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1. 发明申请

US20120184050A1 MULTIPLEX SCREENING FOR LYSOSOMAL STORAGE DISORDERS (LSDS) 有权
标题翻译：多发性淋巴细胞浸润性病变筛查（LSDS）
公开(公告)号：US20120184050A1
公开(公告)日：2012-07-19
申请号：US13432387
申请日：2012-03-28
申请人： Peter John Meikle , John Joseph Hopwood , Douglas Alexander Brooks , Caroline Dean
发明人： Peter John Meikle , John Joseph Hopwood , Douglas Alexander Brooks , Caroline Dean
IPC分类号： G01N21/64 , C07K17/00
CPC分类号： G01N33/543 , A61K49/0058 , A61K49/0091 , G01N33/54313 , G01N33/582 , G01N33/6893
摘要： A novel protein profiling method of testing for Lysosomal Storage Diseases (“LSD”) using discovered normalized lysosomal fingerprint patterns. The fingerprint patterns reveal the health of lysosomal organelles, specific LSD, and clinical severity. Multiplexing bead technology for simultaneous screening of multiple LSD and normalizing measured enzyme activity or protein levels against other lysosomal proteins, enzymes, or enzyme activities. Compounds, reagents, and methods for identifying and quantifying multiple target enzymes and proteins.
摘要翻译：一种使用发现的归一化溶酶体指纹图谱测定溶酶体贮积病（“LSD”）的新型蛋白质分析方法。指纹图谱显示溶酶体细胞器的健康，特异性LSD和临床严重程度。用于同时筛选多个LSD并使测定的酶活性或蛋白质水平与其他溶酶体蛋白质，酶或酶活性正常化的多重珠粒技术。用于鉴定和定量多种靶酶和蛋白质的化合物，试剂和方法。

2. 发明授权

US07230158B2 Arabidopsis thaliana derived frigida gene conferring late flowering 有权
标题翻译：拟南芥衍生的frigida基因赋予晚开花
公开(公告)号：US07230158B2
公开(公告)日：2007-06-12
申请号：US10894230
申请日：2004-07-19
申请人： Urban Johanson , Joanne West , Caroline Dean
发明人： Urban Johanson , Joanne West , Caroline Dean
IPC分类号： C12N15/29 , C12N15/82 , C12N15/87 , C12N5/04 , A01H5/00 , A01H5/10
CPC分类号： C07K14/415 , A01K2217/05 , C12N15/827
摘要： Disclosed are isolated nucleic acids obtainable from the FRI locus of plants which encode polypeptides capable of specifically altering, particularly delaying, the flowering time of a plant into which the nucleic acid is introduced. One preferred embodiment is the FRI nucleotide sequence which encodes the polypeptide of FIG. 6 (see the sequence of FIG. 5, particularly bases 362-2188 thereof) or sequences degeneratively equivalent to these. Also provided are variant sequences (e.g. alleles, orthologues, derivatives) and complementary sequences, plus vectors, host cells, plants and associated processes of production and methods of use e.g. for influencing or affecting flowering time in a plant by expression or suppression of FRI or variant sequences.
摘要翻译：公开了可从植物的FRI基因座获得的分离的核酸，其编码能够特异性改变，特别是延迟引入核酸的植物的开花时间的多肽。一个优选的实施方案是编码图1的多肽的FRI核苷酸序列。 6（参见图5的序列，特别是其基因362-2188）或与其简并等价的序列。还提供了变体序列（例如等位基因，直向同源物，衍生物）和互补序列，加上载体，宿主细胞，植物和相关生产过程以及使用方法，例如。通过表达或抑制FRI或变体序列影响或影响植物中的开花时间。

3. 发明申请

US20070072243A1 Multiplex screening for lysosomal sotrage disorders (lsds) 失效
标题翻译：多重筛选溶酶体动物障碍（lsds）
公开(公告)号：US20070072243A1
公开(公告)日：2007-03-29
申请号：US10551396
申请日：2004-03-31
申请人： Peter Meikle , John Hopwood , Douglas Brooks , Caroline Dean
发明人： Peter Meikle , John Hopwood , Douglas Brooks , Caroline Dean
IPC分类号： G01N33/567 , G01N33/53
CPC分类号： G01N33/543 , A61K49/0058 , A61K49/0091 , G01N33/54313 , G01N33/582 , G01N33/6893
摘要： A novel protein profiling method of testing for Lysosomal Storage Diseases (“LSD”) using discovered normalized lysosomal fingerprint patterns. The fingerprint patterns reveal the health of lysosomal organelles, specific LSD, and clinical severity Multiplexing bead technology for simultaneous screening of multiple LSD and normalizing measured enzyme activity or protein levels against other lysosomal proteins, enzymes, or enzyme activities. Compounds, reagents, and methods for identifying and quantifying multiple target enzymes and proteins.
摘要翻译：一种使用发现的归一化溶酶体指纹图谱测定溶酶体贮积病（“LSD”）的新型蛋白质分析方法。指纹图谱揭示了溶酶体细胞器，特异性LSD和临床严重性的复合珠粒技术，用于同时筛选多种LSD并使测定的酶活性或蛋白质水平与其他溶酶体蛋白质，酶或酶活性正常化。用于鉴定和定量多种靶酶和蛋白质的化合物，试剂和方法。

4. 发明授权

US6140085A Genetic control of flowering 失效
标题翻译：开花的遗传控制
公开(公告)号：US6140085A
公开(公告)日：2000-10-31
申请号：US973273
申请日：1997-12-01
申请人： Caroline Dean , Richard Colin Macknight , Ian Bancroft , Clare Katharine Lister
发明人： Caroline Dean , Richard Colin Macknight , Ian Bancroft , Clare Katharine Lister
IPC分类号： A01H5/00 , C07K14/415 , C12N5/10 , C12N15/09 , C12N15/29 , C12N15/82 , C12P19/34
CPC分类号： C12N15/827 , C07K14/415 , C12N15/8261
摘要： FCA genes of Arabidopsis thaliana and Brassica napus are provided, enabling flowering characteristics, particularly timing of flowering, to be influenced in transgenic plants. Timing of flowering may be delayed or hastened using sense and antisense expression, also various mutants and alleles, including alternatively spliced forms.
摘要翻译： PCT No.PCT / GB96 / 01332 Sec。 371 1997年12月1日第 102（e）1997年12月1日PCT PCT 1996年6月3日PCT公布。公开号WO96 / 38560 日期1996年12月5日提供拟南芥和甘蓝型油菜的FCA基因，使开花特征，特别是开花时间受到转基因植物的影响。使用正义和反义表达，也可以是各种突变体和等位基因（包括可选的剪接形式）可能延迟或加速开花的时间。

5. 发明授权

US5349127A Expression of herbicide metabolizing cytochromes P450 失效
标题翻译：表达除草剂代谢细胞色素P450
公开(公告)号：US5349127A
公开(公告)日：1994-09-20
申请号：US967093
申请日：1992-10-26
申请人： Caroline Dean , Patricia A. Harder , Kenneth J. Leto , Daniel P. O'Keefe , Charles A. Omer , James A. Romesser , James M. Tepperman
发明人： Caroline Dean , Patricia A. Harder , Kenneth J. Leto , Daniel P. O'Keefe , Charles A. Omer , James A. Romesser , James M. Tepperman
IPC分类号： A01H5/00 , C12N1/21 , C12N9/02 , C12N15/09 , C12N15/53 , C12N15/82 , C12R1/465 , A01H4/00
CPC分类号： C12N9/0077 , C12N15/8209 , C12N15/8261 , C12N15/8267 , C12N15/8278 , C12N15/8289
摘要： DNA sequences encoding herbicide metabolizing cytochrome P450 enzymes and iron-sulfur proteins that donate electrons to these enzymes, were introduced into plants and microorganisms rendering them able to produce the encoded gene products and to metabolize herbicides.
摘要翻译：将编码除草剂代谢细胞色素P450酶的DNA序列和向这些酶捐赠电子的铁硫蛋白引入植物和微生物，使其能够产生编码的基因产物并代谢除草剂。

6. 发明授权

US08735173B2 Multiplex screening for lysosomal storage disorders (LSDS) 有权
标题翻译：溶酶体储存障碍（LSDS）的多重筛选
公开(公告)号：US08735173B2
公开(公告)日：2014-05-27
申请号：US13432387
申请日：2012-03-28
申请人： Peter John Meikle , John Joseph Hopwood , Douglas Alexander Brooks , Caroline Dean
发明人： Peter John Meikle , John Joseph Hopwood , Douglas Alexander Brooks , Caroline Dean
IPC分类号： G01N33/543
CPC分类号： G01N33/543 , A61K49/0058 , A61K49/0091 , G01N33/54313 , G01N33/582 , G01N33/6893
摘要： A novel protein profiling method of testing for Lysosomal Storage Diseases (“LSD”) using discovered normalized lysosomal fingerprint patterns. The fingerprint patterns reveal the health of lysosomal organelles, specific LSD, and clinical severity. Multiplexing bead technology for simultaneous screening of multiple LSD and normalizing measured enzyme activity or protein levels against other lysosomal proteins, enzymes, or enzyme activities. Compounds, reagents, and methods for identifying and quantifying multiple target enzymes and proteins.
摘要翻译：一种使用发现的归一化溶酶体指纹图谱测定溶酶体贮积病（“LSD”）的新型蛋白质分析方法。指纹图谱显示溶酶体细胞器的健康，特异性LSD和临床严重程度。用于同时筛选多个LSD并使测定的酶活性或蛋白质水平与其他溶酶体蛋白质，酶或酶活性正常化的多重珠粒技术。用于鉴定和定量多种靶酶和蛋白质的化合物，试剂和方法。

7. 发明申请

US20050060774A1 Arabidopsis thaliana derived frigida gene conferring late flowering 有权
标题翻译：拟南芥衍生的frigida基因赋予晚开花
公开(公告)号：US20050060774A1
公开(公告)日：2005-03-17
申请号：US10894230
申请日：2004-07-19
申请人： Urban Johanson , Joanne West , Caroline Dean
发明人： Urban Johanson , Joanne West , Caroline Dean
IPC分类号： C07K14/415 , C12N15/82 , A01H1/00 , C07H21/04 , C12N5/04 , C12N9/24
CPC分类号： C07K14/415 , A01K2217/05 , C12N15/827
摘要： Disclosed are isolated nucleic acids obtainable from the FRI locus of plants which encode polypeptides capable of specifically altering, particularly delaying, the flowering time of a plant into which the nucleic acid is introduced. One preferred embodiment is the FRI nucleotide sequence which encodes the polypeptide of FIG. 6 (see the sequence of FIG. 5, particularly bases 362-2188 thereof) or sequences degeneratively equivalent to these. Also provided are variant sequences (e.g. alleles, orthologues, derivatives) and complementary sequences, plus vectors, host cells, plants and associated processes of production and methods of use e.g. for influencing or affecting flowering time in a plant by expression or suppression of FRI or variant sequences.
摘要翻译：公开了可从植物的FRI基因座获得的分离的核酸，其编码能够特异性改变，特别是延迟引入核酸的植物的开花时间的多肽。一个优选的实施方案是编码图1的多肽的FRI核苷酸序列。 6（参见图5的序列，特别是其基因362-2188）或与其简并等价的序列。还提供了变体序列（例如等位基因，直向同源物，衍生物）和互补序列，加上载体，宿主细胞，植物和相关生产过程以及使用方法，例如。通过表达或抑制FRI或变体序列影响或影响植物中的开花时间。

8. 发明授权

US4962028A Plant promotors 失效
标题翻译：植物启动子
公开(公告)号：US4962028A
公开(公告)日：1990-10-09
申请号：US883604
申请日：1986-07-09
申请人： John R. Bedbrook , Caroline Dean , Pamela Dunsmuir
发明人： John R. Bedbrook , Caroline Dean , Pamela Dunsmuir
IPC分类号： C12N9/24 , C12N9/88 , C12N15/82
CPC分类号： C12Y302/01014 , C12N15/8216 , C12N15/8223 , C12N9/1007 , C12N9/2442 , C12N9/88 , C12Y201/01127
摘要： Promoter sequences from the gene from the small subunit of ribulose-1,5-bisphosphate carboxylase are disclosed. Expression cassettes containing a promoter sequence, a linker region, and a 3' fragment are also disclosed. The promotor sequences and expression cassettes are useful for expressing foreign genes to high levels in transformed plants.
摘要翻译：公开了来自核酮糖-1,5-二磷酸羧化酶的小亚基的启动子序列。还公开了含有启动子序列，接头区和3'片段的表达盒。启动子序列和表达盒可用于在转化植物中将外源基因表达为高水平。

9. 发明授权

US08173443B2 Multiplex screening for lysosomal storage disorders (LSDs) 失效
标题翻译：溶酶体储存障碍（LSD）的多重筛选
公开(公告)号：US08173443B2
公开(公告)日：2012-05-08
申请号：US10551396
申请日：2004-03-31
申请人： Peter John Meikle , John Joseph Hopwood , Douglas Alexander Brooks , Caroline Dean
发明人： Peter John Meikle , John Joseph Hopwood , Douglas Alexander Brooks , Caroline Dean
IPC分类号： G01N33/543
CPC分类号： G01N33/543 , A61K49/0058 , A61K49/0091 , G01N33/54313 , G01N33/582 , G01N33/6893
摘要： A novel protein profiling method of testing for Lysosomal Storage Diseases (“LSD”) using discovered normalized lysosomal fingerprint patterns. The fingerprint patterns reveal the health of lysosomal organelles, specific LSD, and clinical severity Multiplexing bead technology for simultaneous screening of multiple LSD and normalizing measured enzyme activity or protein levels against other lysosomal proteins, enzymes, or enzyme activities. Compounds, reagents, and methods for identifying and quantifying multiple target enzymes and proteins.
摘要翻译：一种使用发现的归一化溶酶体指纹图谱测定溶酶体贮积病（“LSD”）的新型蛋白质分析方法。指纹图谱揭示了溶酶体细胞器，特异性LSD和临床严重性的复合珠粒技术，用于同时筛选多种LSD并使测定的酶活性或蛋白质水平与其他溶酶体蛋白质，酶或酶活性正常化。用于鉴定和定量多种靶酶和蛋白质的化合物，试剂和方法。

10. 发明授权

US07045682B1 Methods and means for modification of plant flowering characteristics 有权
标题翻译：修改植物开花特征的方法和手段
公开(公告)号：US07045682B1
公开(公告)日：2006-05-16
申请号：US10088187
申请日：2000-09-13
申请人： Caroline Dean , Yaron Yakov Levy
发明人： Caroline Dean , Yaron Yakov Levy
IPC分类号： C12N15/29 , C12N15/82 , C12N5/04 , A01H5/00
CPC分类号： C12N15/827 , C07K14/415 , C12N15/8214 , C12N15/8238
摘要： Provided are isolated nucleic acid molecules which comprise VRN1 nucleotide sequences, which encode a polypeptide which is capable of specifically altering the vernalisation response of a plant into which the nucleic acid is introduced and expressed. Examples include cDNA and gDNA sequences (see e.g., Annex I). Also provided are variant molecules which may be derivatives or homologues (e.g., alleles, or paralogues such as RTV1), plus also complementary molecules. Corresponding polypeptides form a further part of the invention. The invention also provides methods and materials for preparing and using these molecules, e.g., in the production of plants having modified vernalisation characteristics. Also provided are methods for influencing and assessing the vernalisation phenotype of a plant.
摘要翻译：提供了包含VRN1核苷酸序列的分离的核酸分子，其编码能够特异性改变引入和表达核酸的植物的春化反应的多肽。实例包括cDNA和gDNA序列（参见例如附录I）。还提供了可以是衍生物或同系物（例如等位基因或旁系同源物，例如RTV1）的变体分子，以及互补分子。相应的多肽构成本发明的另一部分。本发明还提供了用于制备和使用这些分子的方法和材料，例如在具有改性的春化特性的植物的生产中。还提供了影响和评估植物的春化表型的方法。

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