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1. 发明申请

US20110021370A1 SALIVARY PROTEIN BIOMARKERS FOR HUMAN ORAL CANCER 有权
标题翻译：用于人类口腔癌的SALIVARY蛋白生物标志物
公开(公告)号：US20110021370A1
公开(公告)日：2011-01-27
申请号：US12739703
申请日：2008-10-27
申请人： Shen Hu , David T.W. Wong
发明人： Shen Hu , David T.W. Wong
IPC分类号： C40B30/04 , C12Q1/68 , G01N33/53 , G01N33/50 , C12Q1/30 , G01N33/573 , C07K16/18 , H01J49/00 , G01N21/00
CPC分类号： C12Q1/6886 , G01N33/57407 , G01N33/6893 , G01N2800/18
摘要： The present invention relates to the identification of novel oral cancer and periodontal disease biomarkers. Further, the present invention provides novel methods of diagnosing and for providing a prognosis for oral cancer and periodontal disease. The present invention additionally provides novel methods of distinguishing between oral cancer and periodontal disease. Finally, kits are provided that find use in the practice of the methods of the invention.
摘要翻译：本发明涉及新型口腔癌和牙周病生物标志物的鉴定。此外，本发明提供了诊断和提供口腔癌和牙周病预后的新方法。本发明另外提供了区分口腔癌和牙周病的新方法。最后，提供在实践本发明的方法中使用的试剂盒。

2. 发明申请

US20080280772A1 Salivary Mrna Profiling, Biomarkers and Related Methods and Kits of Parts 审中-公开
标题翻译：唾液Mrna分析，生物标志物及相关方法和试剂盒
公开(公告)号：US20080280772A1
公开(公告)日：2008-11-13
申请号：US10589788
申请日：2005-02-17
申请人： David T.W. Wong , Maie A.R. St. John , Yang Li
发明人： David T.W. Wong , Maie A.R. St. John , Yang Li
IPC分类号： C40B30/04 , C12Q1/68
CPC分类号： G01N33/57488 , C12Q1/6886 , G01N33/5017 , G01N33/6893
摘要： A method to detect a biomarker in saliva wherein the biomarker is an extracellular mRNA, comprises detecting the extracellular mRNA in the cell-free saliva; transcriptome analysis of saliva comprises detecting a transcriptome pattern in the cell-free saliva; a method to detect genetic alterations in an organ or in a gene in the organ by analyzing saliva, comprises detecting a transcriptome pattern and/or the mRNA profiling of the gene in cell-free saliva; a method to diagnose an oral or systemic pathology disease or disorder in a subject, comprises: detecting profile of a biomarker associated with the pathology disease or disorder, in particular mRNA and/or protein, in cell-free saliva and/or serum; kits comprising identifier for at least one biomarker for performing at least one of the methods; and use of salivary biomarker salivary and/or serum mRNAs as biomarkers for oral and/or systemic pathology, disease or disorder.
摘要翻译：检测唾液中生物标志物的方法，其中生物标志物是细胞外mRNA，包括检测无细胞唾液中的细胞外mRNA; 唾液的转录组分析包括检测无细胞唾液中的转录组图谱; 通过分析唾液来检测器官或器官中基因变异的方法，包括检测无细胞唾液中基因的转录组模式和/或mRNA谱图; 用于诊断受试者的口腔或全身病理学疾病或病症的方法包括：在无细胞唾液和/或血清中检测与病理学疾病或病症特别是mRNA和/或蛋白质相关的生物标志物的谱图; 试剂盒包括用于至少一种生物标志物的标识符，用于执行至少一种方法; 并且使用唾液生物标志物唾液和/或血清mRNA作为口服和/或全身病理学，疾病或病症的生物标志物。

3. 发明申请

US20100248231A1 HIGH SPECIFICITY AND HIGH SENSITIVITY DETECTION BASED ON STERIC HINDRANCE & ENZYME-RELATED SIGNAL AMPLIFICATION 审中-公开
标题翻译：基于超声和酶相关信号放大的高特异度和高灵敏度检测
公开(公告)号：US20100248231A1
公开(公告)日：2010-09-30
申请号：US12601774
申请日：2008-05-30
申请人： Fang Wei , Bernhard G. Zimmermann , David T.W. Wong
发明人： Fang Wei , Bernhard G. Zimmermann , David T.W. Wong
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6876 , C12Q1/682 , C12Q1/6825 , C12Q2565/501 , C12Q2565/107 , C12Q2563/131 , C12Q2525/301 , C12Q2565/1025
摘要： The present invention relates to a molecular probe capable of high sensitivity and high specificity detection of target nucleic acid in a sample. Also disclosed is a detection method using this probe.
摘要翻译：本发明涉及能够对样品中靶核酸进行高灵敏度和高特异性检测的分子探针。还公开了使用该探针的检测方法。

4. 发明申请

US20100210023A1 Salivary metabolic biomarkers for human oral cancer detection 审中-公开
标题翻译：唾液代谢生物标志物用于人类口腔癌检测
公开(公告)号：US20100210023A1
公开(公告)日：2010-08-19
申请号：US12585598
申请日：2009-09-18
申请人： David T.W. Wong , Masaru Tomita , Masahiro Sugimoto , Akiyoshi Hirayama , Tomoyoshi Soga
发明人： David T.W. Wong , Masaru Tomita , Masahiro Sugimoto , Akiyoshi Hirayama , Tomoyoshi Soga
IPC分类号： G01N33/68 , G01N33/00 , G01N27/26 , B01D57/02
CPC分类号： G01N33/57488 , G01N33/57407 , G01N2800/18 , Y10T436/145555 , Y10T436/17 , Y10T436/173845 , Y10T436/20
摘要： The present invention provides a novel oral cancer and periodontal disease salivary metabolome for use in the diagnosis or for providing a prognosis for oral cancer and periodontal disease in an individual. The present invention also provides novel methods of diagnosing or providing a prognosis for oral cancer or periodontal disease by detecting metabolites found in the saliva of an individual. Finally, the present invention provides kits for the detection of salivary metabolites useful in the diagnosis or prognosis of oral cancer and periodontal disease in an individual.
摘要翻译：本发明提供了一种用于诊断或提供个体中口腔癌和牙周病的预后的新型口腔癌和牙周病唾液代谢素。本发明还提供了通过检测个体唾液中发现的代谢物来诊断或提供口腔癌或牙周病预后的新方法。最后，本发明提供了用于检测个体中可用于口腔癌和牙周病诊断或预后的唾液代谢物的试剂盒。

5. 发明申请

US20100021906A1 SALIVARY BIOMARKERS FOR SJÖGREN'S SYNDROME 有权
标题翻译： SJÖGREN'S SYNDROME的SALIVARY BIOMARKERS
公开(公告)号：US20100021906A1
公开(公告)日：2010-01-28
申请号：US12475347
申请日：2009-05-29
申请人： David T.W. Wong , Shen Hu , Jianghua Wang
发明人： David T.W. Wong , Shen Hu , Jianghua Wang
IPC分类号： C12Q1/68 , G01N33/53 , C40B30/04 , G01N33/566
CPC分类号： C12Q1/6883 , C12Q2600/158 , G01N33/6893 , G01N2800/101
摘要： The present invention provides for the first time the identification of salivary protein and RNA factors that can be used in the detection of primary Sjögren's Syndrome. The present invention therefore provides methods of diagnosing and providing a prognosis for Sjögren's Syndrome, by examining relevant proteins (including certain autoantigens and autoantibodies) and RNA in a patient's saliva.
摘要翻译：本发明首次提供可用于检测原发性Siegren综合征的唾液蛋白和RNA因子的鉴定。因此，本发明提供了通过检查患者唾液中的相关蛋白质（包括某些自身抗原和自身抗体）和RNA来为Sjögren综合征诊断并提供预后的方法。

6. 发明申请

US20090317820A1 MICRO-RNA PROFILE IN HUMAN SALIVA AND ITS USE FOR DETECTION OF ORAL CANCER 审中-公开
标题翻译：人类沙门菌中的微RNA特征及其用于检测口腔癌的用途
公开(公告)号：US20090317820A1
公开(公告)日：2009-12-24
申请号：US12468766
申请日：2009-05-19
申请人： David T.W. Wong , Noh Jin Park
发明人： David T.W. Wong , Noh Jin Park
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6809 , C12Q2600/178 , C12Q2525/207
摘要： The present invention provides for the first time the detection of micro-RNA in human saliva and the correlation between such micro-RNA and oral cancers. The present invention therefore provides methods and kits for diagnosing oral cancers by examining pertinent micro-RNA in saliva.
摘要翻译：本发明首次提供人唾液中微RNA的检测以及这些微RNA与口腔癌之间的相关性。因此，本发明提供了通过检查唾液中的相关微RNA来诊断口腔癌的方法和试剂盒。

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