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    • 3. 发明授权
    • Coupling elements for surface plasmon resonance sensors
    • 表面等离子体共振传感器的耦合元件
    • US06646744B2
    • 2003-11-11
    • US09908651
    • 2001-07-20
    • Henrik Chresten PedersenCarsten Thirstrup
    • Henrik Chresten PedersenCarsten Thirstrup
    • G01N2155
    • G02B5/1857G01N21/553G02B5/008G02B5/1819
    • The present invention provides configurations and a method of formation of optical coupling elements for surface plasmon resonance sensors. In the method of the present invention, interference patterns between two overlapping monochromatic coherent light beams are created on a photosensitive film disposed on a master substrate. At least one of the light beams has an oblique angle of incidence onto the master substrate, and the focal points of the two overlapping light beams are positioned in order to reduce optical aberrations up to third order. After developing the photosensitive film, the surface relief patterns pattern created on the master substrate is replicated as diffractive optical element onto SPR sensor chips. The diffractive optical elements working as optical coupling elements diffract an incoming light beam into an oblique angle within the range from 40 to ˜80 degrees.
    • 本发明提供了用于表面等离子体共振传感器的光耦合元件的形成和形成方法。 在本发明的方法中,在设置在母板上的感光膜上产生两个重叠的单色相干光束之间的干涉图案。 光束中的至少一个具有与主基板的倾斜入射角,并且两个重叠光束的焦点被定位以便将光学像差降低到三阶。 在显影感光膜之后,在母板上形成的表面浮雕图案图案作为衍射光学元件复制到SPR传感器芯片上。 作为光耦合元件的衍射光学元件将入射光束衍射成在40〜80度的范围内的倾斜角度。
    • 5. 发明授权
    • Surface plasmon resonance sensor
    • 表面等离子体共振传感器
    • US06738141B1
    • 2004-05-18
    • US09493214
    • 2000-01-28
    • Carsten Thirstrup
    • Carsten Thirstrup
    • G01N2155
    • G01N33/18G01N21/553
    • Surface plasmon resonance (SPR) sensors comprise a sensor chip constructed of laterally integrated arrays of planar sensor chip units and an optical transducer constructed of laterally integrated arrays of planar optical transducer units. The replaceable sensor chip is separated from the optical transducer by a gap and perpendicular optical interconnections are between the sensor chip and the optical transducer. The optical interconnections between the sensor chip and the optical transducer are based on collimated light beams incident perpendicularly to the interfaces. Uncritical alignment of the optical transducer and the sensor chip is provided. The direction of the light beams will not be changed when passing through the interfaces between the sensor chip, the gap and the optical transducer eliminating the need of disposing refractive index matching gels in the gap.
    • 表面等离子体共振(SPR)传感器包括由横向集成的平面传感器芯片单元阵列和由横向集成的平面光学传感器单元阵列构成的光学换能器构成的传感器芯片。 可替换的传感器芯片通过间隙与光学换能器分离,并且在传感器芯片和光学换能器之间垂直的光学互连。 传感器芯片和光学传感器之间的光学互连基于垂直于界面入射的准直光束。 提供光学传感器和传感器芯片的非关键对准。 当通过传感器芯片,间隙和光学传感器之间的界面时,光束的方向不会改变,消除了在间隙中设置折射率匹配凝胶的需要。
    • 6. 发明授权
    • Leak sensor
    • 泄漏传感器
    • US08398603B2
    • 2013-03-19
    • US12224507
    • 2007-02-20
    • Carsten ThirstrupDaniel NilssonHenrik PranovLars Lading
    • Carsten ThirstrupDaniel NilssonHenrik PranovLars Lading
    • A61M1/00
    • A61F5/443A61B5/746A61F5/4404A61F5/445A61F13/00051A61F13/02A61F13/0246A61F13/42
    • The present invention relates to a method and dressing for detecting detachment of the dressing, which is applied to a surface of an at least partly electrically conductive object. The dressing comprises an adhesive for attaching the dressing to the electrically conductive object and at least two electrodes arranged in a distance from the electrically conductive object. A voltage is applied to the first and second electrode establishing an electrical circuit comprising a first capacitor between the first electrode and the electrically conductive object and a second capacitor between the second electrode and the electrically conductive object. Changes of the capacitance between at least one of the first and the second electrode and the electrically conductive object are detected, and an alarm is activated when the changes of the capacitance reach a predetermined value. This advantageously provides a method whereby a leak can be detected quickly. Furthermore, this advantageously provides a leak sensor with no direct physical or mechanical contact between the electrically conductive object, e.g. the skin, and the electrodes. This provides for a dressing comprising a leak sensor without compromising the comfort of the user.
    • 本发明涉及一种用于检测敷料剥离的方法和敷料,其应用于至少部分导电物体的表面。 敷料包括用于将敷料附着到导电物体的粘合剂和与导电物体相距一定距离布置的至少两个电极。 向第一和第二电极施加电压,建立包括在第一电极和导电物体之间的第一电容器和在第二电极和导电物体之间的第二电容器的电路。 检测第一和第二电极和导电物体中的至少一个之间的电容的变化,并且当电容的变化达到预定值时,激活警报。 这有利地提供了可以快速检测泄漏的方法。 此外,这有利地提供了在导电物体之间没有直接物理或机械接触的泄漏传感器,例如, 皮肤和电极。 这提供了包括泄漏传感器的敷料,而不损害使用者的舒适度。
    • 7. 发明申请
    • Leak Sensor
    • 泄漏传感器
    • US20100030167A1
    • 2010-02-04
    • US12224507
    • 2007-02-20
    • Carsten ThirstrupDaniel NilssonHenrik PranovLars Lading
    • Carsten ThirstrupDaniel NilssonHenrik PranovLars Lading
    • A61F5/445A61F13/00G08B21/00
    • A61F5/443A61B5/746A61F5/4404A61F5/445A61F13/00051A61F13/02A61F13/0246A61F13/42
    • The present invention relates to a method and dressing for detecting detachment of the dressing, which is applied to a surface of an at least partly electrically conductive object. The dressing comprises an adhesive for attaching the dressing to the electrically conductive object and at least two electrodes arranged in a distance from the electrically conductive object. A voltage is applied to the first and second electrode establishing an electrical circuit comprising a first capacitor between the first electrode and the electrically conductive object and a second capacitor between the second electrode and the electrically conductive object. Changes of the capacitance between at least one of the first and the second electrode and the electrically conductive object are detected, and an alarm is activated when the changes of the capacitance reach a predetermined value. This advantageously provides a method whereby a leak can be detected quickly. Furthermore, this advantageously provides a leak sensor with no direct physical or mechanical contact between the electrically conductive object, e.g. the skin, and the electrodes. This provides for a dressing comprising a leak sensor without compromising the comfort of the user.
    • 本发明涉及一种用于检测敷料剥离的方法和敷料,其应用于至少部分导电物体的表面。 敷料包括用于将敷料附着到导电物体的粘合剂和与导电物体相距一定距离布置的至少两个电极。 向第一和第二电极施加电压,建立包括在第一电极和导电物体之间的第一电容器和在第二电极和导电物体之间的第二电容器的电路。 检测第一和第二电极和导电物体中的至少一个之间的电容的变化,并且当电容的变化达到预定值时,激活警报。 这有利地提供了可以快速检测泄漏的方法。 此外,这有利地提供了在导电物体之间没有直接物理或机械接触的泄漏传感器,例如, 皮肤和电极。 这提供了包括泄漏传感器的敷料,而不损害使用者的舒适度。
    • 8. 发明申请
    • Surface plasmon resonance sensor
    • 表面等离子体共振传感器
    • US20050018194A1
    • 2005-01-27
    • US10492972
    • 2002-10-07
    • Carsten ThirstrupWeiyong ZongHelmut Neff
    • Carsten ThirstrupWeiyong ZongHelmut Neff
    • G01N21/552G01N21/55
    • G01N21/553
    • The invention relates to a surface plasmon resonance sensor comprising a base unit (2) containing a light source (6) for generating light beams (10) and an optical sensor unit (3; 21; 31; 103; 131) for exciting surface plasmons, said sensor unit having a measuring surface (18; 29; 122; 138) that is formed by a thin metal film and that can be brought into contact with a sample (19; 123) to be measured. The aim of the invention is to provide a surface plasmon resonance sensor (1) comprising a compact optical sensor unit (3; 21; 31; 103; 131) that is easy to replace reproducible quality. This is achieved by an optical sensor unit (3; 21; 31; 103; 131) comprising a prism (12; 22; 32; 112; 132) consisting of an optically transparent material. Areas (16, 20; 23, 24; 33, 34; 118, 119; 133, 134) of said prism (12; 22; 32; 112; 132) are configured in such a way, that they focus the light beams (10′) emanating from the base unit (2) onto the measuring surface (18; 29; 122; 138). This is achieved, for example, by a convex curvature of the mirror-coated lateral surfaces or lenses that are integrated into the prism.
    • 本发明涉及一种表面等离子体共振传感器,包括:基体单元(2),包含用于产生光束的光源(6)和用于激发表面等离子体激元的光学传感器单元(3; 21; 31; 103; 131) 所述传感器单元具有测量表面(18; 29; 122; 138),所述测量表面由薄金属膜形成,并且可以与待测量的样品(19; 123)接触。 本发明的目的是提供一种表面等离子体共振传感器(1),其包括容易替代可再现质量的紧凑型光学传感器单元(3; 21; 31; 103; 131)。 这通过包括由光学透明材料组成的棱镜(12; 22; 32; 112; 132)的光学传感器单元(3; 21; 31; 103; 131)来实现。 所述棱镜(12; 22; 32; 112; 132)的区域(16,20; 23,24; 33,34; 118,119; 133,134)以这样的方式配置,使得它们聚焦光束 10')从基座单元(2)发射到测量表面(18; 29; 122; 138)上。 这通过例如集成到棱镜中的镜面涂覆的侧面或透镜的凸曲率来实现。