专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20130059308A1 POLYMER MICROFILTERS AND METHODS OF MANUFACTURING THE SAME 审中-公开
标题翻译：聚合物微粉碎机及其制造方法
公开(公告)号：US20130059308A1
公开(公告)日：2013-03-07
申请号：US13696139
申请日：2011-04-01
申请人： Olga V. Makarova , Cha-Mei Tang , Platte T. Amstutz
发明人： Olga V. Makarova , Cha-Mei Tang , Platte T. Amstutz
IPC分类号： B01D39/16 , C12N5/09 , G03F7/20 , C12Q1/68 , G01N33/574 , B32B38/00 , C12Q1/24
CPC分类号： B41F33/0081 , B31B50/006 , B31B50/88 , B31B2100/0022 , B41F33/0036
摘要： A microfilter comprising a polymer layer formed from epoxy-based photo-definable dry film, and a plurality of apertures each extending through the polymer layer. A method of forming a microfilter is also disclosed. The method includes providing a first layer of epoxy-based photo-definable dry film disposed on a substrate, exposing the first layer to energy through a mask to form a pattern, defmed by the mask, in the first layer of dry film, forming, from the exposed first layer of dry film, a polymer layer having a plurality of apertures extending therethrough, the plurality of apertures having a distribution defined by the pattern, and removing the polymer layer from the substrate.
摘要翻译：一种包含由环氧基可光定影干膜形成的聚合物层的微过滤器，以及遍及聚合物层的多个孔。还公开了一种形成微过滤器的方法。该方法包括提供设置在基底上的第一层环氧基光可定义干膜，通过掩模将第一层暴露于能量以形成在第一层干膜中由掩模定义的图案，从曝光的第一层干膜，具有延伸穿过其中的多个孔的聚合物层，所述多个孔具有由图案限定的分布，以及从基底去除聚合物层。

2. 发明申请

US20100002981A1 Sensitive Emission Light Gathering and Flow Through Detection System 有权
标题翻译：敏感发射光收集和流量检测系统
公开(公告)号：US20100002981A1
公开(公告)日：2010-01-07
申请号：US12494152
申请日：2009-06-29
申请人： Cha-Mei Tang , Platte T. Amstutz, III
发明人： Cha-Mei Tang , Platte T. Amstutz, III
IPC分类号： G02B6/00 , G01N21/00
CPC分类号： G01N21/0303 , G01N21/255 , G01N21/645 , G01N2021/6473
摘要： A method of detecting fluorescence/absorbance/luminescence from 24-well, 48-well, 96-well, 384-well and 1536-well microplates and other sample containers. The sample is pumped into a waveguide. The waveguide efficiently gathers and guides the emission light to the end of the waveguide. The emission light exits the ends of the waveguide and is focused into a detector. To minimize background caused by the excitation light used for fluorescence, the excitation illuminates the waveguides at 90 degrees. To facilitate reuse, the waveguide assembly can be configured to be washed by an appropriate wash solution.
摘要翻译：从24孔，48孔，96孔，384孔和1536孔微孔板和其他样品容器中检测荧光/吸光度/发光的方法。将样品泵送到波导中。波导有效地将发射光聚集并引导到波导的末端。发射光离开波导的端部并聚焦到检测器中。为了最小化用于荧光的激发光引起的背景，激发以90度照射波导。为了便于重新使用，波导组件可以被配置为被适当的洗涤溶液洗涤。

3. 发明授权

US06272207B1 Method and apparatus for obtaining high-resolution digital X-ray and gamma ray images 失效
公开(公告)号：US06272207B1
公开(公告)日：2001-08-07
申请号：US09251737
申请日：1999-02-18
申请人： Cha-Mei Tang
发明人： Cha-Mei Tang
IPC分类号： G21K102
CPC分类号： G21K1/025
摘要： An apparatus and method for obtaining a high-resolution digital image of an object or objects irradiated with radiation having a wavelength in the x-ray or gamma ray spectrum generated by a radiation source, or of an object or objects emitting radiation within the x-ray or gamma ray spectrum. The apparatus comprises a detector matrix and a radiation mask. The detector matrix comprises a plurality of detector pixels, each comprising a detection surface having a respective surface area which generates a signal in response to an energy stimulus. The radiation mask has an opaque portion, and a plurality of apertures. The aperture size and position relative to the detector array determines the image resolution not the size of the detector pixels. The mask is positioned between the detector matrix and the radiation source, such that the opaque portion prevents portions of the radiation from passing through the mask, and each of the apertures permits a portion of the radiation which has passed through or has been emitted from a respective portion of the object to propagate onto an area of the detection surface, less than the surface area, of a respective one of the detector pixels. The signal from a large detector pixel or from a group of small detector pixels represent an image of the respective portion of the object. The detector matrix and radiation mask are moved in synchronism in relation to the object to enable the areas of the detection surfaces of the detector pixels to receive portions of the radiation propagating through or emitted from other portions of the object, and to output signals representative of those other portions. These steps of moving the detector pixels and mask and irradiating the object are repeated until digital images of all portions of the object have been obtained. Alternatively, the x-ray source can be moved to image all portions of the object. The images are then arranged into an image representative of the entire object.

4. 发明授权

US5793152A Gated field-emitters with integrated planar lenses 失效
标题翻译：具有集成平面透镜的门控场发射器
公开(公告)号：US5793152A
公开(公告)日：1998-08-11
申请号：US161667
申请日：1993-12-03
申请人： Cha-Mei Tang , Thomas A. Swyden
发明人： Cha-Mei Tang , Thomas A. Swyden
IPC分类号： H01J3/02 , H01J19/24
CPC分类号： H01J3/022
摘要： The present invention is a device for producing collimated electron beams. The device comprises a gated field emission array having at least one emission tip and a grid electrode having a grid opening disposed above the emission tip in a first direction. The device also comprises an integrated planar lens electrode for producing a focusing effect on electron beams emitted by the emission tip. The planar lens electrode has a lens edge disposed aside at a distance from the grid opening in a second direction perpendicular to the first direction. Preferably, the planar lens electrode is an integrated layer with the gated field emission array on a substrate. The grid electrode and the lens electrode can be on the same layer and separated by a gap of vacuum. The planar lens electrode can be above the grid electrode, separated by an insulative material. Similarly, the planar lens electrode can be below the grid electrode, and separated by an insulator material. Sometimes, the base electrode on which the tips are formed can act as a lens.
摘要翻译：本发明是一种用于产生准直电子束的装置。该装置包括具有至少一个发射尖端的栅控场发射阵列和在第一方向上布置在发射尖端上方的格栅的栅格电极。该装置还包括用于产生对由发射尖端发射的电子束的聚焦效果的集成平面透镜电极。平面透镜电极具有在垂直于第一方向的第二方向上与栅格开口一定距离的透镜边缘。优选地，平面透镜电极是在基板上具有门控场致发射阵列的集成层。栅格电极和透镜电极可以在同一层上，并通过真空间隙分离。平面透镜电极可以在栅电极之上，由绝缘材料隔开。类似地，平面透镜电极可以在栅电极之下，并被绝缘体材料分隔开。有时，其上形成尖端的基极可以用作透镜。

5. 发明授权

US10195570B2 Fabrication of microfilters and nanofilters and their applications 有权
公开(公告)号：US10195570B2
公开(公告)日：2019-02-05
申请号：US13345538
申请日：2012-01-06
申请人： Cha-Mei Tang , Olga Makarova
发明人： Cha-Mei Tang , Olga Makarova
IPC分类号： C03C15/00 , C03C25/68 , B01D67/00 , A61M1/34 , B01D69/12 , C12M1/00 , B01D71/46 , B01D71/64 , B01D61/14 , G01N21/64 , G03F7/20
摘要： Micro- and nanofilters with precision pore sizes and pore layout have applications in many fields including capturing circulating tumor cells and fetal cells in blood, water treatment, pathogen detection in water, etc. Methods to fabricate micro- and nanofilters not using track etching or reactive ion etching are provided, allowing easy fabrication of single layer or stack of films simultaneously, and/or stack of films on rolls. Microfilter can be made using one or more layers of material. Invention enables mass production of microfilters with lithographic quality at low cost. Isolation, enumeration and characterization of circulating tumor cells using microfilters provides (i) guides to cancer treatment selection and personalize dosage, (ii) low cost monitoring for treatment response, disease progression and recurrence, (iii) assessment of pharmacodynamic effects, (iv) information on mechanisms of resistance to therapy, and (v) cancer staging. Microfabrication methods are also applicable to fabrication of any free standing patterned polymeric films.

6. 发明授权

US08351741B2 Sensitive emission light gathering and flow through detection system 有权
标题翻译：敏感发射光采集和流过检测系统
公开(公告)号：US08351741B2
公开(公告)日：2013-01-08
申请号：US12494152
申请日：2009-06-29
申请人： Cha-Mei Tang , Platte T. Amstutz, III
发明人： Cha-Mei Tang , Platte T. Amstutz, III
IPC分类号： G02B6/32 , G02B6/42 , G02B6/00
CPC分类号： G01N21/0303 , G01N21/255 , G01N21/645 , G01N2021/6473
摘要： A method of detecting fluorescence/absorbance/luminescence from 24-well, 48-well, 96-well, 384-well and 1536-well microplates and other sample containers. The sample is pumped into a waveguide. The waveguide efficiently gathers and guides the emission light to the end of the waveguide. The emission light exits the ends of the waveguide and is focused into a detector. To minimize background caused by the excitation light used for fluorescence, the excitation illuminates the waveguides at 90 degrees. To facilitate reuse, the waveguide assembly can be configured to be washed by an appropriate wash solution.
摘要翻译：从24孔，48孔，96孔，384孔和1536孔微孔板和其他样品容器中检测荧光/吸光度/发光的方法。将样品泵送到波导中。波导有效地将发射光聚集并引导到波导的末端。发射光离开波导的端部并聚焦到检测器中。为了最小化用于荧光的激发光引起的背景，激发以90度照射波导。为了便于重新使用，波导组件可以被配置为被适当的洗涤溶液洗涤。

7. 发明申请

US20110039267A1 Sample Preparation And Detection Of Analytes Using Silica Beads 审中-公开
标题翻译：使用二氧化硅珠的样品制备和分析物的检测
公开(公告)号：US20110039267A1
公开(公告)日：2011-02-17
申请号：US12856448
申请日：2010-08-13
申请人： Cha-Mei Tang , Daniel Adams , Steingrimur Stefansson
发明人： Cha-Mei Tang , Daniel Adams , Steingrimur Stefansson
IPC分类号： C12Q1/68 , G01N33/569 , B01D15/04
CPC分类号： G01N33/54313 , G01N33/552
摘要： This invention provides methods for concentration of analyte from biological sample, or various liquid samples and methods for identification of the analyte. The method includes providing silica beads conjugated with analyte recognition element for concentration of analyte from sample, packaging the beads into a cartridge, and attaching the cartridge to a sample holder. After the analyte concentration, additional steps can be implemented to identify the analyte to provide visual positive/negative, qualitative or quantitative results. Another exemplary embodiment of the present invention provides a system for concentration of analyte from biological sample or other various liquid samples using silica beads. According to an exemplary implementation, the system includes a cartridge comprising silica beads conjugated with analyte recognition element to concentrate at least one analyte from the sample, and a sample holder having the cartridge attached thereto. A sample is passed through the cartridge.
摘要翻译：本发明提供了用于浓缩来自生物样品或各种液体样品的分析物浓度和用于鉴定分析物的方法的方法。该方法包括提供与分析物识别元件共轭的二氧化硅珠粒，用于浓缩样品中的分析物，将珠子包装到药筒中，以及将药筒附着到样品架上。在分析物浓度之后，可以实施附加步骤来鉴定分析物，以提供视觉正/负，定性或定量结果。本发明的另一个示例性实施方案提供了一种用于使用二氧化硅珠浓缩来自生物样品或其他各种液体样品的分析物的系统。根据示例性实施方式，该系统包括：包含与分析物识别元件共轭的二氧化硅珠的筒，用于从样品中浓缩至少一种分析物，以及具有附着于其上的盒的样品架。样品通过墨盒。

8. 发明授权

US07565042B2 Sensitive emission light gathering and flow through detection system 有权
标题翻译：敏感发射光采集和流过检测系统
公开(公告)号：US07565042B2
公开(公告)日：2009-07-21
申请号：US11705606
申请日：2007-02-13
申请人： Cha-Mei Tang , Platte T Amstulz, III
发明人： Cha-Mei Tang , Platte T Amstulz, III
IPC分类号： G02B6/32 , G02B6/42 , G02B6/00
CPC分类号： G01N21/0303 , G01N21/255 , G01N21/645
摘要： A luminometer is provided comprising a flow through waveguide and one or more detectors. The flow through waveguide has at least two openings and the sample is free to enter from one opening and exit from the other. The flow through waveguide can be made of material that guides emission light to a bottom end of the flow through waveguide. One or more detectors may be provided which detect the emission light coming out of the bottom of the flow through waveguide. A fluorometer/photometer is also provided that comprises a flow through waveguide, one or more excitation light sources, and one or more optical detectors. The flow through waveguide has a hollow region to hold the sample. The excitation light is introduced at an angle or perpendicular to one surface of the flow through waveguide. The flow through waveguide is made of material that can guide absorption and/or emission light to the bottom end of the flow through waveguide. There are one or more detectors that detect the emission light coming out of the bottom of the flow through waveguide.
摘要翻译：提供了一种发光计，其包括流过波导管和一个或多个检测器。通过波导的流动具有至少两个开口，并且样品自由地从一个开口进入并从另一个开口排出。通过波导的流动可以由将发射光引导到通过波导的流动的底端的材料制成。可以提供一个或多个检测器，其检测从通过波导的流的底部出射的发射光。还提供了一种荧光计/光度计，其包括流过波导管，一个或多个激发光源和一个或多个光学检测器。通过波导的流动具有保持样品的中空区域。激发光以与通过波导的流动的一个表面成一角度或垂直的方式引入。通过波导的流动由能够将吸收和/或发射光引导到通过波导的流动的底端的材料制成。存在一个或多个检测器，其检测从通过波导的流动的底部出来的发射光。

9. 发明申请

US20080019658A1 Sensitive emission light gathering and flow through detection system 有权
标题翻译：敏感发射光采集和流过检测系统
公开(公告)号：US20080019658A1
公开(公告)日：2008-01-24
申请号：US11705606
申请日：2007-02-13
申请人： Cha-Mei Tang , Platte Amstulz
发明人： Cha-Mei Tang , Platte Amstulz
IPC分类号： G02B6/10
CPC分类号： G01N21/0303 , G01N21/255 , G01N21/645
摘要： A luminometer is provided comprising a flow through waveguide and one or more detectors. The flow through waveguide has at least two openings and the sample is free to enter from one opening and exit from the other. The flow through waveguide can be made of material that guides emission light to a bottom end of the flow through waveguide. One or more detectors may be provided which detect the emission light coming out of the bottom of the flow through waveguide. A fluorometer/photometer is also provided that comprises a flow through waveguide, one or more excitation light sources, and one or more optical detectors. The flow through waveguide has a hollow region to hold the sample. The excitation light is introduced at an angle or perpendicular to one surface of the flow through waveguide. The flow through waveguide is made of material that can guide absorption and/or emission light to the bottom end of the flow through waveguide. There are one or more detectors that detect the emission light coming out of the bottom of the flow through waveguide.
摘要翻译：提供了一种发光计，其包括流过波导管和一个或多个检测器。通过波导的流动具有至少两个开口，并且样品自由地从一个开口进入并从另一个开口排出。通过波导的流动可以由将发射光引导到通过波导的流动的底端的材料制成。可以提供一个或多个检测器，其检测从通过波导的流的底部出射的发射光。还提供了一种荧光计/光度计，其包括流过波导管，一个或多个激发光源和一个或多个光学检测器。通过波导的流动具有保持样品的中空区域。激发光以与通过波导的流动的一个表面成一角度或垂直的方式引入。通过波导的流动由能够将吸收和/或发射光引导到通过波导的流动的底端的材料制成。存在一个或多个检测器，其检测从通过波导的流动的底部出来的发射光。

10. 发明授权

US06839408B2 Two-dimensional, anti-scatter grid and collimator designs, and its motion, fabrication and assembly 有权
标题翻译：二维，反散射网格和准直器设计及其运动，制造和组装
公开(公告)号：US06839408B2
公开(公告)日：2005-01-04
申请号：US09734761
申请日：2000-12-13
申请人： Cha-Mei Tang
发明人： Cha-Mei Tang
IPC分类号： G21K1/02 , G21K1/00
CPC分类号： G21K1/025
摘要： A grid, for use with electromagnetic energy emitting devices, includes at least metal layer, which is formed, for example, by electroplating. The metal layer includes top and bottom surfaces, and a plurality of solid integrated walls. Each of the solid integrated walls extends from the top to bottom surface and having a plurality of side surfaces. The side surfaces of the solid integrated walls are arranged to define a plurality of openings extending entirely through the layer. At least some of the walls also can include projections extending into the respective openings formed by the walls. The projections can be of various shapes and sizes, and are arranged so that a total amount of wall material intersected by a line propagating in a direction along an edge of the grid is substantially the same as another total amount of wall material intersected by another line propagating in another direction substantially parallel to the edge of the grid at any distance from the edge.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式