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1. 发明授权

US08632511B2 Multiple thermal sensors in a multiple processor environment for temperature control in a drug delivery device 有权
标题翻译：多处理器环境中的多个热传感器用于药物输送装置中的温度控制
公开(公告)号：US08632511B2
公开(公告)日：2014-01-21
申请号：US12774401
申请日：2010-05-05
申请人： Cesario Pereira Dos Santos , Michael LeRoy Gelvin
发明人： Cesario Pereira Dos Santos , Michael LeRoy Gelvin
IPC分类号： A61F7/00 , A61M31/00 , A61M5/00 , A61F7/12
CPC分类号： A61F9/0017 , A61F7/0085 , A61F2007/0095 , A61M5/44
摘要： In various embodiments, an ophthalmic injection device may include a dispensing chamber, a first thermal sensor coupled to the dispensing chamber, a temperature control layer coupled to the dispensing chamber, a second thermal sensor coupled to the dispensing chamber, and a first processing device. The first processing device may be configured to receive temperature information from the first thermal sensor and the second thermal sensor and control the temperature control layer using the received temperature information. In some embodiments, the first processing device may receive temperature information directly from the second thermal sensor (e.g., in analog form) and may compare the temperature information from the first thermal sensor (e.g., received from the second processing device in digital form) and the second thermal sensor to detect temperature offsets between the two sensors.
摘要翻译：在各种实施例中，眼科注射装置可以包括分配室，耦合到分配室的第一热传感器，耦合到分配腔的温度控制层，耦合到分配室的第二热传感器和第一处理装置。第一处理装置可以被配置为从第一热传感器和第二热传感器接收温度信息，并且使用所接收的温度信息来控制温度控制层。在一些实施例中，第一处理设备可以直接从第二热传感器（例如，以模拟形式）接收温度信息，并且可以将来自第一热传感器的温度信息（例如，以数字形式从第二处理设备接收）和第二个热传感器来检测两个传感器之间的温度偏移。

2. 发明申请

US20090093789A1 Method of Delivering A Rate And Temperature - Dependent Substance Into The Eye 审中-公开
标题翻译：提供速率和温度依赖物质进入眼睛的方法
公开(公告)号：US20090093789A1
公开(公告)日：2009-04-09
申请号：US12243729
申请日：2008-10-01
申请人： Bruno Dacquay , Cesario Pereira Dos Santos , Casey Jean Lind , Robert J. Sanchez, JR.
发明人： Bruno Dacquay , Cesario Pereira Dos Santos , Casey Jean Lind , Robert J. Sanchez, JR.
IPC分类号： A61M5/44
CPC分类号： A61F9/0017 , A61M5/14566 , A61M5/445 , A61M2005/14268 , A61M2205/3606 , A61M2205/3653
摘要： A method of injecting a mixture into an eye includes: providing the mixture in a dispensing chamber with an air gap located between the mixture and an interior surface of a dispensing chamber housing, when the mixture and dispensing chamber housing are near room temperature; bringing the dispensing chamber housing and mixture to a temperature range, other than near room temperature, at which the mixture expands and is in a more liquid state; maintaining air in a needle after the mixture expands and prior to an injection; selecting a drug release rate; and injecting the mixture so as to form a shape with a surface area that results in the selected drug release rate.
摘要翻译：将混合物注入到眼睛中的方法包括：当混合物和分配室壳体接近室温时，将混合物提供在分配腔室中，该混合物位于混合物和分配室壳体的内表面之间的气隙; 使分配室壳体和混合物处于不同于室温附近的温度范围，混合物膨胀并处于更液态的温度范围; 在混合物膨胀并且在注射之前，将空气保持在针中; 选择药物释放率; 并注入混合物以形成具有导致所选择的药物释放速率的表面积的形状。

3. 发明申请

US20100286654A1 Multiple Thermal Sensors in a Multiple Processor Environment for Temperature Control in a Drug Delivery Device 有权
标题翻译：多处理器环境中的多个热传感器用于药物输送装置中的温度控制
公开(公告)号：US20100286654A1
公开(公告)日：2010-11-11
申请号：US12774401
申请日：2010-05-05
申请人： Cesario Pereira Dos Santos , Michael LeRoy Gelvin
发明人： Cesario Pereira Dos Santos , Michael LeRoy Gelvin
IPC分类号： A61F7/00 , A61M5/31
CPC分类号： A61F9/0017 , A61F7/0085 , A61F2007/0095 , A61M5/44
摘要： In various embodiments, an ophthalmic injection device may include a dispensing chamber, a first thermal sensor coupled to the dispensing chamber, a temperature control layer coupled to the dispensing chamber, a second thermal sensor coupled to the dispensing chamber, and a first processing device. The first processing device may be configured to receive temperature information from the first thermal sensor and the second thermal sensor and control the temperature control layer using the received temperature information. In some embodiments, the first processing device may receive temperature information directly from the second thermal sensor (e.g., in analog form) and may compare the temperature information from the first thermal sensor (e.g., received from the second processing device in digital form) and the second thermal sensor to detect temperature offsets between the two sensors.
摘要翻译：在各种实施例中，眼科注射装置可以包括分配室，耦合到分配室的第一热传感器，耦合到分配室的温度控制层，耦合到分配室的第二热传感器和第一处理装置。第一处理装置可以被配置为从第一热传感器和第二热传感器接收温度信息，并且使用所接收的温度信息来控制温度控制层。在一些实施例中，第一处理设备可以直接从第二热传感器（例如，以模拟形式）接收温度信息，并且可以将来自第一热传感器的温度信息（例如，以数字形式从第二处理设备接收）和第二个热传感器来检测两个传感器之间的温度偏移。

4. 发明申请

US20100286632A1 Multi-Layer Heat Assembly For A Drug Delivery Device 有权
标题翻译：用于药物输送装置的多层热组件
公开(公告)号：US20100286632A1
公开(公告)日：2010-11-11
申请号：US12774363
申请日：2010-05-05
申请人： Cesario Pereira Dos Santos
发明人： Cesario Pereira Dos Santos
IPC分类号： A61M35/00
CPC分类号： A61F9/0017 , A61F7/0085 , A61F2007/0095 , A61M5/44
摘要： In various embodiments, an ophthalmic injection device may include a dispensing chamber to hold a substance (e.g., a drug) to be injected into an eye, a thermal feedback layer with at least one thermal sensor, and a temperature control layer to apply or remove heat from the dispensing chamber. In some embodiments, the thermal feedback layer and the temperature control layer may be coupled to each other and/or coupled to the dispensing chamber. In some embodiments, at least one of the thermal sensors may be secured between the temperature control layer and the dispensing chamber using a thermal adhesive.
摘要翻译：在各种实施例中，眼科注射装置可以包括分配腔室，用于保持待注射到眼睛中的物质（例如药物），具有至少一个热传感器的热反馈层和温度控制层以施加或移除来自分配室的热量。在一些实施例中，热反馈层和温度控制层可以彼此耦合和/或耦合到分配室。在一些实施例中，热传感器中的至少一个可以使用热粘合剂固定在温度控制层和分配室之间。

5. 发明申请

US20090093788A1 Thermal Coefficient Driven Drug Pellet Size For Ophthalmic Injection 审中-公开
标题翻译：用于眼科注射的热系数驱动药丸粒径
公开(公告)号：US20090093788A1
公开(公告)日：2009-04-09
申请号：US12243365
申请日：2008-10-01
申请人： Robert J. Sanchez, JR. , Cesario Pereira Dos Santos
发明人： Robert J. Sanchez, JR. , Cesario Pereira Dos Santos
IPC分类号： A61M5/44
CPC分类号： A61F9/0017 , A61K9/0048 , A61K9/0051 , A61M37/0069 , A61M2005/3123
摘要： A method of injecting a mixture into an eye includes: providing the mixture in a dispensing chamber with an air gap located between the mixture and an interior surface of a dispensing chamber housing, when the mixture and dispensing chamber housing are near room temperature; bringing the dispensing chamber housing and mixture to a temperature range at which the mixture expands and is in a more liquid state; maintaining air in a needle after the mixture expands and prior to an injection; and injecting the air in the needle and the mixture into the eye.
摘要翻译：将混合物注入到眼睛中的方法包括：当混合物和分配室壳体接近室温时，将混合物提供在分配腔室中，该混合物位于混合物和分配室壳体的内表面之间的气隙; 使分配腔室和混合物达到混合物膨胀并处于更液体状态的温度范围; 在混合物膨胀并且在注射之前，将空气保持在针中; 并将针中的空气和混合物注入眼睛。

6. 发明授权

US08372036B2 Multi-layer heat assembly for a drug delivery device 有权
标题翻译：用于药物输送装置的多层热装配
公开(公告)号：US08372036B2
公开(公告)日：2013-02-12
申请号：US12774363
申请日：2010-05-05
申请人： Cesario Pereira Dos Santos
发明人： Cesario Pereira Dos Santos
IPC分类号： A61F7/12 , A61M5/00 , A61M35/00 , E21B7/15 , A61C19/00
CPC分类号： A61F9/0017 , A61F7/0085 , A61F2007/0095 , A61M5/44
摘要： In various embodiments, an ophthalmic injection device may include a dispensing chamber to hold a substance (e.g., a drug) to be injected into an eye, a thermal feedback layer with at least one thermal sensor, and a temperature control layer to apply or remove heat from the dispensing chamber. In some embodiments, the thermal feedback layer and the temperature control layer may be coupled to each other and/or coupled to the dispensing chamber. In some embodiments, at least one of the thermal sensors may be secured between the temperature control layer and the dispensing chamber using a thermal adhesive.
摘要翻译：在各种实施例中，眼科注射装置可以包括分配腔室，用于保持待注射到眼睛中的物质（例如药物），具有至少一个热传感器的热反馈层和温度控制层以施加或移除来自分配室的热量。在一些实施例中，热反馈层和温度控制层可以彼此耦合和/或耦合到分配室。在一些实施例中，热传感器中的至少一个可以使用热粘合剂固定在温度控制层和分配室之间。

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