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1. 发明申请

US20120253453A1 DURABLE HIGH STRENGTH POLYMER COMPOSITE SUITABLE FOR IMPLANT AND ARTICLES PRODUCED THEREFROM 有权
标题翻译：耐久高强度聚合物复合材料适用于生产的植入物及其制品
公开(公告)号：US20120253453A1
公开(公告)日：2012-10-04
申请号：US13078774
申请日：2011-04-01
申请人： William C. Bruchman , Paul D. Gassler , Cody L. Hartman , Peter J. Walsh , Charles F. White
发明人： William C. Bruchman , Paul D. Gassler , Cody L. Hartman , Peter J. Walsh , Charles F. White
IPC分类号： A61F2/82
CPC分类号： A61F2/24 , A61F2/2412 , A61F2/2415 , A61F2/2418 , A61F2/2472 , A61F2/2475 , A61F2210/0076 , A61F2220/005 , A61F2230/00 , A61F2230/0006 , A61F2230/0013 , A61F2230/0054 , A61L27/025 , A61L27/40 , A61L27/48 , A61L27/507 , A61L2430/20 , C08L27/00
摘要： A thin, biocompatible, high-strength, composite material is disclosed that is suitable for use in various implanted configurations. In one aspect, the composite material maintains flexibility in high-cycle flexural applications, making it particularly applicable to high-flex implants such as heart pacing lead or heart valve leaflet. The composite material includes a porous expanded fluoropolymer membrane and an elastomer, wherein the elastomer fills substantially all of the pores of the porous expanded fluoropolymer, and the composite material comprising less than about 80% fluoropolymer by weight.
摘要翻译：公开了一种适用于各种植入构型的薄的，生物相容的，高强度的复合材料。在一个方面，复合材料在高周期弯曲应用中保持灵活性，使其特别适用于诸如心脏起搏引线或心脏瓣膜小叶的高柔性植入物。复合材料包括多孔膨胀氟聚合物膜和弹性体，其中弹性体基本上填充多孔膨胀氟聚合物的所有孔，并且复合材料包含按重量计小于约80％的含氟聚合物。

2. 发明授权

US07659219B2 Highly porous self-cohered web materials having haemostatic properties 有权
标题翻译：具有止血特性的高度多孔的自粘性纤维网材料
公开(公告)号：US07659219B2
公开(公告)日：2010-02-09
申请号：US11343509
申请日：2006-01-30
申请人： Roy Biran , Edward H. Cully , Ted R. Farnsworth , Charles Flynn , Philip P. Off , Charles F. White
发明人： Roy Biran , Edward H. Cully , Ted R. Farnsworth , Charles Flynn , Philip P. Off , Charles F. White
IPC分类号： A61B17/03 , A61F13/00 , D04H3/03 , D04H3/16 , B32B27/12
CPC分类号： A61L31/148 , A61B17/07292 , A61L31/146 , A61L31/18 , Y10T442/608 , Y10T442/674 , Y10T442/677 , Y10T442/681 , Y10T442/682 , Y10T442/688
摘要： The present invention is directed to implantable bioabsorbable non-woven self-cohered web materials having a high degree of porosity. The web materials are very supple and soft, while exhibiting proportionally increased mechanical strength in one or more directions. The web materials often possess a high degree of loft. The web materials can be formed into a variety of shapes and forms suitable for use as implantable medical devices or components thereof. The web materials possess haemostatic properties.
摘要翻译：本发明涉及具有高孔隙率的可植入生物可吸收的非织造自粘性纤维网材料。纤维网材料非常柔软和柔软，同时在一个或多个方向上显示成比例地增加的机械强度。网页材料通常具有高度的阁楼。网状材料可以形成适合用作可植入医疗装置或其组件的各种形状和形式。网状材料具有止血性。

3. 发明授权

US07604668B2 Composite self-cohered web materials 有权
标题翻译：复合自粘网材料
公开(公告)号：US07604668B2
公开(公告)日：2009-10-20
申请号：US11193110
申请日：2005-07-29
申请人： Ted R. Farnsworth , Charles Flynn , Charles F. White
发明人： Ted R. Farnsworth , Charles Flynn , Charles F. White
IPC分类号： A61F2/02 , A61K9/70
CPC分类号： A61L31/148 , A61B17/07292 , A61L31/146 , Y10T428/1317 , Y10T428/1372 , Y10T428/1376 , Y10T442/2525 , Y10T442/681
摘要： The present invention is directed to implantable bioabsorbable non-woven self-cohered web materials having a high degree of porosity. The web materials are very supple and soft, while exhibiting proportionally increased mechanical strength in one or more directions. The web materials often possess a high degree of loft. The web materials can be formed into a variety of shapes and forms suitable for use as implantable medical devices or components thereof.
摘要翻译：本发明涉及具有高孔隙率的可植入生物可吸收的非织造自粘性纤维网材料。纤维网材料非常柔软和柔软，同时在一个或多个方向上显示成比例地增加的机械强度。网页材料通常具有高度的阁楼。网状材料可以形成适合用作可植入医疗装置或其组件的各种形状和形式。

4. 发明授权

US08377241B2 Method of making porous self-cohered web materials 有权
标题翻译：制造多孔自粘网材料的方法
公开(公告)号：US08377241B2
公开(公告)日：2013-02-19
申请号：US12939573
申请日：2010-11-04
申请人： Ted R. Farnsworth , Charles Flynn , Charles F. White
发明人： Ted R. Farnsworth , Charles Flynn , Charles F. White
IPC分类号： D04H3/16 , D06C3/00 , B29C55/00
CPC分类号： D04H3/16 , A61L27/52 , A61L27/56
摘要： The present invention is directed to a method of making implantable bioabsorbable non-woven self-cohered web materials having a high degree of porosity. The web materials are very supple and soft, while exhibiting proportionally increased mechanical strength in one or more directions. The web materials often possess a high degree of loft. The web materials can be formed into a variety of shapes and forms suitable for use as implantable medical devices or components thereof.
摘要翻译：本发明涉及一种制造具有高孔隙率的可植入的生物可吸收的非织造自粘性纤维网材料的方法。纤维网材料非常柔软和柔软，同时在一个或多个方向上显示成比例地增加的机械强度。网页材料通常具有高度的阁楼。网状材料可以形成适合用作可植入医疗装置或其组件的各种形状和形式。

5. 发明授权

US07655584B2 Highly porous self-cohered web materials 有权
标题翻译：高度多孔的自粘网材料
公开(公告)号：US07655584B2
公开(公告)日：2010-02-02
申请号：US11193111
申请日：2005-07-29
申请人： Roy Biran , Edward H. Cully , Ted R. Farnsworth , Charles Flynn , Charles F. White
发明人： Roy Biran , Edward H. Cully , Ted R. Farnsworth , Charles Flynn , Charles F. White
IPC分类号： A61B17/03 , A61F13/00 , D04H3/03 , D04H3/16
CPC分类号： A61L31/148 , A61B17/07292 , A61L31/146 , A61L31/18 , Y10T442/608 , Y10T442/674 , Y10T442/677 , Y10T442/681 , Y10T442/682 , Y10T442/688
摘要： The present invention is directed to implantable bioabsorbable non-woven self-cohered web materials having a very high degree of porosity. The web materials are very supple and soft, while exhibiting proportionally increased mechanical strength in one or more directions. The web materials often possess a high degree of loft. The web materials can be formed into a variety of shapes and forms suitable for use as implantable medical devices or components thereof. In some embodiments, the web materials exhibit significant thrombogenic properties.
摘要翻译：本发明涉及具有非常高的孔隙率的可植入的生物可吸收的非织造自粘性纤维网材料。纤维网材料非常柔软和柔软，同时在一个或多个方向上显示成比例地增加的机械强度。网页材料通常具有高度的阁楼。网状材料可以形成适合用作可植入医疗装置或其组件的各种形状和形式。在一些实施方案中，网状材料表现出显着的血栓形成性质。

6. 发明申请

US20100010515A1 Composite self-cohered web materials 有权
公开(公告)号：US20100010515A1
公开(公告)日：2010-01-14
申请号：US12586153
申请日：2009-09-16
申请人： Ted R. Farnsworth , Charles Flynn , Charles F. White
发明人： Ted R. Farnsworth , Charles Flynn , Charles F. White
IPC分类号： A61B17/08
CPC分类号： A61L31/148 , A61B17/07292 , A61L31/146 , Y10T428/1317 , Y10T428/1372 , Y10T428/1376 , Y10T442/2525 , Y10T442/681
摘要： The present invention is directed to implantable bioabsorbable non-woven self-cohered web materials having a high degree of porosity. The web materials are very supple and soft, while exhibiting proportionally increased mechanical strength in one or more directions. The web materials often possess a high degree of loft. The web materials can be formed into a variety of shapes and forms suitable for use as implantable medical devices or components thereof.

7. 发明授权

US09005269B2 Bioabsorbable self-expanding endolumenal devices 有权
标题翻译：生物可吸收的自扩张腔内装置
公开(公告)号：US09005269B2
公开(公告)日：2015-04-14
申请号：US12181197
申请日：2008-07-28
申请人： Joseph R. Armstrong , Paul C. Begovac , Robert L. Cleek , Edward H. Cully , Charles Flynn , Byron K. Hayes , Ryan V. Peterson , Michael J. Vonesh , Charles F. White
发明人： Joseph R. Armstrong , Paul C. Begovac , Robert L. Cleek , Edward H. Cully , Charles Flynn , Byron K. Hayes , Ryan V. Peterson , Michael J. Vonesh , Charles F. White
IPC分类号： A61F2/82 , A61F2/01 , A61B17/12 , A61F2/91 , A61F2/915 , A61L31/06 , A61L31/14 , A61F2/30
CPC分类号： A61F2/01 , A61B17/12022 , A61B17/12118 , A61B17/1214 , A61B2017/1205 , A61F2/91 , A61F2/915 , A61F2002/016 , A61F2002/018 , A61F2002/30062 , A61F2002/91508 , A61F2002/91525 , A61F2002/91533 , A61F2002/9155 , A61F2210/0004 , A61F2210/0076 , A61F2220/0016 , A61F2230/005 , A61F2230/0054 , A61F2230/0069 , A61F2230/008 , A61F2250/003 , A61L31/06 , A61L31/148 , C08L67/04
摘要： Bioabsorbable self-expanding medical devices formed of an integral framework with a multiplicity of fenestrations are provided. The framework is continuous, non-filamentous, non-braided, and non-interlaced. The devices includes a non-blended hydrolysable co-polymeric material comprising an amorphous component with a glass transition temperature that is below ambient body temperature and a crystallizable component that possesses a crystalline melting point in excess of ambient body temperature. The devices radially expand from a compressed first diameter to an uncompressed second diameter equal to or greater than 1.5 times the first diameter within two minutes in an aqueous medium at 37° C. following release of a compressive force placed on the devices. Additionally, the medical device does not change axial length significantly as the radial dimensions of the devices are changed. Further, the medical devices may be constructed of different bioabsorbable polymers, polymer ratios, and/or different geometries and portions may bioabsorb at different rates.
摘要翻译：提供由具有多个开窗的整体框架形成的生物可吸收的自扩张医疗装置。框架是连续的，非丝状的，非编织的和非隔行的。该装置包括非共混的可水解共聚物材料，其包含玻璃化转变温度低于环境体温的非晶组分和具有超过环境体温的结晶熔点的可结晶组分。在放置在装置上的压缩力释放之后，装置在37℃下在含水介质中在两分钟内从压缩的第一直径径向膨胀至等于或大于第一直径的1.5倍的未压缩的第二直径。此外，随着装置的径向尺寸改变，医疗装置不会显着改变轴向长度。此外，医疗装置可以由不同的生物可吸收聚合物，聚合物比率和/或不同的几何形状构成，并且部分可以以不同的速率生物吸收。

8. 发明授权

US08961599B2 Durable high strength polymer composite suitable for implant and articles produced therefrom 有权
标题翻译：耐用的高强度聚合物复合材料适用于植入物和由其制造的制品
公开(公告)号：US08961599B2
公开(公告)日：2015-02-24
申请号：US13078774
申请日：2011-04-01
申请人： William C. Bruchman , Paul D. Gassler , Cody L. Hartman , Peter J. Walsh , Charles F. White
发明人： William C. Bruchman , Paul D. Gassler , Cody L. Hartman , Peter J. Walsh , Charles F. White
IPC分类号： A61L27/40 , A61F2/24 , A61L27/48 , A61L27/50 , A61L27/02
CPC分类号： A61F2/24 , A61F2/2412 , A61F2/2415 , A61F2/2418 , A61F2/2472 , A61F2/2475 , A61F2210/0076 , A61F2220/005 , A61F2230/00 , A61F2230/0006 , A61F2230/0013 , A61F2230/0054 , A61L27/025 , A61L27/40 , A61L27/48 , A61L27/507 , A61L2430/20 , C08L27/00
摘要： A thin, biocompatible, high-strength, composite material is disclosed that is suitable for use in various implanted configurations. In one aspect, the composite material maintains flexibility in high-cycle flexural applications, making it particularly applicable to high-flex implants such as heart pacing lead or heart valve leaflet. The composite material includes a porous expanded fluoropolymer membrane and an elastomer, wherein the elastomer fills substantially all of the pores of the porous expanded fluoropolymer, and the composite material comprising less than about 80% fluoropolymer by weight.
摘要翻译：公开了一种适用于各种植入构型的薄的，生物相容的，高强度的复合材料。在一个方面，复合材料在高周期弯曲应用中保持灵活性，使其特别适用于诸如心脏起搏引线或心脏瓣膜小叶的高柔性植入物。复合材料包括多孔膨胀氟聚合物膜和弹性体，其中弹性体基本上填充多孔膨胀氟聚合物的所有孔，并且复合材料包含按重量计小于约80％的含氟聚合物。

9. 发明申请

US20130183515A1 Articles including expanded polytetrafluoroethylene membranes with serpentine fibrils 审中-公开
标题翻译：制品包括具有蛇纹石原纤维的膨胀聚四氟乙烯膜
公开(公告)号：US20130183515A1
公开(公告)日：2013-07-18
申请号：US13351052
申请日：2012-01-16
申请人： Charles F. White
发明人： Charles F. White
IPC分类号： B32B27/12 , B29C67/24
CPC分类号： B29C55/005 , B29K2027/18 , B29K2105/04 , Y10T428/24994
摘要： Articles including expanded fluoropolymer membranes having serpentine fibrils are provided. The fluoropolymer membranes exhibit high elongation while substantially retaining the strength properties of the fluoropolymer membrane. The membrane may include a fluoropolymer and/or elastomer. Additionally, the article has an elongation in at least one direction of at least about 100% and a matrix tensile strength of at least about 50 MPa. The article may be formed by (1) expanding a dried, extruded fluoropolymer tape in at least one direction to produce an expanded fluoropolymer membrane and (2) retracting the expanded fluoropolymer membrane in at least one direction of expansion by applying heat or by adding a solvent. The application of a tensile force at least partially straightens the serpentine fibrils, thereby elongating the article. The expanded fluoropolymer membrane may include a microstructure of substantially only fibrils. The membranes may be imbibed with an elastomeric material to form a composite.
摘要翻译：提供包括具有蛇纹状原纤维的膨胀的氟聚合物膜的制品。氟聚合物膜显示高伸长率，同时基本上保持含氟聚合物膜的强度性能。膜可以包括含氟聚合物和/或弹性体。此外，制品在至少一个方向上的延伸至少为约100％，基质抗拉强度为至少约50MPa。制品可以通过以下方式形成：（1）在至少一个方向上膨胀干燥的挤出的含氟聚合物胶带以产生膨胀的含氟聚合物膜，和（2）通过施加热量或通过加入膨胀的氟化聚合物膜在至少一个膨胀方向缩回膨胀的氟聚合物膜溶剂。拉伸力的施加至少部分地拉直蛇形原纤维，从而延长制品。膨胀的氟聚合物膜可以包括基本上只有原纤维的微结构。膜可以用弹性体材料吸收以形成复合材料。

10. 发明授权

US07776101B2 Soft tissue defect repair device 有权
标题翻译：软组织缺损修复装置
公开(公告)号：US07776101B2
公开(公告)日：2010-08-17
申请号：US11015147
申请日：2004-12-17
申请人： Jerald M. Crawley , John M. Herman , William D. Montgomery , Charles F. White
发明人： Jerald M. Crawley , John M. Herman , William D. Montgomery , Charles F. White
IPC分类号： A61F2/02
CPC分类号： A61F2/0063 , A61B17/0057 , A61B2017/00597 , A61B2017/00615
摘要： An inguinal hernia repair device in the form of an implantable plug that is affixed at one end to the center region of a sheet of implantable material. The plug takes the form of a plurality of hollow members, arranged so as to be in substantially parallel relationship when implanted into a defect. The hollow members are preferably tubular members and are preferably bundled together by various means, such as bonding or wrapping a band or strand about the plurality of hollow members to maintain them in adjacent and contacting relationship during insertion into a defect. The device is provided with a base member for anchorage made of a composite material having a non-bioabsorable component and a bioabsorbable component.
摘要翻译：一种可植入式栓塞形式的腹股沟疝修补装置，其一端固定在可植入材料片的中心区域。插头采取多个中空构件的形式，当植入缺陷时被布置成基本上平行的关系。中空构件优选地是管状构件，并且优选地通过各种手段捆扎在一起，例如在多个中空构件周围粘合或缠绕带或股线，以在插入缺陷期间保持它们相邻和接触的关系。该装置设置有用于由具有非生物可吸收组分和生物可吸收组分的复合材料制成的锚固的基底构件。

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