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1. 发明授权

US09034824B2 Antioxidant, anti-inflammatory, anti-radiation, metal chelating compounds and uses thereof 有权
标题翻译：抗氧化剂，抗炎剂，抗辐射剂，金属螯合剂及其用途
公开(公告)号：US09034824B2
公开(公告)日：2015-05-19
申请号：US14323576
申请日：2014-07-03
申请人： Josef Mograbi , Daphne Atlas , Shoshana Keynan
发明人： Josef Mograbi , Daphne Atlas , Shoshana Keynan
IPC分类号： A61K38/00 , A61K38/04 , A61K38/07 , C07K7/00 , C07K7/06 , C07K7/08 , C07K9/00 , C07K5/10 , C07K5/02 , C07K5/103 , A61K38/03 , A61K38/10 , A61K38/16 , C07K14/00 , A61K8/64 , A61Q90/00
CPC分类号： C07K5/1013 , A61K8/64 , A61K38/00 , A61K38/03 , A61K38/04 , A61K38/07 , A61K38/10 , A61K38/16 , A61K47/542 , A61K2800/51 , A61K2800/522 , A61Q19/08 , A61Q90/00 , C07K5/0202 , C07K5/10 , C07K7/00 , C07K7/06 , C07K7/08 , C07K9/00 , C07K14/00
摘要： Potent compounds having combined antioxidant, anti-inflammatory, anti-radiation and metal chelating properties are described. Short peptides having these properties, and methods and uses of such short peptides in clinical and cosmetic applications are described.
摘要翻译：描述了具有抗氧化剂，抗炎，抗辐射和金属螯合性能的组合物。描述了具有这些性质的短肽，以及这些短肽在临床和美容应用中的方法和用途。

2. 发明授权

US08802635B2 Antioxidant, anti-inflammatory, anti-radiation, metal chelating compounds and uses thereof 有权
标题翻译：抗氧化剂，抗炎剂，抗辐射剂，金属螯合剂及其用途
公开(公告)号：US08802635B2
公开(公告)日：2014-08-12
申请号：US13963537
申请日：2013-08-09
申请人： Josef Mograbi , Daphne Atlas , Shoshana Keynan
发明人： Josef Mograbi , Daphne Atlas , Shoshana Keynan
IPC分类号： A61K38/07 , A61K38/00 , A61K38/03 , A61K38/04 , A61K38/10 , A61K38/16 , C07K5/10 , C07K7/00 , C07K7/06 , C07K7/08 , C07K9/00 , C07K14/00 , C07K5/103
CPC分类号： C07K5/1013 , A61K8/64 , A61K38/00 , A61K38/03 , A61K38/04 , A61K38/07 , A61K38/10 , A61K38/16 , A61K47/542 , A61K2800/51 , A61K2800/522 , A61Q19/08 , A61Q90/00 , C07K5/0202 , C07K5/10 , C07K7/00 , C07K7/06 , C07K7/08 , C07K9/00 , C07K14/00
摘要： Potent compounds having combined antioxidant, anti-inflammatory, anti-radiation and metal chelating properties are described. Short peptides having these properties, and methods and uses of such short peptides in clinical and cosmetic applications are described.
摘要翻译：描述了具有抗氧化剂，抗炎，抗辐射和金属螯合性能的组合物。描述了具有这些性质的短肽，以及这些短肽在临床和美容应用中的方法和用途。

3. 发明申请

US20110190195A1 MULTI-COMPONENT ANTIOXIDANT COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND THEIR USE FOR REDUCING OR PREVENTING OXIDATIVE STRESS 审中-公开
标题翻译：多组分抗氧化剂，含有它们的药物组合物及其用于减少或预防氧化应激的用途
公开(公告)号：US20110190195A1
公开(公告)日：2011-08-04
申请号：US13086429
申请日：2011-04-14
申请人： Daphne ATLAS
发明人： Daphne ATLAS
IPC分类号： A61K38/07 , C07K5/103 , A61P3/10 , A61P31/04 , A61P31/18 , A61P31/14 , A61P9/12 , A61P9/10 , A61P35/00 , A61P25/28 , A61P25/00 , A61P7/00 , A61P11/06 , A61P39/06
CPC分类号： C07K5/081 , A61K38/00 , C07K5/0606 , C07K5/1013
摘要： An antioxidant compound is disclosed. The compound is characterized by (a) a peptide including at least three amino acid residues of which at least two are cysteine residues, each having a readily oxidizable sulfhydryl group for effecting antioxidation; and at least two peptide bonds, each being cleavable by at least one intracellular peptidase; and (b) a first hydrophobic or non-charged moiety being attached to an amino terminal of the peptide via a first bond and a second hydrophobic or non-charged moiety being attached to a carboxy terminal of the peptide via a second bond, the first hydrophobic or non-charged moiety and the second hydrophobic or non-charged moiety are selected so as to provide the antioxidant compound with membrane miscibility properties for permitting the antioxidant compound to cross cellular membranes; wherein cleavage of the at least two peptide bonds by the at least one intracellular peptidase results in generation of a plurality of antioxidant species, each including one of the cysteine residues having the readily oxidizable sulfhydryl group and which is also active in effecting antioxidation, thereby providing for a plurality of different antioxidant species acting in synergy in exerting antioxidation.
摘要翻译：公开了抗氧化剂化合物。该化合物的特征在于：（a）包含至少三个氨基酸残基的肽，其中至少两个是半胱氨酸残基，每个氨基酸残基具有用于实现抗氧化的容易氧化的巯基; 和至少两个肽键，各自可被至少一个细胞内肽酶切割; 和（b）通过第一键连接到肽的氨基末端的第一疏水或非带电部分和通过第二键连接到肽的羧基末端的第二疏水或非带电部分，第一选择疏水或非带电部分，并且选择第二疏水或非带电部分，以使抗氧化剂化合物具有膜混溶性，以允许抗氧化剂化合物跨越细胞膜; 其中由所述至少一种细胞内肽酶切割所述至少两个肽键导致产生多种抗氧化物质，每种抗氧化物质包含其中一个具有易氧化巯基的半胱氨酸残基，并且其还具有有效的抗氧化作用，从而提供用于多种不同的抗氧化剂物质在协同作用中发挥抗氧化作用。

4. 发明申请

US20140315787A1 Antioxidant, Anti-Inflammatory, Anti-Radiation, Metal Chelating Compounds And Uses Thereof 有权
标题翻译：抗氧化剂，抗炎，抗辐射，金属螯合剂及其用途
公开(公告)号：US20140315787A1
公开(公告)日：2014-10-23
申请号：US14323576
申请日：2014-07-03
申请人： Josef Mograbi , Daphne Atlas , Shoshana Keynan
发明人： Josef Mograbi , Daphne Atlas , Shoshana Keynan
IPC分类号： C07K5/10 , A61Q90/00 , A61K8/64
CPC分类号： C07K5/1013 , A61K8/64 , A61K38/00 , A61K38/03 , A61K38/04 , A61K38/07 , A61K38/10 , A61K38/16 , A61K47/542 , A61K2800/51 , A61K2800/522 , A61Q19/08 , A61Q90/00 , C07K5/0202 , C07K5/10 , C07K7/00 , C07K7/06 , C07K7/08 , C07K9/00 , C07K14/00
摘要： Potent compounds having combined antioxidant, anti-inflammatory, anti-radiation and metal chelating properties are described. Short peptides having these properties, and methods and uses of such short peptides in clinical and cosmetic applications are described.
摘要翻译：描述了具有抗氧化剂，抗炎，抗辐射和金属螯合性能的组合物。描述了具有这些性质的短肽，以及这些短肽在临床和美容应用中的方法和用途。

5. 发明申请

US20120264676A1 MULTI-COMPONENT ANTIOXIDANT COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND THEIR USE FOR REDUCING OR PREVENTING OXIDATIVE STRESS 有权
标题翻译：多组分抗氧化剂，含有它们的药物组合物及其用于减少或预防氧化应激的用途
公开(公告)号：US20120264676A1
公开(公告)日：2012-10-18
申请号：US13455155
申请日：2012-04-25
申请人： Daphne ATLAS
发明人： Daphne ATLAS
IPC分类号： A61K38/07 , A61P25/28 , A61P19/02 , A61P3/10 , A61P31/12 , A61P11/06 , A61P9/10 , A61P9/12 , A61P35/00 , A61P31/18 , A61P25/00 , A61P11/00
CPC分类号： C07K5/081 , A61K38/00 , C07K5/0606 , C07K5/1013
摘要： An antioxidant compound is disclosed, along with pharmaceutical compositions and methods of treatment which utilize said compound. The compound is characterized by a peptide including at least three amino acid residues of which at least two are cysteine residues, and a first hydrophobic or non-charged moiety being attached to an amino terminal of the peptide via a first bond and a second hydrophobic or non-charged moiety being attached to a carboxy terminal of the peptide via a second bond, as described herein. Cleavage of the peptide by an intracellular peptidase results in generation of a plurality of antioxidant species, each including one of the cysteine residues, thereby providing for a plurality of different antioxidant species acting in synergy in exerting antioxidation.
摘要翻译：公开了一种抗氧化剂化合物，以及利用所述化合物的药物组合物和治疗方法。该化合物的特征在于包含至少三个氨基酸残基的肽，其中至少两个是半胱氨酸残基，并且第一疏水或非带电部分经由第一键连接到肽的氨基末端，第二疏水或非 - 非电荷部分通过第二键连接到肽的羧基末端，如本文所述。通过细胞内肽酶切割肽导致产生多种抗氧化物质，每种抗氧化物质各自包含半胱氨酸残基之一，从而提供多种不同的抗氧化剂物质，以协同作用发挥抗氧化作用。

6. 发明申请

US20070287662A1 Multi-component antioxidant compounds, pharmaceutical compositions containing same and their use for reducing or preventing oxidative stress 审中-公开
标题翻译：多组分抗氧化剂，含有它们的药物组合物及其用于减少或预防氧化应激的用途
公开(公告)号：US20070287662A1
公开(公告)日：2007-12-13
申请号：US11797590
申请日：2007-05-04
申请人： Daphne Atlas
发明人： Daphne Atlas
IPC分类号： A61K38/02 , A61P39/06
CPC分类号： C07K5/081 , A61K38/00 , C07K5/0606 , C07K5/1013
摘要： An antioxidant compound is disclosed. The compound is characterized by (a) a peptide including at least three amino acid residues of which at least two are cysteine residues, each having a readily oxidizable sulfhydryl group for effecting antioxidation; and at least two peptide bonds, each being cleavable by at least one intracellular peptidase; and (b) a first hydrophobic or non-charged moiety being attached to an amino terminal of the peptide via a first bond and a second hydrophobic or non-charged moiety being attached to a carboxy terminal of the peptide via a second bond, the first hydrophobic or non-charged moiety and the second hydrophobic or non-charged moiety are selected so as to provide the antioxidant compound with membrane miscibility properties for permitting the antioxidant compound to cross cellular membranes; wherein cleavage of the at least two peptide bonds by the at least one intracellular peptidase results in generation of a plurality of antioxidant species, each including one of the cysteine residues having the readily oxidizable sulfhydryl group and which is also active in effecting antioxidation, thereby providing for a plurality of different antioxidant species acting in synergy in exerting antioxidation.
摘要翻译：公开了抗氧化剂化合物。该化合物的特征在于：（a）包含至少三个氨基酸残基的肽，其中至少两个是半胱氨酸残基，每个氨基酸残基具有用于实现抗氧化的容易氧化的巯基; 和至少两个肽键，各自可被至少一个细胞内肽酶切割; 和（b）通过第一键连接到肽的氨基末端的第一疏水或非带电部分和通过第二键连接到肽的羧基末端的第二疏水或非带电部分，第一选择疏水或非带电部分，并且选择第二疏水或非带电部分，以使抗氧化剂化合物具有膜混溶性，以允许抗氧化剂化合物穿过细胞膜; 其中由所述至少一种细胞内肽酶切割所述至少两个肽键导致产生多种抗氧化物质，每种抗氧化物质包含其中一个具有易氧化巯基的半胱氨酸残基，并且其还具有有效的抗氧化作用，从而提供用于多种不同的抗氧化剂物质在协同作用中发挥抗氧化作用。

7. 发明申请

US20150218211A1 Antioxidant, Anti-Inflammatory, Anti-Radiation, Metal Chelating Compounds And Uses Thereof 有权
标题翻译：抗氧化剂，抗炎，抗辐射，金属螯合剂及其用途
公开(公告)号：US20150218211A1
公开(公告)日：2015-08-06
申请号：US14692476
申请日：2015-04-21
申请人： Josef Mograbi , Daphne Atlas , Shoshana Keynan
发明人： Josef Mograbi , Daphne Atlas , Shoshana Keynan
IPC分类号： C07K5/103
CPC分类号： C07K5/1013 , A61K8/64 , A61K38/00 , A61K38/03 , A61K38/04 , A61K38/07 , A61K38/10 , A61K38/16 , A61K47/542 , A61K2800/51 , A61K2800/522 , A61Q19/08 , A61Q90/00 , C07K5/0202 , C07K5/10 , C07K7/00 , C07K7/06 , C07K7/08 , C07K9/00 , C07K14/00
摘要： Potent compounds having combined antioxidant, anti-inflammatory, anti-radiation and metal chelating properties are described. Short peptides having these properties, and methods and uses of such short peptides in clinical and cosmetic applications are described.
摘要翻译：描述了具有抗氧化剂，抗炎，抗辐射和金属螯合性能的组合物。描述了具有这些性质的短肽，以及这些短肽在临床和美容应用中的方法和用途。

8. 发明授权

US08530407B2 Multi-component antioxidant compounds, pharmaceutical compositions containing same and their use for reducing or preventing oxidative stress 有权
标题翻译：多组分抗氧化剂，含有它们的药物组合物及其用于减少或预防氧化应激的用途
公开(公告)号：US08530407B2
公开(公告)日：2013-09-10
申请号：US13455155
申请日：2012-04-25
申请人： Daphne Atlas
发明人： Daphne Atlas
IPC分类号： A61P11/06 , A61K38/00
CPC分类号： C07K5/081 , A61K38/00 , C07K5/0606 , C07K5/1013
摘要： An antioxidant compound is disclosed, along with pharmaceutical compositions and methods of treatment which utilize said compound. The compound is characterized by a peptide including at least three amino acid residues of which at least two are cysteine residues, and a first hydrophobic or non-charged moiety being attached to an amino terminal of the peptide via a first bond and a second hydrophobic or non-charged moiety being attached to a carboxy terminal of the peptide via a second bond, as described herein. Cleavage of the peptide by an intracellular peptidase results in generation of a plurality of antioxidant species, each including one of the cysteine residues, thereby providing for a plurality of different antioxidant species acting in synergy in exerting antioxidation.
摘要翻译：公开了一种抗氧化剂化合物，以及利用所述化合物的药物组合物和治疗方法。该化合物的特征在于包含至少三个氨基酸残基的肽，其中至少两个是半胱氨酸残基，并且第一疏水或非带电部分经由第一键连接到肽的氨基末端，第二疏水或非 - 非电荷部分通过第二键连接到肽的羧基末端，如本文所述。通过细胞内肽酶切割肽导致产生多种抗氧化物质，每种抗氧化物质各自包含半胱氨酸残基之一，从而提供多种不同的抗氧化剂物质，以协同作用发挥抗氧化作用。

9. 发明授权

US06420429B1 Brain targeted low molecular weight hydrophobic antioxidant compounds 失效
标题翻译：脑靶向低分子量疏水性抗氧化剂
公开(公告)号：US06420429B1
公开(公告)日：2002-07-16
申请号：US09322980
申请日：1999-06-01
申请人： Daphne Atlas , Eldad Melamed , Daniel Offen
发明人： Daphne Atlas , Eldad Melamed , Daniel Offen
IPC分类号： A61K31165
CPC分类号： A61K31/16
摘要： Novel brain targeted low molecular weight, hydrophobic antioxidants and use of antioxidants in treatment of central nervous system neurodegenerative disorders such as Parkinson's, Alzheimer's and Creutzfeldt-Jakob's diseases and in treatment of conditions of peripheral tissues, such as acute respiratory distress syndrome, amyotrophic lateral sclerosis, atheroscierotic cardiovascular disease and multiple organ dysfunction, in which oxidants are overproduced.
摘要翻译：靶向低分子量，疏水性抗氧化剂和抗氧化剂用于治疗中枢神经系统神经退行性疾病如帕金森病，阿尔茨海默病和克雅氏病以及治疗周围组织病症如急性呼吸窘迫综合征，肌萎缩性侧索硬化症，动脉粥样硬化心血管疾病和多器官功能障碍，其中氧化剂过量产生。

10. 发明授权

US5354885A Process for preparing ethyl ester of L-DOPA 失效
标题翻译：制备L-DOPA乙酯的方法
公开(公告)号：US5354885A
公开(公告)日：1994-10-11
申请号：US995847
申请日：1992-12-24
申请人： Isaac Milman , Alexander Veinberg , Daphne Atlas , Eldad Melamed
发明人： Isaac Milman , Alexander Veinberg , Daphne Atlas , Eldad Melamed
IPC分类号： A61K9/08 , A61K31/195 , A61K31/215 , A61K31/216 , A61K47/02 , A61K47/12 , A61P25/00 , A61P25/16 , C07C229/36 , C07C229/00 , A61K31/135
CPC分类号： A61K31/216 , A61K31/195 , A61K31/215
摘要： A composition which comprises a pharmaceutically acceptable carrier and an active ingredient, such active ingredient comprising L-DOPA ethyl ester in an amount which is at least 97%, by weight, of the active ingredient, and L-DOPA in an amount which is less than 1% by weight of such active ingredient is provided by this invention. This invention also provides a process for preparing such a composition. Further, this invention provides a method of treating a patient suffering from Parkinson's disease which comprises administering to a patient a pharmaceutical composition comprising a therapeutically effective amount of L-DOPA ethyl ester and a pharmaceutically acceptable carrier.
摘要翻译：一种组合物，其包含药学上可接受的载体和活性成分，所述活性成分包含至少97重量％的活性成分的L-DOPA乙酯，L-DOPA的量少超过1重量％的这种活性成分由本发明提供。本发明还提供了制备这种组合物的方法。此外，本发明提供了治疗患有帕金森病的患者的方法，其包括向患者施用包含治疗有效量的L-DOPA乙酯和药学上可接受的载体的药物组合物。

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