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1. 发明申请

US20060258695A1 Triazole derivatives as inhibitors of 11-beta hydroxysteroid dehydrogenase-1 有权
标题翻译：作为11-β羟基类固醇脱氢酶-1抑制剂的三唑衍生物
公开(公告)号：US20060258695A1
公开(公告)日：2006-11-16
申请号：US10558454
申请日：2004-05-26
申请人： Sherman Waddell , Gina Santorelli , Milana Maletic , Aaron Leeman , Xin Gu , Donald Graham , James Balkovec , Susan Aster
发明人： Sherman Waddell , Gina Santorelli , Milana Maletic , Aaron Leeman , Xin Gu , Donald Graham , James Balkovec , Susan Aster
IPC分类号： C07D487/02 , A61K31/4196 , A61K31/506 , A61K31/4245
CPC分类号： C07D249/08 , C07D249/16 , C07D413/08 , C07D487/04
摘要： Triazole derivatives of structural formula I are selective inhibitors of the 11β-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dyslipidemia, hyperlipidemia, hypertension, Metabolic Syndrome, and other symptoms associated with NIDDM.
摘要翻译：结构式I的三唑衍生物是11b-羟基类固醇脱氢酶-1的选择性抑制剂。该化合物可用于治疗糖尿病，例如非胰岛素依赖性糖尿病（NIDDM），高血糖症，肥胖症，胰岛素抵抗，血脂异常，高脂血症，高血压，代谢综合征和与NIDDM相关的其他症状。

2. 发明授权

US06193006B1 Dynamic all wheel drive control 有权
标题翻译：动态全轮驱动控制
公开(公告)号：US06193006B1
公开(公告)日：2001-02-27
申请号：US09385553
申请日：1999-08-30
申请人： Brian William Deutschel , Donald Graham Straitiff
发明人： Brian William Deutschel , Donald Graham Straitiff
IPC分类号： B60K17354
CPC分类号： B60K17/35 , B60K17/344 , B60K23/0808
摘要： A selective all wheel drive powertrain has an engine and transaxle adapted to normally drive the front wheels of a vehicle. A transfer gear set, drive shaft, clutch and differential are connectable between the output of transaxle and the rear wheels of the vehicle to selectively provide an all wheel drive system. A pump, which supplies the fluid pressure to engage the clutch, has a pair of relatively rotatable members that are connected to rotate in unison with opposite sides of the clutch such that when the valve is operated, the clutch will be engaged. A selectively operable valve is disposed between a reservoir and the pump and controlled in actuation by the vehicle traction control system (TCS) to connect the pump to the reservoir when a loss of traction is sensed by the TCS. The clutch is effectively controlled by the selectively operable valve that supplies the fluid to the pump. The clutch is disposed in the drive path between the drive shaft and the differential with one set of clutch plates being connected to rotate with the drive shaft and another set of clutch plates being connected to rotate with the input to the differential. The pump has one member rotatable with the drive shaft side of the clutch and another member rotatable with the differential side of the clutch.
摘要翻译：选择性全轮驱动动力总成具有适于正常驱动车辆前轮的发动机和变速驱动桥。传动齿轮组，驱动轴，离合器和差速器可连接在变速驱动桥的输出端和车辆的后轮之间，以选择性地提供全轮驱动系统。提供流体压力以接合离合器的泵具有一对相对可旋转的构件，其连接成与离合器的相对侧一致地旋转，使得当阀被操作时，离合器将被接合。一个选择性操作的阀被设置在储存器和泵之间，并且当车辆牵引力控制系统（TCS）致动时被控制，以便当TCS感测到牵引力的损失时将泵连接到储存器。离合器通过将流体供应到泵的可选择性操作的阀门有效地控制。离合器设置在驱动轴和差速器之间的驱动路径中，一组离合器片被连接以与驱动轴一起旋转，并且另一组离合器片被连接以随着差速器的输入旋转。泵具有一个可离合器的驱动轴侧可旋转的构件，另一个构件可与离合器的差速器侧一起旋转。

3. 发明授权

US5802173A Radiotelephony system 失效
标题翻译：无线电话系统
公开(公告)号：US5802173A
公开(公告)日：1998-09-01
申请号：US820491
申请日：1992-01-14
申请人： Nicholas Francis Hamilton-Piercy , Donald Graham Monteith , Roger David Keay , George Maynard Hart , Meng Yee , Peter Oldfield , Philip Leighton , Edward O'Leary
发明人： Nicholas Francis Hamilton-Piercy , Donald Graham Monteith , Roger David Keay , George Maynard Hart , Meng Yee , Peter Oldfield , Philip Leighton , Edward O'Leary
IPC分类号： H04B7/26 , H04W88/08 , H04Q7/30
CPC分类号： H04W88/085 , H04B7/2609
摘要： A multichannel radiotelephony system provides two way cordless communications with a plurality of multichannel transceivers portable within a coverage area comprised by a plurality of cells, each associated with a base station and antennas, such as to permit channel frequency reuse in cells within the coverage area. For at least part of the coverage area, the locations of the antennas within the cells and the locations of the base stations are independently mapped, the antennas being associated with active antenna systems and the active antenna systems being connected to the base stations utilizing broadband transmission by means of a fixed bi-directional signal distribution network. The network is connected to the base stations and the antenna systems through suitable interfaces incorporating frequency translation so that available frequency bands in the signal distribution network which will normally be shared with other services, may be utilised. Plural base stations may be co-located. The radio link to the transceivers may be frequency or time division multiplexed, but communication over the network will normally be frequency multiplexed, using separate bands for transmission and reception.
摘要翻译：多通道无线电话系统提供与在由多个小区组成的覆盖区域内可移植的多个多信道收发机的双向无绳通信，每个小区与基站和天线相关联，例如允许在覆盖区域内的小区中进行信道频率重用。对于覆盖区域的至少一部分，单元内的天线的位置和基站的位置被独立地映射，天线与有源天线系统相关联，并且有源天线系统利用宽带传输连接到基站通过固定的双向信号分配网络。该网络通过合并了频率转换的合适的接口连接到基站和天线系统，从而可以利用通常与其他业务共享的信号分配网络中的可用频带。多个基站可能位于同一个位置。到收发器的无线电链路可以是频率或时分复用的，但是通过网络的通信通常将被频率复用，使用单独的频带进行发送和接收。

4. 发明申请

US20070149761A1 Hcv rna dependent rna polymerase 失效
标题翻译： Hcv rna依赖性rna聚合酶
公开(公告)号：US20070149761A1
公开(公告)日：2007-06-28
申请号：US10584810
申请日：2005-01-06
申请人： Donald Graham , Amy Simcoe , Steven Ludmerer , Osvaldo Flores , Robert LaFemina
发明人： Donald Graham , Amy Simcoe , Steven Ludmerer , Osvaldo Flores , Robert LaFemina
IPC分类号： C12Q1/68 , C07K14/00 , C07K16/00 , A61K38/00 , C07K17/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00
CPC分类号： C07K14/005 , C07H21/00 , C07H21/04 , C12N9/127 , C12N2770/24222 , G01N2333/18 , G01N2333/9125 , G01N2500/04
摘要： The present invention features NS5B polypeptides from different clinically important HCV genotypes. The polypeptides can be used individually, or as part of a panel of RNA-dependent RNA polymerases, to evaluate the effectiveness of a compound to inhibit NS5B activity.
摘要翻译：本发明特征来自不同临床重要HCV基因型的NS5B多肽。多肽可以单独使用或作为一组RNA依赖性RNA聚合酶的一部分使用，以评估化合物抑制NS5B活性的有效性。

5. 发明申请

US20060266131A1 Sampling tool 审中-公开
标题翻译：抽样工具
公开(公告)号：US20060266131A1
公开(公告)日：2006-11-30
申请号：US10543783
申请日：2004-01-29
申请人： Donald Graham
发明人： Donald Graham
IPC分类号： G01N1/04
CPC分类号： G01N1/08
摘要： A sampling tool (1) including a tool head (3) with a sample retaining portion (5) characterised in that said sampling tool (1) further includes a fluid conduit (6) extending from the sample-retaining portion (5) through the tool head (3), and a method of obtaining a sample (11) using said sampling tool (1), said method including the steps of inserting said tool head (3) into a test material (12); extraction of said tool head (3) from the test material (12) together with a sample (11) of said material (12) retained in said sample retaining portion (5); characterised in that; an elevated pressure is applied via said fluid conduit (6) to said sample-retaining portion (5) to expel said sample (11).
摘要翻译：一种采样工具（1），包括具有样品保持部分（5）的工具头（3），其特征在于所述采样工具（1）还包括从样品保持部分（5）延伸通过工具头（3），以及使用所述采样工具（1）获得样品（11）的方法，所述方法包括以下步骤：将所述工具头（3）插入测试材料（12）中; 从所述测试材料（12）中将所述工具头（3）与保留在所述样品保持部分（5）中的所述材料（12）的样品（11）一起提取; 其特征在于：经由所述流体导管（6）将高压施加到所述样品保持部分（5）以排出所述样品（11）。

6. 发明申请

US20060063746A1 17-carbamoyloxy cortisol derivatives as selective glucocorticoid receptor modulators 失效
标题翻译： 17-氨甲酰氧基皮质醇衍生物作为选择性糖皮质激素受体调节剂
公开(公告)号：US20060063746A1
公开(公告)日：2006-03-23
申请号：US10540757
申请日：2004-01-16
申请人： Amjad Ali , James Balkovec , Donald Graham , Mark Greenlee , Gayle Taylor
发明人： Amjad Ali , James Balkovec , Donald Graham , Mark Greenlee , Gayle Taylor
IPC分类号： C07J43/00 , A61K31/58
CPC分类号： C07J41/005 , C07J43/00
摘要： The present invention encompasses compounds of Formula (I) or pharmaceutically acceptable salts or hydrates thereof, which are useful as selective glucocorticoid receptor ligands for treating a variety of autoimmune and inflammatory diseases or conditions. Pharamaceutical compositions and methods of use are also included.
摘要翻译：本发明包括式（I）化合物或其药学上可接受的盐或水合物，其可用作治疗各种自身免疫性和炎性疾病或病症的选择性糖皮质激素受体配体。还包括制药组合物和使用方法。

7. 发明申请

US20050245588A1 Octahydro-2-h-naphtho[1,2-f]indole-4-carboxamide derivatives as selective glucocorticoid receptor modulators 审中-公开
标题翻译：八氢-2-H-萘并[1,2-f]吲哚-4-甲酰胺衍生物作为选择性糖皮质激素受体调节剂
公开(公告)号：US20050245588A1
公开(公告)日：2005-11-03
申请号：US10527615
申请日：2003-09-17
申请人： Amjad Ali , Susan Aster , James Balkovec , Donald Graham , Julianne Hunt , Florida Kallashi , Peter Sinclair , James Tata , Gayle Taylor , Joung Goulet
发明人： Amjad Ali , Susan Aster , James Balkovec , Donald Graham , Julianne Hunt , Florida Kallashi , Peter Sinclair , James Tata , Gayle Taylor , Joung Goulet
IPC分类号： A61K20060101 , A61K31/4162 , C07D231/44 , C07D231/54 , C07D417/00
CPC分类号： C07J71/0047 , C07D231/54 , C07D401/12 , C07D403/04 , C07D409/12 , C07D413/04 , C07D417/04 , C07D491/113
摘要： The present invention encompasses compounds of Formula I: or pharmaceutically acceptable salts or hydrates thereof, which are useful as selective glucocorticoid receptor ligands for treating a variety of autoimmune and inflammatory diseases or conditions. Pharmaceutical compositions and methods of use are also included.
摘要翻译：本发明包括式I化合物或其药学上可接受的盐或水合物，其可用作治疗各种自身免疫性和炎性疾病或病症的选择性糖皮质激素受体配体。还包括药物组合物和使用方法。

8. 发明授权

US6081660A Method for forming a cohort for use in identification of an individual 失效
标题翻译：形成用于识别个体的队列的方法
公开(公告)号：US6081660A
公开(公告)日：2000-06-27
申请号：US849380
申请日：1997-08-25
申请人： Iain Donald Graham Macleod , John Bruce Millar , Fangxin Chen , William Laverty
发明人： Iain Donald Graham Macleod , John Bruce Millar , Fangxin Chen , William Laverty
IPC分类号： G10L17/00 , G10L17/04 , G10L5/06
CPC分类号： G10L17/00 , G10L17/04
摘要： A method of forming a cohort for use in identification of an individual by comparing a model of characteristics of the individual, such as a model of utterances, with models of the cohort including a model for the client in respect of whom it is desired to test whether the individual is identifiable. Models related to the population excluding the client are tested to determine whether they meet an acceptance threshold test as to identify with a model for the client. Then, from each meeting the threshold test, it is determined whether those models are distributed so as to present at least a substantial probability that models for nonmembers of the population spaced from the client model in all directions will each be closer to a member of the cohort, excluding the client, than to the client. If that probability is less than a predetermined value, a selection is made from the population of another cohort member which will reduce that probability. Alternatively, if the mentioned probability is less than the predetermined value, a "phantom" model is generated for inclusion in the population and which will reduce that probability. The method may employ both the described selection and "phantom" generation techniques.
摘要翻译： PCT No.PCT / AU95 / 00807 Sec。 371日期1997年8月25日第 102（e）日期1997年8月25日PCT 1995年12月1日PCT PCT。 WO96 / 17341 PCT出版物日期1996年6月6日一种通过将个人特征模型（例如话语模型）与队列模型进行比较来形成用于识别个体的队列的方法，包括针对其的客户模型需要测试个人是否可识别。测试与不包括客户在内的人群相关的模型，以确定它们是否符合接受阈值测试，以便为客户端识别模型。然后，从每次会议开始，进行阈值测试，确定这些模型是否分布在一起，以至少显示出与客户端模型在所有方向上间隔开的群体的非成员的模型将至少更接近于队列，不包括客户端，而不是客户端。如果该概率小于预定值，则从另一队列成员的群体中进行选择，这将降低该概率。或者，如果所提到的概率小于预定值，则生成包含在群体中并且将降低该概率的“幻影”模型。该方法可以采用所描述的选择和“幻影”生成技术。

9. 发明申请

US20140076575A1 System and Method for Producing Through a Multi Bore Tubing Hanger to a Subsea Manifold Without BOP Modifications 审中-公开
标题翻译：通过多孔管式衣架生产不经BOP修改的海底歧管的系统和方法
公开(公告)号：US20140076575A1
公开(公告)日：2014-03-20
申请号：US13964345
申请日：2013-08-12
申请人： Donald Graham Allan , David John Parker , Gregory Richard Blome
发明人： Donald Graham Allan , David John Parker , Gregory Richard Blome
IPC分类号： E21B41/04
CPC分类号： E21B41/04 , E21B33/038 , E21B33/047
摘要： A system for producing hydrocarbons from a subsea wellbore includes a primary conductor extending into the seabed. In addition, the system includes a wellhead disposed at an upper end of the primary conductor. Further, the system includes a multi bore tubing hanger seated in the wellhead. Still further, the system includes a production tree mounted to the wellhead. The production tree includes a spool body and a production spool extending radially from the spool body. The production spool has an end comprising a connector. Moreover, the system includes a rotatable production guide base coupled to the primary conductor and configured to rotate about the wellhead. The production guide base includes a rigid alignment spool. The alignment spool has a first end releasably coupled to the production spool, a second end comprising a second connector, and non-linear deviation positioned between the first end and the second end.
摘要翻译：用于从海底井筒生产碳氢化合物的系统包括延伸到海底的主导体。此外，该系统包括设置在主导体的上端的井口。此外，该系统包括坐在井口中的多孔管悬挂架。此外，该系统包括安装到井口的生产树。生产树包括卷轴体和从卷轴体径向延伸的生产卷轴。生产卷轴具有包括连接器的端部。此外，该系统包括联接到主导体并被配置为围绕井口旋转的可旋转的生产引导基座。生产导向底座包括一个刚性的对齐阀芯。所述对准线轴具有可释放地联接到所述生产线轴的第一端，包括第二连接器的第二端和位于所述第一端和所述第二端之间的非线性偏移。

10. 发明申请

US20080076795A1 1H-benzo[F]indazol-5-YL derivatives as selective glucocorticoid receptor modulators 失效
标题翻译： 1H-苯并[F]吲唑-5-YL衍生物作为选择性糖皮质激素受体调节剂
公开(公告)号：US20080076795A1
公开(公告)日：2008-03-27
申请号：US11904186
申请日：2007-09-26
申请人： Amjad Ali , James Balkovec , Donald Graham , Christopher Thompson , Nazia Quraishi
发明人： Amjad Ali , James Balkovec , Donald Graham , Christopher Thompson , Nazia Quraishi
IPC分类号： A61K31/416 , A61K31/4184 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61P29/00 , A61P37/00 , C07D231/54 , C07D401/02 , C07D403/02 , C07D405/02 , C07D409/02 , C07D417/02
CPC分类号： C07D417/06 , C07D231/54 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/10 , C07D405/06 , C07D405/10 , C07D409/06
摘要： The present invention encompasses compounds of Formula I: or pharmaceutically acceptable salts or hydrates thereof, which are useful as selective glucocorticoid receptor ligands for treating a variety of autoimmune and inflammatory diseases or conditions. Pharmaceutical compositions and methods of use are also included.
摘要翻译：本发明包括式I化合物或其药学上可接受的盐或水合物，其可用作用于治疗多种自身免疫性和炎性疾病或病症的选择性糖皮质激素受体配体。还包括药物组合物和使用方法。

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