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1. 发明授权

US07459614B2 Method for generating an artificially patterned substrate for stimulating the crystallation of a biomolecule thereon and method for stimulating the crystallization of biomolecules 有权
标题翻译：用于产生用于刺激生物分子的结晶的人造图案化基底的方法及其刺激生物分子结晶的方法
公开(公告)号：US07459614B2
公开(公告)日：2008-12-02
申请号：US10916472
申请日：2004-08-12
申请人： Celestino Padeste , Christian Kambach , Jens Grobrecht , Harun Solak
发明人： Celestino Padeste , Christian Kambach , Jens Grobrecht , Harun Solak
IPC分类号： C30B7/00 , C30B19/00 , G02B27/00
CPC分类号： G03F7/00 , C07K1/306 , C30B7/00 , C30B29/58 , Y10S977/888
摘要： It is the aim of the invention to provide a technology for the stimulation of the crystallization of biomolecules contained in a liquid solution that leads to significant improvements in the reliability of crystal growth processes and shortens the time and the number of attempts to grow a certain biomolecule crystal, also under the condition that only very small amounts of the biomolecules are available.
摘要翻译：本发明的目的是提供一种用于刺激液体溶液中包含的生物分子的结晶的技术，其导致晶体生长过程的可靠性的显着改善，并缩短了生长某些生物分子的时间和次数晶体，也是在只有非常少量的生物分子可用的条件下。

2. 发明申请

US20060234062A1 Method for grafting a chemical compound to a support substrate 审中-公开
标题翻译：将化学化合物接枝到支撑基底上的方法
公开(公告)号：US20060234062A1
公开(公告)日：2006-10-19
申请号：US10563112
申请日：2004-06-12
申请人： Hans-Peter Brack , Celestino Padeste , Michal Slaski , Harun Solak
发明人： Hans-Peter Brack , Celestino Padeste , Michal Slaski , Harun Solak
IPC分类号： B05D3/00 , G11B5/64 , C23C16/00 , B32B27/00 , B32B27/30
CPC分类号： C08J7/18 , Y10T428/24355 , Y10T428/3154 , Y10T428/31544 , Y10T428/31855 , Y10T428/31935 , Y10T428/31938
摘要： According to the present invention a method for grafting a chemical compound to a predetermined region of a support substrate (4) is disclosed, comprising: a) irradiating selectively the support substrate with electromagnetic radiation and/or particle radiation in order to both define said predetermined region and to form at least one reactive functional group or a precursor thereof in said predetermined region of the support substrate; b) exposing the irradiated support substrate to said chemical compound or to a precursor thereof. Therefore, only these very few steps are needed to effectively grafting the desired chemical compound, such as an organic compound, to the predetermined regions of the support substrate. Moreover, the irradiation step can be carried out in a vastly flexible manner and allows to generate numerous distinct shapes of the predetermined regions. Further, micro- or nano-scale regions in the support substrate capable of forming reactive functional groups or precursors thereof upon exposure to particle or electromagnetic irradiation can be easily achieved.
摘要翻译：根据本发明，公开了一种用于将化学化合物接枝到支撑衬底（4）的预定区域的方法，包括：a）用电磁辐射和/或粒子辐射选择性地照射支撑衬底，以便将所述预定的并且在所述支撑衬底的所述预定区域中形成至少一个反应性官能团或其前体; b）将照射的支撑基底暴露于所述化合物或其前体。因此，为了有效地将期望的化合物（例如有机化合物）接枝到支撑基底的预定区域，仅需要这几个步骤。此外，照射步骤可以以非常灵活的方式进行，并且允许产生许多不同形状的预定区域。此外，可以容易地实现能够在暴露于粒子或电磁辐射时能够形成反应性官能团或其前体的支持基底中的微尺度或纳米级区域。

3. 发明申请

US20070111256A1 Method for generating an artificially patterned substrate for stimulating the crystallation of a biomolecule thereon and method for stimulating the crystallization of biomolecules 有权
标题翻译：用于产生用于刺激生物分子的结晶的人造图案化基底的方法及其刺激生物分子结晶的方法
公开(公告)号：US20070111256A1
公开(公告)日：2007-05-17
申请号：US10916472
申请日：2004-08-12
申请人： Jens Grobrecht , Harun Solak , Celestino Padeste , Christian Kambach
发明人： Jens Grobrecht , Harun Solak , Celestino Padeste , Christian Kambach
IPC分类号： G01N33/53 , G01N33/552 , H01L21/00
CPC分类号： G03F7/00 , C07K1/306 , C30B7/00 , C30B29/58 , Y10S977/888
摘要： It is the aim of the invention to provide a technology for the stimulation of the crystallization of biomolecules contained in a liquid solution that leads to significant improvements in the reliability of crystall growth processes and shortens the time and the number of attempts to grow a certain biomolecule crystal, also under the condition that only very small amounts of the biomolecules are available.
摘要翻译：本发明的目的是提供一种用于刺激液体溶液中包含的生物分子的结晶的技术，其导致结晶生长过程的可靠性的显着改善，并缩短了生长某些生物分子的时间和次数晶体，也是在只有非常少量的生物分子可用的条件下。

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