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1. 发明授权

US06794380B2 Amide derivatives 失效
标题翻译：酰胺衍生物
公开(公告)号：US06794380B2
公开(公告)日：2004-09-21
申请号：US10353127
申请日：2003-01-29
申请人： Dearg S Brown
发明人： Dearg S Brown
IPC分类号： A61K3133
CPC分类号： C07D213/81 , A61K31/444 , C07C237/42 , C07C255/57 , C07D213/82
摘要： The invention concerns amide derivatives of the Formula I wherein X is CH or N; Y is CH or N; m is 0-3; R1 is a group such as hydroxy, halogeno, trifluoromethyl, cyano, mercapto, nitro, amino, carboxy and carbamoyl; n is 0-3; R2 is a group such as hydroxy, halogeno, trifluoromethyl, cyano, mercapto, nitro, amino, carboxy and (1-6C)alkoxycarbonyl; R3 is hydrogen, halogeno, (1-6C)alkyl or (1-6C)alkoxy; q is 0-4; and Q is a group such as aryl, aryloxy, aryl-(1-6C)alkoxy, arylamino, N-(1-6C)alkyl-arylamino and aryl-(1-6C)alkylamino; or pharmaceutically-acceptable salts or in-vivo-cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.
摘要翻译：本发明涉及式I的酰胺衍生物，其中X是CH或N; Y是CH或N; m为0-3; R 1是羟基，卤代，三氟甲基，氰基，巯基，硝基，氨基，羧基和氨基甲酰基等基团。 n为0-3; R 2是羟基，卤代，三氟甲基，氰基，巯基，硝基，氨基，羧基和（1-6C）烷氧基羰基等基团。 R 3是氢，卤代，（1-6C）烷基或（1-6C）烷氧基; q是0-4; Q为芳基，芳氧基，芳基 - （1-6C）烷氧基，芳基氨基，N-（1-6C）烷基 - 芳基氨基和芳基 - （1-6C）烷基氨基; 或其药学上可接受的盐或体内可裂解的酯; 其制备方法，含有它们的药物组合物及其用于治疗由细胞因子介导的疾病或医学病症的用途。

2. 发明授权

US06686467B2 Amide derivatives for the treatment of diseases mediated by cytokines 失效
标题翻译：用于治疗由细胞因子介导的疾病的酰胺衍生物
公开(公告)号：US06686467B2
公开(公告)日：2004-02-03
申请号：US10265736
申请日：2002-10-08
申请人： Dearg S Brown , George R Brown , Philip Cohen
发明人： Dearg S Brown , George R Brown , Philip Cohen
IPC分类号： C07D41300
CPC分类号： C07D295/185 , A61K31/167 , A61K31/196 , A61K31/277 , A61K31/495 , A61K31/5375 , A61K31/5377 , A61K31/54 , C07C235/56 , C07C235/84 , C07C237/40 , C07C237/42 , C07C255/57 , C07C2601/08 , C07C2601/14 , C07D295/155
摘要： The invention concerns the use of amide derivatives of formula (I) wherein: R1 and R2 are substituents such as hydroxy, C1-6alkoxy, mercapto, C1-6alkylthio, amino, C1-6alkylamino and di-(C1-6alkyl)amino; m and p are independently 0-3; R3 is C1-4alkyl; q is 0-4; and R4 is aryl or cycloalkyl; or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for use in the treatment of diseases or medical conditions mediated by cytokines
摘要翻译：本发明涉及式（I）的酰胺衍生物的用途，其中：R 1和R 2是取代基，例如羟基，C 1-6烷氧基，巯基，C 1-6烷硫基，氨基，C 1-6烷基氨基和二（C1 -6-烷基）氨基; m和p独立为0-3; R 3是C 1-4烷基; q为0-4; 和R 4是芳基或环烷基; 或其药学上可接受的盐在制备用于治疗由细胞因子介导的疾病或医学病症的药物中的用途

3. 发明授权

US06956037B2 Benzamide derivatives for the treatment of diseases mediated by cytokines 失效
标题翻译：用于治疗由细胞因子介导的疾病的苯甲酰胺衍生物
公开(公告)号：US06956037B2
公开(公告)日：2005-10-18
申请号：US10424127
申请日：2003-04-28
申请人： Dearg S Brown , George R Brown
发明人： Dearg S Brown , George R Brown
IPC分类号： C07D295/10 , A61K31/165 , A61K31/167 , A61K31/18 , A61K31/216 , A61K31/22 , A61K31/275 , A61K31/40 , A61K31/4164 , A61K31/4402 , A61K31/445 , A61K31/4453 , A61K31/454 , A61K31/495 , A61K31/5375 , A61K31/5377 , A61K31/55 , A61P1/04 , A61P9/02 , A61P9/04 , A61P11/06 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P31/18 , A61P37/00 , A61P43/00 , C07C235/56 , C07C237/40 , C07C255/57 , C07C311/08 , C07D207/08 , C07D207/12 , C07D207/20 , C07D211/22 , C07D211/46 , C07D213/30 , C07D223/08 , C07D233/60 , C07D239/34 , C07D277/24 , C07D295/092 , C07D295/13 , C07D295/14 , C07D295/155 , C07D303/22 , C07D307/20 , C07D521/00 , A61K31/535 , C07D413/02
CPC分类号： C07D213/30 , C07C235/56 , C07C237/40 , C07C255/57 , C07C311/08 , C07C2601/14 , C07D211/22 , C07D211/46 , C07D231/12 , C07D233/56 , C07D239/34 , C07D249/08 , C07D277/24 , C07D295/088 , C07D295/13 , C07D295/155 , C07D303/22 , C07D307/20
摘要： The invention concerns amide derivatives of Formula (I), wherein R3 is (1-6C)alkyl or halogeno; m is 1-3 and R1 is selected from substituents such as: (A) hydroxy, halogeno, (1-6C)alkyl, (1-6C)alkoxy, aryl, heteroaryl and heterocyclyl; and (B) di-[(1-6C)alkyl]amino-(1-6C)alkyl, (1-6C)alkoxy-(2-6C)alkoxy, di-[(1-6C)alkyl]amino-(2-6C)alkoxy, aryloxy, heteroaryloxy, heteroaryl-(1-6C)alkoxy, heterocyclyloxy and heterocyclyl-(1-6C)alkoxy; p is 0-2 and R2 is a substituent such as hydroxy and halogeno; q is 0-4; and R4 is aryl or cycloalkyl which bears 1-3 substituents such as: (C) hydrogen, hydroxy, halogeno and heterocyclyl; and (D) heteroaryl-(1-6C)alkoxy and heterocyclyl-(1-6C)alkoxy, provided that a substituent on R4 is selected from paragraph (C) only if at least one R1 group is selected from paragraph (B); processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.
摘要翻译：本发明涉及式（I）的酰胺衍生物，其中R 3为（1-6C）烷基或卤代; 取代基例如：（A）羟基，卤代，（1-6C）烷基，（1-6C）烷氧基，芳基，杂芳基和杂环基; 和（B）二 - [（1-6C）烷基]氨基 - （1-6C）烷基，（1-6C）烷氧基 - （2-6C）烷氧基，二 - [（1-6C）烷基]氨基 - （ 2-6C）烷氧基，芳氧基，杂芳氧基，杂芳基 - （1-6C）烷氧基，杂环氧基和杂环基 - （1-6C）烷氧基; p为0-2，R 2为取代基，例如羟基和卤素; q为0-4; 和R 4是具有1-3个取代基的芳基或环烷基，例如：（C）氢，羟基，卤代和杂环基; 和（D）杂芳基 - （1-6C）烷氧基和杂环基 - （1-6C）烷氧基，条件是R 4上的取代基选自段落（C），只要至少一个R' SUP> 1 组从段落（B）中选择; 其制备方法，含有它们的药物组合物及其用于治疗由细胞因子介导的疾病或医学病症的用途。

4. 发明授权

US06498274B1 Amide derivatives for the treatment of diseases mediated by cytokines 失效
标题翻译：用于治疗由细胞因子介导的疾病的酰胺衍生物
公开(公告)号：US06498274B1
公开(公告)日：2002-12-24
申请号：US09508055
申请日：2000-03-07
申请人： Dearg S Brown , George R Brown , Philip Cohen
发明人： Dearg S Brown , George R Brown , Philip Cohen
IPC分类号： C07C23305
CPC分类号： C07D295/185 , A61K31/167 , A61K31/196 , A61K31/277 , A61K31/495 , A61K31/5375 , A61K31/5377 , A61K31/54 , C07C235/56 , C07C235/84 , C07C237/40 , C07C237/42 , C07C255/57 , C07C2601/08 , C07C2601/14 , C07D295/155
摘要： The invention concerns the use of amide derivatives of formula (I) wherein: R1 and R2 are substituents such as hydroxy, C1-6alkoxy, mercapto, C1-6alkylthio, amino, C1-6alkylamino and di-(C1-6alkyl)amino; m and p are independently 0-3R3 is C1-4alkyl; q is 0-4; and R4 is aryl or cycloalkyl; or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for use in the treatment of diseases or medical conditions mediated by cytokines
摘要翻译：本发明涉及式（I）的酰胺衍生物的用途，其中：R 1和R 2是取代基，例如羟基，C 1-6烷氧基，巯基，C 1-6烷硫基，氨基，C 1-6烷基氨基和二 - （C 1-6烷基）氨基; m和p独立地为0-3R3为C1-4烷基; q为0-4; R4是芳基或环烷基; 或其药学上可接受的盐在制备用于治疗由细胞因子介导的疾病或医学病症的药物中的用途

5. 发明授权

US06455520B1 Benzamide derivatives and their use as cytokine inhibitors 失效
标题翻译：苯甲酰胺衍生物及其作为细胞因子抑制剂的用途
公开(公告)号：US06455520B1
公开(公告)日：2002-09-24
申请号：US09787882
申请日：2001-03-23
申请人： Dearg S Brown , George R Brown
发明人： Dearg S Brown , George R Brown
IPC分类号： A61K31496
CPC分类号： C07D213/81 , C07D213/82 , C07D215/48 , C07D231/14 , C07D239/42 , C07D241/44 , C07D249/06 , C07D261/18 , C07D271/12 , C07D307/68 , C07D307/79 , C07D307/91 , C07D311/58 , C07D333/38 , C07D333/70 , C07D401/04 , C07D401/12 , C07D409/04 , C07D417/04
摘要： The invention concerns amide derivatives of formula (I) wherein R3 is (1-6C)alkyl or halogeno; m is 0-3, p is 0-2 and q is 0-4; each of R1 and R2 is a group such as hydroxy, halogeno, trifluoromethyl and cyano; R4 is a basic group such as amino, (1-6C)alkylamino, di-[(1-6C)alkyl]amino, di-[(1-6C)alkyl]amino-(1-6C)alkyl, di-[(1-6C)alkyl]amino-(2-6C)alkoxy, heteroaryl, heteroaryloxy, heteroaryl-(1-6C)alkoxy, heterocyclyl, heterocyclyloxy and heterocyclyl-(1-6C)alkoxy; and Q2 is a group such as heteroaryl, heteroaryloxy or heteroaryl-(1-6C)alkoxy which is optionally substituted; or pharmaceutically-acceptable salts or in-vivo-cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.
摘要翻译：本发明涉及其中R 3为（1-6C）烷基或卤代的式（I）的酰胺衍生物; m为0-3，p为0-2，q为0-4; R 1和R 2各自为羟基，卤代，三氟甲基和氰基; R4是碱性基团，例如氨基，（1-6C）烷基氨基，二 - [（1-6C）烷基]氨基，二 - [（1-6C）烷基]氨基 - （1-6C）烷基，（1-6C）烷基]氨基 - （2-6C）烷氧基，杂芳基，杂芳氧基，杂芳基 - （1-6C）烷氧基，杂环基，杂环氧基和杂环基 - （1-6C）和Q2是任选被取代的杂芳基，杂芳氧基或杂芳基 - （1-6C）烷氧基的基团; 或其药学上可接受的盐或体内可裂解的酯; 其制备方法，含有它们的药物组合物及其用于治疗由细胞因子介导的疾病或医学病症的用途。

6. 发明授权

US06432949B1 Amide derivatives useful as inhibitors of the production of cytokines 失效
标题翻译：可用作细胞因子产生抑制剂的酰胺衍生物
公开(公告)号：US06432949B1
公开(公告)日：2002-08-13
申请号：US09762107
申请日：2001-02-02
申请人： Dearg S Brown , George R Brown
发明人： Dearg S Brown , George R Brown
IPC分类号： C07D41312
CPC分类号： C07D213/81 , C07D213/82 , C07D215/48 , C07D239/74 , C07D241/44 , C07D261/18 , C07D277/68 , C07D333/38 , C07D401/12 , C07D401/14 , C07D413/12
摘要： The invention concerns amide derivatives of formula (I) wherein R3 is (1-6C)alkyl or halogeno; Q1 is heteroaryl which is optionally substituted with 1, 2, 3, or 4 substituents such as hydroxy, halogeno, trifluoromethyl, (1-6C)alkyl, (1-6C)alkoxy, hydroxy-(1-6C)alkyl, (1-6C)alkoxy-(1-6C)alkyl, hydroxy-(2-6C)alkoxy, amino-(2-6C)alkylamino, N-(1-6C)alkyl-(1-6C)alkylamino-(2-6C)alkylamino, aryl, heteroaryl and heterocyclyl; p is 0-2 and R2 is a substituent such as hydroxy and halogeno; q is 0-4; and Q2 includes optionally substituted aryl, cycloalkyl, heteroaryl and heterocyclyl; or pharmaceutically-acceptable salts or in vivo-cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.
摘要翻译：本发明涉及其中R 3为（1-6C）烷基或卤代的式（I）的酰胺衍生物; Q1是任选被1,2,3或4个取代基例如羟基，卤代，三氟甲基，（1-6C）烷基，（1-6C）烷氧基，羟基 - （1-6C）烷基，（1）（1-6C）烷基，羟基 - （2-6C）烷氧基，氨基 - （2-6C）烷基氨基，N-（1-6C）烷基 - （1-6C）烷基氨基 - （2-6C ）烷基氨基，芳基，杂芳基和杂环基; p为0-2，R2为羟基和卤代等取代基。 q为0-4; 和Q2包括任选取代的芳基，环烷基，杂芳基和杂环基; 或其药学上可接受的盐或其体内可裂解的酯; 其制备方法，含有它们的药物组合物及其用于治疗由细胞因子介导的疾病或医学病症的用途。

7. 发明授权

US4943578A Piperazine compounds 失效
标题翻译：哌嗪化合物
公开(公告)号：US4943578A
公开(公告)日：1990-07-24
申请号：US355335
申请日：1989-05-23
申请人： Alan Naylor , Duncan B. Judd , Dearg S. Brown
发明人： Alan Naylor , Duncan B. Judd , Dearg S. Brown
IPC分类号： A61K31/495 , A61P9/00 , A61P9/10 , A61P25/04 , A61P25/28 , C07D241/04 , C07D401/06
CPC分类号： C07D401/06 , C07D241/04
摘要： Compounds are disclosed of formula (I) ##STR1## wherein R.sub.1 represents --COR.sub.4, --CO.sub.2 R.sub.4 or --COCO.sub.2 R.sub.4 (where R.sub.4 represents a hydrogen atom or an unsubstituted or substituted C.sub.1-10 hydrocarbon moiety);R.sub.2 and R.sub.3 are the same or different and are C.sub.1-6 alkyl or C.sub.3-6 alkenyl; or --NR.sub.2 R.sub.3 forms a 5-membered (optionally containing an oxygen atom adjacent to the nitrogen) or 6-membered ring, which ring optionally contains one unit of unsaturation and which is unsubstituted or substituted by optionally substituted methylidene, --COR.sub.5 (where R.sub.5 represents C.sub.1-6 alkyl, --OR.sub.6 or --NHR.sub.6 and R.sub.6 represents hydrogen, C.sub.1-6 alkyl, aryl, or ar(C.sub.1-6)alkyl, or N.dbd.NOR.sub.7 (where R.sub.7 represents C.sub.1-6 alkyl);X represents a direct bond, --CH.sub.2 -- or --CH.sub.2 O--;Ar represents a substituted phenyl moiety;and physiologically acceptable salts thereof.The compounds are indicated as useful in the treatment of pain and cerebral ischaemia.Processes and intermediates for their preparation and pharmaceutical compositions containing them are also disclosed.

8. 发明授权

US06821965B1 Amidobenzamide derivatives which are useful as cytokine inhibitors 有权
标题翻译：可用作细胞因子抑制剂的苯甲酰胺衍生物
公开(公告)号：US06821965B1
公开(公告)日：2004-11-23
申请号：US09762106
申请日：2001-02-02
申请人： Dearg S Brown , George R Brown
发明人： Dearg S Brown , George R Brown
IPC分类号： C07C23373
CPC分类号： C07D207/08 , C07C237/42 , C07C255/57 , C07C2601/04 , C07C2601/14 , C07D207/12 , C07D211/22 , C07D211/46 , C07D213/82 , C07D215/48 , C07D223/08 , C07D243/08 , C07D261/18 , C07D277/24 , C07D295/13 , C07D295/135 , C07D295/155 , C07D317/68 , C07D401/04
摘要： The invention concerns amide derivatives of the Formula (I) wherein R3 is (1-6C)alkyl or halogeno; Q is aryl or heteroaryl which optionally bears 1, 2, 3 or 4 substituents such as hydroxy, halogeno, trifluoromethyl, cyano, (1-6C)alkyl, (1-6C)alkoxy, halogeno(1-6C)alkyl, hydroxy-(1-6C)alkyl, di-[(1-6C)alklyl]amino-(1-6C)alkyl, hydroxy-(2-6C)alkoxy, (1-6)alkoxy-(2-6C)alkoxy, di-[(1-6C)alkyl]amino-(2-6C)alkoxy, amino-2(2-6C)alkylamino, N-(1-6C)alkyl-(1-6C)alkylamino-(2-6C)alkylamino, aryl, aryl-(1-6C)alkoxy, heteroaryl, heteroaryl-(1-6C)alkoxy, heterocyclyl, heterocyclyl-(1-6C)alkyl, heterocyclyloxy and heterocyclyl-(1-6C)alkoxy; p is 0-2 and R2 is a substituent such as hydroxy and halogeno; q is 0-4; and R4 includes optionally substituted aryl, cycloalkyl, heteroaryl and heterocyclyl; or pharmaceutically-acceptable salts or in-vivo-cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.
摘要翻译：本发明涉及其中R 3为（1-6C）烷基或卤代的式（I）的酰胺衍生物; Q是芳基或杂芳基，其任选地具有1,2,3或4个取代基，例如羟基，卤代，三氟甲基，氰基，（1-6C）烷基，（1-6C）烷氧基，卤代（1-6C）烷基，羟基 - （1-6C）烷基，二 - [（1-6C）烷基]氨基 - （1-6C）烷基，羟基 - （2-6C）烷氧基，（1-6）烷氧基 - （2-6C）烷氧基， - [（1-6C）烷基]氨基 - （2-6C）烷氧基，氨基-2（2-6C）烷基氨基，N-（1-6C）烷基 - （1-6C）烷基氨基 - （2-6C）芳基，芳基 - （1-6C）烷氧基，杂芳基，杂芳基 - （1-6C）烷氧基，杂环基，杂环基 - （1-6C）烷基，杂环氧基和杂环基 - （1-6C） p为0-2，R 2为取代基，例如羟基和卤素; q为0-4; 且R 4包括任选取代的芳基，环烷基，杂芳基和杂环基; 或其药学上可接受的盐或体内可裂解的酯; 其制备方法，含有它们的药物组合物及其用于治疗由细胞因子介导的疾病或医学病症的用途。

9. 发明授权

US06548514B1 Amide derivatives 失效
标题翻译：酰胺衍生物
公开(公告)号：US06548514B1
公开(公告)日：2003-04-15
申请号：US09936698
申请日：2001-09-17
申请人： Dearg S. Brown
发明人： Dearg S. Brown
IPC分类号： A61K31435
CPC分类号： C07D213/81 , A61K31/444 , C07C237/42 , C07C255/57 , C07D213/82
摘要： The invention concerns amide derivatives of the Formula I wherein X is CH or N; Y is CH or N; m is 0-3; R1 is a group such as hydroxy, halogeno, trifluoromethyl, cyano, mercapto, nitro, amino, carboxy and carbamoyl; n is 0-3; R2 is a group such as hydroxy, halogeno, trifluoromethyl, cyano, mercapto, nitro, amino, carboxy and (1-6C)alkoxycarbonyl; R3 is hydrogen, halogeno, (1-6C)alkyl or (1-6C)alkoxy; q is 0-4; and Q is a group such as aryl, aryloxy, aryl-(1-6C)alkoxy, arylamino, N-(1-6C)alkyl-arylamino and aryl-(1-6C)alkylamino; or pharmaceutically-acceptable salts or in-vivo-cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.
摘要翻译：本发明涉及式I的酰胺衍生物，其中X是CH或N; Y是CH或N; m为0-3; R 1是羟基，卤代，三氟甲基，氰基，巯基，硝基，氨基，羧基和氨基甲酰基等基团。 n为0-3; R2是羟基，卤代，三氟甲基，氰基，巯基，硝基，氨基，羧基和（1-6C）烷氧羰基; R3是氢，卤代，（1-6C）烷基或（1-6C）烷氧基; q为0-4; Q为芳基，芳氧基，芳基 - （1-6C）烷氧基，芳基氨基，N-（1-6C）烷基 - 芳基氨基和芳基 - （1-6C）烷基氨基; 或其药学上可接受的盐或体内可裂解的酯; 其制备方法，含有它们的药物组合物及其用于治疗由细胞因子介导的疾病或医学病症的用途。

10. 发明授权

US5580870A Quinazoline derivatives 失效
标题翻译：喹唑啉衍生物
公开(公告)号：US5580870A
公开(公告)日：1996-12-03
申请号：US164725
申请日：1993-12-10
申请人： Andrew J. Barker , Dearg S. Brown
发明人： Andrew J. Barker , Dearg S. Brown
IPC分类号： A61K31/505 , A61K31/517 , A61K31/519 , A61P35/00 , A61P43/00 , C07D239/94 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D491/04 , C07D491/056 , C07D239/78 , C07D239/84 , C07D239/95
CPC分类号： C07D401/12 , C07D239/94 , C07D403/12 , C07D417/12 , C07D491/04
摘要： The invention concerns quinazoline derivatives of the formula I ##STR1## wherein m is 1, 2 or 3 and each R.sup.1 includes hydroxy, amino, ureido, hydroxyamino, trifluoromethoxy, (1-4C)alkyl, (1-4C)alkoxy and (1-3C)alkylenedioxy; and Q is a 9- or 10-membered bicyclic heterocyclic moiety containing one or two nitrogen heteroatoms and optionally containing a further heteroatom selected from nitrogen, oxygen and sulphur, or Q is a 9- or 10-membered bicyclic aryl moiety which heterocyclic or aryl moiety may optionally bear one or two substituents selected from halogeno, hydroxy, oxo, amino, nitro, carbamoyl, (1-4C)alkyl, (1-4C)alkoxy, (1-4C)alkylamino, di-[(1-4C)alkyl]amino and (2-4C)alkanoylamino; or a pharmaceutically-acceptable salt thereof; processes for their preparation; pharmaceutical compositions containing them; and the use of the receptor tyrosine kinase inhibitory properties of the compounds in the treatment of cancer.
摘要翻译：本发明涉及式I的喹唑啉衍生物，其中m为1,2或3，且每个R 1包括羟基，氨基，脲基，羟基氨基，三氟甲氧基，（1-4C）烷基，（1-4C）烷氧基和（1-4C） 1-3C）亚烷基二氧基; 并且Q是含有一个或两个氮杂原子并且任选地含有选自氮，氧和硫的另外的杂原子的9或10元双环杂环部分，或Q是9或10元双环芳基部分，该杂环或芳基（1-4C）烷基，（1-4C）烷氧基，（1-4C）烷基氨基，二 - [（1-4C））烷基氨基甲酰基，）烷基]氨基和（2-4C）烷酰基氨基; 或其药学上可接受的盐; 其准备过程; 含有它们的药物组合物; 以及使用受体酪氨酸激酶抑制化合物治疗癌症的性质。

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