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1. 发明授权

US07678833B2 Method to increase the bioavailability of cysteine 有权
标题翻译：增加半胱氨酸生物利用度的方法
公开(公告)号：US07678833B2
公开(公告)日：2010-03-16
申请号：US11805637
申请日：2007-05-23
申请人： David M. Ott
发明人： David M. Ott
IPC分类号： A23L1/30 , A61K31/10 , A61K38/02
CPC分类号： A61K31/095
摘要： A method for increasing the bioavailability of cysteine within an animal by reducing extracellular cysteine disulfide molecules to produce extracellular cysteine molecules. A membrane permeable thiol molecule that forms a membrane permeable disulfide molecule after becoming oxidized participates in thiol-disulfide exchange reactions on both sides of the cellular membrane, crossing the membrane randomly via simple diffusion. The membrane permeable disulfide, within or upon entering the highly reductive environment of a cell, becomes reduced to form a membrane permeable thiol molecule. the membrane permeable thiol can then diffuse to the exterior of the cell, where it is available to reduce another cystine molecule. This process can continue cycling, producing net cumulative increase in the concentration of extracellular cysteine. This is beneficial for providing cysteine as a nutrient to cells that require cysteine for nourishment.
摘要翻译：通过减少细胞外半胱氨酸二硫化物分子以产生细胞外半胱氨酸分子来增加动物体内半胱氨酸的生物利用度的方法。在氧化后形成膜可渗透的二硫化物分子的膜可渗透硫醇分子参与细胞膜两侧的硫醇二硫交换反应，通过简单的扩散随机穿过膜。在进入细胞的高度还原环境之内或之后，膜可渗透的二硫化物减少以形成膜可渗透的硫醇分子。膜可渗透的硫醇然后可以扩散到细胞的外部，其中可用于减少另一个胱氨酸分子。该过程可以继续循环，产生细胞外半胱氨酸浓度的净累积增加。这有利于提供半胱氨酸作为需要半胱氨酸营养的细胞的营养物质。

2. 发明授权

US5020122A Automatic document image revision 失效
标题翻译：自动文档图像修订
公开(公告)号：US5020122A
公开(公告)日：1991-05-28
申请号：US321601
申请日：1989-03-10
申请人： John M. Walsh , David M. Ott
发明人： John M. Walsh , David M. Ott
IPC分类号： H04N1/40
CPC分类号： H04N1/40093
摘要： A system for electronically storing revisions or modifications to documents which are already electronically stored in unrevised or unmodified form. The system compares, at the pixel-by-pixel level, a modified document bit map with a stored document bit map and determines from the differences between the two bit maps, at the pixel-by-pixel level, which differences are significant and which are insignificant. A revised document bit map is then formed from the portions of the stored-document bit map exhibiting no significant bit map differences and the significant differences bit map. The result is a revised document bit map in which no unnecessary changes have been introduced into the initial stored-document bit map. The system also includes steps for defining, on a pixel-by-pixel basis, a significant region bit map from the significant difference bit map and for forming the revised document bit map using the significant region bit map.
摘要翻译：一种用于电子存储修改或修改已经以未修改或未修改形式电子存储的文档的系统。该系统在逐像素级别将经修改的文档位图与存储的文档位图进行比较，并且从逐个像素级别的两个位图之间的差异确定哪些差异是显着的，哪些是哪个是微不足道的然后从存储文档位图的不显示有效位图差异和显着差异位图的部分形成经修改的文档位图。结果是修改后的文档位图，其中没有对初始存储文件位图引入不必要的更改。该系统还包括以逐个像素为基础从显着差分位图定义有效区域位图并且使用重要区域位图形成修正文档位图的步骤。

3. 发明授权

US08217084B2 Medicinal products incorporating bound organosulfur groups 有权
标题翻译：结合有机硫基团的药用产品
公开(公告)号：US08217084B2
公开(公告)日：2012-07-10
申请号：US11137747
申请日：2005-05-24
申请人： David M. Ott
发明人： David M. Ott
IPC分类号： A23L1/30 , A61K31/10 , A61K38/02
CPC分类号： A61K31/255 , A23L27/105 , A23L33/105 , A23L33/17 , A23L33/175 , A61K36/8962
摘要： Nutraceutical and dietary supplement formulations for delivering bioavailable thiols to a host, comprising certain organosulfur radicals, such as the allyl mercapto radical, bound to larger molecules such as proteins, resulting in the formation in the host's body of various allium-related compounds such as allicin. The formulations are produced by treating an ingestible material comprising a cysteine-containing protein with a thiol, disulfide, mixed disulfide, thiosufinate or mixed thiosulfinate so as to cause thiol residues to become disulfide bonded to cysteines contained in the protein.
摘要翻译：将生物可利用的硫醇递送到宿主的营养和膳食补充剂制剂，其包含某些有机硫自由基，例如烯丙基巯基，与大分子如蛋白质结合，导致宿主体内形成各种与鎓相关的化合物如大蒜素。通过用硫醇，二硫化物，混合二硫化物，硫代硫酸盐或混合的硫代亚磺酸盐处理包含含半胱氨酸的蛋白质的可摄入物质以使硫醇残基与蛋白质中包含的半胱氨酸二硫键结合来制备制剂。

4. 发明授权

US09226885B2 Personal care and medicinal products incorporating bound organosulfur groups 有权
公开(公告)号：US09226885B2
公开(公告)日：2016-01-05
申请号：US11441292
申请日：2006-05-24
申请人： David M. Ott
发明人： David M. Ott
IPC分类号： A61Q17/04 , A61Q19/00 , A61P17/00 , A61K8/46 , A61K47/20 , A61K8/97 , A61Q11/00 , A61K9/00
CPC分类号： A61K8/46 , A61K8/97 , A61K9/0014 , A61K47/20 , A61K2800/522 , A61Q11/00 , A61Q17/04
摘要： Personal care products useful for the maintenance of personal appearance and good health and minor treatments that do not require professional health care, as well as products that provide a combination of anti-microbial, anti-oxidant, anti-inflammatory, and anti-aging properties and are suitable for use without a prescription. The products utilize a biomembrane permeable organosulfur compound that can redox cycle between thiol, disulfide, and thiosulfinate forms in response to oxidants and antioxidants inside and outside of cells. Example products include an anti-microbial toothpaste with anti-plaque properties, an anti-inflammatory skin lotion with antioxidant, antimicrobial, and deodorant properties, and an anti-toxin skin lotion with anti-arsenicosis properties.

5. 发明申请

US20130143967A1 Organosulfur compounds for the prevention and treatment of neurodegenerative diseases 有权
标题翻译：有机硫化合物用于预防和治疗神经退行性疾病
公开(公告)号：US20130143967A1
公开(公告)日：2013-06-06
申请号：US13373878
申请日：2011-12-05
申请人： David M. Ott
发明人： David M. Ott
IPC分类号： A61K31/198 , A61P25/00 , A61P25/16 , C07C321/18 , A61P25/28
CPC分类号： A61K31/198
摘要： S-allylmercapto-N-acetylcysteine and related compounds are disclosed which can be administered in order to provide protection from the formation of aldehyde-protein adducts, protein carbonylation, protein aggregation, and the resulting neuroinflammation. Various neurodegenerative diseases which are suitable for treatment using these compounds include Alzheimer's disease, senile dementia, Parkinson's disease, multiple sclerosis, Lewy body disease, peripheral neuropathy, spinal cord injury, stroke and cerebral ischemia.
摘要翻译：公开了S-烯丙基巯基-N-乙酰半胱氨酸和相关化合物，其可以被施用以提供保护免于形成醛 - 蛋白质加合物，蛋白质羰基化，蛋白质聚集和所产生的神经炎症。适用于使用这些化合物治疗的各种神经变性疾病包括阿尔茨海默氏病，老年性痴呆，帕金森病，多发性硬化，路易体病，周围神经病，脊髓损伤，中风和脑缺血。

6. 发明申请

US20120295977A1 Organosulfur prodrugs for the prevention and treatment of infectious diseases 审中-公开
标题翻译：有机硫前药用于预防和治疗传染病
公开(公告)号：US20120295977A1
公开(公告)日：2012-11-22
申请号：US13507307
申请日：2012-06-20
申请人： David M. Ott
发明人： David M. Ott
IPC分类号： A61K31/095 , A61P11/00 , A61P29/00 , A61K31/198 , A61P31/00
CPC分类号： A61K31/095
摘要： A method for enhancing the overall beneficial immune system response in a host that works in conjunction with the host's natural immune system response to enhance the host's ability to eliminate infectious microbes while simultaneously suppressing the toxicity of the immune system response to the host. Allium related organosulfur compounds are disclosed which have a various antimicrobial immunomodulatory properties that work together with the host's immune system in the prevention and treatment of disease. Prophylactic and therapeutic treatment is provided by administering an allium related organosulfur compound such that a localized thiosulfinate is caused to be non-enzymatically formed in response to localized generation by activated immune system cells of reactive oxygen species such as hydrogen peroxide. Suitable allium related organosulfur compounds may be administered to the host in an efficient manner through the use of S-AllylMercapto-N-AcetylCysteine (SAMNAC) or similar prodrugs.
摘要翻译：一种用于增强宿主中整体有益的免疫系统应答的方法，其与宿主的天然免疫系统反应结合起来，以增强宿主消除感染性微生物的能力，同时抑制免疫系统对宿主的反应的毒性。公开了具有各种抗微生物免疫调节特性的与葱属有关的有机硫化合物，其与宿主的免疫系统一起预防和治疗疾病。通过施用富鎓相关的有机硫化合物来提供预防和治疗性治疗，使得局部的硫代亚磺酸盐响应于活化的氧物质如过氧化氢的活化的免疫系统细胞的局部产生而被非酶促形成。可以通过使用S-烯丙基巯基-N-乙酰半胱氨酸（SAMNAC）或类似的前药，以有效的方式将合适的与鎓相关的有机硫化合物施用于宿主。

7. 发明授权

US08222299B2 Organosulfur prodrugs for the prevention and treatment of infectious diseases 有权
标题翻译：有机硫前药用于预防和治疗传染病
公开(公告)号：US08222299B2
公开(公告)日：2012-07-17
申请号：US10853415
申请日：2004-05-24
申请人： David M. Ott
发明人： David M. Ott
IPC分类号： A61K31/095
CPC分类号： A61K31/255
摘要： A method for enhancing the overall beneficial immune system response in a host that works in conjunction with the host's natural immune system response to simultaneously enhance the host's ability to eliminate infectious microbes while suppressing the toxicity of the immune system response to the host. Allium related organosulfur compounds have a variety of antimicrobial and immunomodulatory properties that work together with the host's immune system in the prevention and treatment of disease. Prophylactic and therapeutic treatment is provided by administering an allium related organosulfur compound such that a localized thiosulfinate is caused to be formed in response to localized generation of reactive oxygen species such as hydrogen peroxide by the activated immune system cells. Allium related organosulfur compounds may be administered to the host in an efficient manner through the use of protein-bound S-AllylMercaptoCysteine or similar prodrugs.
摘要翻译：一种用于增强宿主中整体有益的免疫系统应答的方法，其与宿主的天然免疫系统响应相结合，以同时增强宿主消除感染性微生物的能力，同时抑制免疫系统对宿主的反应的毒性。大蒜相关的有机硫化合物具有多种抗菌和免疫调节特性，与宿主的免疫系统一起预防和治疗疾病。通过施用含ium相关的有机硫化合物来提供预防和治疗性治疗，使得通过活化的免疫系统细胞局部产生诸如过氧化氢的活性氧物质形成局部的硫代亚磺酸盐。通过使用蛋白质结合的S-烯丙基巯基半胱氨酸或类似的前药，可以有效地将葱属相关的有机硫化合物施用于宿主。

8. 发明授权

US4853970A Apparatus for processing digitized images 失效
标题翻译：用于处理数字化图像的装置
公开(公告)号：US4853970A
公开(公告)日：1989-08-01
申请号：US129383
申请日：1987-11-24
申请人： David M. Ott , Cynthia D. Ott
发明人： David M. Ott , Cynthia D. Ott
IPC分类号： G06T5/00
CPC分类号： G06T7/0083 , G06T5/003 , G06T2207/10016 , G06T2207/30176
摘要： A method and apparatus for processing a video image so as to feature the boundaries between light and dark regions of the image. The method and apparatus are applicable to a video image which is represented by an array of pixels, in which each pixel is associated with a gray scale intensity value. According to the invention a center pixel is selected along with a plurality of pixels forming a two-dimensional neighborhood of the center pixel. From the intensity values associated with the pixels of the neighborhood, a determination is made whether or not the center pixel lies in a transition region, in which the image undergoes a rapid variation between light and dark. A bit value is then assigned to the center pixel, indicating whether the center pixel is to be black or white in the processed image. The bit value is assigned according to one of two predetermined algorithms depending on whether the center pixel was determined to lie within or not to lie within a transition region. For center pixels lying in a transition region, a first algorithm assigns the bit value with respect to a virtual boundary between light and dark. For center pixels not lying in a transition region, a second algorithm distinct from the first algorithm and presenting no virtual boundary assigns the bit value.
摘要翻译：一种用于处理视频图像以使图像的明暗区域之间的边界具有特征的方法和装置。该方法和装置可应用于由像素阵列表示的视频图像，其中每个像素与灰度级强度值相关联。根据本发明，与形成中心像素的二维邻域的多个像素一起选择中心像素。根据与邻域的像素相关联的强度值，确定中心像素是否位于过渡区域中，其中图像在光和暗之间经历快速变化。然后将一个位值分配给中心像素，指示处理图像中的中心像素是黑色还是白色。根据中心像素是否位于或不位于过渡区域内，根据两个预定算法中的一个分配比特值。对于位于过渡区域中的中心像素，第一算法相对于明暗之间的虚拟边界分配比特值。对于不在过渡区域中的中心像素，与第一算法不同的第二个算法并不呈现虚拟边界，分配比特值。

9. 发明授权

US4827330A Automatic document image revision 失效
标题翻译：自动文档图像修订
公开(公告)号：US4827330A
公开(公告)日：1989-05-02
申请号：US75798
申请日：1987-07-20
申请人： John M. Walsh , David M. Ott
发明人： John M. Walsh , David M. Ott
IPC分类号： H04N1/40
CPC分类号： H04N1/40093
摘要： A system for electronically storing revisions or modifications to documents which are already electronically stored in unrevised or unmodified form. The system compares, at the pixel-by-pixel level, a modified document bit map with a stored document bit map and determines from the differences between the two bit maps, at the pixel-by-pixel level, which differences are significant and which are insignificant. A revised document bit map is then formed from the portions of the stored-document bit map exhibiting no significant bit map differences and the significant differences bit map. The result is a revised document bit map in which no unnecessary changes have been introduced into the initial stored-document bit map. The system also includes steps for defining, on a pixel-by-pixel basis, a significant region bit map from the significant difference bit map and for forming the revised document bit map using the significant region bit map.
摘要翻译：一种用于电子存储修改或修改已经以未修改或未修改形式电子存储的文档的系统。该系统在逐像素级别将经修改的文档位图与存储的文档位图进行比较，并且从逐个像素级别的两个位图之间的差异确定哪些差异是显着的，哪些是哪个是微不足道的然后从存储文档位图的不显示有效位图差异和显着差异位图的部分形成经修改的文档位图。结果是修改后的文档位图，其中没有对初始存储文件位图引入不必要的更改。该系统还包括以逐个像素为基础从显着差分位图定义有效区域位图并且使用重要区域位图形成修正文档位图的步骤。

10. 发明授权

US4041456A Method for verifying the denomination of currency 失效
标题翻译：验证货币面额的方法
公开(公告)号：US4041456A
公开(公告)日：1977-08-09
申请号：US710217
申请日：1976-07-30
申请人： David M. Ott , Cynthia Bunce Ott , John G. Stoides
发明人： David M. Ott , Cynthia Bunce Ott , John G. Stoides
IPC分类号： G07D7/12 , G07D7/20 , G06K9/00
CPC分类号： G07D7/20 , G07D7/12 , G07D7/121
摘要： A bill to be verified is scanned lengthwise by a two track optical sensor. For each bill the resulting analog signals are divided into eight segments or windows each segment producing a binary coded pattern produced by delta modulation. This is compared to a stored reference and a number is produced representing the dissimilarity between the bill being scanned and the average bill of that denomination with which it is being compared. Thereafter, a processor compares the foregoing numbers with additional quantitative functions which have previously been stored relating the corresponding segments of the bill denomination being scanned to other bill denominations. With the use of limit and weighting functions they are summed over the eight different effective windows and a decision is made as to whether the proper denomination is present.
摘要翻译：通过双轨光学传感器纵向扫描待验证的钞票。对于每个钞票，所得到的模拟信号被分成八个段或窗口，每个段产生由delta调制产生的二进制编码模式。这与存储的参考进行比较，并且产生代表所扫描的钞票与正在比较的面值的平均纸币之间的不相似性的数字。此后，处理器将前述数字与先前已经存储的附加定量函数进行比较，将所扫描的账单面额的相应段相关联到其他账单面额。通过使用极限和加权函数，它们在八个不同的有效窗口中求和，并且决定是否存在适当的面额。

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