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1. 发明授权

US08461224B2 Single monomer derived linear-like copolymer comprising polyethylenimine and poly(ethylene glycol) for nucleic acid delivery 有权
标题翻译：包含用于核酸递送的聚乙烯亚胺和聚（乙二醇）的单一单体衍生的线状共聚物
公开(公告)号：US08461224B2
公开(公告)日：2013-06-11
申请号：US13041023
申请日：2011-03-04
申请人： Shu-Yi Lin , Chung-Shi Yang , Yeu-Kuang Hwu
发明人： Shu-Yi Lin , Chung-Shi Yang , Yeu-Kuang Hwu
IPC分类号： A61K31/7105 , A61K31/7052 , C08L71/02 , C08L73/00 , C08L79/02
CPC分类号： A61K31/713 , C08G73/024
摘要： A method of synthesizing a random copolymer of polyethyleneimine and polyethylene glycol, comprising exposing ethanolamine in a solution to electromagnetic radiation for a sufficient time to polymerize the ethanolamine (OHCH2CH2NH2) and thereby resulting in formation of the randome copolymer comprising polyethyleneimine and poly(ethylene glycol), wherein the polyethyleneimine comprises ethyleneimine (—CH2CH2NH—) unit and the polyethylene glycol comprises ethylene glycol (—CH2CH2O—) unit, and the polyethylenimine of the random copolymer has a substantially linear backbone.
摘要翻译：一种合成聚乙烯亚胺和聚乙二醇的无规共聚物的方法，包括将溶液中的乙醇胺暴露于电磁辐射足够的时间以聚合乙醇胺（OHCH 2 CH 2 NH 2），从而形成包含聚乙烯亚胺和聚（乙二醇）其中聚乙烯亚胺包含乙烯亚胺（-CH 2 CH 2 NH-）单元，聚乙二醇包括乙二醇（-CH 2 CH 2 O-）单元，无规共聚物的聚乙烯亚胺具有基本线性的主链。

2. 发明授权

US08226596B2 Blood flow control system, tension adjustable instrument and method thereof 有权
标题翻译：血流控制系统，张力调节仪及其方法
公开(公告)号：US08226596B2
公开(公告)日：2012-07-24
申请号：US12219973
申请日：2008-07-31
申请人： Chung-Shi Yang , Leu-Wei Lo
发明人： Chung-Shi Yang , Leu-Wei Lo
IPC分类号： A61M3/00
CPC分类号： A61B5/0261 , A61B5/14532 , A61B5/1455 , A61B5/4244 , A61B17/12
摘要： A blood flow control system, tension adjustable instrument and a method are disclosed. The blood flow control system comprises a detecting unit, a computing and a tension adjustable instrument. The detecting unit real-time monitors the biomolecular response condition of a living organ, and the computing unit dynamically controls the tension adjustable instrument to adjust the tension of the blood vessel based on the detecting result. Therefore the blood flow control system can maintain the biomolecular response condition over a predetermined range to reduce the risk of the liver organ being damaged and augment the curability.
摘要翻译：公开了一种血流控制系统，张力可调仪器和方法。血流控制系统包括检测单元，计算和张力可调仪器。检测单元实时监测活体器官的生物分子反应状况，计算单元根据检测结果动态控制张力调节仪器调节血管张力。因此，血液流量控制系统可以将生物分子反应条件保持在预定范围内，以降低肝器官受损的风险并提高固化性。

3. 发明申请

US20120130053A1 SOLID PHASE GOLD NANOPARTICLE SYNTHESIS 有权
标题翻译：固相金纳米晶合成
公开(公告)号：US20120130053A1
公开(公告)日：2012-05-24
申请号：US13109438
申请日：2011-05-17
申请人： CHIA-HUNG LEE , WEI-NENG LIAO , SHIH-HSUN CHENG , JEN-KUN CHEN , CHUNG-SHI YANG , LEU-WEI LO , YEU-KUANG HWU , FONG-SIAN LIN
发明人： CHIA-HUNG LEE , WEI-NENG LIAO , SHIH-HSUN CHENG , JEN-KUN CHEN , CHUNG-SHI YANG , LEU-WEI LO , YEU-KUANG HWU , FONG-SIAN LIN
IPC分类号： B01J19/12 , B01J19/10 , C07K17/14 , C07F19/00 , B82Y40/00
CPC分类号： C07K17/14 , B01J19/082 , B01J19/084 , B01J19/125 , B01J19/126 , B01J2219/0879 , B82Y30/00 , B82Y40/00
摘要： A method of synthesizing ligand-conjugated gold nanoparticles (AuNPs) is disclosed. The method comprises: a) providing an amine-modified silica particle; b) providing a solution comprising Au+3 ions; c) suspending the amine-modified silica particle in the solution comprising Au+3 ions; d) allowing the Au3+ ions to be adsorbed and/or immobilized onto the surface of the amine-modified silica particle; e) exposing the Au3+ ions immobilized onto the surface of the amine-modified silica particle to radiation to obtain bare gold nanoparticles (AuNPs) adsorbed and/or immobilized onto the surface of the amine-modified silica particle, wherein the bare AuNPs are without organic surface modifications; and f) reacting a ligand with the bare AuNPs adsorbed and/or immobilized onto the surface of the amine-modified SiNP and thereby obtain ligand-conjugated gold nanoparticles (AuNPs).
摘要翻译：公开了一种合成配体结合金纳米粒子（AuNPs）的方法。该方法包括：a）提供胺改性的二氧化硅颗粒; b）提供包含Au + 3离子的溶液; c）将胺改性的二氧化硅颗粒悬浮在包含Au + 3离子的溶液中; d）允许Au 3+离子被吸附和/或固定在胺改性二氧化硅颗粒的表面上; e）将固定在胺改性的二氧化硅颗粒的表面上的Au 3+离子暴露于辐射以获得吸附和/或固定在胺改性的二氧化硅颗粒的表面上的裸金纳米颗粒（AuNP），其中裸露的AuNP是无机的表面修饰和f）将配体与吸附和/或固定在胺修饰的SiNP的表面上的裸AuNP反应，从而获得配体缀合的金纳米颗粒（AuNP）。

4. 发明申请

US20100248297A1 PARTICLES AND MANUFACTURING METHODS THEREOF 审中-公开
标题翻译：颗粒及其制造方法
公开(公告)号：US20100248297A1
公开(公告)日：2010-09-30
申请号：US12545822
申请日：2009-08-22
申请人： Yeu-Kuang Hwu , Chang-Hai Wang , Chi-Jen Liu , Cheng-Liang Wang , Chi-Hsiung Chen , Chung-Shi Yang , Hong-Ming Lin , Jung-Ho Je , Giorgio Margartondo
发明人： Yeu-Kuang Hwu , Chang-Hai Wang , Chi-Jen Liu , Cheng-Liang Wang , Chi-Hsiung Chen , Chung-Shi Yang , Hong-Ming Lin , Jung-Ho Je , Giorgio Margartondo
IPC分类号： B29B9/00 , B22F9/30 , C22C5/02 , C22C5/06 , C22C9/00 , C22C19/03 , C22C5/04 , C22C38/00 , C22C14/00 , C22C16/00 , C22C27/04 , C22C18/00 , B22F1/02 , B32B15/02 , C01B33/12 , C01G25/02 , C01F17/00 , C01G41/02 , C01G23/04 , C01G3/02 , H01B1/12 , B32B3/26 , C12Q1/04
CPC分类号： G01N33/5434 , B22F1/0022 , B22F1/0062 , B22F9/02 , B22F2999/00 , B82Y30/00 , C01B13/36 , C01B33/12 , C01G49/08 , C01P2002/72 , C01P2002/84 , C01P2004/03 , C01P2004/04 , C01P2004/62 , C01P2004/64 , C01P2006/12 , C09C1/0081 , C09C1/04 , C09C1/3072 , C09C1/3081 , C09C1/309 , C09C1/36 , C09C1/62 , C09C3/04 , G01N33/54346 , Y10T428/12181 , Y10T428/249994 , Y10T428/2991 , B22F2202/11
摘要： Particles and manufacturing methods thereof are provided. The manufacturing method of the particle includes providing a precursor solution containing a precursor dissolved in a solution, and irradiating the precursor solution with a high energy and high flux radiation beam to convert the precursor to nano-particles. Particles with desired dispersion, shape, and size are manufactured without adding a stabilizer or surfactant to the precursor solution.
摘要翻译：提供了颗粒及其制造方法。颗粒的制造方法包括提供含有溶解在溶液中的前体的前体溶液，并用高能量和高通量辐射束照射前体溶液以将前体转化为纳米颗粒。在不向前体溶液中添加稳定剂或表面活性剂的情况下制造具有所需分散体，形状和尺寸的颗粒。

5. 发明申请

US20080166540A1 Biodegradable material with nanopores and electric conductivity and the fabricating method thereof 审中-公开
标题翻译：具有纳米孔和导电性的可生物降解材料及其制造方法
公开(公告)号：US20080166540A1
公开(公告)日：2008-07-10
申请号：US11717657
申请日：2007-03-14
申请人： Chung-Shi Yang , Leu-Wei Lo , Pei-Ru Chen
发明人： Chung-Shi Yang , Leu-Wei Lo , Pei-Ru Chen
IPC分类号： B32B3/00 , C12P19/00
CPC分类号： C08B37/003 , C08J9/0071 , C08J9/26 , C08J2201/046 , C08J2489/00 , C08L5/08 , Y10T428/249953 , Y10T428/249967
摘要： A biodegradable material with nanopores and the fabricating method thereof includes steps of providing a polysaccharide polymer; implanting multiple biodegradable nanoparticles on the polysaccharide polymer; and digesting those biodegradable nanoparticles through multiple enzymes to provide multiple nanopores on the polysaccharide polymer; the polysaccharide polymer being further implanted with a group of nano-grade electrically conductive material; and the biodegradable material with nanopores simultaneously providing advantages of biocompatibility, biodegradability, elasticity, retarded elasticity, porosity, and conductivity.
摘要翻译：具有纳米孔的生物可降解材料及其制造方法包括提供多糖聚合物的步骤; 在多糖聚合物上植入多种可生物降解的纳米颗粒; 并通过多种酶消化可生物降解的纳米颗粒，以在多糖聚合物上提供多个纳米孔; 多糖聚合物进一步注入一组纳米级导电材料; 具有纳米孔的生物可降解材料同时具有生物相容性，生物降解性，弹性，延迟弹性，孔隙率和导电性的优点。

6. 发明授权

US06942777B2 Sample analysis system with chip-based electrophoresis device 失效
标题翻译：带芯片电泳装置的样品分析系统
公开(公告)号：US06942777B2
公开(公告)日：2005-09-13
申请号：US09880801
申请日：2001-06-15
申请人： Shu-Hui Chen , Gwo-Bin Lee , Chung-Shi Yang , Yi-Hung Lin , Wan-Chou Sung , Guan-Ruey Huang
发明人： Shu-Hui Chen , Gwo-Bin Lee , Chung-Shi Yang , Yi-Hung Lin , Wan-Chou Sung , Guan-Ruey Huang
IPC分类号： G01N27/447 , C25B11/00 , G01N27/453
CPC分类号： G01N27/44743 , G01N27/44721 , G01N27/44791
摘要： The present invention relates to a sample analysis system with chip-based electrophoresis device, particularly, the chip electrophoresis is connected to the dynamic flow-based auto-sampling device to introduce the sample into the chip-based electrophoresis device. By utilizing the derivatization biochemistry method to have a surface modification on the sample loading channel, it prevents the sample from being adhered to the wall of the sample loading channel, and hence increases the sample loading rate, reduces cross-contamination of samples and performs specific bio-reaction by using the immobilization of matter including antigen, antibody, protein, or enzyme. This invention makes use of the continuous split flow and electric voltage control to work with the detecting unit, signal collecting unit, and signal processing unit so that the sample undergoes a timely, fast, continuous analysis without having interference from the sample of other time.
摘要翻译：本发明涉及一种具有基于芯片的电泳装置的样品分析系统，特别地，芯片电泳连接到基于动态流量的自动采样装置，以将样品引入基于芯片的电泳装置。通过利用衍生生物化学方法在样品加载通道上进行表面改性，可以防止样品粘附到样品加载通道的壁上，从而增加样品加载速率，减少样品的交叉污染，并执行特定的通过使用固定化物质（包括抗原，抗体，蛋白质或酶）进行生物反应。本发明利用连续分流和电压控制与检测单元，信号采集单元和信号处理单元一起工作，使得样品经过及时，快速，连续的分析，而不会受到其他时间样品的干扰。

7. 发明授权

US10114016B2 Particles and manufacturing methods thereof 有权
公开(公告)号：US10114016B2
公开(公告)日：2018-10-30
申请号：US12545822
申请日：2009-08-22
申请人： Yeu-Kuang Hwu , Chang-Hai Wang , Chi-Jen Liu , Cheng-Liang Wang , Chi-Hsiung Chen , Chung-Shi Yang , Hong-Ming Lin , Jung-Ho Je , Giorgio Margartondo
发明人： Yeu-Kuang Hwu , Chang-Hai Wang , Chi-Jen Liu , Cheng-Liang Wang , Chi-Hsiung Chen , Chung-Shi Yang , Hong-Ming Lin , Jung-Ho Je , Giorgio Margartondo
IPC分类号： B22F9/24 , G01N33/543 , B22F1/00 , B22F9/02 , B82Y30/00 , C01B13/36 , C01B33/12 , C01G49/08 , C09C1/00 , C09C1/04 , C09C1/30 , C09C1/36 , C09C1/62 , C09C3/04
摘要： Particles and manufacturing methods thereof are provided. The manufacturing method of the particle includes providing a precursor solution containing a precursor dissolved in a solution, and irradiating the precursor solution with a high energy and high flux radiation beam to convert the precursor to nano-particles. Particles with desired dispersion, shape, and size are manufactured without adding a stabilizer or surfactant to the precursor solution.

8. 发明申请

US20120052573A1 ONE-POT SYNTHESIS OF LINEAR-LIKE POLYETHYLENIMINE FOR INTRACELLULAR IMAGING AND NUCLEIC ACID DELIVERY 审中-公开
标题翻译：用于细胞成像和核酸递送的线性聚乙烯亚胺的一步合成
公开(公告)号：US20120052573A1
公开(公告)日：2012-03-01
申请号：US12868939
申请日：2010-08-26
申请人： Shu-Yi LIN , Fong-Sian LIN , Meng-Kai CHEN , Yu-Chen JAO , Lin-Ren TSAI , Hong-Yi LIN , Chung-Shi YANG , Yeu-Kuang HWU
发明人： Shu-Yi LIN , Fong-Sian LIN , Meng-Kai CHEN , Yu-Chen JAO , Lin-Ren TSAI , Hong-Yi LIN , Chung-Shi YANG , Yeu-Kuang HWU
IPC分类号： C12N5/09 , A61K31/7088 , C08G73/00
CPC分类号： C08G73/0206 , C08G73/0213 , C08L79/02
摘要： A method of synthesizing polyethyleneimine with a substantially linear backbone is disclosed. The method comprises exposing ethylenediamine dissolved in a solution to electromagnetic radiation for a sufficient time to polymerize the ethylenediamine and thereby resulting in formation of polyethylenimine with a substantially linear backbone in the solution. A method of synthesizing a homopolymer with a substantially linear backbone is also disclosed. In addition, a composition comprising polyethylenimine synthesized from the aforementioned method is disclosed, in which the polyethylenimine comprises a backbone conformation that is substantially linear and has a distribution of molecular weights (MW) ranging from 1 kDa to 200 kDa; and the polyethyleneimine has no cytotoxicity at a concentration of 12 μg/ml.
摘要翻译：公开了一种合成具有基本线性主链的聚亚乙基亚胺的方法。该方法包括将溶解在溶液中的乙二胺暴露于电磁辐射足够的时间以使乙二胺聚合，从而导致在溶液中形成具有基本线性主链的聚乙烯亚胺。还公开了一种合成具有基本线性主链的均聚物的方法。另外，公开了包含由上述方法合成的聚乙烯亚胺的组合物，其中聚乙烯亚胺包括基本上线性且具有范围从1kDa至200kDa的分子量（MW）分布的主链构型; 并且聚乙烯亚胺在12μg/ ml的浓度下没有细胞毒性。

9. 发明授权

US07886623B2 Nano-particle containing apparatus, nano-particle detection system and method thereof 有权
标题翻译：含纳米颗粒的装置，纳米颗粒检测系统及其方法
公开(公告)号：US07886623B2
公开(公告)日：2011-02-15
申请号：US11859259
申请日：2007-09-21
申请人： Chung-Shi Yang , Fu-Der Mai , Bega Liu , Jen-Kun Chen , Yong-Chien Ling , Feng-Yin Li
发明人： Chung-Shi Yang , Fu-Der Mai , Bega Liu , Jen-Kun Chen , Yong-Chien Ling , Feng-Yin Li
IPC分类号： G01N17/00
CPC分类号： B82Y30/00
摘要： A nano-particle containing apparatus, a nano-particle detection system and a method are disclosed. The nano-particle containing apparatus includes a casing, an air extracting device, a pressure device and a measuring instrument. The casing has a containing space for disposing a plurality of nano-particles. An internal wall surface of the casing has active self-cleaning function. The pressure control device controls the pressure status of the containing space. The active self-clean function is that nano-particles adhered to the internal surface wall are removed into the containing space. The nano-particles then are pumped by the air extracting device from the containing space. The measuring instrument then detects the status of an object affected by the nano-particles after the object is delivered into the containing space.
摘要翻译：公开了含纳米颗粒的装置，纳米颗粒检测系统和方法。含纳米颗粒的装置包括壳体，空气提取装置，压力装置和测量仪器。壳体具有用于设置多个纳米颗粒的容纳空间。外壳的内壁表面具有主动的自洁功能。压力控制装置控制容纳空间的压力状态。主动自清洁功能是将粘附在内表面壁上的纳米颗粒移入容纳空间。然后，纳米颗粒被空气抽吸装置从容纳空间泵送。然后，测量仪器在对象被传送到容纳空间中之后检测受纳米颗粒影响的物体的状态。

10. 发明申请

US20090043251A1 Blood flow control system, tension adjustable instrument and method thereof 有权
标题翻译：血流控制系统，张力调节仪及其方法
公开(公告)号：US20090043251A1
公开(公告)日：2009-02-12
申请号：US12219973
申请日：2008-07-31
申请人： Chung-Shi Yang , Leu-Wei Lo
发明人： Chung-Shi Yang , Leu-Wei Lo
IPC分类号： A61M5/31
CPC分类号： A61B5/0261 , A61B5/14532 , A61B5/1455 , A61B5/4244 , A61B17/12
摘要： A blood flow control system, tension adjustable instrument and a method are disclosed. The blood. flow control system comprises a detecting unit, a computing and a tension adjustable instrument. The detecting unit real-time monitors the biomolecular response condition of a living organ, and the computing unit dynamically controls the tension adjustable instrument to adjust the tension of the blood vessel based on the detecting result. Therefore the blood flow control system can maintain the biomolecular response condition over a predetermined range to reduce the risk of the liver organ being damaged and augment the curability.
摘要翻译：公开了一种血流控制系统，张力可调仪器和方法。血液。流量控制系统包括检测单元，计算和张力可调仪器。检测单元实时监测活体器官的生物分子反应状况，计算单元根据检测结果动态控制张力调节仪器调节血管张力。因此，血液流量控制系统可以将生物分子反应条件保持在预定范围内，以降低肝器官受损的风险并提高固化性。

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