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1. 发明授权

US5911997A Relaxin-like factor and methods and uses thereof 失效
公开(公告)号：US5911997A
公开(公告)日：1999-06-15
申请号：US484219
申请日：1995-06-07
申请人： Christian Schwabe , Elaine Unemori
发明人： Christian Schwabe , Elaine Unemori
IPC分类号： G01N33/53 , A61K31/00 , A61K38/00 , A61P29/00 , A61P43/00 , C07K14/64 , C12N15/09 , A61K38/22 , C07K14/575
CPC分类号： C07K14/64 , A61K38/00
摘要： The present invention relates to a relaxin-like factor, its derivatives or analogs, and uses thereof. The present invention further relates to compositions comprising a relaxin-like factor, its derivatives or analogs, and relaxin wherein such composition exhibits an additive or synergistic effect.

2. 发明授权

US5753711A Method for treatment of H. pylori 失效
标题翻译：幽门螺杆菌治疗方法
公开(公告)号：US5753711A
公开(公告)日：1998-05-19
申请号：US819734
申请日：1997-03-18
申请人： Christian Schwabe , Robert A. Ashley
发明人： Christian Schwabe , Robert A. Ashley
IPC分类号： A61K31/14
CPC分类号： A61K31/14
摘要： In a method for preventing the spread of Helicobacter pylori from the oral cavity, the oral cavity is contacted with alkyldimethylammonium chloride. The contacting is advantageously used in conjunction with enteric antimicrobial therapy for H. pylori or for prophylaxis thereof.
摘要翻译：在防止幽门螺杆菌从口腔扩散的方法中，口腔与烷基二甲基氯化铵接触。该接触有利地与幽门螺杆菌的肠溶抗微生物治疗联用或用于其预防。

3. 发明授权

US06949506B2 Relaxin-like factor and methods and uses thereof 失效
标题翻译：松弛素样因子及其方法和用途
公开(公告)号：US06949506B2
公开(公告)日：2005-09-27
申请号：US09846149
申请日：2001-04-30
申请人： Christian Schwabe , Elaine Unemori
发明人： Christian Schwabe , Elaine Unemori
IPC分类号： G01N33/53 , A61K31/00 , A61K38/00 , A61P29/00 , A61P43/00 , C07K14/64 , C12N15/09 , A61K38/16 , C07K14/00
CPC分类号： C07K14/64 , A61K38/00
摘要： The present invention relates to a relaxin-like factor, its derivatives or analogs, and uses thereof. The present invention further relates to compositions comprising a relaxin-like factor, its derivatives or analogs, and relaxin wherein such composition exhibits an additive or synergistic effect.
摘要翻译：本发明涉及松弛素样因子，其衍生物或类似物及其用途。本发明还涉及包含松弛素样因子，其衍生物或类似物和松弛素的组合物，其中所述组合物显示出添加剂或协同效应。

4. 发明授权

US06582700B1 Linear antigen supporting units 失效
标题翻译：线性抗原支持单位
公开(公告)号：US06582700B1
公开(公告)日：2003-06-24
申请号：US09191904
申请日：1998-11-13
申请人： Christian Schwabe
发明人： Christian Schwabe
IPC分类号： A61K3900
CPC分类号： C07K7/06 , A61K39/385 , A61K47/646 , A61K2039/6031 , A61K2039/6093 , A61K2039/64 , C07K5/0215 , C07K7/08 , C07K14/001 , C07K14/64
摘要： The present invention concerns a synthetic construct comprising a linear core chain having two or more side chains pending directly from different points on the linear core chain. Each of the side chains comprises an epitopic site of an antigen or a peptide. The synthetic constructs are monomeric units that can be linked together or polymerized to form a polymer. In this embodiment the epitopic sites of the side chains may be the same or different. The linear core chain may be a linear sequence of amino acids having two or more of the same peptide pending directly from different points on the linear sequence. Another aspect of the present invention concerns a support having one or more of the above synthetic constructs or polymers coupled thereto. Another embodiment of the present invention is directed to antibodies raised against the above synthetic constructs or polymers. The antibodies can be purified using the above mentioned supports. Another aspect of the present invention is a vaccine comprising the above synthetic construct. The present invention also includes methods for synthesizing the above constructs and polymers.
摘要翻译：本发明涉及一种合成结构，其包含具有直接悬挂在线性芯链上的不同点的两条或多条侧链的直链核心链。每个侧链包含抗原或肽的表位位点。合成构建体是可以连接在一起或聚合形成聚合物的单体单元。在该实施方案中，侧链的表位位点可以相同或不同。线性核心链可以是具有两个或多个相同肽的直接从线性序列上的不同点排列的氨基酸的线性序列。本发明的另一方面涉及一种具有一种或多种上述合成构型或与其结合的聚合物的载体。本发明的另一个实施方案涉及针对上述合成构建体或聚合物产生的抗体。可以使用上述支持物纯化抗体。本发明的另一方面是包含上述合成构建体的疫苗。本发明还包括合成上述构建体和聚合物的方法。

5. 发明授权

US5811395A Relaxin analogs and derivatives methods and uses thereof 失效
标题翻译：松弛素类似物及其衍生物方法和用途
公开(公告)号：US5811395A
公开(公告)日：1998-09-22
申请号：US483476
申请日：1995-06-07
申请人： Christian Schwabe , Elaine Unemori
发明人： Christian Schwabe , Elaine Unemori
IPC分类号： A61K38/00 , A61K38/22 , C07K14/64 , A61K38/16 , A61K38/17 , C07K7/10
CPC分类号： C07K14/64 , A61K38/2221
摘要： The present invention relates to a relaxin analogs and derivatives, and uses thereof. The present invention further relates to compositions comprising a relaxin analogs and derivatives, and relaxin wherein such composition exhibits an additive or synergistic effect.
摘要翻译：本发明涉及松弛素类似物及其衍生物及其用途。本发明还涉及包含松弛素类似物和衍生物的组合物和松香素，其中这种组合物显示出添加剂或协同效应。

6. 发明授权

US5827503A Method and composition for treating periodontitis 失效
标题翻译：治疗牙周炎的方法和组成
公开(公告)号：US5827503A
公开(公告)日：1998-10-27
申请号：US689403
申请日：1996-08-08
申请人： Christian Schwabe
发明人： Christian Schwabe
IPC分类号： A61K8/20 , A61K8/41 , A61Q11/00 , A61K7/16 , A61K7/22
CPC分类号： A61Q11/00 , A61K8/20 , A61K8/416
摘要： Oral hygiene is improved and diseases of the oral cavity are treated by oral application of a composition containing 0.02 to 0.25 weight percent alkyldimethylbenzylammonium chloride (BAC) and 0.05 to 2.0 weight percent sodium chloride dissolved in water, in the absence of other active ingredients. The BAC and sodium chloride act synergistically to allow the composition to sorb strongly to oral tissues and remain there for several hours.
摘要翻译：在不存在其它活性成分的情况下，通过口服施用含有0.02-0.25重量％烷基二甲基苄基氯化铵（BAC）和0.05-2.0重量％溶于水的氯化钠的组合物来治疗口腔卫生并且口腔疾病。 BAC和氯化钠协同作用，使组合物强烈吸附到口腔组织上并保持数小时。

7. 发明授权

US06200953B1 Relaxin analogs and derivatives compositions 有权
标题翻译：松弛素类似物和衍生物组合物
公开(公告)号：US06200953B1
公开(公告)日：2001-03-13
申请号：US09158706
申请日：1998-09-22
申请人： Christian Schwabe , Elaine Unemori
发明人： Christian Schwabe , Elaine Unemori
IPC分类号： A61K3816
CPC分类号： C07K14/64 , A61K38/2221
摘要： The present invention relates to a relaxin analogs and derivatives, and uses thereof. The present invention further relates to compositions comprising a relaxin analogs and derivatives, and relaxin wherein such composition exhibits an additive or synergistic effect.
摘要翻译：本发明涉及松弛素类似物及其衍生物及其用途。本发明还涉及包含松弛素类似物和衍生物的组合物和松香素，其中这种组合物显示出添加剂或协同效应。

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