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1. 发明授权

US11555221B2 Method for detecting mood disorders 有权
公开(公告)号：US11555221B2
公开(公告)日：2023-01-17
申请号：US16335526
申请日：2017-09-25
申请人： DNA CHIP RESEARCH INC. , NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY
发明人： Seiji Nakamura , Yohei Ishizawa , Ryo Matoba , Kenichi Matsubara , Hiroshi Kunugi , Hiroaki Hori
IPC分类号： C12Q1/6883
摘要： The object of the invention is to provide a method for easily and objectively detecting mood disorders in a subject by measuring the expression levels of prescribed genes in the peripheral blood of the subject, the reliability of the detection result being high. The invention also provides a method for detecting mood disorders in a subject, the method having a step for measuring the gene expression levels of ribosomal protein genes, CDKN1C, or any combination thereof in the peripheral blood derived from the subject, and detecting whether or not the subject has mood disorders on the basis of the measurement results.

2. 发明申请

US20220073988A1 METHOD FOR PREDICTING EFFICACY OF RHEUMATOID ARTHRITIS THERAPEUTIC AGENT AND BIOMARKER USED THEREIN 有权
公开(公告)号：US20220073988A1
公开(公告)日：2022-03-10
申请号：US17299141
申请日：2019-12-05
申请人： DNA CHIP RESEARCH INC. , KEIO UNIVERSITY , Saitama Medical University
发明人： Seiji NAKAMURA , Yumi UEDA , Yohei ISHIZAWA , Madoka HIRAYAMA , Ryo MATOBA , Tsutomu TAKEUCHI , Kunihiro YAMAOKA , Koichi AMANO
IPC分类号： C12Q1/6883
摘要： [Problem to be Solved by the Invention] To predict the efficacy of a rheumatoid arthritis therapeutic agent, or find a simple and highly reproducible hiomarker that can be used to assess the activity of disease conditions and states of rheumatoid arthritis, and provide an effective method.
[Solution] A method for predicting the efficacy of a rheumatoid arthritis therapeutic agent on a. rheumatoid arthritis patient, the method comprising: a step for measuring the expression level of the MS4A4A gene in peripheral blood derived from the patient before administration of the rheumatoid arthritis therapeutic agent; and a step for measuring the expression level of the MS4A4A gene in peripheral blood derived from the patient after a first period of time has passed since administration of the rheumatoid arthritis therapeutic agent, wherein a reduction in the expression level of the MS4A4A gene after the first period time has passed, indicates a reduction in the value of an index related to rheumatoid arthritis occurring in the patient after a second period of time has passed since administration of the therapeutic agent.

3. 发明授权

US11332737B2 Method for counting number of nucleic acid molecules 有权
公开(公告)号：US11332737B2
公开(公告)日：2022-05-17
申请号：US16773570
申请日：2020-01-27
申请人： DNA Chip Research Inc. , Osaka Prefectural Hospital Organization
发明人： Kikuya Kato , Yoji Kukita , Ryo Matoba
IPC分类号： C12Q1/68 , C12Q1/6874 , G16B45/00 , C12N15/10 , C12N15/00
摘要： The object of the invention is to provide a method for counting the number of nucleic acid molecules in a mixture of a plurality of nucleic acid molecules more highly accurately. This is a method for highly accurately counting the number of nucleic acid molecules by detecting the read errors that occur when determining a nucleic acid base sequence, wherein the method has: a step for adding a barcode-sequence-generating oligonucleotide to a mixture of a plurality of nucleic acid molecules, thereby linking barcode sequences unique to the nucleic acid molecules to the base sequences constituting each of the nucleic acid molecules; a step for determining the base sequences of the nucleic acid molecules to which the barcode sequences have been linked; a step for detecting read errors in the barcode sequences for which the base sequences have been determined; and a step for calculating the proportion of barcode sequences free of read errors to all of the barcode sequences for which the base sequences have been determined, on the basis of the number of reads of the barcode sequences for which the base sequences have been determined, the abovementioned barcode-sequence-generating oligonucleotide comprising a maximum of five bases, and the number of barcode sequences free of read errors indicating the number of nucleic acid molecules in the mixture.

4. 发明授权

US10584331B2 Method for counting number of nucleic acid molecules 有权
公开(公告)号：US10584331B2
公开(公告)日：2020-03-10
申请号：US15322883
申请日：2015-07-02
申请人： DNA Chip Research Inc. , Osaka Prefectural Hospital Organization
发明人： Kikuya Kato , Yoji Kukita , Ryo Matoba
IPC分类号： C12Q1/68 , C12N15/10 , G06F19/26 , G16B45/00 , C12N15/00 , C12Q1/6874
摘要： The object of the invention is to provide a method for counting the number of nucleic acid molecules in a mixture of a plurality of nucleic acid molecules more highly accurately. This is a method for highly accurately counting the number of nucleic acid molecules by detecting the read errors that occur when determining a nucleic acid base sequence, wherein the method has: a step for adding a barcode-sequence-generating oligonucleotide to a mixture of a plurality of nucleic acid molecules, thereby linking barcode sequences unique to the nucleic acid molecules to the base sequences constituting each of the nucleic acid molecules; a step for determining the base sequences of the nucleic acid molecules to which the barcode sequences have been linked; a step for detecting read errors in the barcode sequences for which the base sequences have been determined; and a step for calculating the proportion of barcode sequences free of read errors to all of the barcode sequences for which the base sequences have been determined, on the basis of the number of reads of the barcode sequences for which the base sequences have been determined, the abovementioned barcode-sequence-generating oligonucleotide comprising a maximum of five bases, and the number of barcode sequences free of read errors indicating the number of nucleic acid molecules in the mixture.

5. 发明申请

US20200024663A1 METHOD FOR DETECTING MOOD DISORDERS 审中-公开
公开(公告)号：US20200024663A1
公开(公告)日：2020-01-23
申请号：US16335526
申请日：2017-09-25
申请人： DNA CHIP RESEARCH INC. , NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY
发明人： Seiji NAKAMURA , Yohei ISHIZAWA , Ryo MATOBA , Kenichi MATSUBARA , Hiroshi KUNUGI , Hiroaki HORI
IPC分类号： C12Q1/6883
摘要： The object of the invention is to provide a method for easily and objectively detecting mood disorders in a subject by measuring the expression levels of prescribed genes in the peripheral blood of the subject, the reliability of the detection result being high. The invention also provides a method for detecting mood disorders in a subject, the method having a step for measuring the gene expression levels of ribosomal protein genes, CDKN1C, or any combination thereof in the peripheral blood derived from the subject, and detecting whether or not the subject has mood disorders on the basis of the measurement results.

6. 发明申请

US20170204406A1 METHOD FOR COUNTING NUMBER OF NUCLEIC ACID MOLECULES 审中-公开
公开(公告)号：US20170204406A1
公开(公告)日：2017-07-20
申请号：US15322883
申请日：2015-07-02
申请人： DNA Chip Research Inc. , Osaka Prefectural Hospital Organization
发明人： Kikuya KATO , Yoji KUKITA , Ryo MATOBA
IPC分类号： C12N15/10 , G06F19/26 , C12Q1/68
CPC分类号： C12N15/1065 , C12N15/00 , C12Q1/68 , C12Q1/6874 , G16B45/00
摘要： The object of the invention is to provide a method for counting the number of nucleic acid molecules in a mixture of a plurality of nucleic acid molecules more highly accurately. This is a method for highly accurately counting the number of nucleic acid molecules by detecting the read errors that occur when determining a nucleic acid base sequence, wherein the method has: a step for adding a barcode-sequence-generating oligonucleotide to a mixture of a plurality of nucleic acid molecules, thereby linking barcode sequences unique to the nucleic acid molecules to the base sequences constituting each of the nucleic acid molecules; a step for determining the base sequences of the nucleic acid molecules to which the barcode sequences have been linked; a step for detecting read errors in the barcode sequences for which the base sequences have been determined; and a step for calculating the proportion of barcode sequences free of read errors to all of the barcode sequences for which the base sequences have been determined, on the basis of the number of reads of the barcode sequences for which the base sequences have been determined, the abovementioned barcode-sequence-generating oligonucleotide comprising a maximum of five bases, and the number of barcode sequences free of read errors indicating the number of nucleic acid molecules in the mixture.

7. 发明申请

US20040058844A1 Solution for substrate spotting and spotting method 审中-公开
标题翻译：基板检测和点样方法的解决方案
公开(公告)号：US20040058844A1
公开(公告)日：2004-03-25
申请号：US10600365
申请日：2003-06-23
申请人： DNA Chip Research, Inc. , Hitachi Software Engineering Co., Ltd.
发明人： Yasuo Komatsu , Kenichi Matsubara , Eiko Ohtsuka , Ken Nonaka , Noriko Yurino
IPC分类号： C11D001/00
CPC分类号： B82Y30/00 , B01J2219/00387 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00677 , B01J2219/00722 , B01L3/0241 , C40B40/06 , C40B60/14 , G01N2035/1037
摘要： A solution for substrate spotting and spotting method for immobilizing a biological substance or various chemical substances on a substrate at high density. The solution for substrate spotting and the spotting method involve mixing a solution comprising a biological substance or chemical substance to be spotted with a solution to which an inorganic fine powder has been added as a surface tension regulating agent.
摘要翻译：用于将生物物质或各种化学物质以高密度固定在基材上的基板点样和点样方法。用于基板点样和点样方法的方案包括将包含待点样的生物物质或化学物质的溶液与添加有无机细粉末的溶液作为表面张力调节剂进行混合。

8. 发明申请

US20040091899A1 Substrate for immobilization of a biological substance or chemical substance, method of immobilizing a biological substance or chemical substance, and method of coating a substrate 审中-公开
标题翻译：用于固定生物物质或化学物质的基材，固定生物物质或化学物质的方法，以及涂布基质的方法
公开(公告)号：US20040091899A1
公开(公告)日：2004-05-13
申请号：US10601882
申请日：2003-06-24
申请人： DNA Chip Research, Inc. , Hitachi Software Engineering Co., Ltd.
发明人： Yasuo Komatsu , Kenichi Matsubara , Eiko Ohtsuka , Ken Nonaka , Noriko Yurino
IPC分类号： C12Q001/68 , C12M001/34 , A61L002/00 , B05D003/00
CPC分类号： C40B40/06 , C03C17/30 , C03C17/3405 , C07B2200/11 , C40B50/18 , G01N33/54353 , G01N33/552
摘要： A coated substrate for immobilizing a biological substance etc. at high density with low background value. The substrate has a cross-linking reagent represented by general formula AnullLnullB (wherein, A and B represent an identical or different group which reacts with an active group of the coupling agent comprising an active group, selected from an active ester group, isothiocyanate group, isocyanate group, imidazole group, carbodiimide group or aldehyde group, and wherein L is a linking group linking A and B, selected from a straight chain alkyl group, aryl group, allyl group or alkyl group having an amide group) bound thereonto by means of a coupling agent comprising an active group. An biological substance or the like is immobilized on the substrate.
摘要翻译：用于以低背景值高密度固定生物物质等的涂布基材。基材具有由通式ALB表示的交联试剂（其中，A和B表示与包含选自活性酯基，异硫氰酸酯基的活性基团的偶联剂的活性基团反应的相同或不同的基团，异氰酸酯基，咪唑基，碳二亚胺基或醛基，其中L是连接A和B的连接基团，选自直链烷基，芳基，烯丙基或具有酰胺基的烷基）通过包含活性基团的偶联剂。将生物物质等固定在基板上。

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