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    • 10. 发明授权
    • Method for producing 2-hydroxyester compound
    • 2-羟酯化合物的制备方法
    • US07737296B2
    • 2010-06-15
    • US11997856
    • 2006-08-08
    • Ichiro KozonoNaoki FujiwaraDaisuke Hino
    • Ichiro KozonoNaoki FujiwaraDaisuke Hino
    • C07C69/66
    • C07C67/22C07C67/58C07C69/734C07C69/675
    • A simple and easy-to-use method for producing a 2-hydroxyester compound using a cyanohydrin compound, as a raw material, is provided. A method for producing a 2-hydroxyester compound represented by the general formula (1) (provided that ethyl 2-hydroxy-4-phenylbutyrate is excluded), wherein an acid is introduced into a mixture of a cyanohydrin compound represented by the general formula (2), an alcohol, an organic solvent and water:(Chemical Formula 1) R1—CH(OH)—COOR2  (1) R1—CH(OH)(CN)  (2) wherein, R1 is a hydrogen atom, a substituted or unsubstituted aliphatic hydrocarbon group having 1 to 12 carbon atoms, which may contain an oxygen atom, a sulfur atom or a nitrogen atom, a substituted or unsubstituted alicyclic hydrocarbon group having 3 to 12 carbon atoms, which may contain an oxygen atom, a sulfur atom or a nitrogen atom, and a substituted or unsubstituted aryl group or aralkyl group having 3 to 14 carbon atoms, which may contain an oxygen atom, a sulfur atom or a nitrogen atom; and R2 is an alkyl group having 1 to 12 carbon atoms, which may contain an oxygen atom, a sulfur atom or a nitrogen atom.
    • 提供了使用氰醇化合物作为原料制备2-羟基酯化合物的简单且易于使用的方法。 制备由通式(1)表示的2-羟基酯化合物的方法(不包括2-羟基-4-苯基丁酸乙酯),其中将酸引入由通式(2)表示的羟腈化合物 2),醇,有机溶剂和水:(化学式1)R1-CH(OH)-COOR2(1)R1-CH(OH)(CN)(2)其中,R1是氢原子, 或可以含有氧原子,硫原子或氮原子的碳原子数为1〜12的未取代的脂肪族烃基,可以含有氧原子的取代或未取代的碳原子数为3〜12的脂肪族烃基,硫 原子或氮原子,以及可以含有氧原子,硫原子或氮原子的具有3〜14个碳原子的取代或未取代的芳基或芳烷基; R2为碳原子数为1〜12的烷基,可以含有氧原子,硫原子或氮原子。