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1. 发明授权

US07655016B2 Mechanical pump for removal of fragmented matter and methods of manufacture and use 有权
标题翻译：用于去除碎片物质的机械泵及其制造和使用方法
公开(公告)号：US07655016B2
公开(公告)日：2010-02-02
申请号：US10797482
申请日：2004-03-09
申请人： Denise M. Demarais , Stephen A. Leeflang , Michael A. Evans , Gwendolyn A. Watanabe , John C. Tanner, III , Christian S. Eversull
发明人： Denise M. Demarais , Stephen A. Leeflang , Michael A. Evans , Gwendolyn A. Watanabe , John C. Tanner, III , Christian S. Eversull
IPC分类号： A61B17/22
CPC分类号： A61M25/0023 , A61B17/320725 , A61B2017/00685 , A61B2017/320775 , A61M29/02
摘要： Material transport catheters and methods for their use rely on rotation of an impeller within a catheter body and a clearing element for preventing buildup of materials at the opening of the catheter body. The impeller preferably comprises an inner tube or shaft having a helical rotor formed over an outer surface thereof. The clearing element may comprise a free end of a structure near the distal end of the catheter body for disrupting clot, wherein the free end of the structure extends into the distal opening of the catheter body to break up materials as the impeller is rotated. Alternatively, the clearing element may comprise a cutting member disposed at the distal opening of the catheter body.
摘要翻译：材料输送导管及其使用方法依赖于导管主体内的叶轮的旋转和用于防止材料在导管体开口处积累的清除元件。叶轮优选地包括在其外表面上形成有螺旋转子的内管或轴。清除元件可以包括靠近导管主体的远端的结构的自由端，用于破坏凝块，其中结构的自由端延伸到导管主体的远端开口以在叶轮旋转时分解材料。或者，清除元件可以包括设置在导管主体的远端开口处的切割构件。

2. 发明授权

US06097978A Measurement confirmation devices and methods for fluoroscopically directed surgery 失效
标题翻译：用于荧光透视手术的测量确认装置和方法
公开(公告)号：US06097978A
公开(公告)日：2000-08-01
申请号：US887550
申请日：1997-07-03
申请人： Denise M. Demarais , Michael A. Evans , Glen R. Davis , Sascha K. Zarins , Allan R. Will
发明人： Denise M. Demarais , Michael A. Evans , Glen R. Davis , Sascha K. Zarins , Allan R. Will
IPC分类号： A61B19/00 , A61F2/00 , A61F2/06 , A61B5/05
CPC分类号： A61F2/07 , A61B2017/00924 , A61B2090/061 , A61B2090/3925 , A61F2002/065 , A61F2220/0041 , A61F2220/0091 , A61F2250/0097
摘要： The present invention provides methods and apparatus for measuring and/or marking the internal features of a patient body when those features are viewed under fluoroscopy or another medical imaging modality. Although suitable for the physiological measurement of many body lumens, including the intestines, the urethra, and the like, the present invention will find its most immediate use in the measurement of vascular lesions, particularly vascular aneurysms adjacent the aortoiliac junction and other bifurcations. The positions and bend angles of such branching body lumens can be accurately mapped on a panel which remains outside the patient body. By imaging the patient through the panel, and by providing markings on the panel which give a bright contrast when imaged, the panel provides a guide that highlights the length, position, and geometry of the luminal lesion. The guide may be tailored for the specific bifurcated prosthesis to be deployed, and can also graphically illustrate the safe and effective range of target positions in which to deploy the prosthesis.
摘要翻译：本发明提供了当在透视或其他医学成像模式下观察这些特征时，用于测量和/或标记患者体内部特征的方法和装置。尽管适用于包括肠，尿道等在内的许多体腔的生理测量，但是本发明将在血管损伤，特别是与主动脉交界处和其他分叉附近的血管动脉瘤的测量中发现其最直接的用途。这种分支体腔的位置和弯曲角度可以准确地映射到保持在患者身体外部的面板上。通过面板对患者进行成像，并通过在面板上提供标记，在成像时产生明亮的对比度，面板提供突出显示管腔损伤的长度，位置和几何形状的指南。可以针对待部署的特定分叉假体来定制该引导件，并且还可以图形地示出部署假体的目标位置的安全和有效范围。

3. 发明授权

US08062258B2 Mechanical pump for removal of fragmented matter and methods of manufacture and use 有权
标题翻译：用于去除碎片物质的机械泵及其制造和使用方法
公开(公告)号：US08062258B2
公开(公告)日：2011-11-22
申请号：US12638149
申请日：2009-12-15
申请人： Denise M. Demarais , Stephen A. Leeflang , Michael A. Evans , Gwendolyn A. Watanabe , John C. Tanner, III , Christian S. Eversull
发明人： Denise M. Demarais , Stephen A. Leeflang , Michael A. Evans , Gwendolyn A. Watanabe , John C. Tanner, III , Christian S. Eversull
IPC分类号： A61M5/178
CPC分类号： A61M25/0023 , A61B17/320725 , A61B2017/00685 , A61B2017/320775 , A61M29/02
摘要： Material transport catheters and methods for their use rely on rotation of an impeller within a catheter body and a clearing element for preventing buildup of materials at the opening of the catheter body. The impeller preferably comprises an inner tube or shaft having a helical rotor formed over an outer surface thereof. The clearing element may comprise a free end of a structure near the distal end of the catheter body for disrupting clot, wherein the free end of the structure extends into the distal opening of the catheter body to break up materials as the impeller is rotated. Alternatively, the clearing element may comprise a cutting member disposed at the distal opening of the catheter body.
摘要翻译：材料输送导管及其使用方法依赖于导管主体内的叶轮的旋转和用于防止材料在导管体开口处积累的清除元件。叶轮优选地包括在其外表面上形成有螺旋转子的内管或轴。清除元件可以包括靠近导管主体的远端的结构的自由端，用于破坏凝块，其中结构的自由端延伸到导管主体的远端开口以在叶轮旋转时分解材料。或者，清除元件可以包括设置在导管主体的远端开口处的切割构件。

4. 发明授权

US08277470B2 Mechanical pump for removal of fragmented matter and methods of manufacture and use 有权
标题翻译：用于去除碎片物质的机械泵及其制造和使用方法
公开(公告)号：US08277470B2
公开(公告)日：2012-10-02
申请号：US13278210
申请日：2011-10-21
申请人： Denise M. Demarais , Stephen A. Leeflang , Michael A. Evans , Gwendolyn A. Watanabe , John C. Tanner, III , Christian S. Eversull
发明人： Denise M. Demarais , Stephen A. Leeflang , Michael A. Evans , Gwendolyn A. Watanabe , John C. Tanner, III , Christian S. Eversull
IPC分类号： A61B17/22
CPC分类号： A61M25/0023 , A61B17/320725 , A61B2017/00685 , A61B2017/320775 , A61M29/02
摘要： Material transport catheters and methods for their use rely on rotation of an impeller within a catheter body and a clearing element for preventing buildup of materials at the opening of the catheter body. The impeller preferably comprises an inner tube or shaft having a helical rotor formed over an outer surface thereof. The clearing element may comprise a free end of a structure near the distal end of the catheter body for disrupting clot, wherein the free end of the structure extends into the distal opening of the catheter body to break up materials as the impeller is rotated. Alternatively, the clearing element may comprise a cutting member disposed at the distal opening of the catheter body.
摘要翻译：材料输送导管及其使用方法依赖于导管主体内的叶轮的旋转和用于防止材料在导管体开口处积累的清除元件。叶轮优选地包括在其外表面上形成有螺旋转子的内管或轴。清除元件可以包括靠近导管主体的远端的结构的自由端，用于破坏凝块，其中结构的自由端延伸到导管主体的远端开口以在叶轮旋转时分解材料。或者，清除元件可以包括设置在导管主体的远端开口处的切割构件。

5. 发明授权

US06652548B2 Expansible shearing catheters for thrombus removal 有权
公开(公告)号：US06652548B2
公开(公告)日：2003-11-25
申请号：US09823652
申请日：2001-03-30
申请人： Michael A. Evans , Denise M. Demarais , Stephen A. Leeflang , Christian S. Eversull
发明人： Michael A. Evans , Denise M. Demarais , Stephen A. Leeflang , Christian S. Eversull
IPC分类号： A61D102
CPC分类号： A61B17/320725 , A61B17/221 , A61B17/320758 , A61B17/320783 , A61B2017/00685 , A61B2017/22094 , A61B2017/2212 , A61B2090/08021
摘要： Devices, methods, kits, and methods remove clot material from the vasculature and other body lumens. Expansible baskets may be used as cooperating radially expansible shearing members. Helically oriented struts of each basket may wind in a uniform circumferential direction. The struts can be independently flexible, allowing the shearing members to flex axially together. The inner basket may be rotatably driven and may use an axial pump extending proximally from the shearing members and/or a distal penetrator for advancing into an occlusion which inhibits guidewire access. The struts may slide substantially continuously across each other, and may be sufficiently aggressive for highly effective thrombectomy.

6. 发明授权

US08545447B2 Mechanical pump for removal of fragmented matter and methods of manufacture and use 有权
标题翻译：用于去除碎片物质的机械泵及其制造和使用方法
公开(公告)号：US08545447B2
公开(公告)日：2013-10-01
申请号：US13589431
申请日：2012-08-20
申请人： Denise M. Demarais , Stephen A. Leeflang , Michael A. Evans , Gwendolyn A. Watanabe , John C. Tanner, III , Christian S. Eversull
发明人： Denise M. Demarais , Stephen A. Leeflang , Michael A. Evans , Gwendolyn A. Watanabe , John C. Tanner, III , Christian S. Eversull
IPC分类号： A61M5/178
CPC分类号： A61M25/0023 , A61B17/320725 , A61B2017/00685 , A61B2017/320775 , A61M29/02
摘要： Material transport catheters and methods for their use rely on rotation of an impeller within a catheter body and a clearing element for preventing buildup of materials at the opening of the catheter body. The impeller preferably comprises an inner tube or shaft having a helical rotor fainted over an outer surface thereof. The clearing element may comprise a free end of a structure near the distal end of the catheter body for disrupting clot, wherein the free end of the structure extends into the distal opening of the catheter body to break up materials as the impeller is rotated. Alternatively, the clearing element may comprise a cutting member disposed at the distal opening of the catheter body.
摘要翻译：材料输送导管及其使用方法依赖于导管主体内的叶轮的旋转和用于防止材料在导管体开口处积累的清除元件。叶轮优选地包括内管或轴，其具有在其外表面上晕倒的螺旋形转子。清除元件可以包括靠近导管主体的远端的结构的自由端，用于破坏凝块，其中结构的自由端延伸到导管主体的远端开口以在叶轮旋转时分解材料。或者，清除元件可以包括设置在导管主体的远端开口处的切割构件。

7. 发明授权

US08057384B2 Methods and devices for reducing hollow organ volume 有权
标题翻译：减少空心器官体积的方法和装置
公开(公告)号：US08057384B2
公开(公告)日：2011-11-15
申请号：US12030103
申请日：2008-02-12
申请人： Denise M. Demarais
发明人： Denise M. Demarais
IPC分类号： A61F2/00
CPC分类号： A61F5/0036 , A61B17/00491 , A61B17/0401 , A61B17/0487 , A61B17/0644 , A61B17/12099 , A61B17/1227 , A61B2017/00818 , A61B2017/0414 , A61B2017/0496 , A61B2017/1205 , A61B2017/2926 , A61F5/005 , A61F5/0086
摘要： Methods and devices for providing a minimally-invasive placement of a mechanical structure for reducing the volume of a hollow body organ. Intragastric bands may be secured within the hollow body organ and then reduced in diameter to form a stricture within the hollow body organ. The strictures may be placed anywhere within the hollow body organ, and more than one stricture may be formed within the hollow body organ.
摘要翻译：用于提供用于减小中空身体器官的体积的机械结构的微创放置的方法和装置。内脏带可以固定在中空体器官内，然后直径减小以在中空体器官内形成狭窄。狭缝可以放置在空心体器官内的任何位置，并且可以在中空体器官内形成多于一个的狭窄。

8. 发明申请

US20100185208A1 MECHANICAL PUMP FOR REMOVAL OF FRAGMENTED MATTER AND METHODS OF MANUFACTURE AND USE 有权
标题翻译：用于移除机器人的机械泵及其制造和使用方法
公开(公告)号：US20100185208A1
公开(公告)日：2010-07-22
申请号：US12638149
申请日：2009-12-15
申请人： Denise M. Demarais , Stephen A. Leeflang , Michael A. Evans , Gwendolyn A. Watanabe , John C. Tanner, III , Christian S. Eversull
发明人： Denise M. Demarais , Stephen A. Leeflang , Michael A. Evans , Gwendolyn A. Watanabe , John C. Tanner, III , Christian S. Eversull
IPC分类号： A61B17/26
CPC分类号： A61M25/0023 , A61B17/320725 , A61B2017/00685 , A61B2017/320775 , A61M29/02
摘要： Material transport catheters and methods for their use rely on rotation of an impeller within a catheter body and a clearing element for preventing buildup of materials at the opening of the catheter body. The impeller preferably comprises an inner tube or shaft having a helical rotor formed over an outer surface thereof. The clearing element may comprise a free end of a structure near the distal end of the catheter body for disrupting clot, wherein the free end of the structure extends into the distal opening of the catheter body to break up materials as the impeller is rotated. Alternatively, the clearing element may comprise a cutting member disposed at the distal opening of the catheter body.
摘要翻译：材料输送导管及其使用方法依赖于导管主体内的叶轮的旋转和用于防止材料在导管体开口处积累的清除元件。叶轮优选地包括在其外表面上形成有螺旋转子的内管或轴。清除元件可以包括靠近导管主体的远端的结构的自由端，用于破坏凝块，其中结构的自由端延伸到导管主体的远端开口以在叶轮旋转时分解材料。或者，清除元件可以包括设置在导管主体的远端开口处的切割构件。

9. 发明授权

US06702830B1 Mechanical pump for removal of fragmented matter and methods of manufacture and use 有权
标题翻译：用于去除碎片物质的机械泵及其制造和使用方法
公开(公告)号：US06702830B1
公开(公告)日：2004-03-09
申请号：US09590915
申请日：2000-06-09
申请人： Denise M. Demarais , Stephen A. Leeflang , Michael A. Evans , Gwendolyn A. Watanabe , John C. Tanner, III , Christian S. Eversull
发明人： Denise M. Demarais , Stephen A. Leeflang , Michael A. Evans , Gwendolyn A. Watanabe , John C. Tanner, III , Christian S. Eversull
IPC分类号： A61B1722
CPC分类号： A61B17/320725 , A61B2017/00685 , A61M25/0023 , A61M29/02
摘要： Material transport catheters and methods for their use rely on rotation of an impeller within a catheter body. The impeller preferably comprises an inner tube or shaft having a helical rotor formed over an outer surface thereof. Optionally, in the case of a tubular shaft, a second helical rotor may be provided within the shaft lumen in order to induce flow in opposite or in the same direction as induced by the outer helical rotor. Catheters may further comprise structures near their distal ends for disrupting clot, and are preferably introduceable over guidewires where the helical rotors are rotated directly over the guidewire. The catheters may include two or more impellers or impellers having two or more rotors in order to provide for circulation of materials at a target site within a patient body lumen.
摘要翻译：材料输送导管及其使用方法依赖于导管主体内的叶轮的旋转。叶轮优选地包括在其外表面上形成有螺旋转子的内管或轴。可选地，在管状轴的情况下，第二螺旋转子可以设置在轴腔内，以便引起与由外螺旋转子引起的相反或相同方向的流动。导管还可以包括在其远端附近的结构以破坏凝块，并且优选地可以通过导丝线引导，其中螺旋转子直接在导丝上旋转。导管可以包括具有两个或更多个转子的两个或多个叶轮或叶轮，以便提供材料在患者体腔内的目标部位的循环。

10. 发明授权

US06663613B1 System and methods for clot dissolution 有权
标题翻译：凝块溶解的系统和方法
公开(公告)号：US06663613B1
公开(公告)日：2003-12-16
申请号：US09491401
申请日：2000-01-25
申请人： Michael A. Evans , Denise M. Demarais , Christian S. Eversull , Stephen A. Leeflang
发明人： Michael A. Evans , Denise M. Demarais , Christian S. Eversull , Stephen A. Leeflang
IPC分类号： A61M2500
CPC分类号： A61M25/0021 , A61B17/22 , A61B17/320725 , A61B17/320758 , A61B2017/22067 , A61B2017/22084 , A61M25/007 , A61M25/0105
摘要： Clot disruption and dissolution are achieved using a catheter having both an agitator and the ability to deliver a thrombolytic agent. The catheter is introduced to a target region with a blood vessel and the agitator manipulated to engage and disrupt a region of clot therein. The thrombolytic agent, such as tPA, streptokinase, or urokinase, is directly released into the clot at the point where the agitator is engaging the clot. In this way, the thrombolytic activity of the agent is enhanced and the dissolution of the clot is improved.
摘要翻译：使用具有搅拌器和输送溶栓剂的能力的导管实现凝块破裂和溶解。将导管引入具有血管的目标区域，并且搅动器被操纵以接合和破坏其中的血块区域。血栓溶解剂如tPA，链激酶或尿激酶在搅拌器与凝块接合的位置处直接释放到凝块中。以这种方式，药剂的溶栓活性增强，并且凝块的溶解得到改善。

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