate variability.

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