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1. 发明申请

US20090214433A1 HYPERPOLARIZED SOLID MATERIALS WITH LONG SPIN RELAXATION TIMES FOR USE AS IMAGING AGENTS IN MAGNETIC RESONANCE IMAGING 有权
标题翻译：具有长时间旋转松弛时间的高效固体材料用于磁共振成像中的成像剂
公开(公告)号：US20090214433A1
公开(公告)日：2009-08-27
申请号：US12088357
申请日：2006-09-28
申请人： Charles M. Marcus
发明人： Charles M. Marcus
IPC分类号： A61K49/06
CPC分类号： A61K49/18 , A61K49/06 , A61K49/1815 , A61K49/1818 , B82Y5/00
摘要： An imaging agent is disclosed for use in nuclear magnetic resonance imaging. The imaging agent includes a first substance and a second substance. The first substance includes at least one atom having non-zero nuclear spin providing a polarized magnetic orientation. The second substance is bound to the first substance and inhibits physical contact between the at least one atom and other atoms and molecules to thereby inhibit spin relaxation of the polarized magnetic orientation of the at least one atom.
摘要翻译：公开了用于核磁共振成像的成像剂。成像剂包括第一物质和第二物质。第一物质包括提供极化磁取向的至少一个具有非零核自旋的原子。第二物质与第一物质结合并且抑制至少一个原子与其它原子和分子之间的物理接触，从而抑制至少一个原子的极化磁取向的自旋弛豫。

2. 发明申请

US20090252686A1 Ex Vivo Hyperpolarization of Imaging Agents 审中-公开
标题翻译：成像剂的体外超极化
公开(公告)号：US20090252686A1
公开(公告)日：2009-10-08
申请号：US12160327
申请日：2007-01-11
申请人： Charles M. Marcus
发明人： Charles M. Marcus
IPC分类号： A61K49/06 , A61P43/00
CPC分类号： A61K49/18 , A61B5/055 , G01R33/282 , G01R33/5601
摘要： The present invention generally relates to methods for accelerating the ex vivo induction of nuclear hyperpolarization in imaging agents.
摘要翻译：本发明一般涉及用于加速成像剂中核超极化离体诱导的方法。

3. 发明申请

US20080284429A1 Situ Hyperpolarization of Imaging Agents 审中-公开
标题翻译：原位成像剂超极化
公开(公告)号：US20080284429A1
公开(公告)日：2008-11-20
申请号：US12096678
申请日：2006-12-11
申请人： Charles M. Marcus , Jacob W. Aptekar , Alexander C. Johnson , Ronald L. Walsworth
发明人： Charles M. Marcus , Jacob W. Aptekar , Alexander C. Johnson , Ronald L. Walsworth
IPC分类号： A61K49/16 , A61K49/06 , G01R33/56
CPC分类号： A61K49/06 , A61B5/055 , A61K49/18 , G01R33/282 , G01R33/5601 , G01R33/60
摘要： The present invention generally relates to compositions, systems and methods for inducing nuclear hyperpolarization in imaging agents after they have been introduced into a subject.
摘要翻译：本发明一般涉及在成像剂引入受试者之后诱导成像剂中的核超极化的组合物，系统和方法。

4. 发明授权

US08377419B2 Hyperpolarized solid materials with long spin relaxation times for use as imaging agents in magnetic resonance imaging 有权
标题翻译：具有长自旋弛豫时间的超极化固体材料用作磁共振成像中的成像剂
公开(公告)号：US08377419B2
公开(公告)日：2013-02-19
申请号：US12088357
申请日：2006-09-28
申请人： Charles M. Marcus
发明人： Charles M. Marcus
IPC分类号： A61B5/055
CPC分类号： A61K49/18 , A61K49/06 , A61K49/1815 , A61K49/1818 , B82Y5/00
摘要： An imaging agent is disclosed for use in nuclear magnetic resonance imaging. The imaging agent includes a first substance and a second substance. The first substance includes at least one atom having non-zero nuclear spin providing a polarized magnetic orientation. The second substance is bound to the first substance and inhibits physical contact between the at least one atom and other atoms and molecules to thereby inhibit spin relaxation of the polarized magnetic orientation of the at least one atom.
摘要翻译：公开了用于核磁共振成像的成像剂。成像剂包括第一物质和第二物质。第一物质包括提供极化磁取向的至少一个具有非零核自旋的原子。第二物质与第一物质结合并且抑制至少一个原子与其它原子和分子之间的物理接触，从而抑制至少一个原子的极化磁取向的自旋弛豫。

5. 发明授权

US08119032B2 Gas-phase functionalization of surfaces including carbon-based surfaces 有权
标题翻译：包括碳基表面在内的表面的气相官能化
公开(公告)号：US08119032B2
公开(公告)日：2012-02-21
申请号：US12157337
申请日：2008-06-10
申请人： Roy G. Gordon , Damon B. Farmer , Charles M. Marcus , James R. Williams
发明人： Roy G. Gordon , Damon B. Farmer , Charles M. Marcus , James R. Williams
IPC分类号： C23C16/00 , H01B1/00
CPC分类号： H01L51/0049 , B82Y10/00 , B82Y30/00 , B82Y40/00 , C01B32/174 , C01B2202/02 , C01F7/304 , C01P2004/13 , H01L51/057 , H01L51/0595 , Y10S977/734 , Y10S977/755 , Y10S977/842 , Y10S977/847 , Y10S977/89 , Y10T428/2918
摘要： The invention provides methods functionalizing a planar surface of a graphene layer, a graphite surface, or microelectronic structure. The graphene layer, graphite surface, or planar microelectronic structure surface is exposed to at least one vapor including at least one functionalization species that non-covalently bonds to the graphene layer, a graphite surface, or planar microelectronic surface while providing a functionalization layer of chemically functional groups, to produce a functionalized graphene layer, graphite surface, or planar microelectronic surface.
摘要翻译：本发明提供了使石墨烯层，石墨表面或微电子结构的平坦表面官能化的方法。石墨烯层，石墨表面或平面微电子结构表面暴露于至少一种蒸气，其包括至少一种与石墨烯层，石墨表面或平面微电子表面非共价结合的官能化物质，同时提供化学上的官能化层官能团，以产生功能化石墨烯层，石墨表面或平面微电子表面。

6. 发明申请

US20110089404A1 Microfabrication of Carbon-based Devices Such as Gate-Controlled Graphene Devices 审中-公开
标题翻译：诸如门控石墨烯器件的碳基器件的微加工
公开(公告)号：US20110089404A1
公开(公告)日：2011-04-21
申请号：US12936768
申请日：2009-04-23
申请人： Charles M. Marcus , James R. Williams , Hugh Olen Hill Churchill
发明人： Charles M. Marcus , James R. Williams , Hugh Olen Hill Churchill
IPC分类号： H01L29/12 , H01L21/36
CPC分类号： B82Y30/00 , B82Y40/00 , C01B32/174 , C01B32/194 , H01L29/1606
摘要： A graphene device includes a graphene layer and a back gate electrode connected to apply a global electrical bias to the graphene from a first surface of the graphene. At least two graphene device electrodes are each connected to a corresponding and distinct region of the graphene at a second graphene surface. A dielectric layer blanket-coats the second graphene surface and the device electrodes. At least one top gate electrode is disposed on the dielectric layer and extends over a distinct one of the device electrodes and at least a portion of a corresponding graphene region. Each top gate electrode is connected to apply an electrical charge carrier bias to the graphene region over which that top gate electrode extends to produce a selected charge carrier type in that graphene region. Such a carbon structure can be exposed to a beam of electrons to compensate for extrinsic doping of the carbon.
摘要翻译：石墨烯装置包括石墨烯层和背栅极电极，其连接以从石墨烯的第一表面向石墨烯施加全局电偏压。在第二石墨烯表面处，至少两个石墨烯器件电极各自连接到石墨烯的对应且不同的区域。电介质层覆盖 - 涂覆第二石墨烯表面和器件电极。至少一个顶栅电极设置在电介质层上并在不同的一个器件电极和对应的石墨烯区域的至少一部分上延伸。每个顶栅电极被连接以将电荷载流子偏压施加到石墨烯区域，在该石墨烯区域上顶栅电极延伸以在该石墨烯区域中产生选定的电荷载体类型。这样的碳结构可以暴露于电子束以补偿碳的外在掺杂。

7. 发明申请

US20100092390A1 Methods for Making Particles Having Long Spin-Lattice Relaxation Times 审中-公开
标题翻译：制备具有长自旋晶格松弛时间的颗粒的方法
公开(公告)号：US20100092390A1
公开(公告)日：2010-04-15
申请号：US12248672
申请日：2008-10-09
申请人： Charles M. Marcus , Jacob Aptekar , Maja Cassidy
发明人： Charles M. Marcus , Jacob Aptekar , Maja Cassidy
IPC分类号： A61K49/18 , B32B1/00 , B02C17/00 , B02C23/20 , B02C23/08
CPC分类号： A61K49/1824 , A61K49/08 , B82Y5/00 , B82Y15/00 , Y10T428/2982
摘要： Methods for making collections of small particles having spin-lattice relaxation times greater than about 5 minutes are described. The long-T1 particles are useful as imaging agents for nuclear magnetic resonance imaging. In one embodiment, bulk silicon wafers are reduced to particles in a machining process, and the particles processed to obtain a collection of particles having an average size of about 300 nanometers and a T1 relaxation time of about 15 minutes. The particles can be subjected to post-fabrication processing to alter their surface composition or the chemical functionality of their surface. In certain embodiments, porous particles produced by the inventive methods can be loaded with pharmaceutical drugs and used to track and evaluate delivery and effectiveness of drugs.
摘要翻译：描述了具有大于约5分钟的自旋晶格弛豫时间的小颗粒的收集方法。长T1颗粒可用作核磁共振成像的成像剂。在一个实施例中，体积硅晶片在机械加工过程中被还原为颗粒，并且处理颗粒以获得具有约300纳米的平均尺寸和约15分钟的T1弛豫时间的颗粒的集合。颗粒可以进行后期加工以改变其表面组成或其表面的化学官能度。在某些实施方案中，通过本发明方法产生的多孔颗粒可以装载药物并且用于跟踪和评估药物的递送和有效性。

8. 发明申请

US20100322864A1 TELEMETRY THROUGH REMOTE DETECTION OF NMR-ACTIVE PARTICLES 审中-公开
标题翻译：通过远离核磁共振活性颗粒的检测来测试
公开(公告)号：US20100322864A1
公开(公告)日：2010-12-23
申请号：US12812069
申请日：2009-01-09
申请人： Charles M. Marcus , Jonathan Marmurek , Jacob W. Aptekar , Geoffrey Von Maltzahn
发明人： Charles M. Marcus , Jonathan Marmurek , Jacob W. Aptekar , Geoffrey Von Maltzahn
IPC分类号： A61K49/06 , G01R33/44
CPC分类号： G01R33/5601 , B82Y5/00 , G01N24/08 , G01R33/465
摘要： Various methods of telemetry for nuclear magnetic resonance applications are described. NMR-active particles are introduced into a system which is to undergo an NMR measurement. In various embodiments, the NMR-active particles have a resonance peak in a spectral region which is substantially free from any NMR signal originating from material native to the system. In some embodiments, the NMR-active particles are chemically functionalized to target a constituent within the system. In certain applications, changes in the detected resonance peak can be used to quantify certain characteristics about the system, e.g., a concentration of an analyte, whether a targeted constituent is present within the system.
摘要翻译：描述了用于核磁共振应用的各种遥测方法。将NMR活性粒子引入到进行NMR测定的体系中。在各种实施方案中，NMR活性颗粒在光谱区域具有基本上不含任何源自该系统天然材料的NMR信号的共振峰。在一些实施方案中，NMR活性颗粒经化学官能化以靶向体系内的组分。在某些应用中，可以使用检测到的共振峰的变化来量化系统的某些特性，例如分析物的浓度，无论目标成分是否存在于系统内。

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