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1. 发明申请

US20120015375A1 MCM6 AND MCM7 MONOCLONAL ANTIBODIES AND METHODS FOR THEIR USE IN THE DETECTION OF CERVICAL DISEASE 有权
标题翻译： MCM6和MCM7单克隆抗体及其用于检测宫颈疾病的方法
公开(公告)号：US20120015375A1
公开(公告)日：2012-01-19
申请号：US13247614
申请日：2011-09-28
申请人： Douglas P. Malinowski , Timothy J. Fischer , Adriann J. Taylor
发明人： Douglas P. Malinowski , Timothy J. Fischer , Adriann J. Taylor
IPC分类号： G01N33/577
CPC分类号： C07K16/3069 , C07K14/4738 , C07K16/40 , C07K2317/34 , C12Q1/001 , G01N33/57411
摘要： Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM6 or MCM7. Monoclonal antibodies having the binding characteristics of an MCM6 or MCM7 antibody of the invention are further provided. Hybridoma cell lines that produce an MCM6 or MCM7 monoclonal antibody of the invention are also disclosed herein. The compositions find use in practicing methods for diagnosing high-grade cervical disease comprising detecting overexpression of MCM6, MCM7, or both MCM6 and MCM7 in a cervical sample from a patient. Kits for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for an MCM6 or an MCM7 epitope and methods of using these polypeptides in the production of antibodies are also encompassed by the present invention.
摘要翻译：提供用于诊断患者样本中高级宫颈疾病的组成和方法。组合物包括特异性结合MCM6或MCM7的新单克隆抗体及其变体和片段。进一步提供具有本发明的MCM6或MCM7抗体的结合特征的单克隆抗体。产生本发明的MCM6或MCM7单克隆抗体的杂交瘤细胞系也在本文中公开。该组合物用于诊断高级宫颈疾病的实践方法，包括检测来自患者的子宫颈样品中MCM6，MCM7或MCM6和MCM7两者的过表达。还提供了用于实施本发明的方法的试剂盒。包含MCM6或MCM7表位的氨基酸序列的多肽和在产生抗体中使用这些多肽的方法也包括在本发明中。

2. 发明申请

US20090317826A1 MONOCLONAL ANTIBODIES AND METHODS FOR THEIR USE IN THE DETECTION OF CERVICAL DISEASE 有权
标题翻译：用于检测宫颈疾病的单克隆抗体及其使用方法
公开(公告)号：US20090317826A1
公开(公告)日：2009-12-24
申请号：US12545738
申请日：2009-08-21
申请人： Douglas P. Malinowski , Timothy J. Fischer , Adriann J. Taylor
发明人： Douglas P. Malinowski , Timothy J. Fischer , Adriann J. Taylor
IPC分类号： G01N33/53
CPC分类号： G01N33/57411 , C07K14/4738 , C07K16/3069 , C07K2317/34
摘要： Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM2. Monoclonal antibodies having the binding characteristics of an MCM2 antibody of the invention are further provided. Hybridoma cell lines that produce an MCM2 monoclonal antibody of the invention are also disclosed herein. The compositions find use in practicing methods for diagnosing high-grade cervical disease comprising detecting overexpression of MCM2 in a cervical sample from a patient. Kits for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for an MCM2 epitope and methods of using these polypeptides in the production of antibodies are also encompassed by the present invention.
摘要翻译：提供用于诊断患者样本中高级宫颈疾病的组成和方法。组合物包括特异性结合MCM2的新单克隆抗体及其变体和片段。还提供具有本发明的MCM2抗体的结合特征的单克隆抗体。产生本发明的MCM2单克隆抗体的杂交瘤细胞系也在本文中公开。该组合物用于诊断高级宫颈疾病的实践方法，包括检测来自患者的子宫颈样品中MCM2的过表达。还提供了用于实施本发明的方法的试剂盒。包含MCM2表位的氨基酸序列的多肽和在产生抗体中使用这些多肽的方法也包括在本发明中。

3. 发明授权

US07632498B2 MCM6 and MCM7 monoclonal antibodies and methods for their use in the detection of cervical disease 有权
标题翻译： MCM6和MCM7单克隆抗体及其用于检测宫颈疾病的方法
公开(公告)号：US07632498B2
公开(公告)日：2009-12-15
申请号：US11501391
申请日：2006-08-09
申请人： Douglas P. Malinowski , Timothy J. Fischer , Adriann J. Taylor
发明人： Douglas P. Malinowski , Timothy J. Fischer , Adriann J. Taylor
IPC分类号： A61K39/395 , C12N5/06 , G01N33/574
CPC分类号： C07K16/3069 , C07K14/4738 , C07K16/40 , C07K2317/34 , C12Q1/001 , G01N33/57411
摘要： Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM6 or MCM7. Monoclonal antibodies having the binding characteristics of an MCM6 or MCM7 antibody of the invention are further provided. Hybridoma cell lines that produce an MCM6 or MCM7 monoclonal antibody of the invention are also disclosed herein. The compositions find use in practicing methods for diagnosing high-grade cervical disease comprising detecting overexpression of MCM6, MCM7, or both MCM6 and MCM7 in a cervical sample from a patient. Kits for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for an MCM6 or an MCM7 epitope and methods of using these polypeptides in the production of antibodies are also encompassed by the present invention.
摘要翻译：提供用于诊断患者样本中高级宫颈疾病的组成和方法。组合物包括特异性结合MCM6或MCM7的新单克隆抗体及其变体和片段。进一步提供具有本发明的MCM6或MCM7抗体的结合特征的单克隆抗体。产生本发明的MCM6或MCM7单克隆抗体的杂交瘤细胞系也在本文中公开。该组合物用于诊断高级宫颈疾病的实践方法，包括检测来自患者的子宫颈样品中MCM6，MCM7或MCM6和MCM7两者的过表达。还提供了用于实施本发明的方法的试剂盒。包含MCM6或MCM7表位的氨基酸序列的多肽和在产生抗体中使用这些多肽的方法也包括在本发明中。

4. 发明授权

US07157233B2 Methods and compositions for the detection of cervical disease 有权
公开(公告)号：US07157233B2
公开(公告)日：2007-01-02
申请号：US11087227
申请日：2005-03-23
申请人： Timothy J. Fischer , Douglas P. Malinowski , Adriann J. Taylor , Margaret R. Parker
发明人： Timothy J. Fischer , Douglas P. Malinowski , Adriann J. Taylor , Margaret R. Parker
IPC分类号： C12Q1/68
CPC分类号： G01N33/57411 , C07K16/3069 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/6875 , G01N2333/025
摘要： Methods and compositions for identifying high-grade cervical disease in a patient sample are provided. The methods of the invention comprise detecting overexpression of at least one biomarker in a body sample, wherein the biomarker is selectively overexpressed in high-grade cervical disease. In particular claims, the body sample is a cervical smear or monolayer of cervical cells. The biomarkers of the invention include genes and proteins that are involved in cell cycle regulation, signal transduction, and DNA replication and transcription. In particular claims, the biomarker is an S-phase gene. In some aspects of the invention, overexpression of a biomarker of interest is detected at the protein level using biomarker-specific antibodies or at the nucleic acid level using nucleic acid hybridization techniques. Kits for practicing the methods of the invention are further provided.

5. 发明授权

US08372591B2 MCM6 and MCM7 monoclonal antibodies and methods for their use in the detection of cervical disease 有权
公开(公告)号：US08372591B2
公开(公告)日：2013-02-12
申请号：US13247614
申请日：2011-09-28
申请人： Douglas P. Malinowski , Timothy J. Fischer , Adriann J. Taylor
发明人： Douglas P. Malinowski , Timothy J. Fischer , Adriann J. Taylor
IPC分类号： G01N33/577
CPC分类号： C07K16/3069 , C07K14/4738 , C07K16/40 , C07K2317/34 , C12Q1/001 , G01N33/57411
摘要： Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM6 or MCM7. Monoclonal antibodies having the binding characteristics of an MCM6 or MCM7 antibody of the invention are further provided. Hybridoma cell lines that produce an MCM6 or MCM7 monoclonal antibody of the invention are also disclosed herein. The compositions find use in practicing methods for diagnosing high-grade cervical disease comprising detecting overexpression of MCM6, MCM7, or both MCM6 and MCM7 in a cervical sample from a patient. Kits for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for an MCM6 or an MCM7 epitope and methods of using these polypeptides in the production of antibodies are also encompassed by the present invention.

6. 发明授权

US08076093B2 Monoclonal antibodies and methods for their use in the detection of cervical disease 有权
标题翻译：单克隆抗体及其用于检测宫颈疾病的方法
公开(公告)号：US08076093B2
公开(公告)日：2011-12-13
申请号：US12545738
申请日：2009-08-21
申请人： Douglas P. Malinowski , Timothy J. Fischer , Adriann J. Taylor
发明人： Douglas P. Malinowski , Timothy J. Fischer , Adriann J. Taylor
IPC分类号： G01N33/53
CPC分类号： G01N33/57411 , C07K14/4738 , C07K16/3069 , C07K2317/34
摘要： Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM2. Monoclonal antibodies having the binding characteristics of an MCM2 antibody of the invention are further provided. Hybridoma cell lines that produce an MCM2 monoclonal antibody of the invention are also disclosed herein. The compositions find use in practicing methods for diagnosing high-grade cervical disease comprising detecting overexpression of MCM2 in a cervical sample from a patient. Kits for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for an MCM2 epitope and methods of using these polypeptides in the production of antibodies are also encompassed by the present invention.
摘要翻译：提供用于诊断患者样本中高级宫颈疾病的组成和方法。组合物包括与MCM2特异性结合的新单克隆抗体及其变体和片段。还提供具有本发明的MCM2抗体的结合特征的单克隆抗体。产生本发明的MCM2单克隆抗体的杂交瘤细胞系也在本文中公开。该组合物用于诊断高级宫颈疾病的实践方法，包括检测来自患者的子宫颈样品中MCM2的过表达。还提供了用于实施本发明的方法的试剂盒。包含MCM2表位的氨基酸序列的多肽和在产生抗体中使用这些多肽的方法也包括在本发明中。

7. 发明申请

US20090148864A1 METHODS AND COMPOSITIONS FOR THE DETECTION OF CERVICAL DISEASE 审中-公开
公开(公告)号：US20090148864A1
公开(公告)日：2009-06-11
申请号：US12263942
申请日：2008-11-03
申请人： Timothy J. Fischer , Douglas P. Malinowski , Adriann J. Taylor , Margaret R. Parker
发明人： Timothy J. Fischer , Douglas P. Malinowski , Adriann J. Taylor , Margaret R. Parker
IPC分类号： G01N33/53
CPC分类号： G01N33/57411 , C07K16/3069 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/6875 , G01N2333/025
摘要： Methods and compositions for identifying high-grade cervical disease in a patient sample are provided. The methods of the invention comprise detecting overexpression of at least one biomarker in a body sample, wherein the biomarker is selectively overexpressed in high-grade cervical disease. In particular claims, the body sample is a cervical smear or monolayer of cervical cells. The biomarkers of the invention include genes and proteins that are involved in cell cycle regulation, signal transduction, and DNA replication and transcription. In particular claims, the biomarker is an S-phase gene. In some aspects of the invention, overexpression of a biomarker of interest is detected at the protein level using biomarker-specific antibodies or at the nucleic acid level using nucleic acid hybridization techniques. Kits for practicing the methods of the invention are further provided.

8. 发明申请

US20090087849A1 NUCLEIC ACID-BASED METHODS AND COMPOSITIONS FOR THE DETECTION OF OVARIAN CANCER 审中-公开
标题翻译：基于核酸的方法和组合物检测卵巢癌
公开(公告)号：US20090087849A1
公开(公告)日：2009-04-02
申请号：US12205464
申请日：2008-09-05
申请人： Douglas P. Malinowski , Timothy J. Fischer , John W. Groelke
发明人： Douglas P. Malinowski , Timothy J. Fischer , John W. Groelke
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： Methods and compositions for identifying ovarian cancer in a patient sample are provided. The methods of the invention comprise detecting overexpression or underexpression of at least one nucleic acid biomarker in a body sample, wherein the biomarker is selectively overexpressed or underexpressed in ovarian cancer. The body sample may be, for example, an ovarian tissue sample. The biomarkers of the invention include any nucleic acid molecule that is selectively overexpressed in ovarian cancer, including, for example, MMP-7, PAEP, CA125, HE4, PLAUR, MUC-1, SLPI, SSP1, MSLN, SPON1, interleukin-7, folate receptor 1, claudin 3, inhibin A, inhibin BB, inhibin BA, and PAI-1. Overexpression or underexpression of a biomarker of interest is detected at the nucleic acid level using such methods as real-time PCR and various nucleic acid hybridization techniques. Kits for practicing the methods of the invention are further provided.
摘要翻译：提供了用于鉴定患者样品中卵巢癌的方法和组合物。本发明的方法包括检测身体样品中至少一种核酸生物标志物的过表达或低表达，其中所述生物标志物在卵巢癌中选择性地过表达或低表达。身体样品可以是例如卵巢组织样品。本发明的生物标志物包括在卵巢癌中选择性过表达的任何核酸分子，包括例如MMP-7，PAEP，CA125，HE4，PLAUR，MUC-1，SLPI，SSP1，MSLN，SPON1，白介素-7 ，叶酸受体1，紧密连蛋白3，抑制素A，抑制素BB，抑制素BA和PAI-1。使用实时PCR和各种核酸杂交技术的方法，在核酸水平检测感兴趣的生物标志物的过表达或低表达。还提供了用于实施本发明的方法的试剂盒。

9. 发明申请

US20090075300A1 METHODS AND COMPOSITIONS FOR THE DETECTION OF CERVICAL DISEASE 审中-公开
标题翻译：检测宫颈疾病的方法和组成
公开(公告)号：US20090075300A1
公开(公告)日：2009-03-19
申请号：US12263139
申请日：2008-10-31
申请人： Timothy J. Fischer , Douglas P. Malinowski , Adriann J. Taylor , Margaret R. Parker
发明人： Timothy J. Fischer , Douglas P. Malinowski , Adriann J. Taylor , Margaret R. Parker
IPC分类号： G01N33/53
CPC分类号： G01N33/57411 , C07K16/3069 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/6875 , G01N2333/025
摘要： Methods and compositions for identifying high-grade cervical disease in a patient sample are provided. The methods of the invention comprise detecting overexpression of at least one biomarker in a body sample, wherein the biomarker is selectively overexpressed in high-grade cervical disease. In particular claims, the body sample is a cervical smear or monolayer of cervical cells. The biomarkers of the invention include genes and proteins that are involved in cell cycle regulation, signal transduction, and DNA replication and transcription. In particular claims, the biomarker is an S-phase gene. In some aspects of the invention, overexpression of a biomarker of interest is detected at the protein level using biomarker-specific antibodies or at the nucleic acid level using nucleic acid hybridization techniques. Kits for practicing the methods of the invention are further provided.
摘要翻译：提供了用于鉴定患者样品中高级别宫颈疾病的方法和组合物。本发明的方法包括检测身体样品中至少一种生物标志物的过表达，其中生物标志物在高级子宫颈疾病中选择性地过度表达。在具体的权利要求中，身体样品是宫颈涂片或宫颈细胞单层。本发明的生物标志物包括参与细胞周期调节，信号转导和DNA复制和转录的基因和蛋白质。在具体的权利要求中，生物标志物是S期基因。在本发明的一些方面，使用生物标志物特异性抗体或在核酸水平使用核酸杂交技术在蛋白质水平上检测目标生物标志物的过表达。还提供了用于实施本发明的方法的试剂盒。

10. 发明申请

US20080305491A1 MCM6 AND MCM7 MONOCLONAL ANTIBODIES AND METHODS FOR THEIR USE IN THE DETECTION OF CERVICAL DISEASE 有权
标题翻译： MCM6和MCM7单克隆抗体及其用于检测宫颈疾病的方法
公开(公告)号：US20080305491A1
公开(公告)日：2008-12-11
申请号：US12177481
申请日：2008-07-22
申请人： Douglas P. Malinowski , Timothy J. Fischer , Adriann J. Taylor
发明人： Douglas P. Malinowski , Timothy J. Fischer , Adriann J. Taylor
IPC分类号： C12Q1/68 , C07K16/18 , C07K14/00 , C12P21/08 , C12N5/12
CPC分类号： C07K16/3069 , C07K14/4738 , C07K16/40 , C07K2317/34 , C12Q1/001 , G01N33/57411
摘要： Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM6 or MCM7. Monoclonal antibodies having the binding characteristics of an MCM6 or MCM7 antibody of the invention are further provided. Hybridoma cell lines that produce an MCM6 or MCM7 monoclonal antibody of the invention are also disclosed herein. The compositions find use in practicing methods for diagnosing high-grade cervical disease comprising detecting overexpression of MCM6, MCM7, or both MCM6 and MCM7 in a cervical sample from a patient. Kits for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for an MCM6 or an MCM7 epitope and methods of using these polypeptides in the production of antibodies are also encompassed by the present invention.
摘要翻译：提供用于诊断患者样本中高级宫颈疾病的组成和方法。组合物包括特异性结合MCM6或MCM7的新单克隆抗体及其变体和片段。进一步提供具有本发明的MCM6或MCM7抗体的结合特征的单克隆抗体。产生本发明的MCM6或MCM7单克隆抗体的杂交瘤细胞系也在本文中公开。该组合物用于诊断高级宫颈疾病的实践方法，包括检测来自患者的子宫颈样品中MCM6，MCM7或MCM6和MCM7两者的过表达。还提供了用于实施本发明的方法的试剂盒。包含MCM6或MCM7表位的氨基酸序列的多肽和在产生抗体中使用这些多肽的方法也包括在本发明中。

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