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1. 发明授权

US09626366B2 System, methods, and program product to trace content genealogy 有权
公开(公告)号：US09626366B2
公开(公告)日：2017-04-18
申请号：US11305871
申请日：2005-12-16
申请人： Taras Markian Bugir , Cynthia Parrish , Candace Helgerson
发明人： Taras Markian Bugir , Cynthia Parrish , Candace Helgerson
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： G06F17/30038
摘要： Embodiments of systems, program products, and methods to manage content and distribution of media are provided. An embodiment of a system, for example, can include a communication network for transmitting media files, a content management server having a processor and memory coupled to the processor, a database accessible to the processor of the content management server and including media files associated with metadata records, a plurality of content management developer computers to provide content management developers with online access over the communication network to the media files and associated metadata records to thereby edit the metadata records, a plurality of user computers accessible to the communication network to provide the users with access to the media files over the communication network to thereby view and edit at least portions of respective metadata records. The system also includes content management program product stored in the memory of the content management server to manage content and distribution of media.

2. 发明申请

US20070265345A1 Novel Biphenyl Compounds And Their Use 审中-公开
标题翻译：新型联苯化合物及其用途
公开(公告)号：US20070265345A1
公开(公告)日：2007-11-15
申请号：US11632331
申请日：2005-07-27
申请人： Amita Chaudhari , Dashyant Dhanak , Steven Knight , David Morgans , Cynthia Parrish
发明人： Amita Chaudhari , Dashyant Dhanak , Steven Knight , David Morgans , Cynthia Parrish
IPC分类号： A61K31/17 , A61K31/165 , A61P35/00 , A61P37/00 , A61P43/00 , A61P9/00 , C07C233/00 , C07C273/18 , C07C275/00
CPC分类号： C07C275/28 , C07C233/15 , C07C233/43 , C07C259/06 , C07C275/30 , C07C275/40 , C07C275/42 , C07C275/64 , C07C317/24 , C07C317/42 , C07C323/44 , C07C335/16 , C07D209/02 , C07D307/79 , C07D317/66 , C07D319/18
摘要： The invention is directed to certain biphenyl compounds. Specifically, the invention is directed to compounds according to Formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and Y are as defined below, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are KSP inhibitors, particularly human KSP inhibitors, and can be useful for the treatment for a variety of diseases and conditions, such as cancer, hyperplasias, restenosis, cardiac hypertrophy, immune disorders, fungal disorders, and inflammation. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting KSP and treatment of conditions associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention. In an additional aspect, the invention provides methods of screening for compounds that will bind to a KSP kinesin, for example compounds that will displace or compete with the binding of the compounds of the invention. The methods comprise combining a labeled compound of the invention, a KSP kinesin, and at least one candidate agent and determining the binding of the candidate bioactive agent to the KSP kinesin. In a further aspect, the invention provides methods of screening for modulators of KSP kinesin activity. The methods comprise combining a compound of the invention, a KSP kinesin, and at least one candidate agent and determining the effect of the candidate bioactive agent on the KSP kinesin activity.
摘要翻译：本发明涉及某些联苯化合物。具体地说，本发明涉及式Ⅰ化合物：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9和Y如下所定义，及其药学上可接受的盐。本发明的化合物是KSP抑制剂，特别是人KSP抑制剂，并且可用于治疗各种疾病和病症，例如癌症，增生，再狭窄，心脏肥大，免疫疾病，真菌病症和炎症。因此，本发明进一步涉及包含本发明化合物的药物组合物。本发明还涉及使用本发明化合物或包含本发明化合物的药物组合物抑制KSP和治疗与其相关的病症的方法。在另一方面，本发明提供筛选将结合KSP驱动蛋白的化合物的方法，例如将取代或与本发明化合物结合竞争的化合物。所述方法包括组合本发明的标记化合物，KSP驱动蛋白和至少一种候选试剂，并确定候选生物活性剂与KSP驱动蛋白的结合。另一方面，本发明提供筛选KSP驱动蛋白活性调节剂的方法。所述方法包括组合本发明的化合物，KSP驱动蛋白和至少一种候选试剂，并确定候选生物活性剂对KSP驱动蛋白活性的影响。

3. 发明申请

US20070197481A1 Certain chemical entities, compositions, and methods 失效
标题翻译：某些化学实体，组合物和方法
公开(公告)号：US20070197481A1
公开(公告)日：2007-08-23
申请号：US11124608
申请日：2005-05-06
申请人： Xiangping Qian , Andrew McDonald , Han-Jie Zhou , Luke Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David Morgans , Bradley Morgan , Gustave Bergnes , Dashyant Dhanak , Steven Knight , Nicholas Adams , Cynthia Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
发明人： Xiangping Qian , Andrew McDonald , Han-Jie Zhou , Luke Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David Morgans , Bradley Morgan , Gustave Bergnes , Dashyant Dhanak , Steven Knight , Nicholas Adams , Cynthia Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
IPC分类号： A61K31/66 , A61K31/538 , A61K31/4172 , A61K31/4745 , A61K31/426 , A61K31/421
CPC分类号： C07D403/12 , A61K31/4172 , A61K31/421 , A61K31/426 , A61K31/4745 , A61K31/538 , A61K31/66 , A61K45/06 , C07C235/48 , C07C235/50 , C07C237/22 , C07C255/44 , C07C255/57 , C07C255/60 , C07C271/28 , C07C2601/14 , C07D207/273 , C07D211/76 , C07D231/12 , C07D235/18 , C07D239/22 , C07D261/08 , C07D271/06 , C07D277/42 , C07D285/12 , C07D295/15 , C07D333/38 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04 , A61K2300/00
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
摘要翻译：公开了通过调节一种或多种有丝分裂驱动蛋白的活性来治疗细胞增殖性疾病和病症的化合物。

4. 发明申请

US20070142460A1 Compounds, compositions and methods 审中-公开
公开(公告)号：US20070142460A1
公开(公告)日：2007-06-21
申请号：US10583166
申请日：2004-12-17
申请人： Cynthia Parrish , Dashyant Dhanak
发明人： Cynthia Parrish , Dashyant Dhanak
IPC分类号： A61K31/36 , C07D311/78 , C07D317/44 , A61K31/277 , A61K31/16
CPC分类号： C07D317/46 , C07C307/10 , C07D317/44 , C07D317/58 , C07D319/08 , C07D319/20
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.

5. 发明申请

US20070067427A1 System, methods, and program product to trace content genealogy 审中-公开
标题翻译：系统，方法和程序产品追踪内容谱系
公开(公告)号：US20070067427A1
公开(公告)日：2007-03-22
申请号：US11305873
申请日：2005-12-16
申请人： Taras Bugir , Cynthia Parrish , Candace Helgerson
发明人： Taras Bugir , Cynthia Parrish , Candace Helgerson
IPC分类号： G06F15/173
CPC分类号： G06F21/10
摘要： Embodiments of systems, program products, and methods to manage content and distribution of media are provided. An embodiment of a system, for example, can include a communication network for transmitting media files, a content management server having a processor and memory coupled to the processor, a database accessible to the processor of the content management server and including media files associated with metadata records, a plurality of content management developer computers to provide content management developers with online access over the communication network to the media files and associated metadata records to thereby edit the metadata records, a plurality of user computers accessible to the communication network to provide the users with access to the media files over the communication network to thereby view and edit at least portions of respective metadata records. The system also includes content management program product stored in the memory of the content management server to manage content and distribution of media.
摘要翻译：提供了用于管理媒体内容和分发的系统，程序产品和方法的实施例。例如，系统的实施例可以包括用于传送媒体文件的通信网络，具有耦合到处理器的处理器和存储器的内容管理服务器，可由内容管理服务器的处理器访问的数据库，并且包括与元数据记录，多个内容管理开发者计算机，用于向内容管理开发者提供通过通信网络的在线访问到媒体文件和相关联的元数据记录，从而编辑元数据记录，通信网络可访问的多个用户计算机，通过通信网络访问媒体文件的用户，从而查看和编辑相应元数据记录的至少一部分。该系统还包括存储在内容管理服务器的存储器中的内容管理程序产品，以管理媒体的内容和分发。

6. 发明申请

US20080081808A1 AZAINDOLE INHIBITORS OF AURORA KINASES 有权
公开(公告)号：US20080081808A1
公开(公告)日：2008-04-03
申请号：US11855183
申请日：2007-09-14
申请人： Martha Sarpong , Nicholas Adams , Jeffrey Axten , Amita Chaudhari , Dashyant Dhanak , Toshihiro Hamajima , Kenneth Newlander , Cynthia Parrish , Jerry Adams , Domingos Silva , Jun Tang
发明人： Martha Sarpong , Nicholas Adams , Jeffrey Axten , Amita Chaudhari , Dashyant Dhanak , Toshihiro Hamajima , Kenneth Newlander , Cynthia Parrish , Jerry Adams , Domingos Silva , Jun Tang
IPC分类号： A61K31/437 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/54 , A61P35/00 , C07D471/04
CPC分类号： C07D471/04
摘要： The present invention relates to a compound represented by Formula (I): and pharmaceutically acceptable salts. Compounds of the present invention inhibit Aurora kinase, making them especially suitable for the treatment of a number of diseases, including solid tumor cancers and hematological cancers.

8. 发明申请

US20060094708A1 Certain chemical entities, compositions, and methods 有权
标题翻译：某些化学实体，组合物和方法
公开(公告)号：US20060094708A1
公开(公告)日：2006-05-04
申请号：US11121709
申请日：2005-05-03
申请人： Xiangping Qian , Andrew McDonald , Han-Jie Zhou , Luke Ashcraft , Bing Yao , Hong Jiang , Jennifer Chen Huang , Jianchao Wang , David Morgans , Bradley Morgan , Gustave Bergnes , Dashyant Dhanak , Steven Knight , Nicholas Adams , Cynthia Parrish
发明人： Xiangping Qian , Andrew McDonald , Han-Jie Zhou , Luke Ashcraft , Bing Yao , Hong Jiang , Jennifer Chen Huang , Jianchao Wang , David Morgans , Bradley Morgan , Gustave Bergnes , Dashyant Dhanak , Steven Knight , Nicholas Adams , Cynthia Parrish
IPC分类号： A61K31/55 , A61K31/4745 , A61K31/424 , A61K31/421 , A61K31/4196 , A61K31/4184 , C07D491/02 , C07D487/02
CPC分类号： C07D403/12 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/28 , C07C275/40 , C07C281/06 , C07C311/37 , C07C2601/14 , C07D207/273 , C07D211/76 , C07D213/30 , C07D231/12 , C07D233/62 , C07D235/18 , C07D235/26 , C07D261/08 , C07D263/10 , C07D271/06 , C07D277/56 , C07D285/02 , C07D295/155 , C07D333/38 , C07D403/10 , C07D471/04 , C07F9/6506 , C07F9/6561
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
摘要翻译：公开了通过调节一种或多种有丝分裂驱动蛋白的活性来治疗细胞增殖性疾病和病症的化合物。

9. 发明申请

US20120208827A1 BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS 审中-公开
标题翻译：苯扎昔单抗作为脂肪酸合成酶抑制剂
公开(公告)号：US20120208827A1
公开(公告)日：2012-08-16
申请号：US13504547
申请日：2010-10-27
申请人： Steven Dock , Jason Hallman , Christopher Laudeman , Ronggang Liu , Aaron Miller , Michael Lee Moore , David Musso , Cynthia Parrish
发明人： Steven Dock , Jason Hallman , Christopher Laudeman , Ronggang Liu , Aaron Miller , Michael Lee Moore , David Musso , Cynthia Parrish
IPC分类号： A61K31/496 , A61K31/437 , A61K31/4725 , A61K31/428 , A61K31/423 , A61K31/4184 , C07D471/04 , C07D401/14 , C07D417/14 , C07D413/14 , C07D403/14 , C07D405/14 , A61P35/00 , C07D403/06 , A61K31/517
CPC分类号： C07D403/14 , C07D403/06 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： This invention relates to the use of benzimidazole derivatives for the modulation, notably the inhibition of the activity or function of fatty acid synthase (FAS). Suitably, the present invention relates to the use of benzimidazoles in the treatment of cancer.
摘要翻译：本发明涉及苯并咪唑衍生物用于调节，特别是抑制脂肪酸合成酶（FAS）的活性或功能的用途。合适地，本发明涉及苯并咪唑在治疗癌症中的用途。

10. 发明申请

US20070050409A1 System, methods, and program product to trace content genealogy 有权
公开(公告)号：US20070050409A1
公开(公告)日：2007-03-01
申请号：US11305871
申请日：2005-12-16
申请人： Taras Bugir , Cynthia Parrish , Candace Helgerson
发明人： Taras Bugir , Cynthia Parrish , Candace Helgerson
IPC分类号： G06F7/00
CPC分类号： G06F17/30038
摘要： Embodiments of systems, program products, and methods to manage content and distribution of media are provided. An embodiment of a system, for example, can include a communication network for transmitting media files, a content management server having a processor and memory coupled to the processor, a database accessible to the processor of the content management server and including media files associated with metadata records, a plurality of content management developer computers to provide content management developers with online access over the communication network to the media files and associated metadata records to thereby edit the metadata records, a plurality of user computers accessible to the communication network to provide the users with access to the media files over the communication network to thereby view and edit at least portions of respective metadata records. The system also includes content management program product stored in the memory of the content management server to manage content and distribution of media.

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