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1. 发明授权

US5512472A DNA sequence encoding sterol .DELTA.14 reductase 失效
标题翻译：编码固醇DELTA14还原酶的DNA序列
公开(公告)号：US5512472A
公开(公告)日：1996-04-30
申请号：US439131
申请日：1995-05-11
申请人： Margaret H. K. Lai , Donald R. Kirsch , Martin Bard
发明人： Margaret H. K. Lai , Donald R. Kirsch , Martin Bard
IPC分类号： C12N9/02 , C12N15/53 , C12N15/09 , C12N15/81
CPC分类号： C12N9/001
摘要： A gene encoding Saccharomyces cerevisiae sterol .DELTA.14 reductase of the ergosterol biosynthetic pathway is isolated and cloned by selecting strains carrying sequences on a 2.mu. based vector for resistance to a morpholine fungicide such as fenpropimorph. Four distinct plasmid inserts which produce morpholine resistance are obtained, and one of these is characterized and sequenced. The purified and isolated DNA sequence encoding sterol .DELTA.14 reductase encodes a polypeptide exhibiting homology to the S. cerevisiae sterol C-24(28) reductase enzyme in the ergosterol biosynthetic pathway.
摘要翻译：通过选择在2基于载体上携带序列的菌株来分离和克隆麦角甾醇生物合成途径的酿酒酵母甾醇DELTA 14还原酶的基因，以抵抗吗啉杀真菌剂例如茴香霉素。获得产生吗啉抗性的四种不同的质粒插入片段，其中之一被表征和测序。编码固醇DELTA14还原酶的纯化和分离的DNA序列编码与麦角甾醇生物合成途径中的酿酒酵母甾醇C-24（28）还原酶具有同源性的多肽。

2. 发明授权

US5024839A Dactylocycline A and dactylocycline B 失效
标题翻译： Dactylocycline A和Dactylocycline B
公开(公告)号：US5024839A
公开(公告)日：1991-06-18
申请号：US137635
申请日：1987-12-24
申请人： Carol A. Aklonis , Helen A. Ax , Donald R. Kirsch , Joseph O'Sullivan , Adrienne Tymiak , J. Scott Wells
发明人： Carol A. Aklonis , Helen A. Ax , Donald R. Kirsch , Joseph O'Sullivan , Adrienne Tymiak , J. Scott Wells
IPC分类号： A61K35/74 , C12P1/06 , C12P29/00 , C12R1/01
CPC分类号： C12P29/00 , C12P1/06
摘要： Cultivation of a strain of the microorganism Dactylosporangium sp. A.T.C.C. No. 53693, yields the antibiotic substance EM5586 which contains the novel useful components dactylocycline A and dactylocycline B.

3. 发明授权

US4754018A Antibiotic prepared from lysobacter sp. SC 14,067 and analogs thereof 失效
标题翻译：溶解细菌制备的抗生素 SC 14,067及其类似物
公开(公告)号：US4754018A
公开(公告)日：1988-06-28
申请号：US23425
申请日：1987-03-09
申请人： Adrienne A. Tymiak , Donald R. Kirsch , Joseph O'Sullivan , John E. McCullough
发明人： Adrienne A. Tymiak , Donald R. Kirsch , Joseph O'Sullivan , John E. McCullough
IPC分类号： C07G11/00 , A61K35/74 , A61P31/04 , C12P1/04 , C12R1/01 , C07K5/12
CPC分类号： C12P1/04 , Y10S930/19
摘要： A novel antibiotic substance EM5587 is prepared by cultivation of a strain of the microorganism Lysobacter sp. SC 14,067, A.T.C.C. No. 53042. Chemical analogs of EM5587 are prepared by chemical synthesis.
摘要翻译：通过培养微生物溶菌杆菌属菌株制备新型抗生素物质EM5587。 SC 14,067，A.T.C.C. 号53042.通过化学合成制备EM5587的化学类似物。

4. 发明授权

US4735901A Transformation of Candida albicans 失效
标题翻译：白念珠菌的转化
公开(公告)号：US4735901A
公开(公告)日：1988-04-05
申请号：US691303
申请日：1985-01-14
申请人： Myra B. Kurtz , Donald R. Kirsch
发明人： Myra B. Kurtz , Donald R. Kirsch
IPC分类号： C12N15/52 , C12N15/81 , C12N15/00 , C12N5/00 , C12N7/00
CPC分类号： C12N15/52 , C12N15/815 , Y10S435/922
摘要： Candida albicans has been transformed by the insertion of a plasmid comprising a fragment of DNA from Candida albicans containing the intact ADE 2 gene.
摘要翻译：通过插入包含含有完整ADE 2基因的白色假丝酵母的DNA片段的质粒已将白色念珠菌转化。

5. 发明申请

US20160039740A1 Cyclohexane-1,3-Diones for Use in the Treatment of Amyotrophic Lateral Sclerosis 有权
标题翻译：用于治疗肌萎缩性侧索硬化症的环己烷-1,3-二酮
公开(公告)号：US20160039740A1
公开(公告)日：2016-02-11
申请号：US14887550
申请日：2015-10-20
申请人： Donald R. Kirsch , Radhia Benmohamed , Anthony C. Arvanites , Richard J. Morimoto , Wei Zhang , Richard B. Silverman
发明人： Donald R. Kirsch , Radhia Benmohamed , Anthony C. Arvanites , Richard J. Morimoto , Wei Zhang , Richard B. Silverman
IPC分类号： C07C69/75 , C07C49/577 , C07C49/567
CPC分类号： C07C69/75 , A61K31/136 , C07C49/563 , C07C49/567 , C07C49/577
摘要： The present invention relates to the identification of provided cyclohexane-1,3-diones (CHD compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided CHD compounds.
摘要翻译：本发明涉及提供的环己烷-1,3-二酮（CHD化合物）及其药物组合物的鉴定，用于治疗肌萎缩性侧索硬化（ALS）和其它神经变性疾病的受试者。本发明还提供了制备所提供的CHD化合物的方法。

6. 发明申请

US20120264765A1 Cyclohexane-1,3-Diones for Use in the Treatment of Amyotrophic Lateral Sclerosis 有权
标题翻译：用于治疗肌萎缩性侧索硬化症的环己烷-1,3-二酮
公开(公告)号：US20120264765A1
公开(公告)日：2012-10-18
申请号：US13504893
申请日：2010-10-29
申请人： Donald R. Kirsch , Radhia Benmohamed , Anthony C. Arvanties , Richard I. Morimoto , Wei Zhang , Richard B. Silverman
发明人： Donald R. Kirsch , Radhia Benmohamed , Anthony C. Arvanties , Richard I. Morimoto , Wei Zhang , Richard B. Silverman
IPC分类号： A61K31/122 , C07C49/697 , C07C49/753 , C07C225/22 , C07D295/205 , A61P25/28 , C07D307/46 , A61K31/136 , A61K31/495 , A61K31/403 , A61K31/341 , C07C49/657 , C07D209/86
CPC分类号： C07C69/75 , A61K31/136 , C07C49/563 , C07C49/567 , C07C49/577
摘要： The present invention relates to the identification of provided cyclohexane-1,3-diones (CHD compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided CHD compounds.
摘要翻译：本发明涉及提供的环己烷-1,3-二酮（CHD化合物）及其药物组合物的鉴定，用于治疗肌萎缩性侧索硬化（ALS）和其它神经变性疾病的受试者。本发明还提供了制备所提供的CHD化合物的方法。

7. 发明授权

US5591576A Sterol .DELTA.14 reductase screen 失效
标题翻译： Sterol DELTA 14还原酶屏
公开(公告)号：US5591576A
公开(公告)日：1997-01-07
申请号：US107348
申请日：1993-08-16
申请人： Margaret H. K. Lai , Donald R. Kirsch , Martin Bard
发明人： Margaret H. K. Lai , Donald R. Kirsch , Martin Bard
IPC分类号： C12N9/02 , C12N15/53 , C12Q1/18 , C12Q1/26 , C12N15/63 , C12Q1/02 , C12Q1/68
CPC分类号： C12N9/001 , C12Q1/18 , C12Q1/26 , C12Y103/0107
摘要： A binary assay identifies agents that inhibit sterol .DELTA.14 reductase involved in ergosterol biosynthesis. In the primary screen, sterol .DELTA.14 reductase inhibition by a test sample is assayed by adding the test sample to a culture of Neurospora crassa having an erg-3 mutation and also to a culture of a strain having an erg-1 mutation, comparing the extent of growth inhibition after incubation in the two cultures, and identifying as positives those samples that show growth inhibition in the erg-3 culture exceeding that in the erg-1 culture. In the secondary screen, samples that test positive in the primary screen are reassayed by adding the test sample to a culture of a Saccharomyces cerevisiae strain into which has been introduced multiple copies of a gene encoding sterol .DELTA.14 reductase and also to a strain of S. cerevisiae that does not have the introduced gene; positive samples are identified after incubation by observation that growth inhibition in the culture having no introduced reductase gene exceeds growth inhibition in the culture having the introduced reductase gene. In preferred embodiments, a known inhibitor of sterol .DELTA.14 reductase is employed in solidified media in both the primary and the secondary screens, resulting in an assay that is highly sensitive and specific for the detection of sterol .DELTA.14 reductase inhibitors.
摘要翻译：二元测定法鉴定了抑制参与麦角固醇生物合成的甾醇DELTA14还原酶的药剂。在主筛网中，通过将测试样品加入到具有erg-3突变的粗糙脉孢菌培养物中，并将其与具有erg-1突变的菌株的培养物进行比较，来测定测试样品的固醇DELTA 14还原酶抑制在两种培养物中孵育后的生长抑制程度，并且鉴定出在erg-3培养物中显示生长抑制的样品超过erg-1培养物中的那些样品的阳性。在次级屏幕中，通过将测试样品加入到已经引入了多拷贝的编码固醇DELTA14还原酶的基因的Saccharomyces cerevisiae菌株的培养物中，并且还添加到S的菌株没有引入基因的酿酒酵母; 通过观察，通过观察到没有引入的还原酶基因的培养物中的生长抑制超过在具有引入的还原酶基因的培养物中的生长抑制的情况下，鉴定阳性样品。在优选的实施方案中，在初级和次级筛中的固化培养基中使用已知的甾醇DELTA 14还原酶抑制剂，导致对检测固醇DELTA14还原酶抑制剂具有高度敏感性和特异性的测定。

8. 发明授权

US5294725A Scopularin 失效
公开(公告)号：US5294725A
公开(公告)日：1994-03-15
申请号：US305338
申请日：1989-01-31
申请人： Donald R. Kirsch , Joseph O'Sullivan , Douglas W. Phillipson
发明人： Donald R. Kirsch , Joseph O'Sullivan , Douglas W. Phillipson
IPC分类号： C07D309/10 , C07D405/04 , C07H15/12 , C07H15/26
CPC分类号： C07D405/04 , C07D309/10 , C07H15/12 , C07H15/26
摘要： A novel antibiotic substance, Scopularin, is prepared by cultivation of a strain of the microorganism, Scopulariopsis, A.T.C.C. No. 20,914. This compound and its alcohol derivative have also been found to have cytochrome P450 inhibition activity.
摘要翻译：通过培养微生物菌株Scopulariopsis，A.T.C.C.制备新型抗生素物质Scopularin。第20,914号。该化合物及其醇衍生物也被发现具有细胞色素P450抑制活性。

9. 发明授权

US4719109A EM5596--an antibiotic 失效
标题翻译： EM5596-一种抗生素
公开(公告)号：US4719109A
公开(公告)日：1988-01-12
申请号：US30536
申请日：1987-03-27
申请人： Donald R. Kirsch , Edward Meyers , Joseph E. Biskupiak
发明人： Donald R. Kirsch , Edward Meyers , Joseph E. Biskupiak
IPC分类号： C12P1/04 , C12P1/06
CPC分类号： C12P1/04
摘要： A novel antibiotic substance EM5596 is prepared by cultivation of a strain of the microorganism Micrococcus luteus A.T.C.C. No. 53598.
摘要翻译：通过培养微生物微球菌A.T.C.C.的菌株制备新的抗生素物质EM5596。第53598号。

10. 发明授权

US08722939B2 Cyclohexane-1,3-diones for use in the treatment of amyotrophic lateral sclerosis 有权
标题翻译：用于治疗肌萎缩性侧索硬化症的环己烷-1,3-二酮
公开(公告)号：US08722939B2
公开(公告)日：2014-05-13
申请号：US13504893
申请日：2010-10-29
申请人： Donald R. Kirsch , Radhia Benmohamed , Anthony C. Arvanites , Richard I. Morimoto , Wei Zhang , Richard B. Silverman
发明人： Donald R. Kirsch , Radhia Benmohamed , Anthony C. Arvanites , Richard I. Morimoto , Wei Zhang , Richard B. Silverman
IPC分类号： C07C49/697 , C07C225/22 , C07D295/205 , A61K31/136 , A61K31/495 , A61K31/403
CPC分类号： C07C69/75 , A61K31/136 , C07C49/563 , C07C49/567 , C07C49/577
摘要： The present invention relates to the identification of provided cyclohexane-1,3-diones (CHD compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided CHD compounds.
摘要翻译：本发明涉及提供的环己烷-1,3-二酮（CHD化合物）及其药物组合物的鉴定，用于治疗肌萎缩性侧索硬化（ALS）和其它神经变性疾病的受试者。本发明还提供了制备所提供的CHD化合物的方法。

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