专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20140024760A1 THREE-DIMENSIONAL NANOFIBER SCAFFOLD FOR TISSUE REPAIR AND PREPARATION METHOD THEREOF 有权
标题翻译：用于组织修复的三维NANOFIBER SCAFFOLD及其制备方法
公开(公告)号：US20140024760A1
公开(公告)日：2014-01-23
申请号：US14008408
申请日：2012-03-16
申请人： Il Keun Kwon , Chun Ho Kim , Dae Hyeok Yang , Jung Bok Lee , Ha Na Park , Sung In Jeong
发明人： Il Keun Kwon , Chun Ho Kim , Dae Hyeok Yang , Jung Bok Lee , Ha Na Park , Sung In Jeong
IPC分类号： A61L27/14 , C08K5/05
CPC分类号： A61L27/14 , A61L27/48 , A61L27/56 , A61L2400/12 , C08K5/05 , C08L5/08 , C08L89/06 , C08L2205/16 , C12N5/0068 , C12N2533/40
摘要： The present invention provides a three-dimensional nanofibrous scaffold for tissue regeneration, which is increased in porosity and thickness to enlarge the surface area thereof, thereby enabling cell adhesion at a high density, and a method for fabricating the same. The method for fabricating a three-dimensional nanofibrous scaffold for tissue regeneration includes the steps of: (a) preparing a polymer solution; (b) preparing a nanofiber matrix, in which a plurality of nanofibers is entangled with each other, from the polymer solution prepared in step (a) using electrospinning; and (c) immersing the prepared nanofiber matrix in a solution and subjecting the solution to ultrasonication, thereby increasing the thickness and porosity of the nanofiber matrix. According to the inventive scaffold fabricating method, the nanofiber matrix prepared by using electrospinning is ultrasonicated in a solution, so that a three-dimensional nanofibrous scaffold with improved thickness and porosity can be provided in a simple and low-cost manner.
摘要翻译：本发明提供一种用于组织再生的三维纳米纤维支架，其孔隙率和厚度增加以增加其表面积，从而使得能够以高密度进行细胞粘附及其制造方法。用于组织再生的三维纳米纤维支架的制造方法包括以下步骤：（a）制备聚合物溶液; （b）使用静电纺丝从步骤（a）中制备的聚合物溶液制备多个纳米纤维彼此缠结的纳米纤维基质; 和（c）将制备的纳米纤维基质浸入溶液中并使溶液进行超声波处理，从而增加纳米纤维基质的厚度和孔隙率。根据本发明的支架制造方法，将通过静电纺丝制备的纳米纤维基质在溶液中超声波处理，从而可以以简单且低成本的方式提供具有改善的厚度和孔隙率的三维纳米纤维支架。

2. 发明申请

US20080242850A1 Method of producing chitosan scaffold having high tensile strength and chitosan scaffold produced using the method 有权
标题翻译：使用该方法制备具有高拉伸强度的壳聚糖骨架和壳聚糖支架的方法
公开(公告)号：US20080242850A1
公开(公告)日：2008-10-02
申请号：US12157120
申请日：2008-06-09
申请人： Chun-Ho Kim , Seung-Jae Lee , Jin-Ik Lim , Youngsook Son
发明人： Chun-Ho Kim , Seung-Jae Lee , Jin-Ik Lim , Youngsook Son
IPC分类号： C08B37/08
CPC分类号： C12N5/0068 , A61L15/28 , A61L15/425 , A61L27/20 , A61L27/56 , C12N2533/18 , C12N2533/50 , C12N2533/52 , C12N2533/54 , C12N2533/70 , C12N2533/72 , C12N2533/74 , C08L5/08
摘要： Provided are a method of producing a porous chitosan scaffold, the method including: providing an aqueous acidic solution having chitosan and a solvent which does not dissolve the chitosan; and freeze-drying the aqueous acidic solution, wherein the solvent is selected from the group consisting of a C3-C8 aliphatic alcohol having one hydroxy group, ethylene glycol monoethylether, ethylene glycol monobutylether, dioxane, tetrahydrofuran, dimethylcarbonate, acetone and acetonitrile, and a chitosan scaffold produced using the method.
摘要翻译：提供一种生产多孔壳聚糖支架的方法，该方法包括：提供具有壳聚糖的水性酸性溶液和不溶解壳聚糖的溶剂; 并冷冻干燥酸性水溶液，其中溶剂选自具有一个羟基的C 3 -C 8脂族醇，乙二醇单乙醚，乙二醇单丁醚，二恶烷，四氢呋喃，碳酸二甲酯，丙酮和乙腈，和使用该方法生产壳聚糖支架。

3. 发明申请

US20050164388A1 Method of isolating epithelial cells, method of preconditioning cells, and methods of preparing bioartificial skin and dermis with the epithelial cells and preconditioned cells 审中-公开
标题翻译：分离上皮细胞的方法，预处理细胞的方法，以及用上皮细胞和预处理细胞制备生物人造皮肤和真皮的方法
公开(公告)号：US20050164388A1
公开(公告)日：2005-07-28
申请号：US10258987
申请日：2001-11-06
申请人： Young-Sook Son , Hyun-Sook Park , Chun-Ho Kim , Hyun-Ju Kang , Chang-Hwan Kim , Youn-Young Kim , Young-Ju Choi , Su-Hyun Lee , Yong-Jae Gin
发明人： Young-Sook Son , Hyun-Sook Park , Chun-Ho Kim , Hyun-Ju Kang , Chang-Hwan Kim , Youn-Young Kim , Young-Ju Choi , Su-Hyun Lee , Yong-Jae Gin
IPC分类号： A61K35/12 , A61L27/00 , C12N5/071 , C12N5/08 , A61F2/10
CPC分类号： C12N5/0698 , A61K35/12 , C12N5/0629 , C12N2502/094 , C12N2502/1323 , C12N2502/28 , C12N2509/00 , C12N2509/10
摘要： A method of isolating epithelial cells from a human skin tissue or internal organ tissue using trypsin and ethylene-diamine tetraacetic acid (EDTA) simultaneously with the application of magnetic stirring, a method of preconditioning isolated biological cells by the application of physical stimulus, i.e., strain, are provided. Epithelial cells can be isolated by the method with increased yield, colony forming efficiency (CFE), and colony size. Also, the increased percentage of stem cells in isolated cells is advantageous in therapeutic tissue implantation by autologous or allogeneic transplantation. In skin cells preconditioned by the application of strain, cell division is facilitated, and the secretion of extracellular matrix components and growth factors and the activity of matrix metalloproteinases (MMPs) are improved. When preconditioned cells are implanted by autologous or allogeneic transplantation to heal a damaged tissue, the improved cell adhesion, mobility, and viability provides a biological adjustment effect against a variety of stresses or physical stimuli which the cells would undergo after implantation, with improved capability of integration into host tissue, thereby markedly improving the probability of success in skin grafting.
摘要翻译：一种利用磁力搅拌同时使用胰蛋白酶和乙二胺四乙酸（EDTA）从人皮肤组织或内脏器官组织分离上皮细胞的方法，一种通过应用物理刺激预处理分离的生物细胞的方法，应变。可以通过增加产量，菌落形成效率（CFE）和菌落大小的方法分离上皮细胞。此外，分离的细胞中干细胞的增加百分比在通过自体或同种异体移植治疗组织植入方面是有利的。在通过应用菌株预处理的皮肤细胞中，促进细胞分裂，细胞外基质成分和生长因子的分泌以及基质金属蛋白酶（MMPs）的活性得到改善。当通过自体或同种异体移植植入预处理细胞以愈合损伤的组织时，改善的细胞粘附性，迁移性和活力提供了针对细胞在植入后将经历的各种应力或物理刺激的生物调节作用，具有改善的整合到宿主组织中，从而显着提高皮肤移植成功的可能性。

4. 发明授权

US09242024B2 Three-dimensional nanofiber scaffold for tissue repair and preparation method thereof 有权
标题翻译：用于组织修复的三维纳米纤维支架及其制备方法
公开(公告)号：US09242024B2
公开(公告)日：2016-01-26
申请号：US14008408
申请日：2012-03-16
申请人： Il Keun Kwon , Chun Ho Kim , Dae Hyeok Yang , Jung Bok Lee , Ha Na Park , Sung In Jeong
发明人： Il Keun Kwon , Chun Ho Kim , Dae Hyeok Yang , Jung Bok Lee , Ha Na Park , Sung In Jeong
IPC分类号： A61L27/14 , C08K5/05 , A61L27/48 , A61L27/56 , C12N5/00 , C08L5/08 , C08L89/06
CPC分类号： A61L27/14 , A61L27/48 , A61L27/56 , A61L2400/12 , C08K5/05 , C08L5/08 , C08L89/06 , C08L2205/16 , C12N5/0068 , C12N2533/40
摘要： The present invention provides a three-dimensional nanofibrous scaffold for tissue regeneration, which is increased in porosity and thickness to enlarge the surface area thereof, thereby enabling cell adhesion at a high density, and a method for fabricating the same. The method for fabricating a three-dimensional nanofibrous scaffold for tissue regeneration includes the steps of: (a) preparing a polymer solution; (b) preparing a nanofiber matrix, in which a plurality of nanofibers is entangled with each other, from the polymer solution prepared in step (a) using electrospinning; and (c) immersing the prepared nanofiber matrix in a solution and subjecting the solution to ultrasonication, thereby increasing the thickness and porosity of the nanofiber matrix. According to the inventive scaffold fabricating method, the nanofiber matrix prepared by using electrospinning is ultrasonicated in a solution, so that a three-dimensional nanofibrous scaffold with improved thickness and porosity can be provided in a simple and low-cost manner.
摘要翻译：本发明提供一种用于组织再生的三维纳米纤维支架，其孔隙率和厚度增加以增加其表面积，从而使得能够以高密度进行细胞粘附及其制造方法。用于组织再生的三维纳米纤维支架的制造方法包括以下步骤：（a）制备聚合物溶液; （b）使用静电纺丝从步骤（a）中制备的聚合物溶液制备多个纳米纤维彼此缠结的纳米纤维基质; 和（c）将制备的纳米纤维基质浸入溶液中并使溶液进行超声波处理，从而增加纳米纤维基质的厚度和孔隙率。根据本发明的支架制造方法，将通过静电纺丝制备的纳米纤维基质在溶液中超声波处理，从而可以以简单且低成本的方式提供具有改善的厚度和孔隙率的三维纳米纤维支架。

5. 发明授权

US08697415B2 Deacetylation hydrolase of hyaluronic acid, hyaluronic acid deacetylated by same and derivative thereof 有权
标题翻译：透明质酸的脱乙酰化水解酶，透明质酸与其衍生物脱乙酰化
公开(公告)号：US08697415B2
公开(公告)日：2014-04-15
申请号：US13703619
申请日：2011-06-10
申请人： Chun-Ho Kim , Jong-Il Kim
发明人： Chun-Ho Kim , Jong-Il Kim
IPC分类号： C12N9/78
CPC分类号： C12Y305/00 , C12N9/80 , C12P19/04
摘要： The present disclosure relates to a deacetylation hydrolase of a hyaluronic acid a hyaluronic acid deacetylated by same and a derivative thereof. The deacetylated hyaluronic acid and the derivative thereof have the following characteristic: a delayed initial decomposition rate on a living body; minimized decrease of molecular weight and viscosity; accelerated gelation due to a lower gelation temperature than the gelation temperature for a non-deacetylated hyaluronic acid; and an hMSC survival rate that is hardly affected by increased concentration of the deacetylated hyaluronic acid and the derivative thereof in a culture medium. As a result, the deacetylated hyaluronic acid and the derivative thereof can be useful as a bioingredient such a delivery system for a cell, gene, drug, and the like, or a support for tissue engineering, etc.
摘要翻译：本公开内容涉及透明质酸的脱乙酰化水解酶，透明质酸由其脱乙酰化的透明质酸及其衍生物。脱乙酰化透明质酸及其衍生物具有以下特征：生物体上延迟的初始分解速率; 最小化分子量和粘度降低; 由于比非脱乙酰化透明质酸的凝胶化温度低的凝胶化温度，加速凝胶化; 和hMSC存活率几乎不受培养基中脱乙酰化透明质酸及其衍生物浓度的增加的影响。结果，脱乙酰化透明质酸及其衍生物可用作细胞，基因，药物等的递送系统或组织工程的支持物等的生物制剂。

6. 发明授权

US08691973B2 Method of producing chitosan scaffold having high tensile strength and chitosan scaffold produced using the method 有权
标题翻译：使用该方法制备具有高拉伸强度的壳聚糖骨架和壳聚糖支架的方法
公开(公告)号：US08691973B2
公开(公告)日：2014-04-08
申请号：US12157120
申请日：2007-02-21
申请人： Chun-Ho Kim , Seung-Jae Lee , Jin-Ik Lim , Youngsook Son
发明人： Chun-Ho Kim , Seung-Jae Lee , Jin-Ik Lim , Youngsook Son
IPC分类号： C08B37/08
CPC分类号： C12N5/0068 , A61L15/28 , A61L15/425 , A61L27/20 , A61L27/56 , C12N2533/18 , C12N2533/50 , C12N2533/52 , C12N2533/54 , C12N2533/70 , C12N2533/72 , C12N2533/74 , C08L5/08
摘要： Provided are a method of producing a porous chitosan scaffold, the method including: providing an aqueous acidic solution having chitosan and a solvent which does not dissolve the chitosan; and freeze-drying the aqueous acidic solution, wherein the solvent is selected from the group consisting of a C3-C8 aliphatic alcohol having one hydroxy group, ethylene glycol monoethylether, ethylene glycol monobutylether, dioxane, tetrahydrofuran, dimethylcarbonate, acetone and acetonitrile, and a chitosan scaffold produced using the method.
摘要翻译：提供一种生产多孔壳聚糖支架的方法，该方法包括：提供具有壳聚糖的水性酸性溶液和不溶解壳聚糖的溶剂; 并冷冻干燥酸性水溶液，其中溶剂选自具有一个羟基的C 3 -C 8脂族醇，乙二醇单乙醚，乙二醇单丁醚，二恶烷，四氢呋喃，碳酸二甲酯，丙酮和乙腈，和使用该方法生产壳聚糖支架。

7. 发明申请

US20090146999A1 Rasterization engine and three-dimensional graphics system for rasterizing in order adapted to characteristics of polygon 有权
标题翻译：栅格化引擎和三维图形系统，用于光栅化，以适应多边形的特征
公开(公告)号：US20090146999A1
公开(公告)日：2009-06-11
申请号：US12313886
申请日：2008-11-25
申请人： Chun Ho Kim
发明人： Chun Ho Kim
IPC分类号： G06T17/00 , G06T11/20
CPC分类号： G06T15/005 , G06T11/40
摘要： A three-dimensional graphics system is provided. The three-dimensional graphics system rasterizes each of a plurality of polygons generated from vertexes in an order adapted to characteristics of each polygon. The three-dimensional graphics system includes a rasterization engine including a polygon setup unit receiving the vertexes and generating the polygons and rasterization information for each polygon, and a rasterizer rasterizing pixels using the rasterization information received from the polygon setup unit in an order adapted to the characteristics of each polygon. Accordingly, the coherence of the pixels is increased and the hit ratio of cache memory is thus increased. As a result, the performance of the three-dimensional graphics system is improved. With the increase of the hit ratio of the cache memory, buss traffic in the system is reduced and power consumption is thus reduced.
摘要翻译：提供三维图形系统。三维图形系统以适合于每个多边形的特征的顺序光栅化从顶点生成的多个多边形中的每一个。三维图形系统包括光栅化引擎，其包括接收顶点的多边形设置单元，并且为每个多边形生成多边形和光栅化信息;以及光栅化器，使用从多边形设置单元接收的光栅化信息，以适应于每个多边形的特征因此，像素的相干性增加，因此高速缓冲存储器的命中率增加。结果，提高了三维图形系统的性能。随着高速缓冲存储器的命中率的增加，系统中的总线流量减少，从而降低功耗。

8. 发明授权

US5951436A Transmission control system for an electric vehicle 失效
标题翻译：电动车变速箱控制系统
公开(公告)号：US5951436A
公开(公告)日：1999-09-14
申请号：US777948
申请日：1996-12-23
申请人： Chun-ho Kim
发明人： Chun-ho Kim
IPC分类号： F16H61/00 , B60L15/20 , F16H59/36 , F16H59/40 , F16H59/68 , F16H61/04 , B60K41/08
CPC分类号： B60L15/2054 , F16H61/0403 , B60W2520/28 , F16H2059/6807 , F16H59/36 , F16H59/40 , Y02T10/645 , Y02T10/7275 , Y10T477/347
摘要： A transmission control system for an electric vehicle, includes a motor for directly converting electric energy to usable mechanical energy and a transmission connected to the motor without clutch. A motor speed sensor detects motor speed and a wheel speed sensor detects wheel speed. A shift fork sensor detects shift fork movement. An inverter controls the motor and a control unit controls the inverter in accordance with the motor speed sensor signal and the wheel speed sensor signal.
摘要翻译：一种用于电动车辆的变速器控制系统，包括用于将电能直接转换为可用的机械能的电动机和与离合器相连接的电动机的变速器。电机速度传感器检测电机速度，车轮速度传感器检测车轮速度。换档传感器检测换档拨叉的运动。逆变器控制电机，控制单元根据电机速度传感器信号和车轮速度传感器信号控制变频器。

9. 发明申请

US20130085187A1 DEACETYLATION HYDROLASE OF HYALURONIC ACID, HYALURONIC ACID DEACETYLATED BY SAME AND DERIVATIVE THEREOF 有权
标题翻译：羟丙酸脱乙酰壳多糖及其衍生物脱乙酰壳多糖
公开(公告)号：US20130085187A1
公开(公告)日：2013-04-04
申请号：US13703619
申请日：2011-06-10
申请人： Chun-Ho Kim , Jong-Il Kim
发明人： Chun-Ho Kim , Jong-Il Kim
IPC分类号： C12N9/78
CPC分类号： C12Y305/00 , C12N9/80 , C12P19/04
摘要： The present disclosure relates to a deacetylation hydrolase of a hyaluronic acid a hyaluronic acid deacetylated by same and a derivative thereof. The deacetylated hyaluronic acid and the derivative thereof have the following characteristic: a delayed initial decomposition rate on a living body; minimized decrease of molecular weight and viscosity; accelerated gelation due to a lower gelation temperature than the gelation temperature for a non-deacetylated hyaluronic acid; and an hMSC survival rate that is hardly affected by increased concentration of the deacetylated hyaluronic acid and the derivative thereof in a culture medium. As a result, the deacetylated hyaluronic acid and the derivative thereof can be useful as a bioingredient such a delivery system for a cell, gene, drug, and the like, or a support for tissue engineering, etc.
摘要翻译：本公开内容涉及透明质酸的脱乙酰化水解酶，透明质酸由其脱乙酰化的透明质酸及其衍生物。脱乙酰化透明质酸及其衍生物具有以下特征：生物体上延迟的初始分解速率; 最小化分子量和粘度降低; 由于比非脱乙酰化透明质酸的凝胶化温度低的凝胶化温度，加速凝胶化; 和hMSC存活率几乎不受培养基中脱乙酰化透明质酸及其衍生物浓度的增加的影响。结果，脱乙酰化透明质酸及其衍生物可用作细胞，基因，药物等的递送系统或组织工程的支持物等的生物制剂。

10. 发明授权

US5780979A Transmission control system for an electric vehicle 失效
标题翻译：电动车变速箱控制系统
公开(公告)号：US5780979A
公开(公告)日：1998-07-14
申请号：US768087
申请日：1996-12-16
申请人： Chun-ho Kim
发明人： Chun-ho Kim
IPC分类号： B60L11/00 , B60K1/00 , B60L15/20 , F16H59/02 , F16H59/04 , B60K41/06
CPC分类号： F16H59/041 , B60L15/2054 , B60K1/00 , F16H2063/3089 , F16H59/0217 , Y02T10/645 , Y02T10/7275 , Y10T74/1926 , Y10T74/20018
摘要： Disclosed is a transmission control system for an electric vehicle, comprising: a motor; a transmission connected to the motor; a shift fork rod connected to the transmission; a shift lever for speed shifting having a lower end; a shift rod having an end secured to the shift fork and the other end having a hollow hole which has an elastic member; a linkage having an end supported by the elastic memeber and the other end hinged to a lower end of the shift lever; a shift lever sensor for detecting movement of the shift lever; a motor speed sensor for detecting motor speed; a wheel speed sensor for detecting wheel speed; a shift fork sensor for detecting movement of the shift fork; an inverter for controlling the motor; and a control unit for controlling the inverter in accordance with signals of the motor speed sensor, the wheel speed sensor and the shift lever sensor.
摘要翻译：公开了一种电动车辆的变速器控制系统，包括：电动机; 连接到电动机的变速器; 变速拨叉连接到变速箱; 用于变速的变速杆具有下端; 一个变速杆，其一端固定到换档拨叉，另一端具有一个具有弹性件的中空孔; 具有由弹性构件支撑的端部和铰链到变速杆的下端的另一端的连杆; 变速杆传感器，用于检测变速杆的运动; 用于检测电机速度的电机速度传感器; 用于检测车轮速度的车轮速度传感器; 用于检测换档拨叉的移动的换档拨叉传感器; 用于控制电机的逆变器; 以及控制单元，用于根据电动机速度传感器，车轮速度传感器和变速杆传感器的信号控制变频器。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式