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1. 发明授权

US5420042A Method for the analytical determination of the concentration of a component of a medical sample 失效
标题翻译：用于分析测定医用样品的成分浓度的方法
公开(公告)号：US5420042A
公开(公告)日：1995-05-30
申请号：US84008
申请日：1993-06-29
申请人： Rainer Schafer , Christoph Berding , Fridl Lang , Wilheim Kleider , Peter Wolf
发明人： Rainer Schafer , Christoph Berding , Fridl Lang , Wilheim Kleider , Peter Wolf
IPC分类号： G01N33/536 , G01N33/543 , G01N33/68 , G01N33/96 , G01N33/557
CPC分类号： G01N33/54313 , G01N33/68 , G01N33/96 , Y10S436/909 , Y10T436/11
摘要： Method for the analytical determination of the concentration of a component of a medical sample, in which a reaction of the sample with reagents leads to a time-dependent change S(t) in a measured quantity S and the concentration C correlates according to an evaluation curve C(X) with an input variable X derived from S(t), in which the calibration curve is ambiguous for at least a portion of the possible X values. In order to assign an input variable X to one of the sub-sections and thereby to obtain an unambiguous correlation to a particular concentration C, a training run and an analysis run are performed. In the training run, a discrimination algorithm is performed at least once, in which a discriminator set is generated from measurements of S(t), a score is generated in each case from the latter with a multivariate statistical technique and it is checked whether the scores can be divided into separate subsets, in which the concentrations are correctly assigned to the sub-sections of the calibration curve. The discrimination algorithm is repeated with different discriminator sets generated according to different generation methods from the measurements of S(t), in order to establish an operative discrimination algorithm. In the analysis run, an analysis score is calculated from measurements of S(t) according to the operative discrimination algorithm, the analysis score is compared with the boundary score and the measurement result is assigned to one of the sub-curves of the calibration curve by comparison of the analysis score with the boundary score.
摘要翻译：用于分析测定样品与试剂反应导致测量量S和浓度C中的时间依赖性变化S（t）的药物样品成分浓度的分析方法根据评价具有从S（t）导出的输入变量X的曲线C（X），其中校准曲线对于可能的X值的至少一部分是不明确的。为了将输入变量X分配给一个子部分，从而获得与特定浓度C的明确相关性，执行训练运行和分析运行。在训练运行中，至少执行一次鉴别算法，其中通过S（t）的测量产生鉴别器集合，在每种情况下，使用多变量统计技术从后者生成分数，并且检查是否分数可以分为单独的子集，其中浓度被正确分配到校准曲线的子部分。根据不同的生成方法从S（t）的测量中产生的不同鉴别器集重复鉴别算法，以便建立可操作的鉴别算法。在分析运行中，根据手术识别算法从S（t）的测量中计算分析得分，将分析得分与边界得分进行比较，并将测量结果分配给校准曲线的一个子曲线通过比较分析得分与边界得分。

2. 发明授权

US06268167B1 Methods for determining an analyte in a plasma or serum sample which may be contaminated with interfering substances resulting from hemolysis 失效
标题翻译：用于测定血浆或血清样品中可能被溶血产生的干扰物质污染的分析物的方法
公开(公告)号：US06268167B1
公开(公告)日：2001-07-31
申请号：US08963563
申请日：1997-11-03
申请人： Thomas Wild , Friederike Weber , Christoph Berding , Wilhelm Kleider
发明人： Thomas Wild , Friederike Weber , Christoph Berding , Wilhelm Kleider
IPC分类号： C12Q132
CPC分类号： C12Q1/32 , G01N33/72 , Y10T436/25125
摘要： In order to analyze a medical sample while avoiding error contributions due to hemolysis, prior to the main reaction for a component present in the sample, a pre-reaction is produced and measured by which the degree of hemolysis in the sample is determined and the result of the sample to be determined that is subsequently obtained is corrected by this error contribution using the relationship (correlation) that has been found between the degree of hemolysis and the error contribution.
摘要翻译：为了分析医用样品，同时避免由于溶血引起的误差，在样品中存在的成分的主要反应之前，产生并测定样品中的溶血程度并进行测定的预反应，结果使用在溶血度和误差贡献之间已经发现的关系（相关性）通过该误差贡献来校正随后获得的待测定样品。

3. 发明授权

US5565364A Method for the analysis of a component of a medical sample 失效
标题翻译：用于分析医用样品的组分的方法
公开(公告)号：US5565364A
公开(公告)日：1996-10-15
申请号：US393946
申请日：1995-02-22
申请人： Rainer Schaefer , Bela Molnar , Christoph Berding , Peter Wolf , Fridl Lang
发明人： Rainer Schaefer , Bela Molnar , Christoph Berding , Peter Wolf , Fridl Lang
IPC分类号： G01N21/75 , G01N35/00 , G06F15/18 , G06G7/60 , G06N99/00 , G01N30/86 , G01N30/88
CPC分类号： G01N35/00693 , G01N21/75 , G01N2035/00702 , Y10T436/11
摘要： A method for the analysis of a component of a medical sample with the aid of an autoanalyzer, in which the sample is reacted with a reagent system and a physically measurable quantity X resulting from the reaction of the sample with the reagent system is measured in order to determine at least one measured value R for a specified sample and in which this at least one measured value R is further processed with the aid of a processing unit in a processing stage in order to determine an analytical result A. In the processing stage of the invention, use is made of the results of a neural net training, in which, for a number of standard samples for which the analytical result A is known, at least one measured value R, or a measurement result derived from several measured values R.sub.i, is applied to the input of a neural net.
摘要翻译：借助自动分析仪分析医用样品的成分的方法，其中样品与试剂系统反应，并且由样品与试剂系统的反应产生的物理测量量X按顺序测量确定用于指定样本的至少一个测量值R，并且其中在处理阶段中借助于处理单元进一步处理该至少一个测量值R.以便确定分析结果A.在处理阶段本发明使用神经网络训练的结果，其中对于已知其分析结果A的多个标准样本，至少一个测量值R或从若干测量值R得到的测量结果，被应用于神经网络的输入。

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