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    • 4. 发明授权
    • Cytochrome P450 genetic variations
    • 细胞色素P450遗传变异
    • US07195877B2
    • 2007-03-27
    • US10712363
    • 2003-11-12
    • Elliott P. Dawson
    • Elliott P. Dawson
    • C12Q1/68C12P19/34C07H21/04
    • C12Q1/6876C07H21/04C12Q2600/156
    • A primer set used to screen a polynucleotide sample to detect and identify variants in the Cytochrome P450 isoenzyme 2D6 (CYP2D6) gene. A method of screening a polynucleotide sample to detect and identify the presence of one or more than one variant in the CYP2D6 gene in the sample. A method of predicting the potential for altered metabolism of a substance, including one or more than one pharmaceutical drug, by a first individual compared to a second control individual, where the substance is metabolized by the CYP2D6 isoenzyme, and where the second control individual is homozygous for the wild type allele of the CYP2D6*1, SEQ ID NO:1. A method of screening a population to detect and identify the presence of one or more than one variant in the CYP2D6 gene. A purified or isolated variant of SEQ ID NO:1. A purified or isolated variant of SEQ ID NO:3.
    • 用于筛选多聚核苷酸样品以检测和鉴定细胞色素P450同工酶2D6(CYP2D6)基因中的变体的引物组。 筛选多核苷酸样品以检测和鉴定样品中CYP2D6基因中一种或多于一种变体的存在的方法。 一种预测第一个体与第二个对照个体相比物质(包括一种或多于一种药物)的代谢改变潜力的方法,其中该物质被CYP2D6同工酶代谢,而第二个对照个体为 对于CYP2D6 * 1,SEQ ID NO:1的野生型等位基因是纯合的。 筛选群体以检测和鉴定CYP2D6基因中一种或多于一种变体的存在的方法。 SEQ ID NO:1的纯化或分离的变体。 SEQ ID NO:3的纯化或分离的变体。