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2. 发明授权

US06492501B1 Water soluble acrylic membrane-polymer protein amphiphilic complex and application to diagnosis methods 有权
标题翻译：水溶性丙烯酸聚合物蛋白质两亲性复合物及应用于诊断方法
公开(公告)号：US06492501B1
公开(公告)日：2002-12-10
申请号：US09331036
申请日：1999-11-05
申请人： Jean-Luc Popot , Christophe Tribet , Roland Audebert
发明人： Jean-Luc Popot , Christophe Tribet , Roland Audebert
IPC分类号： C07K1708
CPC分类号： G01N33/6803 , C08F8/32 , C08F8/44 , G01N33/5432 , Y10S530/815 , C08F20/06
摘要： The invention concerns a water soluble vinyl membrane-polymer protein amphiphilic complex, characterised in that said vinyl polymer corresponds to formula (I) in which: R1 is a group: COO⊖ M+ M+ being an alkaline cation, COOR7, R7 being a sugar radical; polyoxyalkylene, polyoxyethylene; N-pyrrolidonyl; phenyl sulphonate; CONR8R9, R8 and R9 identical or different being hydrogen atom, a sugar radical, polyoxyalkylene, in particular polyoxyethylene, a zwitterion radical; R4, R5, R6 identical or different are hydrogen atom, or methyl radical; R2 is a COOR12 or CONR13R14 radical, R12 being a linear or branched alkyl or alkylene radical; R13, R14 identical or different have one of the meanings of R12, and moreover one of the two can correspond to hydrogen atom; R3 is a COOR15 or CONR16R17 radical; R15 being a (C1-C5) alkyl radical; R16, R17 having one if the meanings of R15 and moreover one of the two can correspond to hydrogen atom; x, y, z correspond to the respective percentages of units. The complex is applicable for producing reagent and diagnosis kits.
摘要翻译：本发明涉及一种水溶性乙烯基膜 - 聚合物蛋白质两亲性复合物，其特征在于所述乙烯基聚合物对应于式（I），其中：R 1为基团：COO m M + M +为碱性阳离子，COOR 7，R 7为糖基 ; 聚氧化烯，聚氧乙烯; N-吡咯烷酮; 苯基磺酸盐; CONR8R9，R8和R9相同或不同，为氢原子，糖基，聚氧化烯，特别是聚氧乙烯，两性离子基; R4，R5，R6相同或不同，是氢原子或甲基; R2是COOR12或CONR13R14基团，R12是直链或支链烷基或亚烷基; R13，R14相同或不同，具有R12的含义之一，而且两者之一可以对应于氢原子; R3是COOR15或CONR16R17基团; R15为（C1-C5）烷基; R16，R17如果R15的含义和二者之一可以对应于氢原子; x，y，z对应于单位的相应百分比。该复合物适用于生产试剂和诊断试剂盒。

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