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1. 发明申请

US20060159706A1 Novel insertion sites in pox vectors 有权
标题翻译：痘痘载体中的新插入位点
公开(公告)号：US20060159706A1
公开(公告)日：2006-07-20
申请号：US10543944
申请日：2004-02-20
申请人： Dennis Panicali , Gail Mazzara , Linda Gritz , Patricia Greenhalgh
发明人： Dennis Panicali , Gail Mazzara , Linda Gritz , Patricia Greenhalgh
IPC分类号： A61K39/275 , C12N7/00 , C12N15/86
CPC分类号： C12N15/86 , A61K48/00 , A61K2039/525 , C12N2710/24043 , C12N2710/24143 , Y02A50/412
摘要： The present invention provides novel insertion sites for introducing DNA into pox vectors.
摘要翻译：本发明提供了将DNA引入痘痘载体的新的插入位点。

2. 发明授权

US06969609B1 Recombinant vector expressing multiple costimulatory molecules and uses thereof 有权
标题翻译：表达多种共刺激分子的重组载体及其用途
公开(公告)号：US06969609B1
公开(公告)日：2005-11-29
申请号：US09856988
申请日：1999-11-12
申请人： Jeffrey Schlom , James Hodge , Dennis Panicali
发明人： Jeffrey Schlom , James Hodge , Dennis Panicali
IPC分类号： A61K35/12 , A61K39/00 , A61K48/00 , C07K14/705 , C12N15/863 , C12N5/10 , C12N5/16 , C12N5/22 , C12N15/85 , A16K48/00
CPC分类号： C12N15/86 , A61K35/12 , A61K39/00 , A61K48/00 , A61K2039/57 , C07K14/70503 , C07K14/70525 , C07K14/70528 , C07K14/70532 , C12N2710/24043 , C12N2710/24143 , Y02A50/41 , Y02A50/412 , Y02A50/464 , Y02A50/478
摘要： The present invention is a recombinant vector encoding and expressing at least three or more costimulatory molecules. The recombinant vector may additionally contain a gene encoding one or more target antigens or immunological epitope thereof. The synergistic effect of them costimulatory molecules on the enhanced activation of T cells is demonstrated. The degree of T-cell activation using recombinant vectors containing genes encoding three costimulatory molecules was far greater than the sum of recombinant vector constructs containing one costimulatory molecule and greater that the use of two costimulatory molecules. Results employing the triple costimulatory vectors were most dramatic under conditions of either low levels of first signal or low stimulator to T-cell ratios. This phenomenon was observed with both isolated CD4+and CD8+T cells. The recombinant vectors of the present invention are useful as immunogenes and vaccines against cancer and pathogenic micro-organisms, and in providing host cells, including dendritic cells and splenocytes with enhanced and antigen-presenting functions.
摘要翻译：本发明是编码并表达至少三种或更多共刺激分子的重组载体。重组载体可另外含有编码一种或多种靶抗原或其免疫表位的基因。证明了它们共刺激分子对增强的T细胞活化的协同作用。使用含有编码三个共刺激分子的基因的重组载体的T细胞活化程度远远大于含有一个共刺激分子的重组载体构建物的总和，并且使用两个共刺激分子更大。使用三重共刺激载体的结果在低水平的第一信号或低刺激剂与T细胞比率的条件下最显着。在分离的CD4 +和/或CD8 + T细胞中都观察到这种现象。本发明的重组载体可用作抗癌和致病微生物的免疫原和疫苗，并且提供宿主细胞，包括具有增强和抗原呈递功能的树突状细胞和脾细胞。

3. 发明授权

US5110587A Immunogenic composition comprising synthetically modified vaccinia virus 失效
标题翻译：包含合成修饰的痘苗病毒的免疫原性组合物
公开(公告)号：US5110587A
公开(公告)日：1992-05-05
申请号：US537882
申请日：1990-06-14
申请人： Enzo Paoletti , Dennis Panicali
发明人： Enzo Paoletti , Dennis Panicali
IPC分类号： A61K39/00 , C07K14/035 , C07K14/11 , C12N15/863
CPC分类号： C12N15/86 , C07K14/005 , A61K39/00 , C12N2710/16622 , C12N2710/24143 , C12N2760/16122
摘要： Vaccines containing vaccinia virus synthetically modified to contain DNA sequences not naturally occurring in vaccinia virus and provoking an immunological response thereto in host animals inoculated with said vaccines.
摘要翻译：含有痘苗病毒的疫苗被合成修饰以含有不是天然存在于痘苗病毒中的DNA序列，并在用所述疫苗接种的宿主动物中引发免疫应答。

4. 发明授权

US4603112A Modified vaccinia virus 失效
标题翻译：改良痘苗病毒
公开(公告)号：US4603112A
公开(公告)日：1986-07-29
申请号：US446824
申请日：1982-12-08
申请人： Enzo Paoletti , Dennis Panicali
发明人： Enzo Paoletti , Dennis Panicali
IPC分类号： C12N15/09 , A61K39/00 , A61K39/285 , C07H21/04 , C07K14/035 , C07K14/11 , C12N5/10 , C12N7/00 , C12N15/00 , C12N15/63 , C12N15/863 , C12P21/00 , C12Q1/70 , C12R1/19 , C12R1/91 , C12R1/92
CPC分类号： C12N15/86 , C07K14/005 , A61K39/00 , C12N2710/16622 , C12N2710/24143 , C12N2760/16122
摘要： What are disclosed are methods for modifying the genome of vaccinia virus to produce vaccinia mutants, particularly by the introduction into the vaccinia genome of exogenous DNA; modified vaccinia prepared by such methods; certain DNA sequences and unmodified and genetically modified microorganisms involved as intermediates in such methods; and methods for infecting cells and host animals with such vaccinia mutants to provoke the amplification of exogenous DNA and proteins encoded by the exogenous DNA, including antigenic proteins, by said cells and host animals.
摘要翻译：公开的是用于修饰痘苗病毒基因组以产生痘苗突变体的方法，特别是通过引入外源DNA的痘苗基因组; 通过这种方法制备的改良牛痘; 某些DNA序列和未修饰的和遗传修饰的微生物作为中间体参与这些方法; 以及用这种痘苗突变体感染细胞和宿主动物的方法，以引发由所述细胞和宿主动物扩增由外源DNA（包括抗原蛋白）编码的外源DNA和蛋白质。

5. 发明申请

US20070110718A1 System for treating and preventing breast cancer 有权
标题翻译：用于治疗和预防乳腺癌的系统
公开(公告)号：US20070110718A1
公开(公告)日：2007-05-17
申请号：US10579007
申请日：2004-11-12
申请人： Dennis Panicali , Gail Mazzara , Linda Gritz , Jeffrey Schlom , Kwong-Yok Tsang , James Hodge
发明人： Dennis Panicali , Gail Mazzara , Linda Gritz , Jeffrey Schlom , Kwong-Yok Tsang , James Hodge
IPC分类号： A61K48/00
CPC分类号： C12N15/86 , A61K39/0011 , A61K48/005 , A61K2039/53 , A61K2039/545 , A61K2039/55522 , C12N7/00 , C12N2710/24043 , C12N2710/24071 , C12N2710/24143 , C12N2710/24171 , C12N2799/023
摘要： The present invention is directed to a system for treating individuals at risk of or suffering from breast cancer. The system comprises administering to the individual a recombinant poxvirus, where the poxvirus contains in a foreign nucleic acid encoding at least one breast cancer antigen.
摘要翻译：本发明涉及用于治疗患有或患有乳腺癌的个体的系统。该系统包括向个体施用重组痘病毒，其中痘病毒含有编码至少一种乳腺癌抗原的外源核酸。

6. 发明授权

US5583028A Recombinant vaccinia virus as DNA constructs encoding HSV glycoproteins 失效
标题翻译：重组痘苗病毒作为编码HSV糖蛋白的DNA构建体
公开(公告)号：US5583028A
公开(公告)日：1996-12-10
申请号：US306259
申请日：1994-09-13
申请人： Enzo Paoletti , Dennis Panicali
发明人： Enzo Paoletti , Dennis Panicali
IPC分类号： C12N15/09 , A61K39/00 , A61K39/285 , C07H21/04 , C07K14/035 , C07K14/11 , C12N5/10 , C12N7/00 , C12N15/00 , C12N15/63 , C12N15/863 , C12P21/00 , C12Q1/70 , C12R1/19 , C12R1/91 , C12R1/92 , C12N7/01 , C12N15/86
CPC分类号： C12N15/86 , C07K14/005 , A61K39/00 , C12N2710/16622 , C12N2710/24143 , C12N2760/16122
摘要： Disclosed and claimed are DNA constructs encoding HSV glycoproteins. The constructs are recombinant vaccinia virus, and host cells infected by the recombinant vaccinia virus are also disclosed and claimed.
摘要翻译：披露和要求的是编码HSV糖蛋白的DNA构建体。构建体是重组痘苗病毒，并且还公开并要求保护由重组痘苗病毒感染的宿主细胞。

7. 发明授权

US07771715B2 Recombinant vector expressing multiple costimulatory molecules and uses thereof 有权
标题翻译：表达多种共刺激分子的重组载体及其用途
公开(公告)号：US07771715B2
公开(公告)日：2010-08-10
申请号：US11723666
申请日：2007-03-21
申请人： Jeffrey Schlom , James Hodge , Dennis Panicali
发明人： Jeffrey Schlom , James Hodge , Dennis Panicali
IPC分类号： A61K48/00 , C12N15/00
CPC分类号： C12N15/86 , A61K35/12 , A61K39/00 , A61K48/00 , A61K2039/57 , C07K14/70503 , C07K14/70525 , C07K14/70528 , C07K14/70532 , C12N2710/24043 , C12N2710/24143 , Y02A50/41 , Y02A50/412 , Y02A50/464 , Y02A50/478
摘要： The present invention is a recombinant vector encoding and expressing at least three or more costimulatory molecules. The recombinant vector may additionally contain a gene encoding one or more target antigens or immunological epitope thereof. The synergistic effect of these costimulatory molecules on the enhanced activation of T cells is demonstrated. The degree of T-cell activation using recombinant vectors containing genes encoding three costimulatory molecules was far greater than the sum of recombinant vector constructs containing one costimulatory molecule and greater than the use of two costimulatory molecules. Results employing the triple costimulatory vectors were most dramatic under conditions of either low levels of first signal or low stimulator to T-cell ratios. This phenomenon was observed with both isolated CD4+ and CD8+ T cells. The recombinant vectors of the present invention are useful as immunogenes and vaccines against cancer and pathogenic micro-organisms, and in providing host cells, including dendritic cells and splenocytes with enhanced antigen-presenting functions.
摘要翻译：本发明是编码并表达至少三种或更多共刺激分子的重组载体。重组载体可另外含有编码一种或多种靶抗原或其免疫表位的基因。证明了这些共刺激分子对增强的T细胞活化的协同作用。使用含有编码三个共刺激分子的基因的重组载体的T细胞活化程度远远大于含有一个共刺激分子并且大于使用两个共刺激分子的重组载体构建体的总和。使用三重共刺激载体的结果在低水平的第一信号或低刺激剂与T细胞比率的条件下最显着。用分离的CD4 +和CD8 + T细胞观察到这种现象。本发明的重组载体可用作抗癌和致病微生物的免疫原和疫苗，以及提供宿主细胞，包括具有增强的抗原呈递功能的树突状细胞和脾细胞。

8. 发明申请

US20090156519A1 Modified KSA and Uses Thereof 审中-公开
标题翻译：修改的KSA及其用途
公开(公告)号：US20090156519A1
公开(公告)日：2009-06-18
申请号：US10584378
申请日：2004-12-23
申请人： Neil Berinstein , James Tartaglia , Mark Parrington , Dennis Panicali , Linda Gritz
发明人： Neil Berinstein , James Tartaglia , Mark Parrington , Dennis Panicali , Linda Gritz
IPC分类号： A61K48/00 , C12N15/63 , A61P35/00 , C12N15/11
CPC分类号： A61K48/005 , C07K14/4746 , C07K14/705 , C07K14/70503 , C07K14/70525 , C07K14/70528 , C07K14/70532 , C12N2799/023
摘要： The present invention relates to a nucleic acid encoding a polypeptide and the use of the nucleic acid or polypeptide in preventing and/or treating cancer. In particular, the invention relates to improved vectors for the insertion and expression of foreign genes encoding tumor antigens for use in immunotherapeutic treatment of cancer.
摘要翻译：本发明涉及编码多肽的核酸以及核酸或多肽在预防和/或治疗癌症中的用途。特别地，本发明涉及用于插入和表达用于癌症免疫治疗中的编码肿瘤抗原的外源基因的改良载体。

9. 发明申请

US20090041804A1 Recombinant vector expressing multiple costimulatory molecules and uses thereof 有权
标题翻译：表达多种共刺激分子的重组载体及其用途
公开(公告)号：US20090041804A1
公开(公告)日：2009-02-12
申请号：US11723666
申请日：2007-03-21
申请人： Jeffrey Schlom , James Hodge , Dennis Panicali
发明人： Jeffrey Schlom , James Hodge , Dennis Panicali
IPC分类号： A61K39/21 , A61K39/00 , A61K39/275 , A61K39/235 , A61K39/125
CPC分类号： C12N15/86 , A61K35/12 , A61K39/00 , A61K48/00 , A61K2039/57 , C07K14/70503 , C07K14/70525 , C07K14/70528 , C07K14/70532 , C12N2710/24043 , C12N2710/24143 , Y02A50/41 , Y02A50/412 , Y02A50/464 , Y02A50/478
摘要： The present invention is a recombinant vector encoding and expressing at least three or more costimulatory molecules. The recombinant vector may additionally contain a gene encoding one or more target antigens or immunological epitope thereof. The synergistic effect of these costimulatory molecules on the enhanced activation of T cells is demonstrated. The degree of Tell activation using recombinant vectors containing genes encoding three costimulatory molecules was far greater than the sum of recombinant vector constructs containing one costimulatory molecule and greater than the use of two costimulatory molecules. Results employing the triple costimulatory vectors were most dramatic under conditions of either low levels of first signal or low stimulator to T-cell ratios. This phenomenon was observed with both isolated CD4+ and CD8+ T cells. The recombinant vectors of the present invention are useful as immunogenes and vaccines against cancer and pathogenic micro-organisms, and in providing host cells, including dendritic cells and splenocytes with enhanced antigen-presenting functions.
摘要翻译：本发明是编码并表达至少三种或更多共刺激分子的重组载体。重组载体可另外含有编码一种或多种靶抗原或其免疫表位的基因。证明了这些共刺激分子对增强的T细胞活化的协同作用。使用含有编码三个共刺激分子的基因的重组载体的Tell活化程度远远大于含有一个共刺激分子并且大于使用两个共刺激分子的重组载体构建物的总和。使用三重共刺激载体的结果在低水平的第一信号或低刺激剂与T细胞比率的条件下最显着。用分离的CD4 +和CD8 + T细胞观察到这种现象。本发明的重组载体可用作抗癌和致病微生物的免疫原和疫苗，并且提供宿主细胞，包括具有增强的抗原呈递功能的树突状细胞和脾细胞。

10. 发明申请

US20060127360A1 Multi-antigen vectors of melanoma 有权
标题翻译：黑素瘤多抗原载体
公开(公告)号：US20060127360A1
公开(公告)日：2006-06-15
申请号：US10933874
申请日：2004-09-03
申请人： Neil Berinstein , Jim Tartaglia , Mark Parrington , Dennis Panicali , Linda Gritz
发明人： Neil Berinstein , Jim Tartaglia , Mark Parrington , Dennis Panicali , Linda Gritz
IPC分类号： A61K48/00 , C12N15/863
CPC分类号： G01N33/5743 , A61K39/0011 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , C12N2799/023
摘要： The present invention relates to peptides, polypeptides, and nucleic acids and the use of the peptide, polypeptide or nucleic acid in preventing and/or treating cancer. In particular, the invention relates to peptides and nucleic acid sequences encoding such peptides for use in diagnosing, treating, or preventing melanoma.
摘要翻译：本发明涉及肽，多肽和核酸，以及肽，多肽或核酸在预防和/或治疗癌症中的用途。特别地，本发明涉及编码这种肽用于诊断，治疗或预防黑素瘤的肽和核酸序列。

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