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1. 发明申请

US20120288914A1 CRYSTAL STRUCTURE OF GLYPHOSATE ACETYLTRANSFERASE (GLYAT) AND METHODS OF USE 审中-公开
标题翻译：谷氨酸乙酰胆碱酯酶（GLYAT）的晶体结构及其使用方法
公开(公告)号：US20120288914A1
公开(公告)日：2012-11-15
申请号：US13382780
申请日：2010-07-07
申请人： Daniel Siehl , Robert J. Keenan , Zhenglin Hou , Linda A. Castle
发明人： Daniel Siehl , Robert J. Keenan , Zhenglin Hou , Linda A. Castle
IPC分类号： C12N9/10 , G06F19/16
CPC分类号： C12N9/1029 , C07K2299/00
摘要： The presently disclosed subject matter provides compositions and methods for evaluating the potential of candidate polypeptides to associate with glyphosate with a higher binding affinity, higher binding specificity, or both or to have N-acetyltransferase activity with a higher catalytic rate when compared to a native glyphosate acetyltransferase (GLYAT) polypeptide through the provision and comparison of three-dimensional molecular structures of the candidate polypeptides and the GLYAT polypeptides provided herein. The methods further provide for identification of polypeptides with these advantageous properties using the three-dimensional molecular structures of GLYAT polypeptides.
摘要翻译：目前公开的主题提供了组合物和方法，用于与天然草甘膦相比，评估候选多肽与具有更高结合亲和力，更高结合特异性或两者的草甘膦缔合或具有较高催化速率的N-乙酰转移酶活性的潜在性乙酰转移酶（GLYAT）多肽，通过提供和比较本文提供的候选多肽和GLYAT多肽的三维分子结构。所述方法进一步提供了使用GLYAT多肽的三维分子结构鉴定具有这些有利性质的多肽。

2. 发明申请

US20060253923A1 DNA shuffling to produce herbicide selective crops 审中-公开
公开(公告)号：US20060253923A1
公开(公告)日：2006-11-09
申请号：US11436796
申请日：2006-05-17
申请人： Venkiteswaran Subramanian , Willem Stemmer , Linda Castle , Umesh Muchhal , Daniel Siehl
发明人： Venkiteswaran Subramanian , Willem Stemmer , Linda Castle , Umesh Muchhal , Daniel Siehl
IPC分类号： A01H1/00 , C40B30/06 , C40B40/08 , C12N15/82 , C12N5/04
CPC分类号： C12N9/1092 , C12N9/0004 , C12N9/0073 , C12N15/1027 , C12N15/8275
摘要： Methods of shuffling DNA to obtain recombinant herbicide tolerance nucleic acids encoding proteins having new or improved herbicide tolerance activities, libraries of shuffled herbicide tolerance nucleic acids, transgenic plants and DNA shuffling mixtures are provided.

3. 发明申请

US20050060767A1 DNA shuffling to produce herbicide selective crops 审中-公开
标题翻译： DNA改组以产生除草剂选择作物
公开(公告)号：US20050060767A1
公开(公告)日：2005-03-17
申请号：US10627449
申请日：2003-07-25
申请人： Venkiteswaran Subramanian , Willem Stemmer , Linda Castle , Umesh Muchhal , Daniel Siehl
发明人： Venkiteswaran Subramanian , Willem Stemmer , Linda Castle , Umesh Muchhal , Daniel Siehl
IPC分类号： A01H1/00 , C12N1/20 , C12N1/21 , C12N5/10 , C12N9/02 , C12N9/10 , C12N15/01 , C12N15/09 , C12N15/10 , C12N15/82 , C12Q1/02 , C12R1/19 , C12R1/91
CPC分类号： C12N9/1092 , C12N9/0004 , C12N9/0073 , C12N15/1027 , C12N15/8275
摘要： Methods of shuffling DNA to obtain recombinant herbicide tolerance nucleic acids encoding proteins having new or improved herbicide tolerance activities, libraries of shuffled herbicide tolerance nucleic acids, transgenic plants and DNA shuffling mixtures are provided.
摘要翻译：提供了用于混合DNA以获得编码具有新的或改进的除草剂耐受活性的蛋白质的重组除草剂耐受性核酸的方法，洗牌的除草剂耐受性核酸的文库，转基因植物和DNA混洗混合物。

4. 发明申请

US20060242731A1 DNA shuffling to produce herbicide selective crops 审中-公开
公开(公告)号：US20060242731A1
公开(公告)日：2006-10-26
申请号：US11436462
申请日：2006-05-17
申请人： Venkiteswaran Subramanian , Willem Stemmer , Linda Castle , Umesh Muchhal , Daniel Siehl
发明人： Venkiteswaran Subramanian , Willem Stemmer , Linda Castle , Umesh Muchhal , Daniel Siehl
IPC分类号： A01H1/00 , C12Q1/68 , C12N15/82 , C12N5/04
CPC分类号： C12N9/1092 , C12N15/8275
摘要： Methods of shuffling DNA to obtain recombinant herbicide tolerance nucleic acids encoding proteins having new or improved herbicide tolerance activities, libraries of shuffled herbicide tolerance nucleic acids, transgenic plants and DNA shuffling mixtures are provided.

5. 发明申请

US20060253922A1 DNA shuffling to produce herbicide selective crops 审中-公开
公开(公告)号：US20060253922A1
公开(公告)日：2006-11-09
申请号：US11436488
申请日：2006-05-17
申请人： Venkiteswaran Subramanian , Willem Stemmer , Linda Castle , Umesh Muchhal , Daniel Siehl
发明人： Venkiteswaran Subramanian , Willem Stemmer , Linda Castle , Umesh Muchhal , Daniel Siehl
IPC分类号： A01H1/00 , C40B30/06 , C40B40/08 , C12N5/04 , C12N15/82
CPC分类号： C12N9/1092 , C12N9/0004 , C12N9/0073 , C12N15/1027 , C12N15/8275
摘要： Methods of shuffling DNA to obtain recombinant herbicide tolerance nucleic acids encoding proteins having new or improved herbicide tolerance activities, libraries of shuffled herbicide tolerance nucleic acids, transgenic plants and DNA shuffling mixtures are provided.

6. 发明申请

US20100115661A1 METHODS AND COMPOSITIONS FOR THE MODULATION OF AMINO ACID BIOSYNTHESIS 审中-公开
标题翻译：用于调节氨基酸生物合成的方法和组合物
公开(公告)号：US20100115661A1
公开(公告)日：2010-05-06
申请号：US12581331
申请日：2009-10-19
申请人： John H. Duesing , Anthony J. Kinney , Daniel Siehl
发明人： John H. Duesing , Anthony J. Kinney , Daniel Siehl
IPC分类号： C12N15/82 , A01H5/00
CPC分类号： C12N15/8243 , C12N15/8251 , C12N15/8253 , C12N15/8254
摘要： Compositions and methods for increasing the level of one or more selected free ε and/or α-N-acetylated amino acids in a selected tissue or organ of a plant are provided. In specific embodiments, the plant, plant part, seed or grain comprises a free α-N-acetylated amino acid content of at least 200 ppm or a ratio of free α-N-acetylated amino acid content to free non-α-N-acetylated amino acid content of about 3 to about 1000. Compositions comprising plants, plant parts, seed and grain having stably incorporated into their genome a heterologous polynucleotide encoding an amino acid-N-acetyltransferase polypeptide operably linked to a promoter active in the seed are provided. Further provided are compositions comprising a plant, plant part, seed or grain having stably incorporated into their genome a first heterologous polynucleotide encoding a first amino acid-N-acetyltransferase polypeptide operably linked to a first promoter active in the seed and a second heterologous polynucleotide encoding a second amino acid-N-acetyltransferase polypeptide operably linked to a second promoter active in the seed, wherein the first and the second amino acid-N-acetyltransferase polypeptide acetylate the α-amine of distinct amino acids. Compositions comprising food sources, feed and supplements, along with methods of increasing the nutritional value of a plant, plant part, seed or grain, are further provided.
摘要翻译：用于增加一个或多个所选择的免费等级的组合和方法和/或α-N-乙酰化氨基酸在植物的选定组织或器官中。在具体实施方案中，植物，植物部分，种子或颗粒包含至少200ppm的游离α-N-乙酰化氨基酸含量或游离的α-N-乙酰化氨基酸含量与游离的非α-N- 提供约3至约1000的乙酰化氨基酸含量。提供包含植物，植物部分，种子和颗粒的组合物，其稳定地并入其基因组中，编码与种子中活性物质活化的启动子可操作地连接的氨基酸-N-乙酰转移酶多肽的异源多核苷酸。进一步提供的是包含植物，植物部分，种子或谷物的组合物，其稳定地并入其基因组中，第一异源多核苷酸编码与种子中有活性的第一启动子可操作地连接的第一氨基酸-N-乙酰转移酶多肽和第二异源多核苷酸编码可操作地连接到在种子中有活性的第二启动子的第二氨基酸-N-乙酰转移酶多肽，其中所述第一和第二氨基酸-N-乙酰转移酶多肽对不同氨基酸的α-胺进行乙酰化。还提供了包含食物来源，饲料和补充剂的组合物，以及增加植物，植物部分，种子或谷物的营养价值的方法。

7. 发明申请

US20060205003A1 Methods, systems, and software for identifying functional biomolecules 有权
标题翻译：用于鉴定功能性生物分子的方法，系统和软件
公开(公告)号：US20060205003A1
公开(公告)日：2006-09-14
申请号：US11429628
申请日：2006-05-05
申请人： Claes Gustafsson , Sridhar Govindarajan , Robin Emig , Richard Fox , Ajoy Roy , Jeremy Minshull , S. Davis , Anthony Cox , Phillip Patten , Linda Castle , Daniel Siehl , Rebecca Gorton , Teddy Chen
发明人： Claes Gustafsson , Sridhar Govindarajan , Robin Emig , Richard Fox , Ajoy Roy , Jeremy Minshull , S. Davis , Anthony Cox , Phillip Patten , Linda Castle , Daniel Siehl , Rebecca Gorton , Teddy Chen
IPC分类号： C40B40/08 , C40B50/02 , C40B30/02
CPC分类号： G06F19/18 , C40B30/02 , C40B50/02 , G06F19/22 , G06F19/24
摘要： The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.
摘要翻译：本发明一般涉及快速有效地搜索生物相关数据空间的方法。更具体地，本发明包括从复杂的生物分子文库或这些文库集合鉴定具有所需性质或最适合于获得这些性质的生物分子的方法。本发明还提供了对序列活性关系建模的方法。由于许多方法是计算机实现的，本发明另外提供用于执行这些方法的数字系统和软件。

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