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1. 发明申请

US20150284308A1 EXTRACTION AND PURIFICATION OF URUSHIOL FROM BOTANICAL SOURCES 有权
标题翻译：从植物来源提取和纯化尿素
公开(公告)号：US20150284308A1
公开(公告)日：2015-10-08
申请号：US14646198
申请日：2013-11-21
申请人： Catherine F. YANG , Weixing LI , Ryan ELLIOTT , Nikita ILTCHENCKO , ROWAN UNIVERSITY
发明人： Catherine F. Yang , Weixing Li , Ryan Elliott , Nikita Iltchencko
IPC分类号： C07C35/14 , B01D11/02
CPC分类号： C07C35/14 , A61K36/22 , A61K2236/00 , B01D11/02 , B01D11/0288
摘要： The disclosure relates to methods for preparing urushiol from plants including, for example, poison ivy or poison oak. The methods include extraction of plant material using a primary organic solvent more polar than ethanol, followed by a solvent extraction using substantially immiscible solvents having substantially different polarities, such as hexane and acetonitrile. The method can include further purification, such as by fractionation of solvent-extracted materials using a thiazole-derivatized silica gel chromatography medium. The extracts thus generated can exhibit greater purity, higher concentration, and greater stability than extracts made using previously-known methods. The extracts can be particularly suitable for use in immunotherapeutic methods, such as desensitizing individuals who normally develop allergic contact dermatitis attributable to poison ivy or poison oak.
摘要翻译：本公开涉及从植物制备漆酚的方法，包括例如毒藤或毒栎。所述方法包括使用比乙醇更极性的主要有机溶剂提取植物材料，然后使用基本上不相溶的溶剂（其具有基本上不同的极性，例如己烷和乙腈）进行溶剂萃取。该方法可以包括进一步纯化，例如通过使用噻唑衍生的硅胶色谱介质对溶剂萃取物进行分级分离。由此产生的提取物可以表现出比使用先前已知方法制备的提取物更高的纯度，更高的浓度和更高的稳定性。提取物可以特别适用于免疫治疗方法，例如通常发生归因于毒藤或毒栎的过敏性接触性皮炎的个体脱敏。

2. 发明授权

US6071965A Phosphinic alkanoic acid derivatives 失效
标题翻译：膦酸链烷酸衍生物
公开(公告)号：US6071965A
公开(公告)日：2000-06-06
申请号：US2147
申请日：1997-12-31
申请人： Paul F. Jackson , Weixing Li , Keith M. Maclin , Kevin L. Tays , Takashi Tsukamoto , Barbara S. Slusher
发明人： Paul F. Jackson , Weixing Li , Keith M. Maclin , Kevin L. Tays , Takashi Tsukamoto , Barbara S. Slusher
IPC分类号： A61K31/00 , A61K31/194 , A61K31/66 , A61K31/665 , A61K31/67 , A61K31/675 , A61K38/05 , A61K38/06 , C07F9/30 , C07F9/32 , C07F9/38 , C07F9/40 , C07F9/44 , C07F9/58 , C07F9/655 , C07F9/6553 , C12N9/99 , C07F9/28
CPC分类号： C07F9/582 , A61K31/00 , A61K31/194 , A61K31/66 , A61K31/661 , A61K31/662 , A61K31/664 , A61K31/665 , A61K31/67 , A61K31/675 , A61K38/05 , A61K38/06 , C07F9/301 , C07F9/3211 , C07F9/3808 , C07F9/3826 , C07F9/4075 , C07F9/4465 , C07F9/65515 , C07F9/6552 , C07F9/655345
摘要： The present invention relate to phosphinic alkanoic acid derivatives that inhibit N-Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising the same, and methods of using the same to inhibit NAALADase activity and to treat glutamate abnormalities and prostate diseases.
摘要翻译：本发明涉及抑制N-乙酰化的α-酸性二酸二肽酶（NAALADase）酶活性的次膦酸链烷酸衍生物，含有它们的药物组合物及其使用方法抑制NAALADase活性和治疗谷氨酸异常和前列腺疾病。

3. 发明申请

US20140210862A9 ICON GENERATION METHOD 有权
标题翻译：图标生成方法
公开(公告)号：US20140210862A9
公开(公告)日：2014-07-31
申请号：US14005216
申请日：2012-03-13
申请人： Weixing Li , Tian Ren , Wanqiang Li , Jiangji Huang
发明人： Weixing Li , Tian Ren , Wanqiang Li , Jiangji Huang
IPC分类号： G06F3/0481
CPC分类号： G06F3/04817 , G06F8/38 , G06T11/00 , G06T11/001
摘要： Disclosed is an icon generation method, comprising: adjusting an original icon to a preset size for a certain resolution environment; determining statistics for the color values of all pixels of the original icon and calculating a dominant hue of the original icon; generating a background color based on a hue angle of the dominant hue and preset values of color saturation and brightness; applying the background color to a preset color gradient template to generate an icon background; cutting the adjusted icon by using a preset icon edge cutting template; and combining the icon background, the cut icon, and a preset icon foreground template to generate a final icon. Through the disclosed solution, new icons complying with a unified system style can be generated, and content consistency of the new icons can be best ensured.
摘要翻译：公开了一种图标生成方法，包括：在特定分辨率环境下将原始图标调整为预设大小; 确定原始图标的所有像素的颜色值的统计量并计算原始图标的主色调; 根据主色调的色相角和颜色饱和度和亮度的预设值生成背景颜色; 将背景颜色应用于预设的颜色渐变模板以生成图标背景; 使用预设图标边缘切割模板切割调整后的图标; 并组合图标背景，剪切图标和预设图标前景模板以生成最终图标。通过公开的解决方案，可以生成符合统一系统风格的新图标，最大限度地保证新图标的内容一致性。

4. 发明申请

US20110210001A1 CLEANING PROCESS OF PRODUCING LACTIC ACID 有权
标题翻译：生产酸乳的清洁工艺
公开(公告)号：US20110210001A1
公开(公告)日：2011-09-01
申请号：US13127307
申请日：2009-04-20
申请人： Nanping Xu , Weixing Li , Weihong Xing , Yiqun Fan
发明人： Nanping Xu , Weixing Li , Weihong Xing , Yiqun Fan
IPC分类号： C12P7/56 , B01D61/44 , C07C59/08 , C12R1/225
CPC分类号： B01D61/445 , B01D61/027 , B01D61/422 , B01D61/58 , C07C51/44 , C12N1/22 , C12P7/56 , C07C59/08
摘要： Provided is a cleaning process of producing lactic acid. Firstly saccharification liquid is prepared through saccharated materials, then fermented with nutritive materials and lactic acid bacteria, and liquid alkali is used to adjust the pH. The fermentation broth is filtrated with porous membrane, and the lactic acid bacteria in the interception liquid are then reintroduced into the porous membrane for recycling. The permeate from porous membrane is subjected to nanofiltration to be decoloured and purified. The concentrated solution from nanofiltration and the cleaning liquid from fermentation tank and its affiliated equipment are filtrated and sterilized by using ceramic membrane, and then are reintroduced into the fermentation unit for recycling. The permeate from nanofiltration is then subjected to bipolar electrodialysis system to prepare lactic acid, and the liquid alkali produced at the same time is reintroduced into the fermentation tank for recycling. The lactic acid is finally concentrated by using vacuum distillation. The process recycles the bacteria in the liquid alkali and matured fermentation broth, and is characterized by low material consumption and emission, low pollution, reduced cost and cleanness and environmentally protection of the whole production process.
摘要翻译：提供了生产乳酸的清洗方法。首先通过糖化物质制备糖化液，然后用营养物质和乳酸菌发酵，并使用液态碱调节pH值。用多孔膜过滤发酵肉汤，然后将拦截液中的乳酸菌重新引入多孔膜进行再循环。对来自多孔膜的渗透物进行纳米过滤以进行脱色和纯化。来自纳滤的浓缩溶液和来自发酵罐及其附属设备的清洗液通过陶瓷膜过滤灭菌，然后重新引入发酵单元进行再循环。然后将来自纳滤的渗透物进行双极电渗析系统以制备乳酸，同时产生的液碱再次引入发酵罐中进行再循环。最后通过真空蒸馏浓缩乳酸。该工艺循环利用液态碱和成熟发酵液中的细菌，其特点是材料消耗低，污染少，成本低廉，整个生产过程的清洁和环保。

5. 发明授权

US09310964B2 Icon generation method 有权
标题翻译：图标生成方法
公开(公告)号：US09310964B2
公开(公告)日：2016-04-12
申请号：US14005216
申请日：2012-03-13
申请人： Weixing Li , Tian Ren , Wanqiang Li , Jiangji Huang
发明人： Weixing Li , Tian Ren , Wanqiang Li , Jiangji Huang
IPC分类号： G06F3/0481 , G09G5/00 , G06F9/44 , G06T11/00
CPC分类号： G06F3/04817 , G06F8/38 , G06T11/00 , G06T11/001
摘要： Disclosed is an icon generation method, comprising: adjusting an original icon to a preset size for a certain resolution environment; determining statistics for the color values of all pixels of the original icon and calculating a dominant hue of the original icon; generating a background color based on a hue angle of the dominant hue and preset values of color saturation and brightness; applying the background color to a preset color gradient template to generate an icon background; cutting the adjusted icon by using a preset icon edge cutting template; and combining the icon background, the cut icon, and a preset icon foreground template to generate a final icon. Through the disclosed solution, new icons complying with a unified system style can be generated, and content consistency of the new icons can be best ensured.
摘要翻译：公开了一种图标生成方法，包括：在特定分辨率环境下将原始图标调整为预设大小; 确定原始图标的所有像素的颜色值的统计量并计算原始图标的主色调; 根据主色调的色相角和颜色饱和度和亮度的预设值生成背景颜色; 将背景颜色应用于预设的颜色渐变模板以生成图标背景; 使用预设图标边缘切割模板切割调整后的图标; 并组合图标背景，剪切图标和预设图标前景模板以生成最终图标。通过公开的解决方案，可以生成符合统一系统风格的新图标，最大限度地保证新图标的内容一致性。

6. 发明授权

US09115082B2 Dipeptidyl-peptidase-IV inhibitors for treatment of type 2 diabetes complex with hypertension 有权
标题翻译：用于治疗高血压的2型糖尿病复合物的二肽基肽酶-IV抑制剂
公开(公告)号：US09115082B2
公开(公告)日：2015-08-25
申请号：US13744795
申请日：2013-01-18
申请人： Catherine Yang , Weixing Li
发明人： Catherine Yang , Weixing Li
IPC分类号： C07D207/16 , A61K31/40
CPC分类号： C07D207/16 , A61K31/40 , C07D295/185 , C07D295/192
摘要： The invention comprises novel inhibitors of dipeptidyl peptidase IV (DPP-IV) with beta blocker activity, pharmaceutical compositions comprising therapeutically effective amounts of novel inhibitors of DPP-IV, and novel methods of treating medical conditions are provided. The novel inhibitors of DPP-IV described herein are useful in the treatment of neurological disorders, diabetes, inflammatory disorders such as arthritis, obesity, osteoporosis, hypertension, and glaucoma of such other enumerated conditions as can be treated with inhibitors of DPP-IV and beta blockers.
摘要翻译：本发明包括具有β-阻滞剂活性的二肽基肽酶IV（DPP-IV）的新型抑制剂，包含治疗有效量的DPP-IV新型抑制剂的药物组合物，以及治疗医学病症的新方法。本文描述的DPP-IV的新型抑制剂可用于治疗神经障碍，糖尿病，诸如关节炎，肥胖症，骨质疏松症，高血压和青光眼的炎症性疾病，其可以用DPP-IV抑制剂和 β受体阻滞剂

7. 发明申请

US20130184322A1 NOVEL DIPEPTIDYL-PEPTIDASE-IV INHIBITORS 审中-公开
标题翻译：新型DIPEPTIDYL-PEPTIDASE-IV抑制剂
公开(公告)号：US20130184322A1
公开(公告)日：2013-07-18
申请号：US13744795
申请日：2013-01-18
申请人： Weixing Li , Catherine Yang
发明人： Weixing Li , Catherine Yang
IPC分类号： C07D207/16
CPC分类号： C07D207/16 , A61K31/40 , C07D295/185 , C07D295/192
摘要： The invention comprises novel inhibitors of dipeptidyl peptidase IV (DPP-IV) with beta blocker activity, pharmaceutical compositions comprising therapeutically effective amounts of novel inhibitors of DPP-IV, and novel methods of treating medical conditions are provided. The novel inhibitors of DPP-IV described herein are useful in the treatment of neurological disorders, diabetes, inflammatory disorders such as arthritis, obesity, osteoporosis, hypertension, and glaucoma of such other enumerated conditions as can be treated with inhibitors of DPP-IV and beta blockers.
摘要翻译：本发明包括具有β-阻滞剂活性的二肽基肽酶IV（DPP-IV）的新型抑制剂，包含治疗有效量的DPP-IV新型抑制剂的药物组合物，以及治疗医学病症的新方法。本文描述的DPP-IV的新型抑制剂可用于治疗神经障碍，糖尿病，诸如关节炎，肥胖症，骨质疏松症，高血压和青光眼的炎症性疾病，其可以用DPP-IV抑制剂和 β受体阻滞剂

8. 发明申请

US20050070719A1 Inhibitors of dipeptidyl peptidase iv 审中-公开
标题翻译：二肽基肽酶抑制剂
公开(公告)号：US20050070719A1
公开(公告)日：2005-03-31
申请号：US10499675
申请日：2002-12-26
申请人： Sergei Belyakov , Gregory Hamilton , David Hurst , Vincent Kalish , Weixing Li , Eric Wang , Douglas Wilkinson , Yong-Qian Wu , Weizheng Xu
发明人： Sergei Belyakov , Gregory Hamilton , David Hurst , Vincent Kalish , Weixing Li , Eric Wang , Douglas Wilkinson , Yong-Qian Wu , Weizheng Xu
IPC分类号： C07D295/18 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/404 , A61K31/426 , A61K31/427 , A61K31/4453 , A61K31/472 , A61K31/4725 , A61K31/5375 , A61K38/00 , A61K45/00 , A61P1/14 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , A61P7/02 , A61P9/00 , A61P9/10 , A61P15/00 , A61P15/16 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/10 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/04 , A61P37/00 , A61P37/06 , A61P39/02 , A61P41/00 , A61P43/00 , C07D205/04 , C07D207/04 , C07D207/16 , C07D207/20 , C07D207/22 , C07D209/18 , C07D209/42 , C07D209/46 , C07D209/48 , C07D217/14 , C07D217/16 , C07D217/22 , C07D217/26 , C07D233/60 , C07D263/06 , C07D277/04 , C07D277/06 , C07D295/125 , C07D295/185 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D409/06 , C07D417/06 , C07K5/078 , C07K5/097
CPC分类号： C07D209/48 , A61K38/00 , C04B35/632 , C07D205/04 , C07D207/04 , C07D207/16 , C07D207/20 , C07D207/22 , C07D209/42 , C07D209/46 , C07D217/14 , C07D217/16 , C07D217/26 , C07D263/06 , C07D277/04 , C07D277/06 , C07D295/125 , C07D295/185 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D409/06 , C07D417/06 , C07K5/06156 , C07K5/0821
摘要： Novel inhibitors of dipeptidyl peptidase IV (DPP IV), pharmaceutical compositions comprising therapeutically effective amounts of novel inhibitors of DPP IV, and novel methods of treating medical conditions are provided. The novel inhibitors of DPP IV described herein are useful in the treatment of neurological disorders, diabetes, inflammatory disorders such as arthritis, obesity, osteoporosis, and of such other enumerated conditions as can be treated with inhibitors of DPP IV.
摘要翻译：提供了二肽基肽酶IV（DPP IV）的新型抑制剂，包含治疗有效量的新型DPP IV抑制剂的药物组合物，以及治疗医学病症的新方法。本文描述的DPP IV的新型抑制剂可用于治疗神经障碍，糖尿病，炎症性疾病如关节炎，肥胖症，骨质疏松症以及可用DPP IV抑制剂治疗的其他列举的病症。

9. 发明授权

US06635786B2 Symmetrically disubstituted aromatic compounds and pharmaceutical compositions for inhibiting poly (ADP-ribose) glycohydrolase, and methods for their use 失效
公开(公告)号：US06635786B2
公开(公告)日：2003-10-21
申请号：US09829827
申请日：2001-04-10
申请人： Jia-He Li , Dana Victor Ferraris , Paul W. Kletzly , Weixing Li , Eric Yanjun Wang , Amy D. Xing , Weizheng Xu , Jie Zhang
发明人： Jia-He Li , Dana Victor Ferraris , Paul W. Kletzly , Weixing Li , Eric Yanjun Wang , Amy D. Xing , Weizheng Xu , Jie Zhang
IPC分类号： C07C23300
CPC分类号： C07D207/325 , C07C69/76 , C07C225/16 , C07C233/65 , C07C233/66 , C07C233/69 , C07C233/73 , C07C255/46 , C07C311/46 , C07C2601/14 , C07C2603/18 , C07C2603/40 , C07D213/30 , C07D213/40 , C07D295/13 , C07D295/192 , C07D311/82 , C07D311/86 , C07D327/08 , C07D411/12
摘要： Symmetrically disubstituted aromatic compounds and pharmaceutical compositions containing such compounds that inhibit and/or modulate the activity of poly(ADP-ribose) glycohydrolase, also known as PARG, are described. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.

10. 发明申请

US20140325195A1 METHOD FOR UNLOCKING A MOBILE DEVICE 审中-公开
标题翻译：解锁移动设备的方法
公开(公告)号：US20140325195A1
公开(公告)日：2014-10-30
申请号：US14128761
申请日：2012-03-19
申请人： Ruijun Xu , Fei Xu , Fan Jin , Feng Liang , Tian Ren , Weixing Li , Guangdou Sun , Zhifan Qin , Wanqiang Li , Jiangji Huang
发明人： Ruijun Xu , Fei Xu , Fan Jin , Feng Liang , Tian Ren , Weixing Li , Guangdou Sun , Zhifan Qin , Wanqiang Li , Jiangji Huang
IPC分类号： G06F9/00
CPC分类号： G06F9/00 , H04M1/67 , H04M1/72544
摘要： The present disclosure is drawn to a method for unlocking a mobile device. The method comprises the steps of adopting a configuration file to define an operational input for unlocking the mobile device, adopting the configuration file to define at least one animation and/or effect, adopting the configuration file to establish a relationship between the operational input and the at least one animation and/or effect, and triggering the animation and/or effect when unlocking the mobile device. The technical scheme of the present disclosure combines the operational input for unlocking the mobile device with the animation and/or effect, helping to improve the user experience of unlocking a mobile device.
摘要翻译：本公开涉及用于解锁移动设备的方法。该方法包括以下步骤：采用配置文件来定义用于解锁移动设备的操作输入，采用配置文件来定义至少一个动画和/或效果，采用配置文件建立操作输入与至少一个动画和/或效果，并且当解锁移动设备时触发动画和/或效果。本公开的技术方案将用于解锁移动设备的操作输入与动画和/或效果相结合，有助于改善解锁移动设备的用户体验。

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