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    • 3. 发明授权
    • Plasminogen activator to prevent corneal and subepithelial haze after laser vision correction surgery
    • 激光视力矫正手术后纤溶酶原激活剂可预防角膜和上皮下雾
    • US07179461B2
    • 2007-02-20
    • US10398677
    • 2001-10-12
    • David M. SilverAdrienne CsutakAndras BertaJozsef Tozser
    • David M. SilverAdrienne CsutakAndras BertaJozsef Tozser
    • A61N1/30A61K38/48
    • A61K38/166A61K38/49
    • The present invention is directed to a method to prevent or reduce postoperative corneal subepithelial haze after excimer laser photorefractive keratectomy (PRK), laser in situ keratomileusis (LASIK) surgery. According to the method, a therapeutically effective amount of one or more plasminogen activators, most preferably urokinase (uPA), is administered topically to the surface of the affected eye at levels between 0.1 and 2,500 IU/ml, about eight to twelve times on the day of surgery, and four to eight times per day for about the next six to twelve days thereafter. The most preferred therapeutic amount is from about 0.1–1 IU uPA/ml, and also 1–10 IU/ml. Plasminogen activators that can be used in the inventions include urokinase, prourokinase, streptokinase and mutants thereof. The invention also covers topical ophthalmic compositions that include one or more plasminogen activators, most preferably uPA, to prevent or reduce postoperative corneal subepithelial haze.
    • 本发明涉及一种在准分子激光屈光角膜切除术(PRK),激光原位角膜磨镶术(LASIK)手术后预防或减少术后角膜上皮下雾的方法。 根据该方法,将治疗有效量的一种或多种纤溶酶原激活剂,最优选尿激酶(uPA)以0.1至2,500IU / ml的水平局部施用于受影响眼睛的表面,约8-12倍 大约在接下来的六到十二天,每天四到八次。 最优选的治疗量为约0.1-1IU uPA / ml,也为1-10IU / ml。 可用于本发明的纤溶酶原激活剂包括尿激酶,原尿激酶,链激酶及其突变体。 本发明还包括局部眼用组合物,其包括一种或多种纤溶酶原激活剂,最优选uPA,以预防或减少术后角膜上皮下浊度。
    • 7. 发明授权
    • Method and apparatus for fostering immersive reading of electronic documents
    • 促进电子文件沉浸式阅读的方法和设备
    • US07437683B1
    • 2008-10-14
    • US09465879
    • 1999-12-16
    • John L. BeezerWilliam HillLeroy B. KeelyDarryl E. RubinDavid M. SilverSusan D. WoolfJean Pierre De Vries
    • John L. BeezerWilliam HillLeroy B. KeelyDarryl E. RubinDavid M. SilverSusan D. WoolfJean Pierre De Vries
    • G06F3/00
    • G06F15/0283G06F3/0481
    • An apparatus and method for presenting electronic documents to users in the form of immersive reading pages. Immersive reading pages mimic the presentation that is provided by printed paper documents. There are no traditional user interface features displayed to the user, yet the user has access to the enhanced functionality that can be provided by computer-implemented documents. In an illustrative embodiment, the user has access to intrabook (or inside-the-book), interbook (or outside-the-book) navigational features, and content interactive features, such as highlighting, annotating, drawing or looking up definitions or synonyms of words in the document. Enhanced functionality is transparently associated with elements on the immersive reading page such that the immersive reading page is without visible indicators of the association. A training mode for permitting the user to learn the transparent association behind the immersive reading pages provides visual guides to the user. The guides may be turned off after the user learns the association.
    • 一种用于以沉浸式阅读页面的形式向用户呈现电子文档的装置和方法。 沉浸式阅读页面模仿由打印纸文档提供的演示文稿。 没有向用户显示传统的用户界面功能,但用户可以访问可由计算机实现的文档提供的增强功能。 在说明性实施例中,用户可以访问桌面内部(或书本内部),书本(或书外)导航特征和内容交互特征,例如突出显示,注释,绘图或查找定义或同义词 的文字。 增强的功能与沉浸式阅读页面上的元素透明地相关联,使得沉浸式阅读页面没有关联的可见指示符。 用于允许用户学习沉浸式阅读页面之后的透明关联的训练模式为用户提供了视觉指南。 在用户学习关联之后,指南可能会被关闭。
    • 9. 发明授权
    • Annotations for electronic content
    • 电子内容注释
    • US08555198B2
    • 2013-10-08
    • US12499721
    • 2009-07-08
    • John L. BeezerMarco A. DemelloDavid M. Silver
    • John L. BeezerMarco A. DemelloDavid M. Silver
    • G06F17/21
    • G06F17/241
    • Embodiments are described for capturing, displaying, and navigating text annotations in a non-modifiable document. In some embodiments, a determination is made that a text annotation is to be created and a system determines the file position of the selected object. The file position of the selected object can be stored along with the created text annotation in another file or a non-read only portion of a file storing the document. Using the file position, the text annotation may be identified with the selected object without modifying the non-modifiable document. In some embodiments, once a text annotation is displayed a user may easily navigate among the captured annotations.
    • 描述了用于在不可修改的文档中捕获,显示和导航文本注释的实施例。 在一些实施例中,确定要创建文本注释并且系统确定所选对象的文件位置。 所选对象的文件位置可以与创建的文本注释一起存储在存储文档的文件的另一个文件或不可读部分中。 使用文件位置,可以使用所选择的对象来标识文本注释而不修改不可修改的文档。 在一些实施例中,一旦显示文本注释,用户可以容易地在捕获的注释之间导航。