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1. 发明申请

US20140037062A1 IMAGE GUIDED RADIATION THERAPY 审中-公开
标题翻译：图像指导辐射治疗
公开(公告)号：US20140037062A1
公开(公告)日：2014-02-06
申请号：US13563788
申请日：2012-08-01
申请人： Daniel Robert ELGORT , Lucian Remus ALBU , Clemens BOS
发明人： Daniel Robert ELGORT , Lucian Remus ALBU , Clemens BOS
IPC分类号： A61B6/08
CPC分类号： G01R33/4808 , A61B5/055 , A61B5/70 , A61N5/1049 , A61N2005/1055
摘要： An image guided radiation therapy system comprises a radiation source to generate radiation. Radiation optics forms a therapeutic radiation beam from the therapeutic radiation from the radiation source. An imaging system forms an image of a target zone to control the radiation optics to direct the therapeutic radiation beam onto the target zone. The radiation optics is provided with an optics module configured to generate an imaging photonic beam endowed with optical angular momentum. The imaging system comprises a magnetic resonance assembly to receive magnetic resonance signals the from the target zone generated by imaging photonic beam endowed with optical angular momentum.
摘要翻译：图像引导放射治疗系统包括产生辐射的辐射源。辐射光学器件形成来自辐射源的治疗辐射的治疗辐射束。成像系统形成目标区域的图像，以控制辐射光学器件将治疗辐射束引导到目标区域上。辐射光学器件设置有被配置为产生具有光学角动量的成像光子束的光学模块。该成像系统包括一个磁共振组件，用于接收来自由具有光学角动量的成像光子束产生的目标区域的磁共振信号。

2. 发明授权

US07508205B2 Magnetic resonance imaging system, a method of magnetic resonance imaging and a computer program 失效
标题翻译：磁共振成像系统，磁共振成像方法和计算机程序
公开(公告)号：US07508205B2
公开(公告)日：2009-03-24
申请号：US11568325
申请日：2005-04-27
申请人： Guillaume Rudolf Petrus Thelissen , Clemens Bos
发明人： Guillaume Rudolf Petrus Thelissen , Clemens Bos
IPC分类号： G01V3/00
CPC分类号： G01R33/4804
摘要： A magnetic resonance imaging system (1) includes a data acquisition system (11) with a main magnet (12) with an imaging volume. A gradient system (G) generates field gradients (Gx), (Gy) and (Gz). An RF excitation system (10) generates radio-frequency (RF) excitation pulses. In a receiving mode, an RF coil senses a response, for example in the form of free induction decay signals, including echo signals. An image processor (26) is arranged to extract thermometry data and longitudinal relaxation time data from the acquired MR signals and to forward corresponding reconstructed images to a display unit (28).
摘要翻译：磁共振成像系统（1）包括具有成像体积的主磁体（12）的数据采集系统（11）。梯度系统（G）产生场梯度（Gx），（Gy）和（Gz）。 RF激励系统（10）产生射频（RF）激励脉冲。在接收模式中，RF线圈以例如包括回波信号的自由感应衰减信号的形式来感测响应。图像处理器（26）被布置成从所获取的MR信号中提取测温数据和纵向弛豫时间数据，并将相应的重建图像转发到显示单元（28）。

3. 发明授权

US09488709B2 Restriction of the imaging region for MRI in an inhomogeneous magnetic field 有权
标题翻译： MRI在不均匀磁场中的成像区域的限制
公开(公告)号：US09488709B2
公开(公告)日：2016-11-08
申请号：US14004823
申请日：2012-02-14
申请人： Johan Michiel Den Harder , Clemens Bos , Ulrike Andrea Blume
发明人： Johan Michiel Den Harder , Clemens Bos , Ulrike Andrea Blume
IPC分类号： G01R33/54 , G01R33/44 , G01R33/565
CPC分类号： G01R33/543 , G01R33/445 , G01R33/56536 , G01R33/56563
摘要： When magnetic resonance imaging in the vicinity of a metallic object (like, for instance, a metal implant), severe spatial perturbations of the static magnetic field occur. In order to suppress the back-folding of distant off-resonant signals into the region of interest, the imaging volume is spatially restricted by selection gradients applied concurrently with the excitation and the refocusing RF pulses in a spin echo sequence. The selection gradient applied during the excitation pulse has an amplitude and/or a polarity different from that of the selection gradient applied during the refocusing pulse so that the respectively selected slices in an off-resonance frequency versus spatial coordinate diagram become tilted with respect to one another. The applied imaging technique may of the SEMAC or MAVRIC type and may incorporate compressed sensing, parallel imaging, fat suppression and/or SVD-based noise reduction.
摘要翻译：当金属物体（例如金属植入物）附近的磁共振成像发生静态磁场的严重空间扰动时。为了抑制远离非共振信号向感兴趣区域的反向折叠，成像体积受空间限制，该选择梯度与自旋回波序列中的激发和重聚焦RF脉冲同时应用。在激励脉冲期间施加的选择梯度具有与在再聚焦脉冲期间施加的选择梯度的幅度和/或极性不同的幅度和/或极性，使得非共振频率对空间坐标图中的分别选择的切片相对于一个倾斜另一个。所应用的成像技术可以是SEMAC或MAVRIC型，并且可以包括压缩感测，平行成像，基于脂肪抑制和/或基于SVD的降噪。

4. 发明申请

US20070216410A1 Magnetic Resonance Imaging System, a Method of Magnetic Resonance Imaging and a Computer Program 失效
公开(公告)号：US20070216410A1
公开(公告)日：2007-09-20
申请号：US11568325
申请日：2005-04-27
申请人： Guillaume Thelissen , Clemens Bos
发明人： Guillaume Thelissen , Clemens Bos
IPC分类号： G01R33/48
CPC分类号： G01R33/4804
摘要： The magnetic resonance imaging system 1 according to the invention comprises a data acquisition system 11 with a main magnet 12 with an imaging volume (not shown) therein. Gradient system (G) arranged for generating field gradients Gx indicated as 14, Gy indicated as 16 and Gz indicated as 17 is provided. An RF excitation system (10) is provided for generating radio-frequency (RF) pulses for flipping aligned spins into a transverse plane such as the XY plane or to have a component in the XY plane. The system (10) for flipping the spins comprises RF coils (not shown) in the magnet 12 and a pulse transmitter 18. The pulse transmitter frequency may be supplied by a synthesizer 19 and can be controlled by a control system 21. The control system 21 is arranged to control the time and amplitude of the outputs of the various component parts making up the magnetic resonance apparatus. The transmitted pulse is supplied from the transmitter 18 through a transmitter-receiver selection switch 22 to an RF coil (not shown) in the magnet. The systhesizer signal is coupled to the transmitter 18 when the system is in the transmitting mode through a second transmitter-receiver switch 23. In the receiving mode, the RF coil in the magnet senses a response of the investigated object to the RF pulses, for example in the form of a free induction decay signals, including echo signals. The signals received at the RF coil are supplied through switch 22 when it is switched by the control system 21 into the receiving mode to connect the RF coil to the receiver The receiver signal then passes through an analog-to-digital converter 25. The digital output of the converter 25 is applied to an image reconstructor 26, preferably having an associated memory 27. The image reconstructor 26 is arranged to extract thermometry data and longitudinal relaxation time data from the acquired MR signals and to forward corresponding reconstructed images to the display unit 28. The invention further relates to a method of magnetic resonance imaging and a computer program.

5. 发明授权

US09585594B2 Method of producing personalized RF coil array for MR imaging guided interventions 有权
标题翻译：制作用于MR成像指导干预的个性化RF线圈阵列的方法
公开(公告)号：US09585594B2
公开(公告)日：2017-03-07
申请号：US14117556
申请日：2012-05-09
申请人： Hubert Cecile Francois Martens , Elizabeth Anne Moore , Celilia Possanzini , Marco Hubertus Johannes Nijenhuis , Michel Gerardus Pardoel , Clemens Bos , Aaldert Jan Elevelt , Daniel Wirtz
发明人： Hubert Cecile Francois Martens , Elizabeth Anne Moore , Celilia Possanzini , Marco Hubertus Johannes Nijenhuis , Michel Gerardus Pardoel , Clemens Bos , Aaldert Jan Elevelt , Daniel Wirtz
IPC分类号： A61B5/05 , G01R33/34 , H01F41/04 , A61B5/055 , H01F3/02 , B29C67/00 , G06F17/50
CPC分类号： A61B5/055 , A61B34/20 , A61B2034/2065 , A61B2090/374 , B29C64/386 , B29C67/0088 , G01R33/34007 , G01R33/34084 , G06F17/50 , H01F3/02 , H01F41/04 , Y10T29/49018 , Y10T29/49069 , Y10T29/49073 , Y10T29/49075 , Y10T29/532
摘要： A method of manufacturing a personalized radio frequency (RF) coil array for magnetic resonance (MR) imaging guided interventions includes: acquiring diagnostic image data reflecting the anatomy of a portion of a patient's body; planning an intervention on the basis of the diagnostic image data, wherein a field of the intervention within the patient's body portion is determined; and arranging one or more RF coils on a substrate which is adapted to the patient's anatomy, in such a manner that the signal-to-noise ratio of MR signal acquisition via the one or more RF coils from the field of the intervention is optimized.
摘要翻译：制造用于磁共振（MR）成像引导干预的个性化射频（RF）线圈阵列的方法包括：获取反映患者身体的一部分的解剖结构的诊断图像数据; 基于诊断图像数据规划干预，其中确定患者身体部位内的介入场; 以及将一个或多个RF线圈布置在适于患者解剖结构的衬底上，使得经由来自干预领域的一个或多个RF线圈的MR信号采集的信噪比得以优化。

6. 发明申请

US20150000112A1 PERSONALIZED RF COIL ARRAY FOR MR IMAGING GUIDED INTERVENTIONS 有权
标题翻译：用于MR成像引导干预的个性化RF线圈阵列
公开(公告)号：US20150000112A1
公开(公告)日：2015-01-01
申请号：US14117556
申请日：2012-05-09
申请人： Hubert Cecile Francois Martens , Elizabeth Anne Moore , Celilia Possanzini , Marco Hubertus Johannes Nijenhuis , Michel Gerardus Pardoel , Clemens Bos , Aaldert Jan Elevelt , Daniel Wirtz
发明人： Hubert Cecile Francois Martens , Elizabeth Anne Moore , Celilia Possanzini , Marco Hubertus Johannes Nijenhuis , Michel Gerardus Pardoel , Clemens Bos , Aaldert Jan Elevelt , Daniel Wirtz
IPC分类号： A61B5/055 , B29C67/00 , G06F17/50 , A61B19/00 , G01R33/34
CPC分类号： A61B5/055 , A61B34/20 , A61B2034/2065 , A61B2090/374 , B29C64/386 , B29C67/0088 , G01R33/34007 , G01R33/34084 , G06F17/50 , H01F3/02 , H01F41/04 , Y10T29/49018 , Y10T29/49069 , Y10T29/49073 , Y10T29/49075 , Y10T29/532
摘要： The invention relates to a method of manufacturing a personalized RF coil array for MR imaging guided interventions. The method comprises the steps of: —acquiring diagnostic image data reflecting the anatomy of a portion of a patient's body (10); —planning an intervention on the basis of the diagnostic image data, wherein a field of the intervention within the patient's body (10) portion is determined; —arranging one or more RF antennae (11, 12, 13) on a substrate (19), which is adapted to the patient's anatomy, in such a manner that the signal-to-noise ratio of MR signal acquisition via the one or more RF antennae (11, 12, 13) from the field of the intervention is optimized. Moreover, the invention relates to a computer program and to a computer workstation.
摘要翻译：本发明涉及制造用于MR成像引导干预的个性化RF线圈阵列的方法。该方法包括以下步骤： - 获取反映患者身体（10）的一部分的解剖结构的诊断图像数据; - 根据所述诊断图像数据计划干预，其中确定所述患者体内（10）部分内的介入场; - 将一个或多个RF天线（11,12,13）布置在适于患者解剖结构的衬底（19）上，使得经由所述一个或多个的MR信号获取的信噪比优化了来自干预领域的射频天线（11,12,13）。此外，本发明涉及计算机程序和计算机工作站。

7. 发明申请

US20140002080A1 RESTRICTION OF THE IMAGING REGION FOR MRI IN AN INHOMOGENEOUS MAGNETIC FIELD 有权
标题翻译：磁共振成像磁场的成像区域的限制
公开(公告)号：US20140002080A1
公开(公告)日：2014-01-02
申请号：US14004823
申请日：2012-02-14
申请人： Johan Michell Den Harder , Clemens Bos , Ulrike Andrea Blume
发明人： Johan Michell Den Harder , Clemens Bos , Ulrike Andrea Blume
IPC分类号： G01R33/54
CPC分类号： G01R33/543 , G01R33/445 , G01R33/56536 , G01R33/56563
摘要： The invention relates to magnetic resonance imaging in the vicinity of a metallic object (like, for instance, a metal implant) where severe spatial perturbations of the static magnetic field occur. In order to suppress the back-folding of distant off-resonant signals into the region of interest, the imaging volume is spatially restricted by means of selection gradients applied concurrently with the excitation and the refocusing RF pulses in a spin echo sequence. The selection gradient applied during the excitation pulse has an amplitude and/or a polarity different from that of the selection gradient applied during the refocusing pulse so that the respectively selected slices in an off-resonance frequency versus spatial coordinate diagram become tilted with respect to one another. The applied imaging technique may of the SEMAC or MAVRIC type and may incorporate compressed sensing, parallel imaging, fat suppression and/or SVD-based noise reduction.
摘要翻译：本发明涉及在发生静态磁场的严重空间扰动的金属物体（例如金属植入物）附近的磁共振成像。为了抑制远离非共振信号向感兴趣区域的反向折叠，通过与自旋回波序列中的激发和重聚焦RF脉冲同时施加的选择梯度，成像体积受空间限制。在激励脉冲期间施加的选择梯度具有与在再聚焦脉冲期间施加的选择梯度的幅度和/或极性不同的幅度和/或极性，使得非共振频率对空间坐标图中的分别选择的切片相对于一个倾斜另一个。所应用的成像技术可以是SEMAC或MAVRIC型，并且可以包括压缩感测，平行成像，基于脂肪抑制和/或基于SVD的降噪。

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