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1. 发明申请

US20210322453A1 DNA ORIGAMI NANOSTRUCTURES FOR TREATMENT OF ACUTE KIDNEY INJURY 有权
公开(公告)号：US20210322453A1
公开(公告)日：2021-10-21
申请号：US17239034
申请日：2021-04-23
申请人： Hao YAN , Dawei JIANG , Zhilei GE , Hyung-Jun IM , Christopher ENGLAND , Peng HUANG , Chunhai FAN , Weibo CAI
发明人： Hao YAN , Dawei JIANG , Zhilei GE , Hyung-Jun IM , Christopher ENGLAND , Peng HUANG , Chunhai FAN , Weibo CAI
IPC分类号： A61K31/711 , A61P13/12 , A61K9/51 , A61K49/00 , G01N33/543 , G01N33/58
摘要： Disclosed herein are methods of treating acute kidney injury. The method can include administering a sufficient amount of a DNA origami nanostructure to a subject afflicted with AKI to increase an excretory function of said subject. In some examples, the the DNA origami nanostructure includes a scaffold strand and a plurality of staple strands, in which the scaffold strand comprises a M13 viral genome having a length of 7249 base pairs; and each staple strand of the plurality of staple strands has a length of about 20 to 60 base pairs.

2. 发明授权

US4440733A Thermochemical generation of hydrogen and carbon dioxide 失效
标题翻译：氢和二氧化碳的热化学生成
公开(公告)号：US4440733A
公开(公告)日：1984-04-03
申请号：US204477
申请日：1980-11-06
申请人： Daniel D. Lawson , Christopher England
发明人： Daniel D. Lawson , Christopher England
IPC分类号： C01B3/06 , C01B13/00
CPC分类号： C01B3/068 , Y02E60/36
摘要： Mixing of carbon in the form of high sulfur coal with sulfuric acid reduces the temperature of sulfuric acid decomposition from 830.degree. C. to between 300.degree. C. and 400.degree. C. The low temperature sulfuric acid decomposition is particularly useful in thermal chemical cycles for splitting water to produce hydrogen. Carbon dioxide is produced as a commercially desirable byproduct. Lowering of the temperature for the sulfuric acid decomposition or oxygen release step simplifies equipment requirements, lowers thermal energy input and reduces corrosion problems presented by sulfuric acid at conventional cracking temperatures. Use of high sulfur coal as the source of carbon for the sulfuric acid decomposition provides an environmentally safe and energy efficient utilization of this normally polluting fuel.
摘要翻译：将高硫煤与硫酸混合的碳将硫酸的分解温度从830℃降至300℃至400℃。低温硫酸分解在热化学循环中特别有用分解水以产生氢气。产生二氧化碳作为商业上需要的副产物。降低硫酸分解或释氧步骤的温度简化了设备要求，降低了热能输入，并降低了在常规裂解温度下由硫酸引起的腐蚀问题。使用高硫煤作为硫酸分解的碳源可以使环境安全和节能的利用这种正常污染的燃料。

3. 发明申请

US20060258004A1 Cell sodding method and apparatus 有权
标题翻译：细胞浸渍法和装置
公开(公告)号：US20060258004A1
公开(公告)日：2006-11-16
申请号：US11314281
申请日：2005-12-22
申请人： Paul Kosnik , Christopher England , Robert Dennis , Stuart Williams
发明人： Paul Kosnik , Christopher England , Robert Dennis , Stuart Williams
IPC分类号： C12N5/08 , A61F2/06
CPC分类号： C12N5/0697 , C12M21/08 , C12M25/10 , C12M25/14 , C12M27/10 , C12M29/10 , C12N2533/30
摘要： Tissue engineering methods and biochamber apparatus are provided for making tissue grafts for implantation into a patient. The methods include applying a sustained low magnitude pressure gradient transmurally across a permeable scaffold material using a media containing cells, preferably microvascular epithelial cells, to be deposited on the scaffold for the production of tissue grafts, preferably vascular grafts, to promote accelerated adhesion and maturation of cells on the scaffold material. Biochambers for preparing tubular tissue grafts are provided which contain connectors for holding a graft substrate, proximal and distal tubing for connection to an optional perfusion system, and structure for switching between transmural flow of a cell suspension across the graft substrate and translumenal flow through the lumen of the graft.
摘要翻译：提供组织工程方法和生物处理设备用于制造植入患者体内的组织移植物。所述方法包括使用包含细胞（优选微血管上皮细胞）的培养基透过可渗透的支架材料跨度施加持续的低幅度压力梯度，以沉积在支架上用于生产组织移植物，优选血管移植物，以促进加速粘附和成熟的细胞在脚手架材料上。提供了用于制备管状组织移植物的生物体，其包含用于保持移植物基质的连接器，用于连接到任选的灌注系统的近端和远端管，以及用于在穿过移植物基质的细胞悬浮液的跨壁流和通过内腔的经血流之间切换的结构的移植物。

4. 发明授权

US10987373B2 DNA origami nanostructures for treatment of acute kidney injury 有权
公开(公告)号：US10987373B2
公开(公告)日：2021-04-27
申请号：US16492099
申请日：2018-03-08
申请人： Hao Yan , Dawei Jiang , Zhilei Ge , Hyung-jun Im , Christopher England , Peng Huang , Chunhai Fan , Weibo Cai
发明人： Hao Yan , Dawei Jiang , Zhilei Ge , Hyung-jun Im , Christopher England , Peng Huang , Chunhai Fan , Weibo Cai
IPC分类号： A61K31/711 , A61P13/12 , A61K9/51 , A61K49/00 , G01N33/543 , G01N33/58 , A61K9/00 , B82Y5/00
摘要： Disclosed herein are methods of treating acute kidney injury. The A method can include administering a sufficient amount of a DNA origami nanostructure to a subject afflicted with AKI to increase an excretory function of said subject. In some examples, the DNA origami nanostructure includes a scaffold strand and a plurality of staple strands, in which the scaffold strand comprises a M1 3 viral genome having a length of 7249 base pairs; and each staple strand of the plurality of staple strands has a length of about 20 to 60 base pairs.

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