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1. 发明公开

US20240139523A9 SYSTEMS, DEVICES, AND METHODS FOR ELECTROMECHANICAL SENSING AND MAPPING 有权
公开(公告)号：US20240139523A9
公开(公告)日：2024-05-02
申请号：US17863735
申请日：2022-07-13
申请人： EBR Systems, Inc.
发明人： N. Parker Willis
IPC分类号： A61N1/365 , A61N1/02 , A61N1/372
CPC分类号： A61N1/36578 , A61N1/025 , A61N1/37217 , A61B5/1102
摘要： Systems, devices, and methods for tracking and determining the motion of a cardiac implant is disclosed. The motion of the implant is determined by transmitting acoustic energy to a tissue location using an acoustic controller-transmitter comprising an array of acoustic transducers; wherein the implant is configured to convert the transmitted acoustic energy to electrical energy; and the tracking is achieved by determining the electrical energy delivered to the tissue throughout one or more cardiac cycles in order to create a motion profile of the cardiac implant.

2. 发明公开

US20240075303A1 SYSTEMS AND METHODS FOR DIRECT VISUALIZATION OF A TISSUE LOCATION, SUCH AS AN ENDOCARDIAL LOCATION 审中-公开
公开(公告)号：US20240075303A1
公开(公告)日：2024-03-07
申请号：US18240939
申请日：2023-08-31
申请人： EBR Systems, Inc.
发明人： Nathaniel Parker Willis
IPC分类号： A61N1/372 , G06T1/00
CPC分类号： A61N1/372 , G06T1/0007 , G06T2207/30004
摘要： The present technology is generally directed to delivery systems for medical implants, such as stimulation assemblies for stimulating tissue of a human patent, and associated methods. In some embodiments, a delivery system includes (i) an elongate sheath having a distal portion with a distal opening, (ii) an attachment mechanism positioned within the elongate sheath and configured to be releasably coupled to an electrical stimulation implant, and (iii) an elongate optical component movably positioned within the elongate sheath. The optical component is configured to capture image data, and is movable from a first configuration to a second configuration. In the first configuration, the optical component is positioned proximally of the implant. In the second configuration, the optical component is positioned at least partially adjacent to the implant to capture image data proximate the distal opening, thereby facilitating direct visualization of a target location for implantation of the implant.

3. 发明公开

US20240017079A1 IMPLANTABLE WIRELESS ACOUSTIC STIMULATORS WITH HIGH ENERGY CONVERSION EFFICIENCIES 审中-公开
公开(公告)号：US20240017079A1
公开(公告)日：2024-01-18
申请号：US18331781
申请日：2023-06-08
申请人： EBR Systems, Inc.
发明人： David F. Moore , Paul Mohr , Nathaniel Parker Willis , Axel F. Brisken
IPC分类号： A61N1/378 , A61N1/375 , A61N1/362 , A61N1/372 , H02N2/18 , H10N30/03 , H10N30/30 , A61N1/02 , A61N1/05
CPC分类号： A61N1/3787 , A61N1/3758 , A61N1/3756 , A61N1/362 , A61N1/37205 , H02N2/181 , H02N2/186 , H02N2/188 , H10N30/03 , H10N30/30 , A61N1/02 , A61N1/05 , Y10T29/42 , A61B2560/0214
摘要： A controller-transmitter transmits acoustic energy through the body to an implanted acoustic receiver-stimulator. The receiver-stimulator converts the acoustic energy into electrical energy and delivers the electrical energy to tissue using an electrode assembly. The receiver-stimulator limits the output voltage delivered to the tissue to a predetermined maximum output voltage. In the presence of interfering acoustic energy sources output voltages are thereby limited prior to being delivered to the tissue.

4. 发明授权

US11752352B2 Temporary electrode connection for wireless pacing systems 有权
公开(公告)号：US11752352B2
公开(公告)日：2023-09-12
申请号：US16879530
申请日：2020-05-20
申请人： EBR Systems, Inc.
发明人： David F. Moore , Mark W. Cowan , Nathaniel Parker Willis
IPC分类号： A61N1/378 , A61N1/372 , A61N1/375 , A61N1/362 , A61B5/283 , A61N1/37 , A61B17/34
CPC分类号： A61N1/3787 , A61B5/283 , A61N1/362 , A61N1/3702 , A61N1/3756 , A61N1/37205 , A61B17/3468 , A61N1/37223
摘要： Delivery of an implantable wireless receiver-stimulator (R-S) into the heart using delivery catheter is described. R-S comprises a cathode and an anode and wirelessly receives and converts energy, such as acoustic ultrasound energy, to electrical energy to stimulate the heart. Conductive wires routed through the delivery system temporarily connect R-S electrodes to external monitor and pacing controller. R-S comprises a first temporary electrical connection from the catheter to the cathode, and a second temporary electrical connection from the catheter to the anode. Temporary electrical connections allow external monitoring of heart's electrical activity as sensed by R-S electrodes to determine tissue viability for excitation as well as to assess energy conversion efficiency.

5. 发明申请

US20200179704A1 SYSTEMS, DEVICES, AND METHODS FOR ELECTROMECHANICAL SENSING AND MAPPING 审中-公开
公开(公告)号：US20200179704A1
公开(公告)日：2020-06-11
申请号：US16637130
申请日：2018-08-01
申请人： EBR Systems, Inc.
发明人： N. Parker Willis
IPC分类号： A61N1/365 , A61N1/372 , A61N1/02
摘要： Systems, devices, and methods for tracking and determining the motion of a cardiac implant is disclosed. The motion of the implant is determined by transmitting acoustic energy to a tissue location using an acoustic controller-transmitter comprising an array of acoustic transducers; wherein the implant is configured to convert the transmitted acoustic energy to electrical energy; and the tracking is achieved by determining the electrical energy delivered to the tissue throughout one or more cardiac cycles in order to create a motion profile of the cardiac implant.

6. 发明申请

US20190151667A1 IMPLANTABLE WIRELESS ACCOUSTIC STIMULATORS WITH HIGH ENERGY CONVERSION EFFICIENCIES 审中-公开
公开(公告)号：US20190151667A1
公开(公告)日：2019-05-23
申请号：US16250943
申请日：2019-01-17
申请人： EBR Systems, Inc.
发明人： David F. Moore , Paul Mohr , N. Parker Willis , Axel F. Brisken
IPC分类号： A61N1/378 , A61N1/375 , A61N1/05 , A61N1/372 , A61N1/362 , H01L41/25 , H02N2/18 , A61N1/02 , H01L41/113
CPC分类号： A61B2560/0214 , A61N1/02 , A61N1/05 , A61N1/362 , A61N1/37205 , A61N1/3756 , A61N1/3758 , A61N1/3787 , H01L41/113 , H01L41/25 , H02N2/181 , H02N2/186 , H02N2/188 , Y10T29/42
摘要： A controller-transmitter transmits acoustic energy through the body to an implanted acoustic receiver-stimulator. The receiver-stimulator converts the acoustic energy into electrical energy and delivers the electrical energy to tissue using an electrode assembly. The receiver-stimulator limits the output voltage delivered to the tissue to a predetermined maximum output voltage. In the presence of interfering acoustic energy sources output voltages are thereby limited prior to being delivered to the tissue.Furthermore, the controller-transmitter estimates the output voltage that is delivered to the tissue by the implanted receiver-stimulator. The controller-transmitter measures a query spike voltage resulting from the electrical energy delivered to the tissue by the receiver-stimulator, and computes a ratio of the predetermined maximum output voltage and a maximum query spike voltage. The maximum query spike voltage is computed by detecting a query spike voltage plateau. Based on this ratio, the controller-transmitter uses a measured query spike voltage to estimate the output voltage delivered by the receiver-stimulator to tissue.

7. 发明授权

US10080903B2 Optimizing energy transmission in a leadless tissue stimulation system 有权
公开(公告)号：US10080903B2
公开(公告)日：2018-09-25
申请号：US14221040
申请日：2014-03-20
申请人： EBR Systems, Inc.
发明人： N. Parker Willis , Axel F. Brisken , Mark W. Cowan , Michael Pare , Robert Fowler , James Brennan
IPC分类号： A61N1/378 , A61N1/372 , A61N1/375
CPC分类号： A61N1/3787 , A61N1/37217 , A61N1/37235 , A61N1/3756
摘要： Method and systems for optimizing acoustic energy transmission in implantable devices are disclosed. Transducer elements transmit acoustic locator signals towards a receiver assembly, and the receiver responds with a location signal. The location signal can reveal information related to the location of the receiver and the efficiency of the transmitted acoustic beam received by the receiver. This information enables the transmitter to target the receiver and optimize the acoustic energy transfer between the transmitter and the receiver. The energy can be used for therapeutic purposes, for example, stimulating tissue or for diagnostic purposes.

8. 发明申请

US20160114176A1 LOCAL LEAD TO IMPROVE ENERGY EFFICIENCY IN IMPLANTABLE WIRELESS ACOUSTIC STIMULATORS 有权
标题翻译：本地领先提高可伸缩无线呼吸刺激仪的能量效率
公开(公告)号：US20160114176A1
公开(公告)日：2016-04-28
申请号：US14979359
申请日：2015-12-22
申请人： EBR Systems, Inc.
发明人： Nathanial P. Willis , Richard E. Riley , Mark W. Cowan
IPC分类号： A61N1/372 , A61N1/05 , A61N1/362
CPC分类号： A61N1/37217 , A61N1/056 , A61N1/0587 , A61N1/362 , A61N1/3684 , A61N1/37205 , A61N1/3756 , A61N1/3787
摘要： A wireless cardiac stimulation device is disclosed comprising a controller-transmitter, a receiver, and a stimulating electrode, wherein the stimulating electrode and the receiver are separately implantable at cardiac tissue locations of the heart and are connected by a local lead. Having separately implantable receiver and stimulating electrodes improves the efficiency of ultrasound mediated wireless stimulation by allowing the receiver to be placed optimally for reception efficiency, thereby resulting in longer battery life, and by allowing the stimulating electrode to be placed optimally for stimulus delivery. Another advantage is a reduced risk of embolization, since the receiver and stimulating electrode ensemble is attached at two locations of the heart wall, with the connecting local leads serving as a safety tether should either the receiver or the stimulating electrode become dislodged.
摘要翻译：公开了一种无线心脏刺激装置，其包括控制器发射器，接收器和刺激电极，其中刺激电极和接收器可分别植入心脏的心脏组织位置并且通过局部引线连接。具有单独可植入的接收器和刺激电极通过允许接收器最佳地放置接收效率来提高超声介导的无线刺激的效率，从而导致更长的电池寿命，并且通过允许刺激电极被最优地放置用于刺激递送。另一个优点是降低了栓塞的风险，因为接收器和刺激电极组合附接在心脏壁的两个位置处，连接的局部引线作为安全系绳应该被接收器或刺激电极移开。

9. 发明申请

US20130282070A1 SYSTEMS AND METHODS FOR IMPLANTABLE LEADLESS TISSUE STIMULATION 有权
标题翻译：无牵引组织刺激的系统和方法
公开(公告)号：US20130282070A1
公开(公告)日：2013-10-24
申请号：US13922937
申请日：2013-06-20
申请人： EBR Systems, Inc.
发明人： Mark W. Cowan , Richard E. Riley , Axel F. Brisken , Debra S. Echt
IPC分类号： A61N1/36
CPC分类号： A61N1/3787 , A61N1/326 , A61N1/36 , A61N1/36007 , A61N1/36021 , A61N1/36036 , A61N1/3604 , A61N1/36071 , A61N1/37217 , A61N1/37288 , A61N1/3756
摘要： Systems and methods are disclosed to stimulate tissue to treat medical conditions involving tissues such as the bone, spine, stomach, nerves, brain and the cochlea. The disclosed invention uses electrical stimulation of the tissue, where vibrational (or acoustic) energy from a source is received by an implanted device and converted to electrical energy and the converted electrical energy is used by implanted electrodes to stimulate the pre-determined tissue sites. The vibrational energy is generated by a controller-transmitter, which could be either implanted or located externally. The vibrational energy is received by a receiver-stimulator, which could be located at or close to the stimulation site.
摘要翻译：公开了系统和方法来刺激组织以治疗涉及诸如骨骼，脊椎，胃，神经，脑和耳蜗的组织的医学状况。所公开的发明使用组织的电刺激，其中来自源的振动（或声学）能量被注入的装置接收并转换成电能，并且转换的电能被注入的电极用于刺激预定的组织部位。振动能量由控制器 - 发射器产生，其可以被植入或位于外部。振动能量由接收器刺激器接收，其可以位于或靠近刺激部位。

10. 发明授权

US11712572B2 Implantable wireless acoustic stimulators with high energy conversion efficiencies 有权
公开(公告)号：US11712572B2
公开(公告)日：2023-08-01
申请号：US17030846
申请日：2020-09-24
申请人： EBR Systems, Inc.
发明人： David F. Moore , Paul Mohr , N. Parker Willis , Axel F. Brisken
IPC分类号： A61N1/362 , A61N1/378 , A61N1/375 , A61N1/372 , H02N2/18 , H10N30/03 , H10N30/30 , A61N1/02 , A61N1/05
CPC分类号： A61N1/3787 , A61N1/02 , A61N1/05 , A61N1/362 , A61N1/3756 , A61N1/3758 , A61N1/37205 , H02N2/181 , H02N2/186 , H02N2/188 , H10N30/03 , H10N30/30 , A61B2560/0214 , Y10T29/42
摘要： A controller-transmitter transmits acoustic energy through the body to an implanted acoustic receiver-stimulator. The receiver-stimulator converts the acoustic energy into electrical energy and delivers the electrical energy to tissue using an electrode assembly. The receiver-stimulator limits the output voltage delivered to the tissue to a predetermined maximum output voltage. In the presence of interfering acoustic energy sources output voltages are thereby limited prior to being delivered to the tissue.

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