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    • 6. 发明授权
    • Up and down travelling disc valve assembly apparatus
    • 上下行进的圆盘阀组装装置
    • US5205361A
    • 1993-04-27
    • US801958
    • 1991-12-02
    • David FarleyKent T. Fink
    • David FarleyKent T. Fink
    • E21B34/06E21B34/10E21B34/14E21B43/04
    • E21B34/14E21B34/063E21B34/10E21B43/045
    • A travelling disc valve assembly, comprising a length of tubing lowered down a cased wellbore; a crossover tool secured to the lower end of the length of tubing; a length of wash pipe secured to the lower end of the crossover tool; a disc valve assembly secured to the wash pipe and positioned to a lower circulation position in the well bore; a disc valve secured in a bore of the assembly; a shearing device in the upper portion of the assembly for shearing off the connection between the wash pipe and the disc valve assembly, when the disc valve assembly is in an upper position, providing a way to prevent fluid from flowing into the formation below the disc valve and to prevent production flow to the surface; and a rupturer/disengager to rupture and/or disengage the disc valve at a predetermined time so that the production within the formation is allowed to flow through the assembly bore to the surface.
    • 一种行进盘式阀组件,其包括一段管道,其下降到套管井眼; 固定在管子长度的下端的交叉工具; 固定在交叉工具的下端的洗涤管的长度; 一个固定在洗涤管上并定位在井眼下部循环位置的盘阀组件; 固定在所述组件的孔中的盘阀; 在组件的上部的剪切装置用于剪切洗涤管和盘阀组件之间的连接,当盘阀组件处于上部位置时,提供了防止流体流入盘下方的地层中的方式 阀门,防止生产流向表面; 以及在预定时间破裂和/或断开盘阀的破裂/分离器,使得地层内的生产允许通过组件孔流到表面。
    • 10. 发明授权
    • Implant compositions containing a biologically active protein, peptide
or polypeptide
    • 含有生物活性蛋白质,肽或多肽的植入物组合物
    • US5801141A
    • 1998-09-01
    • US456167
    • 1995-05-31
    • William David SteberSusan Mancini CadyDavid Farley JohnsonTheresa Rice Haughey
    • William David SteberSusan Mancini CadyDavid Farley JohnsonTheresa Rice Haughey
    • A61K38/27A61K9/24A61K38/18
    • A61K38/27
    • The invention relates to implants for the parenteral administration of an essentially uniform and continuous amount of a biologically active protein, peptide or polypeptide over an extended period of time which comprises a compacted, indented and partially coated composition containing from one to three layers of a homogeneous core mixture comprising about 20% to about 80% of a biologically active protein, a peptide or a polypeptide; about 10% to about 75% of a fat, a wax or a mixture thereof; 0% to about 25% of a buffer, a salt, a sugar or a mixture thereof; 0% to about 15% of a filler, on a weight basis of the total weight of the core mixture. The partial coating of a semipermeable material comprises about 5% to about 50%, on a weight basis of the total weight of the implant. The invention also relates to methods for increasing and maintaining elevated blood levels of biologically active proteins, peptides and polypeptides in animals by the administration of said implants.
    • 本发明涉及用于在延长的时间段内胃肠外施用基本上均匀和连续量的生物活性蛋白质,肽或多肽的植入物,其包含压实的,凹进的和部分涂覆的组合物,其含有一至三层均质 核心混合物,其包含约20%至约80%的生物活性蛋白质,肽或多肽; 约10%至约75%的脂肪,蜡或其混合物; 0%至约25%的缓冲液,盐,糖或其混合物; 0%至约15%的填料,以核心混合物的总重量为基准。 半透膜材料的部分涂覆包括约5%至约50%,基于植入物总重量的重量。 本发明还涉及通过施用所述植入物来增加和维持动物中生物活性蛋白质,肽和多肽的血液水平升高的方法。