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1. 发明授权

US08435957B2 Use of lignan compound for anti-wrinkle treatment 有权
标题翻译：使用木酚素化合物进行抗皱治疗
公开(公告)号：US08435957B2
公开(公告)日：2013-05-07
申请号：US12665206
申请日：2008-06-20
申请人： Jae-Kwan Hwang , Hae Ji Lee , Jae Young Lee , Jae-Seok Shim , Jeong Hwan Kim , Do Un Kim , Heechul Chung , Jae Youn Chung
发明人： Jae-Kwan Hwang , Hae Ji Lee , Jae Young Lee , Jae-Seok Shim , Jeong Hwan Kim , Do Un Kim , Heechul Chung , Jae Youn Chung
IPC分类号： A61K31/70
CPC分类号： A61K8/97 , A61K8/347 , A61K8/498 , A61Q19/08
摘要： The present invention relates to a novel use of lignan compounds, which are isolated and purified from nutmeg or the aril of nutmeg for anti-wrinkle, and more particularly, the present invention relates to a novel use for anti-wrinkle of an extract of the nutmeg or an extract of the aril of the nutmeg, fragrin A, austobailignan 7, licarin E, and macelignan. The extracts and lignan compounds of the present invention have activities in suppressing collagen degradation enzyme-1 (MMP-I, matrix metalloprotei-nase-1) and formation of new collagen (type-1 procollagen), thereby having effect on inhibitng wrinkle caused by photoaging. Accordingly, the extracts and lignan compounds of the present invention may be useful for preventing or treating wrinkle caused by photoaging.
摘要翻译：本发明涉及木糖素化合物的新用途，其从肉豆蔻或肉豆蔻的肠道中分离和纯化用于抗皱，更具体地，本发明涉及用于抗皱的提取物的抗皱纹的新用途肉豆蔻或肉豆蔻，fragrin A，奥维菌素7，licarin E和肉豆蔻衣木脂的提取物。本发明的提取物和木脂素化合物具有抑制胶原降解酶-1（MMP-1，基质金属蛋白酶-1）和新型胶原（1型前胶原）的形成的作用，从而具有抑制由光老化因此，本发明的提取物和木酚素化合物可用于预防或治疗由光老化引起的皱纹。

2. 发明申请

US20100285154A1 USE OF LIGNAN COMPOUNDS FOR TREATING OR PREVENTING INFLAMMATORY DISEASE 有权
标题翻译：使用化合物治疗或预防炎症疾病
公开(公告)号：US20100285154A1
公开(公告)日：2010-11-11
申请号：US12766255
申请日：2010-04-23
申请人： Jae-Kwan Hwang , Do-Un Kim , Jae-Youn Chung , Hee-Chul Chung , Kyu-Lee Han
发明人： Jae-Kwan Hwang , Do-Un Kim , Jae-Youn Chung , Hee-Chul Chung , Kyu-Lee Han
IPC分类号： A61K36/185 , A61P19/02 , A61P29/00 , A61P17/00 , A61P11/06 , A61K31/36
CPC分类号： A61K31/36 , A61K9/0095 , A61K9/2054 , A61K36/185 , Y02A50/401 , Y10S514/859 , Y10S514/886
摘要： The present invention relates to the use of lignan compounds for treating or preventing an inflammatory disease. More particularly, it relates to a method for preventing or treating an inflammatory disease, comprising administering to a subject in need thereof an effective amount of macelignan represented by Chemical Formula I or a pharmaceutically acceptable salt thereof. The lignan compound has the effect of inhibiting inflammatory reactions by inhibiting the production or expression of inflammation mediators NO, iNOS, PGE2, COX-2 and TNF-α and by treating or preventing inflammatory disease in vivo. Accordingly, the lignan compound or a Myristica fragrans extract will be highly useful for the treatment or prevention of an inflammatory disease.
摘要翻译：本发明涉及木素素化合物用于治疗或预防炎性疾病的用途。更具体地说，本发明涉及一种预防或治疗炎性疾病的方法，其包括向有需要的受试者施用有效量的由化学式I表示的肉豆蔻衣木脂或其药学上可接受的盐。木酚素化合物具有通过抑制炎症介质NO，iNOS，PGE2，COX-2和TNF-α的产生或表达并通过在体内治疗或预防炎性疾病来抑制炎症反应的作用。因此，木脂素化合物或肉豆蔻提取物对于治疗或预防炎性疾病是非常有用的。

3. 发明申请

US20120088840A1 NOVEL USE OF PANDURATIN DERIVATIVE OR BOESENBERGIA PANDURATA EXTRACT 有权
标题翻译：使用潘多林衍生物或槟榔酚提取物
公开(公告)号：US20120088840A1
公开(公告)日：2012-04-12
申请号：US13123519
申请日：2009-10-09
申请人： Jae-Kwan Hwang , Do Un Kim
发明人： Jae-Kwan Hwang , Do Un Kim
IPC分类号： A61K31/12 , C07C49/835 , A61P3/10 , A61P3/04 , A61P3/06 , A61P7/00 , C07C49/84 , A61P3/00
CPC分类号： A23C9/152 , A23L2/02 , A23L2/52 , A23L13/67 , A23L23/00 , A23L33/105 , A23L33/30 , A61K31/121 , A61K36/906
摘要： The present invention relates to a novel use of a panduratin derivative or a Boesenbergia pandurata extract. More specifically, the invention relates to a composition for preventing and treating/relieving a metabolic disease selected from a group consisting of obesity, hyperlipidemia, hypercholesterolemia and diabetes, containing a panduratin derivative represented by Chemical Formula 1, 2 or 3 or a Boesenbergia pandurata extract as an active ingredient, a method for treating a metabolic disease selected from a group consisting of obesity, hyperlipidemia, hypercholesterolemia and diabetes, by administering an effective amount of the panduratin derivative or the Boesenbergia pandurata extract to a subject in need thereof, and a use of the panduratin derivative or the Boesenbergia pandurata extract to prepare a reagent for preventing and treating/relieving a metabolic disease selected from a group consisting of obesity, hyperlipidemia, hypercholesterolemia and diabetes. As can be seen foregoing, the present invention provides a novel use of a panduratin derivative or a Boesenbergia pandurata extract. A panduratin derivative or a Boesenbergia pandurata extract of the present invention shows excellent effects on a metabolic disease such as obesity, hyperlipidemia, hypercholesterolemia and diabetes by decreasing highly related causes of metabolic diseases such as on weight, body fat and lipid-content. Since a composition of the present invention is originated from natural materials, it can be used without side effect and provides novel method for preventing and treating/relieving a metabolic disease through body weight loss and body fat loss and the like.
摘要翻译：本发明涉及一种潘多汀衍生物或蒲公英提取物的新用途。更具体地说，本发明涉及用于预防和治疗或减轻选自肥胖，高脂血症，高胆固醇血症和糖尿病的代谢疾病的组合物，其含有由化学式1,2或3表示的潘多肽衍生物或泛酸鲍氏菌提取物作为活性成分，可以通过向有需要的受试者施用有效量的潘多汀衍生物或泛黄柏提取物来治疗选自肥胖症，高脂血症，高胆固醇血症和糖尿病的代谢疾病的方法，以及使用的潘多汀衍生物或Boesenbergia pandurata提取物，以制备用于预防和治疗/减轻选自肥胖症，高脂血症，高胆固醇血症和糖尿病的代谢疾病的试剂。从前面可以看出，本发明提供了一种潘多汀衍生物或Boesenbergia pandurata提取物的新用途。本发明的潘多林衍生物或潘氏白僵菌提取物通过降低代谢性疾病如重量，体脂肪和脂质含量的高度相关原因，对肥胖症，高脂血症，高胆固醇血症和糖尿病等代谢疾病表现出优异的效果。由于本发明的组合物来自天然材料，所以可以无副作用地使用，并且通过体重减轻和身体脂肪减少等提供预防和治疗/减轻代谢疾病的新方法。

4. 发明申请

US20110071221A1 METHOD FOR TREATING CONDITIONS MEDIATED BY PPAR USING MACELIGNAN 有权
标题翻译：用于处理使用MACELIGNAN的PPAR介导的条件的方法
公开(公告)号：US20110071221A1
公开(公告)日：2011-03-24
申请号：US11922509
申请日：2006-06-27
申请人： Jae-Kwan Hwang , Kyu-Lee Han , Jong-Hee Sohn , Ah-Jin Kim , Jeong-Han Choo , Jae-Young Lee , Jeong-Hwan Kim , Do Un Kim , Heechul Chung , Jae Youn Chung
发明人： Jae-Kwan Hwang , Kyu-Lee Han , Jong-Hee Sohn , Ah-Jin Kim , Jeong-Han Choo , Jae-Young Lee , Jeong-Hwan Kim , Do Un Kim , Heechul Chung , Jae Youn Chung
IPC分类号： A61K31/357 , A61P3/00
CPC分类号： A61K31/357
摘要： Disclosed is a method for treating PPAR (peroxisome proliferator activated receptor)mediated diseases, such as diabetes mellitus and diabetic complications, which includes administering to a subject an effective amount of macelignan represented by the following Formula (I): or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明公开了一种治疗PPAR（过氧化物酶体增殖物激活受体）介导的疾病如糖尿病和糖尿病并发症的方法，其包括向受试者施用有效量的由下式（I）表示的肉豆蔻衣木脂或其药学上可接受的盐。

5. 发明授权

US07902254B1 Method for treating conditions mediated by PPAR using macelignan 有权
标题翻译：用肉豆蔻衣木素治疗PPAR介导的病症的方法
公开(公告)号：US07902254B1
公开(公告)日：2011-03-08
申请号：US11922509
申请日：2006-06-27
申请人： Jae-Kwan Hwang , Kyu-Lee Han , Jong-Hee Sohn , Ah-Jin Kim , Jeong-Han Choo , Jae-Young Lee , Jeong-Hwan Kim , Do Un Kim , Heechul Chung , Jae Youn Chung
发明人： Jae-Kwan Hwang , Kyu-Lee Han , Jong-Hee Sohn , Ah-Jin Kim , Jeong-Han Choo , Jae-Young Lee , Jeong-Hwan Kim , Do Un Kim , Heechul Chung , Jae Youn Chung
IPC分类号： A61K31/36
CPC分类号： A61K31/357
摘要： Disclosed is a method for treating PPAR (peroxisome proliferator activated receptor)-mediated diseases, such as diabetes mellitus, which includes administering to a subject an effective amount of macelignan represented by the following Formula (I): or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明公开了一种治疗PPAR（过氧化物酶体增殖物激活受体）介导的疾病如糖尿病的方法，其包括向受试者施用有效量的由下式（I）表示的肉豆蔻衣木脂或其药学上可接受的盐。

6. 发明申请

US20120288579A1 USE OF LIGNAN COMPOUND FOR ANTI-WRINKLE TREATMENT 有权
标题翻译： LIGNAN化合物用于抗皱治疗的用途
公开(公告)号：US20120288579A1
公开(公告)日：2012-11-15
申请号：US12665206
申请日：2009-06-20
申请人： Jae-Kwan Hwang , Hae Ji Lee , Jae Young Lee , Jae-Seok Shim , Jeong Hwan Kim , Do Un Kim , Heechul Chung , Jae Youn Chung
发明人： Jae-Kwan Hwang , Hae Ji Lee , Jae Young Lee , Jae-Seok Shim , Jeong Hwan Kim , Do Un Kim , Heechul Chung , Jae Youn Chung
IPC分类号： A61K36/575 , A61K31/075 , A61P17/00 , C07D317/46 , C07C43/23 , A61K31/357 , C07D407/10
CPC分类号： A61Q19/08 , A61K8/347 , A61K8/498 , A61K8/9789
摘要： The present invention relates to a novel use of lignan compounds, which are isolated and purified from nutmeg or the aril of nutmeg for anti-wrinkle, and more particularly, the present invention relates to a novel use for anti-wrinkle of an extract of the nutmeg or an extract of the aril of the nutmeg, fragrin A, austobailignan 7, licarin E, and macelignan. The extracts and lignan compounds of the present invention have activities in suppressing collagen degradation enzyme-1 (MMP-1, matrix metalloprotei-nase-1) and formation of new collagen (type-1 procollagen), thereby having effect on inhibitng wrinkle caused by photoaging. Accordingly, the extracts and lignan compounds of the present invention may be useful for preventing or treating wrinkle caused by photoaging.
摘要翻译：本发明涉及木糖素化合物的新用途，其从肉豆蔻或肉豆蔻的肠道中分离和纯化用于抗皱，更具体地，本发明涉及用于抗皱的提取物的抗皱纹的新用途肉豆蔻或肉豆蔻，fragrin A，奥维菌素7，licarin E和肉豆蔻衣木脂的提取物。本发明的提取物和木脂素化合物具有抑制胶原降解酶-1（MMP-1，基质金属蛋白酶-1）和新型胶原（1型前胶原）的形成的作用，从而具有抑制由光老化因此，本发明的提取物和木酚素化合物可用于预防或治疗由光老化引起的皱纹。

7. 发明申请

US20110118346A1 NOVEL USE OF LIGNAN-TYPE COMPOUNDS OR EXTRACT OF NUTMEG OR ARIL OF NUTMEG COMPRISING THE SAME 有权
标题翻译：新型使用LIGNAN型化合物或提取NUTMEG或包含其的NUTMEG
公开(公告)号：US20110118346A1
公开(公告)日：2011-05-19
申请号：US12738626
申请日：2008-10-17
申请人： Jae Kwan Hwang , Yu-Mi Cho , Gyu Hoi Kim , Jeong Hwan Kim , Hae Ji Lee , Do Un Kim , Hee Chul Chung , Jae Youn Chung , Hyun In Oh
发明人： Jae Kwan Hwang , Yu-Mi Cho , Gyu Hoi Kim , Jeong Hwan Kim , Hae Ji Lee , Do Un Kim , Hee Chul Chung , Jae Youn Chung , Hyun In Oh
IPC分类号： A61K31/357 , A61Q19/02
CPC分类号： A61Q19/02 , A61K8/4973 , A61K8/97 , A61K31/357 , A61K36/185
摘要： The present invention relates to a new use of lignan-type compounds or an extract of nutmeg or aril of nutmeg comprising the same. More particularly, the present invention relates to a composition for skin whitening comprising a lignan-type compound or an extract of nutmeg or aril of nutmeg comprising the same. Because the lignan compound represented by Chemical Formulas 1 to 3 or the extract of nutmeg or aril of nutmeg has superior skin whitening activity by inhibiting melanin production and tyrosinase activity, it can be used for the preparation of a cosmetic composition, food composition or pharmaceutical composition for skin whitening.
摘要翻译：本发明涉及木素素型化合物或含有该木素素类化合物的肉豆蔻或肉豆蔻酸提取物的新用途。更具体地，本发明涉及一种皮肤美白组合物，其包含木素素型化合物或包含该组合物的肉豆蔻或肉豆蔻酸的提取物。由于化学式1〜3所示的木酚素化合物或肉豆蔻肉豆蔻酸提取物通过抑制黑色素生成和酪氨酸酶活性而具有优异的皮肤美白活性，因此可用于制备化妆品组合物，食品组合物或药物组合物用于皮肤美白。

8. 发明授权

US08853264B2 Use of lignan compounds for treating or preventing inflammatory disease 有权
标题翻译：木脂素化合物用于治疗或预防炎症性疾病
公开(公告)号：US08853264B2
公开(公告)日：2014-10-07
申请号：US12766255
申请日：2010-04-23
申请人： Jae-Kwan Hwang , Do-Un Kim , Jae-Youn Chung , Hee-Chul Chung , Kyu-Lee Han
发明人： Jae-Kwan Hwang , Do-Un Kim , Jae-Youn Chung , Hee-Chul Chung , Kyu-Lee Han
IPC分类号： A61K36/185 , A61K31/36 , A61P17/00 , A61P29/00 , A61K9/00 , A61K9/20
CPC分类号： A61K31/36 , A61K9/0095 , A61K9/2054 , A61K36/185 , Y02A50/401 , Y10S514/859 , Y10S514/886
摘要： The present invention relates to the use of lignan compounds for treating or preventing an inflammatory disease. More particularly, it relates to a method for preventing or treating an inflammatory disease, comprising administering to a subject in need thereof an effective amount of macelignan represented by Chemical Formula I or a pharmaceutically acceptable salt thereof. The lignan compound has the effect of inhibiting inflammatory reactions by inhibiting the production or expression of inflammation mediators NO, iNOS, PGE2, COX-2 and TNF-α and by treating or preventing inflammatory disease in vivo. Accordingly, the lignan compound or a Myristica fragrans extract will be highly useful for the treatment or prevention of an inflammatory disease.
摘要翻译：本发明涉及木素素化合物用于治疗或预防炎性疾病的用途。更具体地说，本发明涉及一种预防或治疗炎性疾病的方法，其包括向有需要的受试者施用有效量的由化学式I表示的肉豆蔻衣木脂或其药学上可接受的盐。木酚素化合物具有通过抑制炎症介质NO，iNOS，PGE2，COX-2和TNF-α的产生或表达并通过在体内治疗或预防炎性疾病来抑制炎症反应的作用。因此，木脂素化合物或肉豆蔻提取物对于治疗或预防炎性疾病是非常有用的。

9. 发明授权

US08653143B2 Use of panduratin derivative or Boesenbergia pandurata extract 有权
标题翻译：使用潘多汀衍生物或Boesenbergia pandurata提取物
公开(公告)号：US08653143B2
公开(公告)日：2014-02-18
申请号：US13123519
申请日：2009-10-09
申请人： Jae-Kwan Hwang , Do Un Kim
发明人： Jae-Kwan Hwang , Do Un Kim
IPC分类号： A61K31/12
CPC分类号： A23C9/152 , A23L2/02 , A23L2/52 , A23L13/67 , A23L23/00 , A23L33/105 , A23L33/30 , A61K31/121 , A61K36/906
摘要： The present invention relates to a novel use of a panduratin derivative or a Boesenbergia pandurata extract. More specifically, the invention relates to a composition for preventing and treating/relieving a metabolic disease selected from a group consisting of obesity, hyperlipidemia, hypercholesterolemia and diabetes, containing a panduratin derivative represented by Chemical Formula 1, 2 or 3 or a Boesenbergia pandurata extract as an active ingredient, a method for treating a metabolic disease selected from a group consisting of obesity, hyperlipidemia, hypercholesterolemia and diabetes, by administering an effective amount of the panduratin derivative or the Boesenbergia pandurata extract to a subject in need thereof, and a use of the panduratin derivative or the Boesenbergia pandurata extract to prepare a reagent for preventing and treating/relieving a metabolic disease selected from a group consisting of obesity, hyperlipidemia, hypercholesterolemia and diabetes.
摘要翻译：本发明涉及一种潘多汀衍生物或蒲公英提取物的新用途。更具体地说，本发明涉及用于预防和治疗或减轻选自肥胖，高脂血症，高胆固醇血症和糖尿病的代谢疾病的组合物，其含有由化学式1,2或3表示的潘多肽衍生物或泛酸鲍氏菌提取物作为活性成分，可以通过向有需要的受试者施用有效量的潘多汀衍生物或泛黄柏提取物来治疗选自肥胖症，高脂血症，高胆固醇血症和糖尿病的代谢疾病的方法，以及使用的潘多汀衍生物或Boesenbergia pandurata提取物，以制备用于预防和治疗/减轻选自肥胖症，高脂血症，高胆固醇血症和糖尿病的代谢疾病的试剂。

10. 发明授权

US08969408B2 Use of lignan-type compounds or extract of nutmeg or aril of nutmeg comprising the same 有权
标题翻译：使用木质素类化合物或包含其的肉豆蔻或肉豆蔻的提取物
公开(公告)号：US08969408B2
公开(公告)日：2015-03-03
申请号：US12738626
申请日：2008-10-17
申请人： Jae Kwan Hwang , Yu-Mi Cho , Gyu Hoi Kim , Jeong Hwan Kim , Hae Ji Lee , Do Un Kim , Hee Chul Chung , Jae Youn Chung , Hyun In Oh
发明人： Jae Kwan Hwang , Yu-Mi Cho , Gyu Hoi Kim , Jeong Hwan Kim , Hae Ji Lee , Do Un Kim , Hee Chul Chung , Jae Youn Chung , Hyun In Oh
IPC分类号： A61K31/36 , A61K31/34 , A61Q19/02 , A61K8/49 , A61K8/97
CPC分类号： A61Q19/02 , A61K8/4973 , A61K8/97 , A61K31/357 , A61K36/185
摘要： The present invention relates to a new use of lignan-type compounds or an extract of nutmeg or aril of nutmeg comprising the same. More particularly, the present invention relates to a composition for skin whitening comprising a lignan-type compound or an extract of nutmeg or aril of nutmeg comprising the same. Because the lignan compound represented by Chemical Formulas 1 to 3 or the extract of nutmeg or aril of nutmeg has superior skin whitening activity by inhibiting melanin production and tyrosinase activity, it can be used for the preparation of a cosmetic composition, food composition or pharmaceutical composition for skin whitening.
摘要翻译：本发明涉及木素素型化合物或含有该木素素类化合物的肉豆蔻或肉豆蔻酸提取物的新用途。更具体地，本发明涉及一种皮肤美白组合物，其包含木素素型化合物或包含该组合物的肉豆蔻或肉豆蔻酸的提取物。由于化学式1〜3所示的木酚素化合物或肉豆蔻肉豆蔻酸提取物通过抑制黑色素生成和酪氨酸酶活性而具有优异的皮肤美白活性，因此可用于制备化妆品组合物，食品组合物或药物组合物用于皮肤美白。

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