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1. 发明授权

US5660790A PH and amine test elements 失效
标题翻译： PH和胺测试元件
公开(公告)号：US5660790A
公开(公告)日：1997-08-26
申请号：US689758
申请日：1996-08-13
申请人： Paul J. Lawrence , Peter U. Ly , David R. Shockey
发明人： Paul J. Lawrence , Peter U. Ly , David R. Shockey
IPC分类号： G01N31/00 , G01N31/22 , G01N33/50 , G01N33/52 , G01N33/84 , G01N33/48
CPC分类号： G01N31/221 , G01N33/52 , G01N33/84 , Y10T436/173845
摘要： Tests for elevated pH and volatile amines in aqueous fluids are disclosed, including tests useful in the diagnosis of bacterial vaginosis and in other biological conditions. By using formulated indicators and indicators held in matrices that are permeable to gas but not to liquid, the tests provide clear and sharp transitions detectable by visual or machine-readable means rather than by subjective judgments such as small gradations in color or olfactory determinations. The tests lend themselves readily to iconic readouts of the test indications and to the inclusion of positive and negative controls.
摘要翻译：公开了在含水流体中升高的pH和挥发性胺的测试，包括可用于诊断细菌性阴道炎和其它生物学条件的测试。通过使用在气体可渗透而不是液体的矩阵中进行配制的指标和指标，测试可以通过视觉或机器可读方式进行检测，而不是主观判断，例如颜色或嗅觉测定中的小等级。这些测试可以很容易地显示测试指示的标志性读数，以及包含正面和负面控制。

2. 发明授权

US5910447A pH and amine test to diagnosis of vaginal infections 失效
标题翻译： pH和胺测试以诊断阴道感染
公开(公告)号：US5910447A
公开(公告)日：1999-06-08
申请号：US819789
申请日：1997-03-18
申请人： Paul J. Lawrence , Peter U. Ly , David R. Shockey
发明人： Paul J. Lawrence , Peter U. Ly , David R. Shockey
IPC分类号： G01N31/00 , G01N31/22 , G01N33/50 , G01N33/52 , G01N33/84 , G01N33/48
CPC分类号： G01N31/221 , G01N33/52 , G01N33/84 , Y10T436/173845
摘要： Tests for elevated pH and volatile amines in aqueous fluids are disclosed, including tests useful in the diagnosis of bacterial vaginosis and in other biological conditions. By using formulated indicators and indicators held in matrices that are permeable to gas but not to liquid, the tests provide clear and sharp transitions detectable by visual or machine-readable means rather than by subjective judgments such as small gradations in color or olfactory determinations. The tests lend themselves readily to iconic readouts of the test indications and to the inclusion of positive and negative controls.
摘要翻译：公开了在含水流体中升高的pH和挥发性胺的测试，包括可用于诊断细菌性阴道炎和其它生物学条件的测试。通过使用在气体可渗透而不是液体的矩阵中进行配制的指标和指标，测试可以通过视觉或机器可读方式进行检测，而不是主观判断，例如颜色或嗅觉测定中的小等级。测试可以轻松地标志性地读出测试指示以及包含正面和负面的控制。

3. 发明授权

US6099801A pH and amine test elements and applications to diagnosis of vaginal infections 失效
标题翻译： pH和胺测试元素和应用于诊断阴道感染
公开(公告)号：US6099801A
公开(公告)日：2000-08-08
申请号：US40105
申请日：1998-03-17
申请人： Paul J. Lawrence , Peter U. Ly , David R. Shockey
发明人： Paul J. Lawrence , Peter U. Ly , David R. Shockey
IPC分类号： G01N31/00 , G01N31/22 , G01N33/50 , G01N33/52 , G01N33/84 , G01N21/00
CPC分类号： G01N31/221 , G01N33/52 , G01N33/84 , Y10T436/173845
摘要： Tests for elevated pH and volatile amines in aqueous fluids are disclosed, including tests useful in the diagnosis of bacterial vaginosis and in other biological conditions. By using formulated indicators and indicators held in matrices that are permeable to gas but not to liquid, the tests provide clear and sharp transitions detectable by visual or machine-readable device rather than by subjective judgments such as small gradations in color or olfactory determinations. The tests lend themselves readily to iconic readouts of the test indications and to the inclusion of positive and negative controls.
摘要翻译：公开了在含水流体中升高的pH和挥发性胺的测试，包括可用于诊断细菌性阴道炎和其它生物学条件的测试。通过使用在气体可渗透而不是液体的基质中保持的配方指标和指标，测试提供了可视化或机器可读设备可检测到的清晰和清晰的转变，而不是主观判断，如颜色或嗅觉测定中的小等级。测试可以轻松地标志性地读出测试指示以及包含正面和负面的控制。

4. 发明授权

US6113856A Method of making a pH and amine test element 失效
标题翻译：制备pH和胺测试元件的方法
公开(公告)号：US6113856A
公开(公告)日：2000-09-05
申请号：US040151
申请日：1998-03-17
申请人： Paul J. Lawrence , Peter U. Ly , David R. Shockey
发明人： Paul J. Lawrence , Peter U. Ly , David R. Shockey
IPC分类号： G01N31/00 , G01N31/22 , G01N33/50 , G01N33/52 , G01N33/84 , G01N33/48
CPC分类号： G01N31/221 , G01N33/52 , G01N33/84 , Y10T436/173845
摘要： Tests for elevated pH and volatile amines in aqueous fluids are disclosed, including tests useful in the diagnosis of bacterial vaginosis and in other biological conditions. By using formulated indicators and indicators held in matrices that are permeable to gas but not to liquid, the tests provide clear and sharp transitions detectable by visual or machine-readable means rather than by subjective judgments such as small gradations in color or olfactory determinations. The tests lend themselves readily to iconic readouts of the test indications and to the inclusion of positive and negative controls.
摘要翻译：公开了在含水流体中升高的pH和挥发性胺的测试，包括可用于诊断细菌性阴道炎和其它生物学条件的测试。通过使用在气体可渗透而不是液体的矩阵中进行配制的指标和指标，测试可以通过视觉或机器可读方式进行检测，而不是主观判断，例如颜色或嗅觉测定中的小等级。这些测试可以很容易地显示测试指示的标志性读数，以及包含正面和负面控制。

5. 发明授权

US5897834A pH test elements 失效
标题翻译： pH测试元素
公开(公告)号：US5897834A
公开(公告)日：1999-04-27
申请号：US819790
申请日：1997-03-18
申请人： Paul J. Lawrence , Peter U. Ly , David R. Shockey
发明人： Paul J. Lawrence , Peter U. Ly , David R. Shockey
IPC分类号： G01N31/00 , G01N31/22 , G01N33/50 , G01N33/52 , G01N33/84
CPC分类号： G01N31/221 , G01N33/52 , G01N33/84 , Y10T436/173845
摘要： Tests for elevated pH and volatile amines in aqueous fluids are disclosed, including tests useful in the diagnosis of bacterial vaginosis and in other biological conditions. By using formulated indicators and indicators held in matrices that are permeable to gas but not to liquid, the tests provide clear and sharp transitions detectable by visual or machine-readable means rather than by subjective judgments such as small gradations in color or olfactory determinations. The tests lend themselves readily to iconic readouts of the test indications and to the inclusion of positive and negative controls.
摘要翻译：公开了在含水流体中升高的pH和挥发性胺的测试，包括可用于诊断细菌性阴道炎和其它生物学条件的测试。通过使用在气体可渗透而不是液体的矩阵中进行配制的指标和指标，测试可以通过视觉或机器可读方式进行检测，而不是主观判断，例如颜色或嗅觉测定中的小等级。测试可以轻松地标志性地读出测试指示以及包含正面和负面的控制。

6. 发明授权

US5100619A Device and method for collecting fecal occult blood specimens 失效
标题翻译：用于收集FECAL OCCULT血液样本的装置和方法
公开(公告)号：US5100619A
公开(公告)日：1992-03-31
申请号：US349245
申请日：1989-05-09
申请人： Josefina T. Baker , David R. Shockey , Anthony DiBiase
发明人： Josefina T. Baker , David R. Shockey , Anthony DiBiase
IPC分类号： B01L3/00 , G01N33/72
CPC分类号： B01L3/5055 , G01N33/726 , Y10S435/805
摘要： A method and specimen slide for obtaining fecal occult blood specimens. The slide includes first and second portions each including front and back panels. The first portion includes one or more apertures formed through its front panel which exposes a reagent-carrying sheet and the back panel of the first portion includes a flap that may be opened for the application of additional reagents to the back of the sheet. The second portion includes an aperture in its front panel and a flap formed in its back panel. A sheet is carried between the front and back panels of the second portion onto which a fecal specimen may be smeared. The sheet includes pre-perforated removable portions that may be easily accessed through the flap. As an alternative embodiment, the back panel of the second portion may include a removable tab to which is fixed the specimen sheet. The tab and specimen sheet may be removed for easy access to the removable portions of the specimen sheet.
摘要翻译：一种用于获得粪便潜血标本的方法和标本片。滑动件包括第一和第二部分，每个部分包括前面板和后面板。第一部分包括通过其前面板形成的一个或多个孔，其暴露试剂载体片，并且第一部分的后面板包括可以打开以用于向片材背面施加附加试剂的瓣片。第二部分包括其前面板中的孔和在其后面板中形成的挡板。在第二部分的前面板和后面板之间承载有一个粪便标本可能被弄脏的片材。片材包括预穿孔的可移除部分，其可以容易地通过翼片进入。作为替代实施例，第二部分的后面板可以包括可移除的突片，固定样本片。为了容易地进入样品片的可移除部分，可以去除片和样品片。

7. 发明授权

US4678757A Device and method for whole blood separation and analysis 失效
标题翻译：全血分离和分析的装置和方法
公开(公告)号：US4678757A
公开(公告)日：1987-07-07
申请号：US722231
申请日：1985-04-11
申请人： Myron C. Rapkin , Ronald J. Schoengold , David R. Shockey , Pierre C. Van Rysselberghe
发明人： Myron C. Rapkin , Ronald J. Schoengold , David R. Shockey , Pierre C. Van Rysselberghe
IPC分类号： G01N33/48 , G01N33/52 , G01N1/18 , G01N21/77 , G01N31/22
CPC分类号： G01N33/523 , Y10S435/805 , Y10T436/25375 , Y10T436/255
摘要： A method and device for separating blood into fluid and cellular fractions for diagnostic tests. The whole blood is introduced to a carrier containing a layer of carbohydrate which results in the rapid separation of the fluid from the cellular fractions. In a preferred embodiment, the device is fabricated in a sandwich design containing layers of carbohydrate and reagent material between two layers of plastic.
摘要翻译：用于将血液分离成流体和细胞部分用于诊断测试的方法和装置。将全血引入到含有碳水化合物层的载体上，导致流体与细胞级分的快速分离。在一个优选实施例中，该装置制造成包含两层塑料层之间的碳水化合物和试剂材料层的三明治设计。

8. 发明授权

US5571684A Assay for proline iminopeptidase and other hydrolytic activities 失效
标题翻译：测定脯氨酸亚氨基肽酶等水解活性
公开(公告)号：US5571684A
公开(公告)日：1996-11-05
申请号：US374487
申请日：1995-01-17
申请人： Paul J. Lawrence , Terrence J. Andreasen , David R. Shockey
发明人： Paul J. Lawrence , Terrence J. Andreasen , David R. Shockey
IPC分类号： C12Q1/34 , C12Q1/37 , C12N11/08 , G01N21/00
CPC分类号： C12Q1/37 , C12Q1/34 , C12Q2334/70 , C12Q2337/30 , Y10S435/805 , Y10S435/81
摘要： The presence of an enzymatically active hydrolase in a fluid sample is detected by contacting the sample with a solid-phase conjugate which is susceptible to cleavage by the hydrolase, and simultaneously or shortly thereafter, contacting the sample with an indicator which undergoes a detectable change upon the action of a reporter group. The reporter group is part of the conjugate and is liberated from it either partly or entirely by the action of the hydrolase. The indicator is susceptible to action by the reporter group only upon decoupling of the reporter group from the remainder of the conjugate, the decoupling occurring either in part or entirely upon action of the hydrolase. Also provided by this invention are various forms of a dry, self-contained test device which contains the conjugate described above plus the indicator and all other reagents and components necessary to achieve a detectable indication of the presence or absence of a catalytically active hydrolase. Preferred embodiments of the device also contain positive and negative controls.
摘要翻译：通过使样品与容易受水解酶切割的固相缀合物接触，并同时或不久之后将样品与经历可检测变化的指示剂接触，来检测流体样品中酶活性水解酶的存在记者组的行动。报告基团是缀合物的一部分，部分或完全由水解酶的作用释放。只有报告基团与缀合物的其余部分脱钩，该指示剂才能受到报告基团的作用，部分或完全在水解酶的作用下发生脱离。本发明还提供了各种形式的干燥，独立的测试装置，其包含上述缀合物加上指示剂以及实现可检测指示有无催化活性水解酶所必需的所有其它试剂和组分。该装置的优选实施方案还包含阳性和阴性对照。

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