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1. 发明授权

US09532904B2 Corneal vitrification, methods and devices to produce corneal vitrification and methods of use thereof 有权
标题翻译：角膜玻璃化，产生角膜玻璃化的方法和装置及其使用方法
公开(公告)号：US09532904B2
公开(公告)日：2017-01-03
申请号：US14674890
申请日：2015-03-31
申请人： Olivia Serdarevic , Michael Berry , Donald F. Heller
发明人： Olivia Serdarevic , Michael Berry , Donald F. Heller
IPC分类号： A61B19/00 , A61F9/008 , A61F9/007 , A61N7/00
CPC分类号： A61F9/008 , A61F2/142 , A61F9/0079 , A61F9/00814 , A61F2009/00872 , A61N7/00 , A61N2007/0004
摘要： The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased elastic modulus; methods for producing and using the new composition of matter for modifying corneal structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photovitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters. A reverse template can be added to corneal vitrification systems to increase vitrification and modifications of structure and properties.
摘要翻译：本发明包括：一种新的物质组合物（包括在原位眼中的天然存在的体内角膜以及在天然存在的角膜基质组织内形成的至少一个玻璃化非天然存在的角膜基质组织体积的复合物），其中玻璃化组织的结构和性质从其天然存在的状态改变成非天然存在的玻璃状状态，其中包括但不限于增加的弹性模量; 用于生产和使用用于修饰角膜结构和性质的新组合物的方法，包括但不限于角膜光学像差; 伤口闭合粘连和移植附着力; 以及用于产生包含至少一个具有可控处理参数的光子源的新组合物的光生产系统。可以向角膜玻璃化系统添加反向模板，以增加玻璃化和结构和性质的修改。

2. 发明授权

US09526656B2 Corneal vitrification, methods and devices to produce corneal vitrification and methods of use thereof 有权
标题翻译：角膜玻璃化，产生角膜玻璃化的方法和装置及其使用方法
公开(公告)号：US09526656B2
公开(公告)日：2016-12-27
申请号：US14674992
申请日：2015-03-31
申请人： Olivia Serdarevic , Michael Berry , Donald F. Heller
发明人： Olivia Serdarevic , Michael Berry , Donald F. Heller
IPC分类号： A61B18/18 , A61F9/008 , A61F9/007
CPC分类号： A61F9/008 , A61F2/142 , A61F9/0079 , A61F9/00814 , A61F2009/00872 , A61N7/00 , A61N2007/0004
摘要： The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased elastic modulus; methods for producing and using the new composition of matter for modifying corneal structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photo vitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters. A reverse template can be added to corneal vitrification systems to increase vitrification and modifications of structure and properties.
摘要翻译：本发明包括：一种新的物质组合物（包括在原位眼中的天然存在的体内角膜以及在天然存在的角膜基质组织内形成的至少一个玻璃化非天然存在的角膜基质组织体积的复合物），其中玻璃化组织的结构和性质从其天然存在的状态改变成非天然存在的玻璃状状态，其中包括但不限于增加的弹性模量; 用于生产和使用用于修饰角膜结构和性质的新组合物的方法，包括但不限于角膜光学像差; 伤口闭合粘连和移植附着力; 以及用于产生包含至少一个具有可控处理参数的光子源的新组合物的照相玻璃化系统。可以向角膜玻璃化系统添加反向模板，以增加玻璃化和结构和性质的修改。

3. 发明授权

US09351793B2 Laser devices utilizing alexandrite laser operating at or near its gain peak as shorter-wavelength pumping sources and methods of use thereof 有权
标题翻译：利用在其增益峰值附近操作的亚历山大·雷射激光器的激光装置作为较短波长泵浦源及其使用方法
公开(公告)号：US09351793B2
公开(公告)日：2016-05-31
申请号：US14216387
申请日：2014-03-17
申请人： Chunbai Wu , Donald F. Heller
发明人： Chunbai Wu , Donald F. Heller
IPC分类号： H01S3/16 , A61B18/20 , H01S3/04 , H01S3/06 , A61B18/00 , H01S3/094 , H01S3/00 , H01S3/02 , H01S3/042
CPC分类号： A61B18/203 , A61B2018/00452 , A61B2018/2035 , A61B2018/2065 , H01S3/0007 , H01S3/005 , H01S3/025 , H01S3/0404 , H01S3/0405 , H01S3/042 , H01S3/061 , H01S3/094038 , H01S3/1616 , H01S3/1643
摘要： In some embodiments, the instant invention provides for a system that includes at least the following components: (i) an Alexandrite laser pumping subsystem; where the Alexandrite laser pumping subsystem is configured to: 1) produce wavelengths between 700 and 820 nm, and 2) produce a pump pulse having: i) a duration between 1 to 10 milliseconds, and ii) an energy measuring up to 100 Joules; where the Alexandrite laser pumping subsystem includes: 1) an optical fiber, and 2) a Lens system, (ii) a Thulium doped Yttrium Aluminum Garnet (Tm:YAG) laser subsystem; where the Tm:YAG laser subsystem includes: 1) a Tm:YAG gain medium, 2) a rod heat sink, and 3) at least one cooling device, (iii) a wavelength selecting device, where the wavelength selecting device is configured to deliver a wavelength between 1.75 microns to 2.1 microns; and where the system is configured to produce a high energy conversion efficiency.
摘要翻译：在一些实施例中，本发明提供了至少包括以下部件的系统：（i）亚历山大号激光泵浦子系统; 其中Alexandrite激光泵浦子系统被配置为：1）产生700和820nm之间的波长，以及2）产生泵浦脉冲，其具有：i）1至10毫秒之间的持续时间，以及ii）测量高达100焦耳的能量; Alexandrite激光泵浦子系统包括：1）光纤，2）透镜系统，（ii）掺a钇铝石榴石（Tm：YAG）激光子系统; 其中Tm：YAG激光子系统包括：1）Tm：YAG增益介质，2）棒状散热器，以及3）至少一个冷却装置，（iii）波长选择装置，其中波长选择装置被配置为传递1.75微米至2.1微米的波长; 并且其中系统被配置为产生高能量转换效率。

4. 发明授权

US06876689B2 Narrow spectral bandwidth tunable pulsed solid-state laser system 有权
标题翻译：窄谱带宽可调脉冲固态激光系统
公开(公告)号：US06876689B2
公开(公告)日：2005-04-05
申请号：US09876678
申请日：2001-06-07
申请人： John Curtis Walling , Donald F. Heller
发明人： John Curtis Walling , Donald F. Heller
IPC分类号： H01S3/083 , H01S3/109 , H01S3/16 , H01S3/23 , H01S5/12
CPC分类号： H01S3/10092 , H01S3/083 , H01S3/109 , H01S3/1633 , H01S3/1636 , H01S3/1648 , H01S5/12
摘要： A tunable solid-state laser system whose bandwidth and wavelength are controlled by the injection of light from a semiconductor diode laser. This laser system is capable of providing output light pulses over substantially all wavelength ranges in the electromagnetic spectrum. When suitably configured, it creates wavelength tunable (or fixed wavelength) pulses having spectral bandwidths that are Fourier transform limited and wavelength stabilized. The coupling means between the semiconductor diode laser and the ring laser cavity incorporates a means for optically isolating the diode laser source from optical feedback from the ring laser, ensuring diode laser source stability.
摘要翻译：一种可调谐固态激光系统，其带宽和波长通过从半导体二极管激光器的光注入来控制。该激光系统能够在电磁光谱中的基本上所有波长范围上提供输出光脉冲。当适当配置时，它产生波长可调谐（或固定波长）脉冲，其具有被傅里叶变换限制和波长稳定的频谱带宽。半导体二极管激光器和环形激光腔之间的耦合装置包括用于将二极管激光源与环形激光器的光学反馈光学隔离的装置，确保二极管激光源的稳定性。

5. 发明授权

US4350577A Electronically induced multiphoton absorption 失效
标题翻译：电子诱导多光子吸收
公开(公告)号：US4350577A
公开(公告)日：1982-09-21
申请号：US93659
申请日：1979-11-13
申请人： Donald F. Heller
发明人： Donald F. Heller
IPC分类号： B01D59/34 , B01D59/00
CPC分类号： B01D59/34
摘要： Electronic excitation of polyatomic molecules followed by nonradiative decay provides states from which efficient multiphoton infrared excitation can be achieved. Initial (electronic) excitation can be molecule-specific or isotope-selective. Subsequent multiphoton excitation has a threshold which can be an order of magnitude or more lower than for multiphoton excitation from the ground state. By this method, laser-induced chemical reactions or isotope separation can be achieved with lower infrared laser fluence and/or higher concentration of polyatomic molecules than with prior art methods.
摘要翻译：多原子分子的电子激发随后是非辐射衰减，提供可以实现有效的多光子红外激发的状态。初始（电子）激发可以是分子特异性或同位素选择性的。随后的多光子激发具有的阈值可以比来自基态的多光子激发低一个数量级或更多。通过这种方法，与现有技术方法相比，激光诱导的化学反应或同位素分离可以用较低的红外激光注量和/或更高浓度的多原子分子来实现。

6. 发明授权

US09545339B2 Corneal vitrification, methods and devices to produce corneal vitrification and methods of use thereof 有权
标题翻译：角膜玻璃化，产生角膜玻璃化的方法和装置及其使用方法
公开(公告)号：US09545339B2
公开(公告)日：2017-01-17
申请号：US14512952
申请日：2014-10-13
申请人： Olivia Serdarevic , Michael Berry , Donald F. Heller
发明人： Olivia Serdarevic , Michael Berry , Donald F. Heller
IPC分类号： A61F9/008 , A61F9/007 , A61N7/00
CPC分类号： A61F9/008 , A61F2/142 , A61F9/0079 , A61F9/00814 , A61F2009/00872 , A61N7/00 , A61N2007/0004
摘要： The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased eletastic modulus; methods for producing and using the new composition of matter for modifying cortical structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photovitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters. A reverse template can be added to corneal vitrification systems to increase vitrification and modifications of structure and properties.
摘要翻译：本发明包括：一种新的物质组合物（包括在原位眼中的天然存在的体内角膜以及在天然存在的角膜基质组织内形成的至少一个玻璃化非天然存在的角膜基质组织体积的复合物），其中玻璃化组织在结构和性质上从其天然存在的状态改变成非天然存在的玻璃样状态，其中包括但不限于增加的电化学模量; 用于生产和使用新的组合物用于改变皮层结构和性质的方法，包括但不限于角膜光学像差; 伤口闭合粘连和移植附着力; 以及用于产生包含至少一个具有可控处理参数的光子源的新组合物的光生产系统。可以向角膜玻璃化系统添加反向模板，以增加玻璃化和结构和性质的修改。

7. 发明申请

US20140276686A1 LASER DEVICES UTILIZING ALEXANDRITE LASER OPERATING AT OR NEAR ITS GAIN PEAK AS SHORTER-WAVELENGTH PUMPING SOURCES AND METHODS OF USE THEREOF 有权
标题翻译：激光器件利用亚临界激光器在其波峰值波峰或其附近工作或其附近的波峰波长电流源及其使用方法
公开(公告)号：US20140276686A1
公开(公告)日：2014-09-18
申请号：US14216387
申请日：2014-03-17
申请人： Chunbai Wu , Donald F. Heller
发明人： Chunbai Wu , Donald F. Heller
IPC分类号： A61B18/22 , A61B18/20 , H01S3/06 , H01S3/094 , H01S3/04
CPC分类号： A61B18/203 , A61B2018/00452 , A61B2018/2035 , A61B2018/2065 , H01S3/0007 , H01S3/005 , H01S3/025 , H01S3/0404 , H01S3/0405 , H01S3/042 , H01S3/061 , H01S3/094038 , H01S3/1616 , H01S3/1643
摘要： In some embodiments, the instant invention provides for a system that includes at least the following components: (i) an Alexandrite laser pumping subsystem; where the Alexandrite laser pumping subsystem is configured to: 1) produce wavelengths between 700 and 820 nm, and 2) produce a pump pulse having: i) a duration between 1 to 10 milliseconds, and ii) an energy measuring up to 100 Joules; where the Alexandrite laser pumping subsystem includes: 1) an optical fiber, and 2) a Lens system, (ii) a Thulium doped Yttrium Aluminum Garnet (Tm:YAG) laser subsystem; where the Tm:YAG laser subsystem includes: 1) a Tm:YAG gain medium, 2) a rod heat sink, and 3) at least one cooling device, (iii) a wavelength selecting device, where the wavelength selecting device is configured to deliver a wavelength between 1.75 microns to 2.1 microns; and where the system is configured to produce a high energy conversion efficiency.
摘要翻译：在一些实施例中，本发明提供了至少包括以下部件的系统：（i）亚历山大号激光泵浦子系统; 其中Alexandrite激光泵浦子系统被配置为：1）产生700和820nm之间的波长，以及2）产生泵浦脉冲，其具有：i）1至10毫秒之间的持续时间，以及ii）测量高达100焦耳的能量; Alexandrite激光泵浦子系统包括：1）光纤，2）透镜系统，（ii）掺a钇铝石榴石（Tm：YAG）激光子系统; 其中Tm：YAG激光子系统包括：1）Tm：YAG增益介质，2）棒状散热器，以及3）至少一个冷却装置，（iii）波长选择装置，其中波长选择装置被配置为传递1.75微米至2.1微米的波长; 并且其中系统被配置为产生高能量转换效率。

8. 发明授权

US6009114A Method and apparatus for pumping of transition metal ion containing solid state lasers using diode laser sources 失效
标题翻译：使用二极管激光源泵浦含有固态激光器的过渡金属离子的方法和装置
公开(公告)号：US6009114A
公开(公告)日：1999-12-28
申请号：US592897
申请日：1996-01-29
申请人： Donald F. Heller , Timothy Chow-Keong Chin , Jerzy Slawomir Krasinski
发明人： Donald F. Heller , Timothy Chow-Keong Chin , Jerzy Slawomir Krasinski
IPC分类号： H01S3/094 , H01S3/0941 , H01S3/16 , H01S3/91
CPC分类号： H01S3/09415 , H01S3/16 , H01S3/09408 , H01S3/0941 , H01S3/162 , H01S3/1623 , H01S3/1625 , H01S3/1633 , H01S3/1636 , H01S3/1648
摘要： The present invention encompasses an apparatus for pumping a laser (vibronic or otherwise), which comprises: a transition-metal ion-containing solid state laser gain medium; a means for exciting said laser medium to emit coherent radiation said exciting means being a pumping source comprising at least one laser diode operating at a wavelength shorter than 800 nm; and an optical resonator means for generating and controlling said coherent radiation.The present invention also encompasses a method of pumping a laser (vibronic or otherwise) comprising the steps of: generating a laser diode pumping beam at a wavelength shorter than 800 nm; exciting a transition-metal ion-containing solid state laser gain medium by impinging said laser diode pumping beam on said transition-metal ion-containing solid state laser gain medium, so as to excite the laser medium; and an optical resonator to emit coherent radiation.
摘要翻译：本发明包括用于泵浦激光（振动或其他）的装置，其包括：含过渡金属离子的固态激光增益介质; 用于激发所述激光介质发射相干辐射的装置，所述激励装置是泵浦源，其包括以短于800nm的波长工作的至少一个激光二极管; 以及用于产生和控制所述相干辐射的光学谐振器装置。本发明还包括泵浦激光（振动或其他）的方法，包括以下步骤：产生波长短于800nm的激光二极管泵浦光束; 通过将所述激光二极管泵浦光束照射在所述含过渡金属离子的固态激光增益介质上来激发含过渡金属离子的固态激光增益介质，以激发激光介质; 以及发射相干辐射的光学谐振器。

9. 发明授权

US5142548A Broadband tuning and laser line narrowing utilizing birefringent laser hosts 失效
标题翻译：利用双折射激光主机进行宽带调谐和激光线窄化
公开(公告)号：US5142548A
公开(公告)日：1992-08-25
申请号：US509392
申请日：1990-04-13
申请人： Jerzy S. Krasinski , Paul A. Papanestor , Yehuda B. Band , Donald F. Heller , Robert C. Morris , Timothy C. K. Chin
发明人： Jerzy S. Krasinski , Paul A. Papanestor , Yehuda B. Band , Donald F. Heller , Robert C. Morris , Timothy C. K. Chin
IPC分类号： H01S3/06 , H01S3/106
CPC分类号： H01S3/106 , H01S3/061 , H01S3/08054 , H01S3/083 , H01S3/1633
摘要： Rotational displacement of the birefringent lasing medium in a lasing cavity containing a polarizing element varies the spectral width of the generated laser light. The combination in a lasing cavity of a birefringent lasing medium, a polarizing element, a tuning element and a birefringent compensator permits output of narrow bandwidth spectrally tuned laser light continuously over the total gain bandwidth of the lasing medium by rotating the lasing medium, tuning to desired wavelength, and adjusting the birefringent compensator to optimize output of laser light.
摘要翻译：双折射激光介质在包含偏振元件的激光腔中的旋转位移改变所产生的激光的光谱宽度。在双折射激光介质，偏振元件，调谐元件和双折射补偿器的激光腔中的组合允许通过旋转激光介质在激光介质的总增益带宽下连续输出窄带宽频谱调谐的激光，调谐到所需波长，并调整双折射补偿器以优化激光输出。

10. 发明申请

US20140276678A1 SYSTEMS AND DEVICES FOR SHAPING HUMAN CORNEA AND METHODS OF USE THEREOF 审中-公开
标题翻译：用于形成人造脊椎的系统和装置及其使用方法
公开(公告)号：US20140276678A1
公开(公告)日：2014-09-18
申请号：US14215772
申请日：2014-03-17
申请人： Michael Berry , Olivia Serdarevic , Donald F. Heller
发明人： Michael Berry , Olivia Serdarevic , Donald F. Heller
IPC分类号： A61F9/008
CPC分类号： A61F9/009 , A61F2009/00872
摘要： In some embodiments, the instant invention provides for a system for shaping a human cornea of an eye that includes at least the following components: a sapphire applanation window/suction ring (SAWSR) system, where the SAWSR system includes a sapphire applanation window/suction ring (SAWSR), a conical holder, an illuminator, and a temperature control, where the SAWSR system is configured to: (i) be positioned on the eye, (ii) applanate the human cornea of the eye, (iii) generate and position a centration aid, and (iv) maintain temperature control; an optical delivery system, where the optical delivery system includes: (i) a laser, (ii) a fiber delivery holder, and (iii) a laser control subsystem, where the laser control subsystem is configured to display a user interface to: 1) control a power and a temporal waveform of each of the beamlets of light, and 2) irradiate the human cornea of the eye.
摘要翻译：在一些实施例中，本发明提供了一种用于整形眼睛的人类角膜的系统，该系统至少包括以下部件：蓝宝石压平窗/吸力环（SAWSR）系统，其中SAWSR系统包括蓝宝石压平窗/抽吸（SAWSR），锥形保持器，照明器和温度控制器，其中SAWSR系统被配置为：（i）定位在眼睛上，（ii）压制眼睛的人类角膜，（iii）产生和定位助剂，（iv）保持温度控制; 光学传送系统，其中所述光学传送系统包括：（i）激光器，（ii）光纤传送保持器，以及（iii）激光控制子系统，其中所述激光控制子系统被配置为显示用户界面以：1 ）控制每个子束光的功率和时间波形，以及2）照射眼睛的人角膜。

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