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1. 发明申请

US20180127747A1 SIRNA STRUCTURE FOR MINIMIZING OFF-TARGET EFFECTS AND RELAXING SATURATION OF RNAI MACHINERY AND THE USE THEREOF 审中-公开
公开(公告)号：US20180127747A1
公开(公告)日：2018-05-10
申请号：US15678823
申请日：2017-08-16
申请人： Dong Ki Lee , Chan Il Chang
发明人： Dong Ki Lee , Chan Il Chang
IPC分类号： C12N15/11
CPC分类号： C12N15/111 , C12N2310/14 , C12N2320/50
摘要： The present invention relates to a siRNA structure and the use thereof. More particularly, the invention relates to a double-stranded small interfering RNA molecule (siRNA molecule) comprising a 19-21 nucleotide (nt) antisense strand and a 15-19 nt sense strand having a sequence complementary to the antisense sequence, wherein the 5′ end of the antisense strand has a blunt end and the 3′ end of the antisense strand has an overhang, and to a method for silencing the expression of a target gene using the siRNA molecule.

2. 发明授权

US09260470B2 SiRNA structure for minimizing off-target effects caused by antisense strands, and use thereof 有权
标题翻译：用于最小化由反义链引起的脱靶效应的SiRNA结构及其用途
公开(公告)号：US09260470B2
公开(公告)日：2016-02-16
申请号：US13505965
申请日：2010-11-04
申请人： Dong Ki Lee , Dua Pooja
发明人： Dong Ki Lee , Dua Pooja
IPC分类号： C07H21/04 , C07H21/02 , C12N15/11 , C12N15/113
CPC分类号： C07H21/02 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/533 , C12N2320/53
摘要： The present invention relates to a novel siRNA structure and the use thereof, and more particularly to a double-stranded siRNA molecule comprising an antisense strand and a sense strand, wherein the siRNA molecule has at least one single nucleotide bulge formed by introducing a single nucleotide into the antisense strand, particularly at position 2 from the 5′ end, and to a method of using the same to silence a target gene. The siRNA molecule of the invention shows high target gene silencing efficiency while minimizing off-target effects caused by the antisense strand, and thus has improved target selectivity. Accordingly, the siRNA molecule of the invention can be substituted for conventional siRNA molecules and can be widely be used in siRNA-based gene silencing techniques, including gene therapy.
摘要翻译：本发明涉及新型siRNA结构及其用途，更具体地涉及包含反义链和有义链的双链siRNA分子，其中siRNA分子具有通过引入单个核苷酸形成的至少一个单核苷酸突出进入反义链，特别是在5'末端的2位，以及使用该反义链沉默靶基因的方法。本发明的siRNA分子显示出高的靶基因沉默效率，同时最小化由反义链引起的脱靶效应，从而提高目标选择性。因此，本发明的siRNA分子可以代替常规的siRNA分子，可广泛用于基于siRNA的基因沉默技术，包括基因治疗。

3. 发明授权

US09046952B2 Display device integrated with touch screen panel 有权
标题翻译：显示设备与触摸屏面板集成
公开(公告)号：US09046952B2
公开(公告)日：2015-06-02
申请号：US13463528
申请日：2012-05-03
申请人： Gun-Shik Kim , Dong-Ki Lee
发明人： Gun-Shik Kim , Dong-Ki Lee
IPC分类号： G06F3/041 , G06F3/044
CPC分类号： G06F3/0412 , G06F3/044 , G06F2203/04103
摘要： A display device integrated with a touch screen panel. The display device includes a plurality of pixels formed on a substrate, color filter patterns on a surface of the display device, corresponding to the pixels and containing a conductive material, and a black matrix formed between the color filter patterns. Each of the color filter patterns is electrically connected to an adjacent one of the color filter patterns to be used as sense electrodes of a touch screen panel.
摘要翻译：与触摸屏面板集成的显示设备。显示装置包括形成在基板上的多个像素，与显示装置的表面对应的像素并且包含导电材料的滤色器图案，以及形成在滤色器图案之间的黑矩阵。每个滤色器图案电连接到用作触摸屏面板的感测电极的滤色器图案中的相邻的一个。

4. 发明授权

US08513884B2 Flat panel display apparatus and organic light-emitting display apparatus 有权
标题翻译：平板显示装置和有机发光显示装置
公开(公告)号：US08513884B2
公开(公告)日：2013-08-20
申请号：US12976937
申请日：2010-12-22
申请人： Kie-Hyun Nam , Hoon Kim , Dong-Ki Lee , Jin-Wook Seong , Hong Chen , Jung-Mi Choi , Ji-Sil Lee
发明人： Kie-Hyun Nam , Hoon Kim , Dong-Ki Lee , Jin-Wook Seong , Hong Chen , Jung-Mi Choi , Ji-Sil Lee
IPC分类号： H05B33/04
CPC分类号： H01L51/5243 , H01L51/5246 , H01L51/5253
摘要： A flat panel display apparatus includes a substrate; a display unit which is formed on the substrate and displays an image; a metal sheet which faces towards the substrate; a sealant which fills the entire free space between the substrate and the metal sheet and seals the space between the substrate and the metal sheet; and a polymer layer which is disposed on a surface of the metal sheet and has a lower thermal expansion coefficient than the metal sheet. An organic light-emitting display (OLED) apparatus including a sealant which fills an entire space between a substrate and a metal sheet is also disclosed.
摘要翻译：平板显示装置包括：基板; 显示单元，其形成在所述基板上并显示图像; 面向基板的金属板; 填充基板和金属板之间的整个自由空间并密封基板和金属板之间的空间的密封剂; 以及聚合物层，其设置在金属片的表面上并且具有比金属片低的热膨胀系数。还公开了一种包括填充基板和金属片之间的整个空间的密封剂的有机发光显示器（OLED）设备。

5. 发明申请

US20120168451A1 DRINKING CUP THAT ROTATABLY ATTACHES TO A PLASTIC BOTTLE FOR CLOSURE AND PROTECTION 审中-公开
标题翻译：饮料杯，可旋转连接到塑料瓶上，用于封闭和保护
公开(公告)号：US20120168451A1
公开(公告)日：2012-07-05
申请号：US12980332
申请日：2010-12-29
申请人： Dong Ki Lee
发明人： Dong Ki Lee
IPC分类号： A47G19/22
CPC分类号： A47G19/2205 , B65D41/26
摘要： A drinking cup with a tubular protrusion molded to the bottom and having an internal thread that allows it to be rotatably attached to and detached from a bottle with a small cylindrical neck. The internal thread cooperates with an external thread that is molded on the small cylindrical neck of the bottle so that the drinking cup can function as a cap to close and seal the bottle when it is inverted and placed over the neck of the bottle.
摘要翻译：具有模制到底部并具有内螺纹的管状突起的饮杯，其允许其可旋转地附接到具有小圆柱形颈部的瓶子上并从瓶子上拆下。内螺纹与模制在瓶的小圆柱形颈部上的外螺纹配合，使得饮杯可以用作盖子，以在瓶子倒置并放置在瓶颈上时关闭和密封瓶子。

6. 发明授权

US08017143B2 Coating agent for drug releasing stent, preparation method thereof and drug releasing stent coated therewith 有权
标题翻译：用于药物释放支架的涂层剂，其制备方法和涂覆的药物释放支架
公开(公告)号：US08017143B2
公开(公告)日：2011-09-13
申请号：US12154864
申请日：2008-05-28
申请人： Kyong-Min Shin , Dong-ki Lee , Don-haeng Lee , Kun Na , Eun-ae Jo
发明人： Kyong-Min Shin , Dong-ki Lee , Don-haeng Lee , Kun Na , Eun-ae Jo
IPC分类号： A61K31/337 , A61K47/36 , A61K47/34
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/606 , C08L5/00 , C08L75/04
摘要： Disclosed are a coating agent for drug releasing stents, a method for preparing the same and a drug releasing stent coated therewith. The coating agent comprises a biologically active material and a coating material selected from among pullulan acetate, represented by the following Chemical Formula 1, and a polyurethane-surfactant mixture.
摘要翻译：公开了用于药物释放支架的包衣剂，其制备方法和涂覆有药物释放支架的药物释放支架。涂层剂包括生物活性材料和选自下列化学式1表示的醋酸支链淀粉中的涂料和聚氨酯 - 表面活性剂混合物。

7. 发明授权

US07994213B2 Coating agent for drug releasing stent, preparation method thereof and drug releasing stent coated therewith 有权
标题翻译：用于药物释放支架的涂层剂，其制备方法和涂覆的药物释放支架
公开(公告)号：US07994213B2
公开(公告)日：2011-08-09
申请号：US12154863
申请日：2008-05-28
申请人： Kyong-Min Shin , Dong-ki Lee , Don-haeng Lee , Kun Na , Eun-ae Jo
发明人： Kyong-Min Shin , Dong-ki Lee , Don-haeng Lee , Kun Na , Eun-ae Jo
IPC分类号： A61K31/337 , A61K9/14 , A61K47/48 , A61K31/56 , A61K31/131 , A01N43/02 , A61F2/82 , A61F13/00
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/624 , A61L2400/12 , C08L79/02
摘要： Disclosed are a coating agent for drug releasing stents, a method for preparing the same and a drug releasing stent coated therewith. The coating agent for drug releasing stents comprises nanoparticles with a biologically active material entrapped therein, wherein the particles are formed of a polyethyleneimine (PEI)-deoxycholic acid (DOCA) polymer (PDo) in which 1˜8 moles of DOCA are grafted per mole of PEI.
摘要翻译：公开了用于药物释放支架的包衣剂，其制备方法和涂覆有药物释放支架的药物释放支架。用于药物释放支架的包衣剂包含其中包含生物活性物质的纳米颗粒，其中所述颗粒由聚乙烯亚胺（PEI） - 脱氧胆酸（DOC）聚合物（PDo）形成，其中每摩尔接枝1〜8摩尔DOCA 的PEI。

8. 发明申请

US20110109662A1 DRIVING APPARATUS AND DRIVING METHOD OF LIQUID CRYSTAL DISPLAY 审中-公开
标题翻译：液晶显示器的驱动装置和驱动方法
公开(公告)号：US20110109662A1
公开(公告)日：2011-05-12
申请号：US12902553
申请日：2010-10-12
申请人： Sang-Mi CHO , Young-Min CHOI , Sang-Chul LEE , Jae-Seob CHUNG , Jong-Hee NA , Dong-Ki LEE
发明人： Sang-Mi CHO , Young-Min CHOI , Sang-Chul LEE , Jae-Seob CHUNG , Jong-Hee NA , Dong-Ki LEE
IPC分类号： G09G5/10 , G09G3/36
CPC分类号： G09G3/3688 , G09G3/3614 , G09G2320/0242 , G09G2320/0276
摘要： A driving apparatus for a liquid crystal display, which includes a first pixel, a second pixel and a third pixel that display different colors, includes: an image signal compensation unit that compensates input image signals corresponding to the first pixel, the second pixel, and the third pixel to generate compensated input image signals; and a data driver that supplies data voltages to the first pixel, the second pixel and the third pixel based on the compensated input image signals. The image signal compensation unit shifts a value of the input image signal corresponding to the first pixel by a first value with respect to a common voltage, shifts a value of the input image signal corresponding to the second pixel by a second value with respect to the common voltage, and shifts a value of the input image signal corresponding to the third pixel by a third value with respect to the common voltage.
摘要翻译：一种用于液晶显示器的驱动装置，其包括第一像素，第二像素和显示不同颜色的第三像素，包括：图像信号补偿单元，其补偿与第一像素，第二像素和第二像素对应的输入图像信号，所述第三像素产生补偿输入图像信号; 以及基于经补偿的输入图像信号向第一像素，第二像素和第三像素提供数据电压的数据驱动器。图像信号补偿单元将对应于第一像素的输入图像信号的值相对于公共电压移位第一值，将对应于第二像素的输入图像信号的值相对于第二像素偏移第二值公共电压，并将与第三像素对应的输入图像信号的值相对于公共电压移位第三值。

9. 发明申请

US20100134426A1 TOUCH SENSIBLE ORGANIC LIGHT EMITTING DEVICE 有权
标题翻译：触摸式有机发光器件
公开(公告)号：US20100134426A1
公开(公告)日：2010-06-03
申请号：US12421641
申请日：2009-04-10
申请人： Dong-Ki LEE , Hoon-Kee MIN
发明人： Dong-Ki LEE , Hoon-Kee MIN
IPC分类号： G06F3/041 , H01J1/62
CPC分类号： H01L27/323 , G06F3/0412 , G06F3/0416 , G06F3/044 , G06F3/045 , G09G3/3225 , G09G3/3258 , G09G3/3266 , G09G3/3275 , H01L27/3244 , H01L27/3248 , H01L27/3276 , H01L51/5253
摘要： Embodiments of the present invention generally relate to a touch sensible organic light emitting device. The organic light emitting device according to an exemplary embodiment of the present invention comprises: a substrate; a thin film transistor disposed on the substrate; an organic light emitting element connected to the thin film transistor and receiving a data voltage; a plurality of encapsulation thin films disposed on the organic light emitting element, and encapsulating the thin film transistor and the organic light emitting element; a planarization layer disposed on the encapsulation thin film; and a touch sensor disposed on the planarization layer.
摘要翻译：本发明的实施方案一般涉及一种触感有机发光装置。根据本发明的示例性实施例的有机发光器件包括：基板; 设置在所述基板上的薄膜晶体管; 连接到薄膜晶体管并接收数据电压的有机发光元件; 设置在所述有机发光元件上的多个封装薄膜，并且封装所述薄膜晶体管和所述有机发光元件; 设置在所述封装薄膜上的平坦化层; 以及设置在平坦化层上的触摸传感器。

10. 发明申请

US20090286864A1 Coating agent for drug releasing stent, preparation method thereof and drug releasing stent coated therewith 有权
标题翻译：用于药物释放支架的涂层剂，其制备方法和涂覆的药物释放支架
公开(公告)号：US20090286864A1
公开(公告)日：2009-11-19
申请号：US12154863
申请日：2008-05-28
申请人： Kyong-Min Shin , Dong-ki Lee , Don-haeng Lee , Kun Na , Eun-ae Jo
发明人： Kyong-Min Shin , Dong-ki Lee , Don-haeng Lee , Kun Na , Eun-ae Jo
IPC分类号： A61K31/337
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/624 , A61L2400/12 , C08L79/02
摘要： Disclosed are a coating agent for drug releasing stents, a method for preparing the same and a drug releasing stent coated therewith. The coating agent for drug releasing stents comprises nanoparticles with a biologically active material entrapped therein, wherein the particles are formed of a polyethyleneimine (PEI)-deoxycholic acid (DOCA) polymer (PDo) in which 1˜8 moles of DOCA are grafted per mole of PEI.
摘要翻译：公开了用于药物释放支架的包衣剂，其制备方法和涂覆有药物释放支架的药物释放支架。用于药物释放支架的包衣剂包含其中包含生物活性物质的纳米颗粒，其中所述颗粒由聚乙烯亚胺（PEI） - 脱氧胆酸（DOC）聚合物（PDo）形成，其中每摩尔接枝1〜8摩尔DOCA 的PEI。

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