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1. 发明授权

US5353792A Sensing device 失效
标题翻译：感应装置
公开(公告)号：US5353792A
公开(公告)日：1994-10-11
申请号：US96409
申请日：1993-07-26
申请人： Dietrich W. Lubbers , Hellfried Karpf
发明人： Dietrich W. Lubbers , Hellfried Karpf
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1459 , G01N21/77 , G01N21/80
CPC分类号： A61B5/14528 , A61B5/1459 , A61B5/686
摘要： In order to simultaneously determine the concentrations of different analytes in several places in a tissue by means of a thin, biocompatible tube or cannula which is inserted into the tissue, the tube is provided with several areas along its length which contain either identical or different optically excitable and readable, preferably luminescence-optical, indicating substances for measuring the local distribution of one parameter, such as O.sub.2 concentration or O.sub.2 partial pressure, or for simultaneous measurement of at least two different parameters, e.g., pO.sub.2, pCO.sub.2 or pH.
摘要翻译：为了同时通过插入到组织中的薄的，生物相容的管或插管来确定组织中几个位置中不同分析物的浓度，该管沿其长度设置有多个相同或不同光学的区域可激发和可读，优选发光光学，指示用于测量一个参数的局部分布的物质，例如O 2浓度或O 2分压，或用于同时测量至少两个不同参数，例如pO 2，pCO 2或pH。

2. 发明授权

US5059396A Arrangement for optical measuring of concentration of substances 失效
标题翻译：用于光学测量物质浓度的安排
公开(公告)号：US5059396A
公开(公告)日：1991-10-22
申请号：US249586
申请日：1988-09-26
申请人： Norbert Opitz , Dietrich W. Lubbers , Bernhard Schrader
发明人： Norbert Opitz , Dietrich W. Lubbers , Bernhard Schrader
IPC分类号： G01N21/27 , A61B5/00 , G01N21/03 , G01N21/3504 , G01N21/49 , G01N21/552 , G01N21/65 , G01N21/77
CPC分类号： G01N21/552 , A61B5/1455 , G01N2021/0385 , G01N21/3504 , G01N21/65
摘要： An arrangement for optical measuring concentration of substances has a measuring space which is composed of a material selectively permeable for particles to be measured, acting back on the particles and transparent for a measuring radiation, and a measuring space is arranged in working connection with the object to be measured and the measuring radiation passes through the measuring space. The measuring space has a layer that is a water-insoluble solvent or made of poly(ethylene terephthalate) or polytetrafluoroethylene. The layer excludes a reaction from the particles to be measured.
摘要翻译：用于光学测量物质浓度的装置具有测量空间，该测量空间由对待测量颗粒选择性可渗透的材料组成，作用在颗粒上并且透明以用于测量辐射，并且测量空间被布置成与物体工作连接被测量并且测量辐射通过测量空间。测量空间具有作为水不溶性溶剂的层或由聚对苯二甲酸乙二醇酯或聚四氟乙烯制成的层。该层排除了待测颗粒的反应。

3. 发明授权

US5057431A Device for optical measuring of physical dimensions and material concentrations 失效
标题翻译：用于光学测量物理尺寸和材料浓度的装置
公开(公告)号：US5057431A
公开(公告)日：1991-10-15
申请号：US245342
申请日：1988-09-15
申请人： Dietrich W. Lubbers , Klaus P. Volkl , Norbert Opitz
发明人： Dietrich W. Lubbers , Klaus P. Volkl , Norbert Opitz
IPC分类号： G01K1/00 , G01K11/00 , G01N21/64
CPC分类号： G01N21/643 , G01K1/00 , G01K11/00 , Y10S435/817 , Y10T436/255
摘要： An optode designed to prevent washing away of the indicator and reagent from a membrane is located within an optical device that measures substance concentrations. The reagent and indicator materials are covalently bound on the membrane. The membrane can be a polysaccharide, especially cellulose, an acid glycol ester, or it can contain silicon. The indicator and/or reagent can be covalently bound to the membrane by a bridge molecular, particularly a multifunctional aldehyde, glutaraldehyde or a silane.
摘要翻译：设计用于防止指示剂和试剂从膜上洗掉的光学设备位于测量物质浓度的光学装置内。试剂和指示剂材料共价结合在膜上。膜可以是多糖，特别是纤维素，酸性乙二醇酯，或者它可以含有硅。指示剂和/或试剂可以通过桥分子，特别是多官能醛，戊二醛或硅烷共价结合到膜上。

4. 发明授权

US4597392A Arrangement for measuring diffusing particles 失效
标题翻译：漫射粒子测定装置
公开(公告)号：US4597392A
公开(公告)日：1986-07-01
申请号：US597105
申请日：1984-04-02
申请人： Norbert Opitz , Dietrich W. Lubbers
发明人： Norbert Opitz , Dietrich W. Lubbers
IPC分类号： A61B5/145 , A61B3/00 , A61B5/00 , A61B5/1455 , G01N21/64 , G01N33/49 , G01N33/50
CPC分类号： A61B5/14556 , A61B3/0008 , A61B5/1459 , G01N21/6428 , G01N2021/7786
摘要： An arrangement for measuring diffusing particles has at least one monochromatic radiation source and a light measuring device, as well as at least one material limited particle-permeable indicator chamber provided with an optical fluorescent indicator which is optically changeable by the particles to be measured, and a carrier body having a surface which is arranged to face an eyelid and has depressions in which the indicator chambers are arranged.
摘要翻译：用于测量漫射颗粒的布置具有至少一个单色辐射源和光测量装置，以及至少一个材料限制的可透过粒子的指示器室，其具有光学荧光指示器，该光学荧光指示器可被被测量的颗粒光学改变;以及具有被设置为面对眼睑并且具有其中布置有指示器室的凹陷的表面的载体主体。

5. 发明授权

US4511660A Process and arrangement for measuring ion strength 失效
标题翻译：测量离子强度的过程和布置
公开(公告)号：US4511660A
公开(公告)日：1985-04-16
申请号：US503251
申请日：1983-06-10
申请人： Dietrich W. Lubbers , Norbert Opitz
发明人： Dietrich W. Lubbers , Norbert Opitz
IPC分类号： G01N21/80 , G01N27/416 , G01N31/00 , G01N31/22 , G01N33/84 , G01N21/00 , G01N21/77 , G01N27/36
CPC分类号： G01N33/84
摘要： Process and apparatus for directly measuring the ion strength of an electrolyte solution is disclosed. The pH value of the electrolyte is measured by means of a first measurement with a first indicator dependent on the ion strength and by means of a second measurement with a second indicator dependent on ion strength in a manner different from the first indicator whereby the ion strength is computed by means of the approximation ##EQU1## J=ion strength Jo=ion strength upon calibrationpH'(N)=pH value, measured with a first indicator N dependent on the ion strength (HPTS)pH'(X)=pH value, measured with a second indicator X dependent on the ion strength, the ion strength dependence of which is different from that of the first indicatorW(N)=valency of the first indicatorW(X)=valency of the second indicatorwith ##EQU2## The ion strengths of other ions and of unknown electrolyte may also be computed.
摘要翻译：公开了用于直接测量电解质溶液的离子强度的方法和装置。电解质的pH值通过第一测量来测量，其中第一指示剂取决于离子强度，并且借助于第二指示剂以与第一指示剂不同的方式依赖于离子强度的第二指示剂来测量，由此离子强度（2）J =离子强度Jo =校准时的离子强度pH值（N）= pH值，取决于离子强度（HPTS）pH'（X）的第一指示剂N测量）= pH值，其取决于离子强度的第二指示剂X，其离子强度依赖性不同于第一指示剂W（N）=第一指示剂的化合价W（X）=第二指示剂的化合价指示器（2a）可以计算其他离子和未知电解质的离子强度。

6. 发明授权

US4273442A Spectral photometer for medical applications 失效
标题翻译：光谱光度计用于医疗应用
公开(公告)号：US4273442A
公开(公告)日：1981-06-16
申请号：US27850
申请日：1979-04-06
申请人： Dietrich W. Lubbers
发明人： Dietrich W. Lubbers
IPC分类号： A61B5/00 , G01J3/28 , G01J3/34 , G01N33/48
CPC分类号： A61B5/1455 , G01J3/28 , G01J2003/2866
摘要： A spectral photometer emits light towards an object of interest, receives e light reflected back from the object of interest, and includes a timer or synchronizer operative for causing the spectral photometer to produce an output signal whose successive values correspond to the intensity of the spectrum derived from the object of interest at successive wavelengths. The spectral photometer output signal is applied to an oscilloscope for display of the thusly generated spectrum. The oscilloscope screen is provided with interpretation marks at characteristic points of the displayed spectrum, either by providing such marks on a transparent plate mounted in front of the screen, or by applying to the oscilloscope signals causing the scope itself to generate these marks. These marks may be curves shaped and located to be intersected by both maxima of an oxygenated-hemoglobin spectrum irrespective of the degree of oxygenation. The distance between the interpretation marks automatically provided can be automatically measured to generate an indication of their wavelength difference. The interpretation marks can also be in the form of a complete reference or comparison spectrum, selected out from a storage storing a plurality of such reference spectra, and applied as a signal to the scope to effect superimposed display of both the spectrum derived from the spectral photometer and the selected reference spectrum.
摘要翻译：光谱光度计朝向感兴趣的物体发射光，接收从感兴趣对象反射回来的光，并且包括定时器或同步器，其操作用于使光谱光度计产生输出信号，其连续值对应于衍生的光谱的强度从感兴趣的对象在连续的波长。光谱光度计输出信号被施加到示波器以显示由此产生的光谱。通过在安装在屏幕前面的透明板上提供这些标记，或者通过向示波器应用信号，使示波器本身产生这些标记，示波器屏幕将在显示频谱的特征点处提供解释标记。这些标记可以是曲线形状并且被定位成与氧合血红蛋白谱的最大值相交，而与氧合程度无关。可以自动测量自动提供的解释标记之间的距离，以产生其波长差的指示。解释标记还可以是从存储多个这样的参考光谱的存储器中选出的完整的参考或比较光谱的形式，并且作为信号施加到范围以实现从光谱导出的光谱的叠加显示光度计和所选参考光谱。

7. 发明授权

US4272484A Filling for optodes 失效
标题翻译：灌装光电
公开(公告)号：US4272484A
公开(公告)日：1981-06-09
申请号：US72780
申请日：1979-09-05
申请人： Dietrich W. Lubbers
发明人： Dietrich W. Lubbers
IPC分类号： C12M1/34 , C12Q1/26 , G01N21/77 , G01N31/22 , G01N33/52 , G01N33/543 , G01N21/78 , G01N21/64
CPC分类号： G01N31/22 , G01N21/77 , G01N33/521 , G01N33/54373
摘要： In order to improve the selectivity of an indicator chamber or optode conting of an indicator and a membrane impermeable to the indicator and surrounding it, for use in the measurement of concentration of component particles by means of an optical light measurement system including a light source, a light receiver and a readout device, a substance which reacts with the particle to be measured is provided within the indicator chamber, and the reaction product then modifies the optical properties of the indicator.
摘要翻译：为了提高由指示剂组成的指示器或光学器件的选择性，以及指示器不可渗透的膜并围绕该指示器，用于通过包括光源的光学测量系统测量组分颗粒的浓度，光接收器和读出装置，在指示器室内设置与被测量颗粒反应的物质，然后使反应产物改变指示剂的光学特性。

8. 发明授权

US4255053A Photometer including auxiliary indicator means 失效
标题翻译：光度计包括辅助指示装置
公开(公告)号：US4255053A
公开(公告)日：1981-03-10
申请号：US903411
申请日：1978-05-08
申请人： Dietrich W. Lubbers , Norbert Opitz
发明人： Dietrich W. Lubbers , Norbert Opitz
IPC分类号： G01N21/27 , G01J3/443 , G01N9/24 , G01N21/64 , G01N21/63
CPC分类号： G01N21/643
摘要： An apparatus for an optical measurement of the concentration of substancesncluding at least one monochromator means, one photometer means and one optometric means. A further reference indicator means is added to the indicator means. This further indicator means changes the measuring light and will not be changed by the concentration of the substance to be measured.
摘要翻译：一种用于光学测量包括至少一个单色仪装置，一个光度计装置和一个验光装置的物质浓度的装置。另外的参考指示装置被添加到指示装置。该进一步的指标意味着改变测量光，并且不会被待测物质的浓度改变。

9. 发明授权

US4230122A Transcutaneous monitoring of critical perfusion-efficiency situations 失效
标题翻译：经皮监测关键灌注效率情况
公开(公告)号：US4230122A
公开(公告)日：1980-10-28
申请号：US937946
申请日：1978-09-14
申请人： Dietrich W. Lubbers , Albert Huch
发明人： Dietrich W. Lubbers , Albert Huch
IPC分类号： A61B5/00 , A61B5/026 , A61B5/02
CPC分类号： A61B5/14542 , A61B5/026 , A61B5/1477 , A61B5/1491
摘要： First and second probes are laid against the skin to transcutaneously measure perfusion and e.g., oxygen concentration and generate corresponding first and second signals. These signals are fed to a signal-processing unit which triggers an alarm whenever changes in these signals meet predetermined rate-of-change criteria. Among these criteria is parallel increase in both perfusion and e.g., oxygen concentration, parallel decrease in both perfusion and e.g., oxygen concentration, and unchanging perfusion accompanied by decreasing e.g., oxygen concentration. The probes are occasionally pressed against the skin, for example under the control of a timer, with a pressure in excess of 1 g/cm.sup.2, to occasionally induce hyperemic conditions and see whether parallel changes in perfusion and concentration result.
摘要翻译：将第一和第二探针放置在皮肤上以经皮测量灌注，例如氧浓度并产生相应的第一和第二信号。这些信号被馈送到信号处理单元，每当这些信号的改变满足预定的变化率标准时触发警报。在这些标准中，这两个标准是平行增加灌注，例如氧气浓度，两个灌注中的平行减少，例如氧浓度，以及不断变化的灌注，伴随着例如氧浓度的降低。探针有时会压在皮肤上，例如在定时器的控制下，压力超过1g / cm2，偶尔会诱发充血条件，看是否产生灌注和浓度的平行变化。

10. 发明授权

US5376336A Apparatus for determining the flow of matter passing through a boundary surface 失效
标题翻译：用于确定通过边界表面的物质的流动的装置
公开(公告)号：US5376336A
公开(公告)日：1994-12-27
申请号：US878294
申请日：1992-05-06
申请人： Dietrich W. Lubbers , Hellfried Karpe
发明人： Dietrich W. Lubbers , Hellfried Karpe
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1455 , C12M1/34 , C12Q1/26 , C12Q1/32 , C12Q1/54 , G01N13/00 , G01N21/62 , G01N21/63 , G01N21/64 , G01N21/77 , G01N21/78 , G01N31/22 , G01N21/27 , C12M1/40
CPC分类号： A61B5/14551 , C12Q1/54 , G01N13/00 , G01N31/223 , G01N31/224 , A61B5/14532 , Y10S435/808
摘要： An apparatus for determining the flow of matter passing through a boundary surface, which is provided with at least one sensing layer corresponding to the boundary surface, and presents a known or predetermined, finite resistance to the material flow, and wherein an optical indicator is provided in the sensing layer for obtaining a first measured value of a quantity dependent on the mean concentration of matter in the sensing layer, and wherein a second measured value of this quantity is known on one side of the sensing layer, or can be determined by means of another optical indicator provided in a second sensing layer, and, further, wherein an evaluation unit is provided for inferring the material flow from the difference of the two values measured.
摘要翻译：一种用于确定通过边界表面的物质的流动的装置，其设置有对应于边界表面的至少一个感测层，并且对材料流提供已知或预定的有限阻力，并且其中提供光学指示器在感测层中，用于获得取决于感测层中的物质的平均浓度的量的第一测量值，并且其中该量的第二测量值在感测层的一侧是已知的，或者可以通过手段设置在第二感测层中的另一光学指示器，并且还提供了一个评估单元，用于根据所测量的两个值的差来推断材料流。

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