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1. 发明申请

US20150088156A1 SYSTEMS AND METHODS FOR TREATMENT OF DRY EYE 有权
公开(公告)号：US20150088156A1
公开(公告)日：2015-03-26
申请号：US14561107
申请日：2014-12-04
申请人： Douglas Michael ACKERMANN , Daniel PALANKER , James Donald LOUDIN , Garrett Cale SMITH , Victor Wayne MCCRAY , Brandon McNary FELKINS
发明人： Douglas Michael ACKERMANN , Daniel PALANKER , James Donald LOUDIN , Garrett Cale SMITH , Victor Wayne MCCRAY , Brandon McNary FELKINS
IPC分类号： A61N1/372 , A61N1/378 , A61N1/36 , A61N1/375
CPC分类号： A61N1/37205 , A61N1/36046 , A61N1/36057 , A61N1/3606 , A61N1/36142 , A61N1/37211 , A61N1/3756 , A61N1/3787
摘要： A stimulation system stimulates anatomical targets in a patient for treatment of dry eye. The system may include a controller and a microstimulator. The controller may be implemented externally to or internally within the microstimulator. The components of the controller and microstimulator may be implemented in a single unit or in separate devices. When implemented separately, the controller and microstimulator may communicate wirelessly or via a wired connection. The microstimulator may generate pulses from a controller signal and apply the signal via one or more electrodes to an anatomical target. The microstimulator may not have any intelligence or logic to shape or modify a signal. The microstimulator may be a passive device configured to generate a pulse based on a signal received from the controller. The microstimulator may shape or modify a signal. Waveforms having different frequency, amplitude and period characteristics may stimulate different anatomical targets in a patient.

2. 发明授权

US08591501B2 Coherent fiber bundle system and method for ophthalmic intervention 有权
标题翻译：相干纤维束系统和眼科干预方法
公开(公告)号：US08591501B2
公开(公告)日：2013-11-26
申请号：US13042429
申请日：2011-03-07
申请人： David Mintz , Daniel Palanker , Gregory Kintz
发明人： David Mintz , Daniel Palanker , Gregory Kintz
IPC分类号： A61F9/008 , A61B18/22 , G02B6/06
CPC分类号： A61F9/00802 , A61F9/00821 , A61F2009/00863 , A61F2009/00891
摘要： Systems and processes are described relating to laser-based ophthalmic intervention technologies, and, more specifically, to techniques for creating lesions on an eye using a modular system featuring one or more coherent fiber bundles configured to deliver laser energy to the eye from a separate housing wherein a laser source is located. The subject technology may be utilized to not only separate a patient from certain portions of the hardware, but also to facilitate patterned lesion creation using mobile devices such as LIO and laser endoprobe devices.
摘要翻译：描述了与基于激光的眼科干预技术相关的系统和过程，更具体地，涉及用于使用具有一个或多个相干光纤束的模块化系统来创建眼睛上的损伤的技术，其被配置为将激光能量从单独的壳体其中定位有激光源。主题技术可以用于不仅将患者与硬件的某些部分分开，而且还可以利用诸如LIO和激光内窥镜装置之类的移动装置来促进图案化损伤创建。

3. 发明申请

US20050244301A1 Microfluidic devices and methods for producing pulsed microfluidic jets in a liquid environment 审中-公开
标题翻译：用于在液体环境中产生脉冲微流体喷流的微流体装置和方法
公开(公告)号：US20050244301A1
公开(公告)日：2005-11-03
申请号：US11149675
申请日：2005-06-09
申请人： Daniel Fletcher , Daniel Palanker
发明人： Daniel Fletcher , Daniel Palanker
IPC分类号： A61B17/22 , A61B17/32 , A61F9/007 , A61F9/011 , B01D57/02
CPC分类号： A61B17/3203 , A61B2017/22008 , A61B2017/32032 , A61B2018/263 , A61F9/00736 , A61F9/00825
摘要： Microfluidic devices and methods for their use in producing pulsed microfluidic jets in a fluid environment are provided. The subject microfluidic devices are characterized by the presence of a microfluid chamber at their distal ends. The microfluid chamber is bounded by an opening at one end, a vapor producing means opposite the opening, and side walls between the opening and the vapor producing means. The microfluid chambers are further characterized in that the only way fluid can exit the microfluid chambers is through the opening. In using the subject devices to produce a fluid jet in a fluid environment, the chamber is first contacted with the fluid environment. The vapor producing means is then actuated in a manner sufficient to produce a vapor bubble in the chamber which, in turn, produces a microfluidic jet in the fluid environment. The subject devices and methods find use in a variety of different applications, e.g., cutting tissue, introducing fluid into a cell, and the like.
摘要翻译：提供了用于在流体环境中生产脉冲微流体射流中的微流体装置和方法。目标微流体装置的特征在于在其远端处存在微流体室。微流体室由一端的开口，与开口相对的蒸气产生装置以及开口和蒸气产生装置之间的侧壁界定。微流体室的特征还在于，流体可以离开微流体室的唯一方式是通过开口。在使用主体装置在流体环境中产生流体射流时，腔室首先与流体环境接触。然后以足以在室中产生蒸汽气泡的方式致动蒸汽产生装置，这又在流体环境中产生微流体射流。本发明的装置和方法可用于各种不同的应用，例如切割组织，将流体引入细胞等。

4. 发明申请

US20050021028A1 Electro-adhesive tissue manipulator 审中-公开
标题翻译：电粘组织机械手
公开(公告)号：US20050021028A1
公开(公告)日：2005-01-27
申请号：US10871697
申请日：2004-06-18
申请人： Daniel Palanker , Alexander Vankov
发明人： Daniel Palanker , Alexander Vankov
IPC分类号： A61B20060101 , A61B17/00 , A61B17/30 , A61B18/14 , A61B18/18 , A61B19/00 , A61F9/00 , A61F9/007
CPC分类号： A61B17/30 , A61B18/12 , A61B18/14 , A61B34/70 , A61B90/30 , A61B2017/00176 , A61B2017/306 , A61B2018/1462 , A61F9/00 , A61F9/007
摘要： An electro-adhesive tissue manipulator capable of manipulating tissue with a single conducting element is provided. The manipulator includes a conducting element, an electrical means and a control means capable of generating a first and a second pulse on demand. The first pulse generates an adhesive state between the conducting element and the tissue layer strong enough to manipulate the tissue layer. The second pulse, which has higher pulse energy than the first pulse, generates a non-adhesive state to detach the adhered tissue layer from the conducting element. The electro-adhesive device could be combined with a medical instrument to enhance the capabilities of the medical instrument so that it can manipulate tissue. The advantage of the present invention, in contrast to mechanical tools, is that tissue can be manipulated with a single tip of a conducting element, without folding and piercing of the tissue, thus avoiding damage to the tissue.
摘要翻译：提供能够用单个导电元件操纵组织的电粘组织操纵器。机械手包括导电元件，电气装置和能够根据需要产生第一和第二脉冲的控制装置。第一脉冲在导电元件和组织层之间产生强度足以操纵组织层的粘合状态。具有比第一脉冲更高的脉冲能量的第二脉冲产生非粘合状态以将粘附的组织层与导电元件分离。电粘合装置可以与医疗器械组合以增强医疗器械的能力，使得其可以操纵组织。与机械工具相比，本发明的优点在于，组织可以用传导元件的单个尖端来操纵，而不会折叠和刺穿组织，从而避免损坏组织。

5. 发明授权

US09821159B2 Stimulation devices and methods 有权
公开(公告)号：US09821159B2
公开(公告)日：2017-11-21
申请号：US13441806
申请日：2012-04-06
申请人： Douglas Michael Ackermann , James Donald Loudin , Janusz Kuzma , Daniel Palanker , Scott Franklin Wetenkamp
发明人： Douglas Michael Ackermann , James Donald Loudin , Janusz Kuzma , Daniel Palanker , Scott Franklin Wetenkamp
IPC分类号： A61N1/36 , A61N1/372 , A61N1/375
CPC分类号： A61N1/36046 , A61N1/36057 , A61N1/3606 , A61N1/37205 , A61N1/37211 , A61N1/3756
摘要： Described here are stimulation systems and methods for stimulating one or more anatomical targets in a patient for treatment conditions such as dry eye. The stimulation system may include a controller and a microstimulator. The components of the controller and microstimulator may be implemented in a single unit or in separate devices. When implemented separately, the controller and microstimulator may communicate wirelessly or via a wired connection. The microstimulator may generate pulses from a signal received from the controller and apply the signal via one or more electrodes to an anatomical target. In some variations, the microstimulator may include a passive generation circuit configured to generate a pulse based on a signal received from the controller.

6. 发明申请

US20170143202A1 SYSTEM AND METHOD FOR PROVIDING ANALYSIS OF VISUAL FUNCTION USING A MOBILE DEVICE WITH DISPLAY 审中-公开
公开(公告)号：US20170143202A1
公开(公告)日：2017-05-25
申请号：US15424733
申请日：2017-02-03
申请人： Daniel PALANKER , Mark BLUMENKRANZ
发明人： Daniel PALANKER , Mark BLUMENKRANZ
IPC分类号： A61B3/00 , G06F19/00 , A61B3/024 , A61B5/00 , A61B3/02 , A61B3/06
CPC分类号： A61B3/0025 , A61B3/0033 , A61B3/0041 , A61B3/022 , A61B3/024 , A61B3/032 , A61B3/06 , A61B3/18 , A61B5/7275 , G06F19/3418 , G06Q50/22
摘要： A visual function evaluation is performed using a sequence of interactions with a mobile device. A patient user may perform a variety of visual tests using the mobile device. The mobile device transmits the test results to a remote server implementing analysis of the visual function results using network service. The network service receives the test results, processes the results, and provides the processed results to a healthcare provider. The processed results may include trends of the user's visual function test performance. The healthcare provider, such as a physician, may optimize and administer treatment based on the data. Early detection of changes in visual function can enable the healthcare provider to individualize treatment, helping to prevent vision loss while minimizing visits to the office, discomfort, and expense.

7. 发明申请

US20160374551A1 METAMORPHOPSIA TESTING AND RELATED METHODS 审中-公开
公开(公告)号：US20160374551A1
公开(公告)日：2016-12-29
申请号：US15260203
申请日：2016-09-08
申请人： Daniel PALANKER
发明人： Daniel PALANKER
IPC分类号： A61B3/032 , A61B5/00 , A61B3/00
CPC分类号： A61B3/032 , A61B3/0025 , A61B3/0033 , A61B3/0058 , A61B3/0091 , A61B5/0022 , A61B5/6898 , A61B5/7275
摘要： A visual distortion test is disclosed using a sequence of binary interactions with a mobile device, in which segments of the grid having no distortions are eliminated, and the segments with distortions are divided into smaller segments for further analysis. The test can quantify the visual distortion using a decreased number of steps, compared to sequential analysis of all the segments of the grid. The binary interaction or input to the mobile device is also easier for patients than graphic interactions with a conventional Amsler Grid. Early detection of changes in the visual distortion can enable the healthcare provider to individualize treatment, helping to prevent vision loss while minimizing visits to the office, discomfort, and expense.

8. 发明申请

US20080119842A1 Electro-adhesive tissue manipulation method 审中-公开
标题翻译：电粘组织操作方法
公开(公告)号：US20080119842A1
公开(公告)日：2008-05-22
申请号：US11974611
申请日：2007-10-12
申请人： Daniel Palanker , Alexander Vankov
发明人： Daniel Palanker , Alexander Vankov
IPC分类号： A61B17/28
CPC分类号： A61B17/30 , A61B18/12 , A61B18/14 , A61B34/70 , A61B90/30 , A61B2017/00176 , A61B2017/306 , A61B2018/1462 , A61F9/00 , A61F9/007
摘要： An electro-adhesive tissue manipulation method capable of manipulating tissue with a single conducting element is provided. The manipulator includes a conducting element, a pulse generator and a controller capable of generating a first and a second pulse on demand. The first pulse generates an adhesive state between the conducting element and the tissue layer strong enough to manipulate the tissue layer. The second pulse, which has higher pulse energy than the first pulse, generates a non-adhesive state to detach the adhered tissue layer from the conducting element. The electro-adhesive device could be combined with a medical instrument to enhance the capabilities of the medical instrument so that it can manipulate tissue. Thereby tissue can be manipulated with a single tip of a conducting element, without folding and piercing of the tissue, thus avoiding damage to the tissue.
摘要翻译：提供了能够用单个导电元件操作组织的电粘组织操作方法。操纵器包括导电元件，脉冲发生器和能够根据需要产生第一和第二脉冲的控制器。第一脉冲在导电元件和组织层之间产生强度足以操纵组织层的粘合状态。具有比第一脉冲更高的脉冲能量的第二脉冲产生非粘合状态以将粘附的组织层与导电元件分离。电粘合装置可以与医疗器械组合以增强医疗器械的能力，使得其可以操纵组织。由此，可以用传导元件的单个尖端来操纵组织，而不会折叠和刺穿组织，从而避免损坏组织。

9. 发明申请

US20060217691A1 Real-time therapeutic dosimetry based on dynamic response of treated tissue 审中-公开
标题翻译：基于处理组织的动态响应的实时治疗剂量测定
公开(公告)号：US20060217691A1
公开(公告)日：2006-09-28
申请号：US11361890
申请日：2006-02-23
申请人： Georg Schuele , Fannl Moinar , Daniel Palanker
发明人： Georg Schuele , Fannl Moinar , Daniel Palanker
IPC分类号： A61N5/06 , A61B18/18
CPC分类号： A61F9/008 , A61F9/00821 , A61F2009/00844 , A61F2009/00863 , A61N5/062
摘要： Improved optical therapy is provided. In a first aspect, improved dosimetry is provided by the use of spectrally resolved tissue reflectance as a real-time dosimetry signal. Spectrally resolving the reflectance substantially improves the sensitivity for dosimetry. An increase of spectrally resolved tissue reflectance (relative to a pre-treatment baseline) is indicative of a reversible tissue response to therapy, while a decrease of spectrally resolved tissue reflectance is indicative of approach to a threshold for irreversible tissue damage. In a second aspect, improved temperature uniformity within laser treated tissue is provided by using a treatment beam having an on-axis beam intensity substantially less than an off-axis beam intensity. The combined effects of heat flow within the treated tissue and illumination with such a beam profile can provide improved temperature uniformity compared to illumination with a conventional “top-hat” beam profile.
摘要翻译：提供改进的光学治疗。在第一方面，通过使用光谱分辨的组织反射作为实时剂量测定信号来提供改进的剂量测定。光谱分辨反射率大大提高了剂量测定的灵敏度。光谱分辨的组织反射率（相对于预处理基线）的增加指示对治疗的可逆组织响应，而光谱分辨的组织反射率的降低指示接近不可逆组织损伤的阈值。在第二方面，通过使用具有基本上小于离轴光束强度的轴上光束强度的处理光束来提供激光处理的组织内的改善的温度均匀性。处理过的组织中的热流和这种光束轮廓的照射的组合效应可以提供与使用常规“顶帽”光束轮廓的照明相比改善的温度均匀性。

10. 发明申请

US20060195076A1 Method and apparatus for patterned plasma-mediated laser trephination of the lens capsule and three dimensional phaco-segmentation 有权
公开(公告)号：US20060195076A1
公开(公告)日：2006-08-31
申请号：US11328970
申请日：2006-01-09
申请人： Mark Blumenkranz , Daniel Palanker , David Mordaunt , Dan Andersen
发明人： Mark Blumenkranz , Daniel Palanker , David Mordaunt , Dan Andersen
IPC分类号： A61B18/18
CPC分类号： A61F9/008 , A61B18/20 , A61B90/361 , A61B2018/00577 , A61F2/1602 , A61F9/00736 , A61F9/00754 , A61F9/00812 , A61F9/00814 , A61F9/00825 , A61F9/00831 , A61F9/00834 , A61F9/00836 , A61F9/00838 , A61F9/0084 , A61F9/009 , A61F2009/00844 , A61F2009/00851 , A61F2009/00865 , A61F2009/0087 , A61F2009/00878 , A61F2009/00882 , A61F2009/00887 , A61F2009/00889 , A61F2009/00895 , A61F2009/00897
摘要： System and method for making incisions in eye tissue at different depths. The system and method focuses light, possibly in a pattern, at various focal points which are at various depths within the eye tissue. A segmented lens can be used to create multiple focal points simultaneously. Optimal incisions can be achieved by sequentially or simultaneously focusing lights at different depths, creating an expanded column of plasma, and creating a beam with an elongated waist.

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