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1. 发明申请

US20200222531A1 METHODS OF POPULATING PRECIPITATED PARTICLES OF A MODIFIED OR SYNTHESIZED SUBSTANCE IN A TISSUE 审中-公开
公开(公告)号：US20200222531A1
公开(公告)日：2020-07-16
申请号：US16664849
申请日：2019-10-26
申请人： Robert E. Coifman , Catherine F. Yang
发明人： Robert E. Coifman , Catherine F. Yang
IPC分类号： A61K39/35 , A61K39/00 , A61K9/00 , A61K47/02
摘要： Provided herein are methods of populating a target tissue of interest of a subject with precipitated particles of a modified or synthesized substance of interest, in which tissue the precipitated particles remain where they are formed for a sufficient time to begin their interaction with the physiology of the recipient in the physical state and locations in which they were formed, when the unmodified/unsynthesized form of the substance does not innately have the requisite solubility properties to be delivered to such tissues within the body of a designated target tissue by precipitation. The present methods include precipitating particles of the modified or synthesized substance within the target tissue by administering a solution to the target tissue of interest of a subject. The solution includes a pharmaceutically acceptable, water-miscible, non-aqueous solvent that is freely miscible with tissue fluids of the target tissue; and the modified or synthesized substance of interest, which is modified or synthesized to confer the presently required solubility properties of being soluble in the solvent and insoluble in tissue fluids of the target tissue of interest.

2. 发明申请

US20150284308A1 EXTRACTION AND PURIFICATION OF URUSHIOL FROM BOTANICAL SOURCES 有权
标题翻译：从植物来源提取和纯化尿素
公开(公告)号：US20150284308A1
公开(公告)日：2015-10-08
申请号：US14646198
申请日：2013-11-21
申请人： Catherine F. YANG , Weixing LI , Ryan ELLIOTT , Nikita ILTCHENCKO , ROWAN UNIVERSITY
发明人： Catherine F. Yang , Weixing Li , Ryan Elliott , Nikita Iltchencko
IPC分类号： C07C35/14 , B01D11/02
CPC分类号： C07C35/14 , A61K36/22 , A61K2236/00 , B01D11/02 , B01D11/0288
摘要： The disclosure relates to methods for preparing urushiol from plants including, for example, poison ivy or poison oak. The methods include extraction of plant material using a primary organic solvent more polar than ethanol, followed by a solvent extraction using substantially immiscible solvents having substantially different polarities, such as hexane and acetonitrile. The method can include further purification, such as by fractionation of solvent-extracted materials using a thiazole-derivatized silica gel chromatography medium. The extracts thus generated can exhibit greater purity, higher concentration, and greater stability than extracts made using previously-known methods. The extracts can be particularly suitable for use in immunotherapeutic methods, such as desensitizing individuals who normally develop allergic contact dermatitis attributable to poison ivy or poison oak.
摘要翻译：本公开涉及从植物制备漆酚的方法，包括例如毒藤或毒栎。所述方法包括使用比乙醇更极性的主要有机溶剂提取植物材料，然后使用基本上不相溶的溶剂（其具有基本上不同的极性，例如己烷和乙腈）进行溶剂萃取。该方法可以包括进一步纯化，例如通过使用噻唑衍生的硅胶色谱介质对溶剂萃取物进行分级分离。由此产生的提取物可以表现出比使用先前已知方法制备的提取物更高的纯度，更高的浓度和更高的稳定性。提取物可以特别适用于免疫治疗方法，例如通常发生归因于毒藤或毒栎的过敏性接触性皮炎的个体脱敏。

3. 发明申请

US20150140040A1 METHODS OF DEPOSITING PARTICLES OF A SUBSTANCE IN A TISSUE 审中-公开
标题翻译：沉积组织中物质颗粒的方法
公开(公告)号：US20150140040A1
公开(公告)日：2015-05-21
申请号：US14567500
申请日：2014-12-11
申请人： Robert E. COIFMAN , Catherine F. YANG
发明人： Robert E. COIFMAN , Catherine F. YANG
IPC分类号： A61K39/35
CPC分类号： A61K39/35 , A61K2039/54 , A61K2039/55505 , A61K2039/55511 , A61K2039/577
摘要： Provided herein are methods of populating a target tissue of interest of a subject with particles of a substance of interest by precipitation. Example methods include administering a solution to a subject, the solution including the substance of interest and a pharmaceutically acceptable solvent. The substance of interest must be soluble in a pharmaceutically acceptable, water-miscible solvent but insoluble in tissue fluids of the target tissue of interest; and the pharmaceutically acceptable solvent must be freely miscible with the tissue fluids of the target tissue of interest. According to example embodiments, the solution is administered in a volume of the pharmaceutically acceptable solvent that will be diluted by tissue fluids in the target tissue of interest following administration at a rate that will result in precipitation of an effective amount of particles of the substance of interest in a range of sizes that will accomplish a purpose for which the substance is administered. Examples of the present methods include administering the solution to tissue of an animal, such that the substance of interest in the solution precipitates and provides an effective amount of insoluble particles of the substance of interest to the tissue. Also provided are kits that include the solution or components thereof; and methods of making such solutions.
摘要翻译：本文提供了通过沉淀将目标物质的目标物质填充到感兴趣物质的目标组织的方法。示例性方法包括向受试者施用溶液，所述溶液包括目标物质和药学上可接受的溶剂。感兴趣的物质必须可溶于药学上可接受的与水混溶的溶剂，但不溶于感兴趣的靶组织的组织液中; 并且药学上可接受的溶剂必须与感兴趣的目标组织的组织液自由混溶。根据示例性实施方案，溶液以一定体积的药学上可接受的溶剂施用，其将在施用后以目标组织中的组织液稀释，速率将导致有效量的物质颗粒沉淀对一系列尺寸的兴趣，这些尺寸将达到实施该物质的目的。本方法的实例包括将溶液施用于动物的组织，使得溶液中的目标物质沉淀，并向组织提供有效量的目标物质的不溶性颗粒。还提供了包括溶液或其组分的试剂盒; 以及制作这种解决方案的方法。

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