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1. 发明授权

US5617626A Method of telescopically assembling a flexible pinch valve element with a length of flexible tubing 失效
标题翻译：将柔性夹管阀元件伸缩组装成一段柔性管道的方法
公开(公告)号：US5617626A
公开(公告)日：1997-04-08
申请号：US531674
申请日：1995-09-21
申请人： Carl J. Piontek , Bradford L. Buck
发明人： Carl J. Piontek , Bradford L. Buck
IPC分类号： A61M39/28 , B23P11/02
CPC分类号： A61M39/288 , A61M2209/04 , Y10T137/0402 , Y10T29/4987
摘要： A method of assembling telescopically a flexible tubular segment with a length of tubing involves the use of an assembly apparatus which controllably stretches a tubular segment. The free end of a portion of an end of a length of tubing is inserted through the stretched tubular segment a preselected distance. The stretched tubular segment is allowed to relax around the inserted portion of an end of the length of tubing, thus assembling the tubular segment with the end portion of a length of tubing. The tubular segment and portion of an end of a length of tubing that have been assembled together are then ejected simultaneously from the assembly apparatus.
摘要翻译：可伸缩地组装具有一段管道的柔性管状段的方法涉及使用可控地拉伸管状段的组装设备。一段长度的管的一端的一部分的自由端通过延伸的管状段插入预选距离。允许拉伸的管状部分围绕长度管的端部的插入部分松弛，从而将管状部分与一段管道的端部组装。已组装在一起的管状段和一段长度的管的一部分然后同时从组装设备中排出。

2. 发明授权

US5549550A Method of adding marker dye to nutritional product during enteral tube feeding 失效
标题翻译：在肠管喂养期间向营养产品添加标记染料的方法
公开(公告)号：US5549550A
公开(公告)日：1996-08-27
申请号：US372613
申请日：1995-01-13
申请人： Terrence B. Mazer , Joseph E. Walton , Ronita K. Geckle , Carl J. Piontek , Susan B. Duel , Andre Daab-Krzykowski , Robert L. Joseph , William G. Pierson , Thomas D. Loughrin , Thomas W. Osip
发明人： Terrence B. Mazer , Joseph E. Walton , Ronita K. Geckle , Carl J. Piontek , Susan B. Duel , Andre Daab-Krzykowski , Robert L. Joseph , William G. Pierson , Thomas D. Loughrin , Thomas W. Osip
IPC分类号： A61J15/00 , A61M5/00 , A61M5/14 , A61M31/00 , A61M37/00
CPC分类号： A61M31/002 , A61J15/0026 , A61J15/0069 , A61M5/007 , A61M5/1407 , A61J15/00
摘要： A method for dye marking a liquid enteral nutritional product during delivery thereof from a supply container to a feeding tube delivering the nutritional product to the gastrointestinal tract of a patient includes the steps of: (1) providing apparatus such as a formulation chamber, e.g., a drip chamber, connectable to the supply container, with at least one sustained release reservoir containing a physiologically acceptable and dispersible marker dye positioned within the formulation chamber, and, liquid communication means connecting the formulation chamber to the feeding tube of a patient; (2) providing a supply container containing the nutritional product; (3) connecting the formulation chamber to the supply container and the liquid commmunication means to the feeding tube; and (4) flowing the dye-marked nutritional product through the apparatus and into the feeding tube. The sustained release reservoir may be a conventional slow release coated tablet, microspheres, or capsule type or an osmotically driven device. The marker dye may be a colorant dye or a fluorescing dye or a mixture thereof. If quick coloration is desired, the sustained release reservoir may be coated with a soluble layer of the marker dye or marker dye not in a sustained release reservoir may be placed in the formulation chamber along with a sustained release reservoir containing dye.
摘要翻译：一种将液体肠内营养产品从供应容器输送至将营养产品输送到患者的胃肠道的喂食管中的染色标记方法包括以下步骤：（1）提供诸如配制室的装置，可连接到供应容器的滴水室与至少一个包含位于配制室内的生理上可接受和可分散的标记染料的缓释储存器，以及将配制室连接到患者的进料管的液体连通装置; （2）提供容纳营养产品的供应容器; （3）将制剂室与供给容器和液体通信装置连接到进料管; 和（4）使染料标记的营养产品通过设备流入饲管。持续释放储存器可以是常规的缓释包衣片剂，微球体或胶囊型或渗透驱动装置。标记染料可以是着色剂染料或荧光染料或其混合物。如果需要快速着色，则持续释放储存器可以涂覆有标记染料的可溶层或不在持续释放储存器中的标记染料，可以与含有染料的持续释放储存器一起放置在配制室中。

3. 发明授权

US5531681A Apparatus for altering composition of nutritional product during enteral tube feeding 失效
标题翻译：用于改变肠管喂养期间营养产品组成的装置
公开(公告)号：US5531681A
公开(公告)日：1996-07-02
申请号：US372407
申请日：1995-01-13
申请人： Joseph E. Walton , Terrence B. Mazer , Ronita K. Geckle , Carl J. Piontek , Susan B. Duel , Andre Daab-Krzykowski , Mark A. McCamish , Robert L. Joseph , William G. Pierson
发明人： Joseph E. Walton , Terrence B. Mazer , Ronita K. Geckle , Carl J. Piontek , Susan B. Duel , Andre Daab-Krzykowski , Mark A. McCamish , Robert L. Joseph , William G. Pierson
IPC分类号： A61J15/00 , A61M5/00 , A61M5/14 , A61M31/00 , A61M37/00
CPC分类号： A61M31/002 , A61J15/0026 , A61J15/0069 , A61M5/007 , A61M5/1407 , A61J15/00
摘要： An apparatus is disclosed for modifying a liquid enteral nutritional product during delivery thereof from a supply thereof, such as a hangable container, to a feeding tube delivering the liquid enteral nutritional product to the gastrointestinal tract of a patient. The apparatus has at least one formulation chamber, such as a drip chamber, with at least one controlled release dosage form unit in the form of a coated tablet, osmotically driven device, coated capsule, microencapsulated microspheres, agglomerated molecular sieving type material, or a quantity of fine hollow permeable fibers located therein. The controlled release dosage form unit or units contain at least one beneficial agent selected from nutrients, medicaments, probiotics, or diagnostic agents or mixtures thereof, to any of which a physiologically acceptable marker dye in controlled release dosage form and/or the same or different beneficial agent not in controlled release dosage form may be added. A liquid nutritional product flows through the formulation chamber during enteral tube feeding of a patient.
摘要翻译：公开了一种用于在将液体肠内营养产品从其供应源（例如可吊起的容器）递送到将食用液体肠营养产品输送到患者的胃肠道的进料管中的情况下将液体肠内营养产品改性的装置。该装置具有至少一个配方腔室，例如滴注室，其中至少一个以包衣片剂，渗透驱动装置，包衣胶囊，微胶囊化微球，聚集分子筛型材料形式的控释剂型单元，或在其中的细中空可渗透纤维的数量。控制释放剂型单元或单元含有至少一种选自营养物质，药物，益生菌或诊断剂或其混合物的有益剂，其中任何一种生物学可接受的控制释放剂型标记染料和/或相同或不同可以加入不在控释剂型中的有益剂。在患者的肠管喂养期间，液体营养产品流过制剂室。

4. 发明授权

US5098378A Method of jejunal feeding 失效
标题翻译：空肠喂养方法
公开(公告)号：US5098378A
公开(公告)日：1992-03-24
申请号：US732965
申请日：1991-07-19
申请人： Carl J. Piontek , Kent E. Iversen , William H. Hirsch , Arthur A. Dahl
发明人： Carl J. Piontek , Kent E. Iversen , William H. Hirsch , Arthur A. Dahl
IPC分类号： A61J15/00
CPC分类号： A61J15/0015 , A61J15/0042 , A61J15/0069 , A61J15/0073 , A61J15/0061 , A61M2025/0233
摘要： A replacement gastrostomy tube device is provided comprising a catheter shaft having an outer surface wall, with the shaft enclosing a feeding lumen of substantially circular cross-section and a fluid flow channel. A port housing is located at the proximal end of the shaft with the port housing having a main food inlet port, a Y-port and a fluid inlet port. Near the distal end of the tube are an expandable component member and a food outlet port, which port is preferably located at the distal end. The feeding lumen is of a greater diameter than that of the fluid flow channel. The outer surface wall is of a non-circular cross-section. The feeding lumen is of a circular cross-section which permits the passage therethrough of a jejunal tube. The main food inlet port is of a greater diameter than that associated with the Y-port. The method for using this device permits jejunal feeding through a replacement gastrostomy tube without retraumatizing the patient.
摘要翻译：提供了一种替代性胃造口管装置，其包括具有外表面壁的导管轴，该轴包围具有基本圆形横截面的输送内腔和流体流动通道。端口壳体位于轴的近端，端口壳体具有主食品入口，Y端口和流体入口。在管的远端附近是可扩张的部件和食品出口，该端口优选位于远端。进料腔的直径大于流体流动通道的直径。外表面壁是非圆形横截面。进食腔是圆形横截面，允许空肠管通过。主食品进口口径大于与Y口相关的口径。使用该装置的方法允许通过置换胃造口管进行空肠喂养，而不对患者进行再吸入。

5. 发明授权

US5071405A Gastrostomy tube 失效
标题翻译：胃肠管
公开(公告)号：US5071405A
公开(公告)日：1991-12-10
申请号：US360814
申请日：1989-06-02
申请人： Carl J. Piontek , Kent E. Iversen , William H. Hirsch , Arthur A. Dahl
发明人： Carl J. Piontek , Kent E. Iversen , William H. Hirsch , Arthur A. Dahl
IPC分类号： A61M25/00 , A61J15/00
CPC分类号： A61J15/0015 , A61J15/0042 , A61J15/0069 , A61J15/0073 , A61J15/0061 , A61M2025/0233
摘要： A replacement gastrostomy tube device is provided comprising a catheter shaft having an outer surface wall, with the shaft enclosing a feeding lumen of substantially circular cross-section and a fluid flow channel. A port housing is located at the proximal end of the shaft with the port housing having a main food inlet port, a Y-port and a fluid inlet port. Near the distal end of the tube are an expandable component member and a food outlet port, which port is preferably located at the distal end. The feeding lumen is of a greater diameter than that of the fluid flow channel. The outer surface wall is of a non-circular cross-section. The feeding lumen is of a circular cross-section which permits the passage therethrough of a jejunal tube. The main food inlet port is of a greater diameter than that associated with the Y-port. The method for using this device permits jejunal feeding through a replacement gastrostomy tube without retraumatizing the patient.

6. 发明授权

US06277092B1 Apparatus for altering composition of nutritional product during enteral tube feeding 失效
标题翻译：用于改变肠管喂养期间营养产品组成的装置
公开(公告)号：US06277092B1
公开(公告)日：2001-08-21
申请号：US09032072
申请日：1998-02-27
申请人： Rhonda L. Cole , Ronita K. Geckle , Terrence B. Mazer , Frank A. Murawski , Carl J. Piontek , Gregory James Stephens , Joseph E. Walton
发明人： Rhonda L. Cole , Ronita K. Geckle , Terrence B. Mazer , Frank A. Murawski , Carl J. Piontek , Gregory James Stephens , Joseph E. Walton
IPC分类号： A61M3700
CPC分类号： A61M5/007 , A61J15/00 , A61J15/0026 , A61J15/0069 , A61M5/1407 , A61M5/1409 , A61M31/002
摘要： An apparatus for modifying a liquid enteral nutritional product. The apparatus includes a chamber having an inlet and an outlet. The inlet of the chamber is constructed to be fluidly connected to a supply container containing a liquid enteral nutritional. The chamber defines an interior space. The apparatus further includes a retainer disposed in the interior space defined by the chamber. The retainer is constructed to receive one or more dosage form units of beneficial agent therein. The apparatus further includes at least one dosage form unit of beneficial agent retained by the retainer.
摘要翻译：一种用于改变液体肠内营养产品的装置。该装置包括具有入口和出口的室。腔室的入口被构造成流体连接到容纳液体肠内营养的供应容器。室定义了一个内部空间。该装置还包括设置在由腔限定的内部空间中的保持器。保持器构造成在其中接收一种或多种有益剂的剂型单元。该装置还包括由保持器保留的有益剂的至少一个剂型单元。

7. 发明授权

US5594981A Apparatus for telescopically assembling a tubing segment on a length of tubing 失效
标题翻译：用于在一段管道上套管组装管段的装置
公开(公告)号：US5594981A
公开(公告)日：1997-01-21
申请号：US531541
申请日：1995-09-21
申请人： Carl J. Piontek , Bradford L. Buck
发明人： Carl J. Piontek , Bradford L. Buck
IPC分类号： B25B27/10 , B25B27/28 , B29C55/24 , B23P19/02
CPC分类号： B25B27/10 , B25B27/28 , B29C55/24 , Y10T279/1074 , Y10T279/1926 , Y10T29/49911 , Y10T29/53657 , Y10T29/53987
摘要： An apparatus is disclosed which has utility for assembling a flexible tubular segment telescopically upon an end portion of a length of tubing when the tubing has an outer diameter which is substantially the same or greater than the inner diameter of the tubular segment. The apparatus has the capacity to controllably stretch the flexible tubular segment sufficiently to facilitate passage therethrough of an end portion of a length of the tubing. The end portion of the length of tubing is then positioned inside the stretched flexible tubular segment such that the stretched tubular segment is located a pre-selected distance from the free end of the end portion of the length of tubing. The tubular segment is then allowed to contract around the the end portion. The assembled tubular segment and end portion of the length of tubing are then ejected from the apparatus while maintaining the pre-selected distance of the tubular segment from the free end of the end portion of the length of tubing.
摘要翻译：公开了一种用于当管道具有基本上等于或大于管状部分的内径的外径时将柔性管状部分可伸缩地组装在一段管道的端部上的实用性。该设备具有足够的可控地拉伸柔性管状部分的能力，以便于通过一段长度管道的端部的通道。然后将管长度的端部定位在拉伸的柔性管状段内，使得拉伸的管状段位于距离管的长度端部的自由端的预选距离处。然后允许管状部分围绕端部收缩。然后将组装的管段和管长度的端部从设备中排出，同时保持管段的预选距离远离管长度端部的自由端。

8. 发明授权

US5533973A Alteration of nutritional product during enteral tube feeding 失效
标题翻译：肠管喂养期间营养产品的改变
公开(公告)号：US5533973A
公开(公告)日：1996-07-09
申请号：US372624
申请日：1995-01-13
申请人： Carl J. Piontek , Terrence B. Mazer , Joseph E. Walton , Ronita K. Geckle
发明人： Carl J. Piontek , Terrence B. Mazer , Joseph E. Walton , Ronita K. Geckle
IPC分类号： A61J15/00 , A61M5/14 , A61M37/00
CPC分类号： A61M5/1409 , A61J15/0026 , A61J15/0069 , A61J15/00
摘要： An apparatus and method are disclosed for modifying a liquid enteral nutritional product during delivery thereof from a supply to a feeding tube delivering the modified liquid enteral nutritional product to the gastrointestinal tract of a patient. At least one beneficial agent not in controlled release dosage form in a useful, dose unit, amount, is disposed within a formulation chamber so as to be taken up in a liquid enteral nutritional product traversing the formulation chamber while feeding the modified nutritional product into the gastrointestinal tract of a patient. The beneficial additive(s) are selected from nutrients, medicaments, probiotics, or diagnostic agents, or mixtures thereof, each in a dosage form that is dispersible in the medium of the liquid enteral nutritional product in less than two hours.
摘要翻译：公开了一种用于在将液体肠内营养产品从供应管道输送到患者的胃肠道的供给管中的过程中改变液体肠内营养产品的装置和方法。至少一种不是控制释放剂型的有益药剂以有用的剂量单位量配置在制剂室内，以便在经过配制室的液体肠内营养产品中吸收，同时将改良的营养产品喂入患者的胃肠道。有益的添加剂选自营养物质，药物，益生菌或诊断剂或其混合物，各自为可在不到两小时内分散于液体肠内营养产品的介质中的剂型。

9. 发明授权

US5531734A Method of altering composition of nutritional product during enteral tube feeding 失效
标题翻译：改变肠管喂养期间营养产品组成的方法
公开(公告)号：US5531734A
公开(公告)日：1996-07-02
申请号：US372408
申请日：1995-01-13
申请人： Ronita K. Geckle , Terrence B. Mazer , Joseph E. Walton , Carl J. Piontek , Susan B. Duel , Andre Daab-Krzykowski , Mark A. McCamish , Robert L. Joseph , William G. Pierson
发明人： Ronita K. Geckle , Terrence B. Mazer , Joseph E. Walton , Carl J. Piontek , Susan B. Duel , Andre Daab-Krzykowski , Mark A. McCamish , Robert L. Joseph , William G. Pierson
IPC分类号： A61J15/00 , A61K9/22 , A61M5/00 , A61M5/14 , A61M31/00
CPC分类号： A61M31/002 , A61J15/0026 , A61J15/0069 , A61M5/007 , A61M5/1407 , A61J15/00
摘要： A method is disclosed for modifying a liquid enteral nutritional product during delivery thereof from a supply container to a feeding tube delivering the nutritional product to the gastrointestinal tract of a patient. During enteral tube feeding the nutritional product passes through a formulation chamber, e.g., a drip chamber, having located therein at least one controlled release dosage form unit containing at least one beneficial agent. The beneficial agent may be selected from nutrients, medicaments, probiotics, or diagnostic agents or mixtures thereof, and any such together with a physiologically acceptable marker dye in controlled release dosage form and/or the same or different additional beneficial agent not in controlled release dosage form. Controlled release dosage forms may be of a conventional sustained release type or an osmotically driven delivery device.
摘要翻译：公开了一种用于在将液体肠内营养产品从供应容器输送到将营养产品输送到患者的胃肠道的进料管中时，用于改变液体肠内营养产品的方法。在肠管喂养期间，营养产品通过配制室，例如滴注室，其中至少含有至少一种含有至少一种有益剂的控释剂型单元。有益药物可以选自营养物，药物，益生菌或诊断剂或其混合物，以及任何这些与控制释放剂型中的生理学上可接受的标记染料和/或不是控制释放剂量的相同或不同的附加有益剂形成。受控释放剂型可以是常规的缓释型或渗透驱动的输送装置。

10. 发明授权

US5531682A Apparatus for adding marker dye to nutritional product during enternal tube feeding 失效
标题翻译：在内管喂养期间添加标记染料至营养产品的装置
公开(公告)号：US5531682A
公开(公告)日：1996-07-02
申请号：US372266
申请日：1995-01-13
申请人： Terrence B. Mazer , Joseph E. Walton , Ronita K. Geckle , Carl J. Piontek , Susan B. Duel , Andre Daab-Krzykowski , Robert L. Joseph , William G. Pierson , Thomas D. Loughrin , Thomas W. Osip
发明人： Terrence B. Mazer , Joseph E. Walton , Ronita K. Geckle , Carl J. Piontek , Susan B. Duel , Andre Daab-Krzykowski , Robert L. Joseph , William G. Pierson , Thomas D. Loughrin , Thomas W. Osip
IPC分类号： A61J15/00 , A61M5/00 , A61M5/14 , A61M5/168 , A61M31/00 , G01N27/327 , A61M37/00
CPC分类号： A61M31/002 , A61J15/0026 , A61J15/0069 , A61M5/007 , A61M5/1407 , A61J15/00 , G01N33/02
摘要： An apparatus is useful for dye marking a liquid enteral nutritional product during delivery thereof from a supply container to a feeding tube delivering the nutritional product to the gastrointestinal tract of a patient. A formulation chamber, such as a drip chamber, is connectable to the supply container. At least one sustained release reservoir containing a physiologically acceptable marker dye is positioned within the formulation chamber, or if not, is included as part of a kit. The sustained release reservoir may be in the form of a coated tablet, osmotically driven device, coated capsule, microencapsulated microspheres, agglomerated molecular sieving material, or chopped hollow fibers having permeable walls. A liquid communication means connects the formulation chamber to the feeding tube of a patient. The marker dye may be a colorant dye or a fluorescing dye or a mixture thereof. In using the apparatus for dye marking the nutritional product is flowed through the apparatus and a feeding tube to enter the gastrointestinal tract of a patient.
摘要翻译：一种装置可用于将液体肠内营养产品在从供应容器输送到将营养产品输送到患者的胃肠道的喂食管中时进行标记。诸如滴水室的配制室可连接到供应容器。包含生理上可接受的标记染料的至少一个持续释放储存器位于制剂室内，或者如果不包含，则作为试剂盒的一部分。持续释放储存器可以是包衣片剂，渗透驱动装置，包衣胶囊，微囊化微球，聚集分子筛材料或具有可渗透壁的切碎中空纤维的形式。液体连通装置将制剂室连接到患者的进料管。标记染料可以是着色剂染料或荧光染料或其混合物。在使用染色标记设备时，营养产品流过设备和进料管进入患者的胃肠道。

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