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1. 发明授权

US07879001B2 Devices and methods for treatment of ocular disorders 有权
标题翻译：用于治疗眼部疾病的装置和方法
公开(公告)号：US07879001B2
公开(公告)日：2011-02-01
申请号：US11836106
申请日：2007-08-08
申请人： David Haffner , Gregory T Smedley , Hosheng Tu
发明人： David Haffner , Gregory T Smedley , Hosheng Tu
IPC分类号： A61M5/00 , A61M1/00 , A61F11/00 , A61M31/00
CPC分类号： A61F9/00781
摘要： Intraocular implants and delivery instruments are disclosed for treating ophthalmic conditions and ocular disorders, such as glaucoma. The implants are configured to extend between the anterior chamber of the eye and a fluid outflow path or physiologic outflow pathway, such as Schlemm's canal, of the eye for enhancing outflow of aqueous from the anterior chamber so as to reduce intraocular pressure. The implants can have features for anchoring the implant into the physiologic outflow pathway as well as preventing the walls of the physiologic outflow pathway from closing the outlet of the implants. The delivery instruments can be steerable so as to make implantation easier. Additionally, the delivery instruments can be configured to hold a plurality of implants so that multiple implants can be implanted through one incision without removing the delivery instrument from the incision between serial implantations.
摘要翻译：公开了用于治疗眼部疾病和眼部疾病如青光眼的眼内植入物和递送仪器。植入物构造成在眼睛的前房和眼睛的流体流出路径或生理流出路径（例如施莱姆氏管）之间延伸，以增强从前房的水流出，从而降低眼内压。植入物可以具有用于将植入物锚定到生理流出路径中的特征，以及防止生理流出路径的壁关闭植入物的出口。输送仪器可以引导，使植入更容易。另外，输送器械可被配置为保持多个植入物，使得可以通过一个切口植入多个植入物，而不需要从串联植入物之间的切口移除输送器械。

2. 发明授权

US07857782B2 Ocular implant delivery system and method thereof 有权
标题翻译：眼植入物递送系统及其方法
公开(公告)号：US07857782B2
公开(公告)日：2010-12-28
申请号：US12366585
申请日：2009-02-05
申请人： Hosheng Tu , Gregory T Smedley , David Haffner , Barbara A Niksch
发明人： Hosheng Tu , Gregory T Smedley , David Haffner , Barbara A Niksch
IPC分类号： A61M5/00 , A61F11/00
CPC分类号： A61M27/00 , A61F9/00781
摘要： Systems and methods for treating ocular disorders are disclosed. One system has a delivery instrument, with a non-linear axis, configured to be inserted into an anterior chamber of an eye and moved to a location proximate a physiologic outflow pathway of the eye. The delivery instrument carries an implant that has a distal end sized for insertion into tissue such that aqueous humor drains from the anterior chamber to the physiologic outflow pathway. One method involves inserting a non-linear portion of a delivery device into the anterior chamber to position an implant within the eye. Another method involves using a delivery device with a curved distal portion to implant an implant at a location communicating with the physiologic outflow pathway. The delivery can be through a corneal incision and the implant can comprise a drug.
摘要翻译：公开了用于治疗眼部疾病的系统和方法。一个系统具有带非线性轴线的输送器具，其配置成插入眼睛的前房并移动到靠近眼睛生理流出路径的位置。递送仪器携带植入物，其具有大小适于插入组织的远端，使得房水从前房排出至生理流出路径。一种方法包括将输送装置的非线性部分插入前房以将植入物定位在眼睛内。另一种方法包括使用具有弯曲远端部分的递送装置，以在与生理流出路径连通的位置处植入植入物。输送可以通过角膜切口并且植入物可以包含药物。

3. 发明授权

US08882781B2 Combined treatment for cataract and glaucoma treatment 有权
标题翻译：联合治疗白内障和青光眼治疗
公开(公告)号：US08882781B2
公开(公告)日：2014-11-11
申请号：US13118338
申请日：2011-05-27
申请人： Gregory T Smedley , David Haffner , Barbara Niksch , Hosheng Tu , Thomas W Burns
发明人： Gregory T Smedley , David Haffner , Barbara Niksch , Hosheng Tu , Thomas W Burns
IPC分类号： A61F9/00 , A61F9/007
CPC分类号： A61F9/00781 , A61F9/0017 , A61F9/00736 , A61F9/00754
摘要： A method is provided for treatment of cataract in combination with a glaucoma procedure while maintaining the intraocular pressure by permitting aqueous to flow out of an anterior chamber of the eye through a surgically stented pathway. A trabecular stent is adapted for implantation within the trabecular meshwork of an eye such that intraocular liquid flows controllably from the anterior chamber of the eye to Schlemm's canal, bypassing the trabecular meshwork. Depending upon the specific treatment contemplated, pharmaceuticals may be utilized in conjunction with the trabecular stent enabling post-cataract healing processes.
摘要翻译：提供一种用于治疗与青光眼手术相结合的白内障的方法，同时通过允许水通过手术支架的通路从眼前房流出而保持眼内压。小梁支架适于植入眼睛的小梁网内，使眼内液体从眼睛前房流向Schlemm运河，绕过小梁网。根据预期的具体治疗，可以将药物与小梁支架结合使用，以实现白内障后愈合过程。

4. 发明授权

US08062244B2 Self-trephining implant and methods thereof for treatment of ocular disorders 有权
标题翻译：自植物植入物及其治疗眼部疾病的方法
公开(公告)号：US08062244B2
公开(公告)日：2011-11-22
申请号：US12366508
申请日：2009-02-05
申请人： Hosheng Tu , Gregory T Smedley , David Haffner , Barbara A Niksch
发明人： Hosheng Tu , Gregory T Smedley , David Haffner , Barbara A Niksch
IPC分类号： A61M5/00
CPC分类号： A61M27/00 , A61F9/00781
摘要： Implants and methods for treating ocular disorders are disclosed. One implant has a tubular member, with inlet and outlet ends, and a cutting member connected thereto. The tubular member is configured to extend through eye tissue such that the inlet and outlet ends reside respectively in an anterior chamber and a physiologic outflow pathway of the eye. Desirably, the cutting member is configured to make an incision in the eye tissue for receiving at least a portion of the tubular member. One method involves introducing an implant, with proximal and distal ends, into the anterior chamber and penetrating eye tissue using an implant distal portion. The implant is advanced from the anterior chamber into the penetrated eye tissue to locate the distal and proximal ends respectively in the physiologic outflow pathway and the anterior chamber. Aqueous humor is conducted between the proximal and distal ends.
摘要翻译：公开了用于治疗眼部疾病的植入物和方法。一个植入物具有管状构件，其具有入口端和出口端以及与其连接的切割构件。管状构件构造成延伸穿过眼睛组织，使得入口端和出口端分别位于眼睛的前房和生理流出路径中。期望地，切割构件被配置为在眼组织中进行切口以接收管状构件的至少一部分。一种方法包括使用植入物远端部分将具有近端和远端的植入物引入前房和穿透眼组织。植入物从前房进入穿透的眼组织，将远端和近端分别定位在生理流出道和前房中。在近端和远端之间进行水性幽默。

5. 发明申请

US20110092878A1 OCULAR IMPLANT DELIVERY SYSTEM AND METHODS THEREOF 有权
标题翻译： OCULAR植物输送系统及其方法
公开(公告)号：US20110092878A1
公开(公告)日：2011-04-21
申请号：US12979249
申请日：2010-12-27
申请人： Hosheng Tu , Gregory T Smedley , David Haffner , Barbara A. Niksch
发明人： Hosheng Tu , Gregory T Smedley , David Haffner , Barbara A. Niksch
IPC分类号： A61F9/007
CPC分类号： A61M27/00 , A61F9/00781
摘要： Systems and methods for treating ocular disorders are disclosed. One system has a delivery instrument, with a non-linear axis, configured to be inserted into an anterior chamber of an eye and moved to a location proximate a physiologic outflow pathway of the eye. The delivery instrument carries an implant that has a distal end sized for insertion into tissue such that aqueous humor drains from the anterior chamber to the physiologic outflow pathway. One method involves inserting a non-linear portion of a delivery device into the anterior chamber to position an implant within the eye. Another method involves using a delivery device with a curved distal portion to implant an implant at a location communicating with the physiologic outflow pathway. The delivery can be through a corneal incision and the implant can comprise a drug.
摘要翻译：公开了用于治疗眼部疾病的系统和方法。一个系统具有带非线性轴线的输送器具，其配置成插入眼睛的前房并移动到靠近眼睛生理流出路径的位置。递送仪器携带植入物，其具有大小适于插入组织的远端，使得房水从前房排出至生理流出路径。一种方法包括将输送装置的非线性部分插入前房以将植入物定位在眼睛内。另一种方法包括使用具有弯曲远端部分的递送装置，以在与生理流出路径连通的位置处植入植入物。输送可以通过角膜切口并且植入物可以包含药物。

6. 发明授权

US09597230B2 Devices and methods for glaucoma treatment 有权
公开(公告)号：US09597230B2
公开(公告)日：2017-03-21
申请号：US11836112
申请日：2007-08-08
申请人： David Steven Haffner , Gregory T Smedley , Hosheng Tu , Thomas W. Burns
发明人： David Steven Haffner , Gregory T Smedley , Hosheng Tu , Thomas W. Burns
IPC分类号： A61M1/00 , A61F9/007
CPC分类号： A61F9/00781
摘要： Intraocular implants and delivery instruments are disclosed for treating ophthalmic conditions and ocular disorders, such as glaucoma. The implants are configured to extend between the anterior chamber of the eye and a fluid outflow path or physiologic outflow pathway, such as Schlemm's canal, of the eye for enhancing outflow of aqueous from the anterior chamber so as to reduce intraocular pressure. The implants can have features for anchoring the implant into the physiologic outflow pathway as well as preventing the walls of the physiologic outflow pathway from closing the outlet of the implants. The delivery instruments can be steerable so as to make implantation easier. Additionally, the delivery instruments can be configured to hold a plurality of implants so that multiple implants can be implanted through one incision without removing the delivery instrument from the incision between serial implantations.

7. 发明授权

US08337445B2 Ocular implant with double anchor mechanism 有权
标题翻译：双锚机构眼植入
公开(公告)号：US08337445B2
公开(公告)日：2012-12-25
申请号：US11860785
申请日：2007-09-25
申请人： Hosheng Tu , Gregory T Smedley , Barbara A Niksch , David S Haffner
发明人： Hosheng Tu , Gregory T Smedley , Barbara A Niksch , David S Haffner
IPC分类号： A61M5/00 , A61M25/00 , A61M31/00 , A61M29/00 , A61F2/14 , A61F2/82 , A61F2/94
CPC分类号： A61F2/16 , A61F9/00781 , A61K9/0048
摘要： The invention relates generally to medical devices and methods for the treatment of ocular disorders. One method provides an implant having an inlet portion with a first anchor and an outlet portion with a second anchor. The implant is implanted in tissue of an eye such the implant conducts fluid from an anterior chamber of the eye to a physiological outflow pathway of the eye. The implanting involves positioning the first anchor adjacent eye tissue, positioning the second anchor within the physiological outflow pathway, and deploying the second anchor such that the second anchor secures the implant within the physiological outflow pathway and a distal end of the second anchor is positioned further into the physiological outflow pathway than an outlet of the outlet portion.
摘要翻译：本发明一般涉及用于治疗眼部疾病的医疗装置和方法。一种方法提供了一种具有入口部分的植入体，该入口部分具有第一锚固件和具有第二锚固件的出口部分将植入物植入眼睛的组织中，使得植入物将流体从眼睛的前房传导到眼睛的生理流出路径。所述植入涉及将所述第一锚固件邻近眼睛组织定位，将所述第二锚固件定位在所述生理流出路径内，以及展开所述第二锚固件，使得所述第二锚固件将所述植入物固定在所述生理流出路径内，并且所述第二锚固件的远端进一步定位进入生理流出路径而不是出口部分的出口。

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