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1. 发明授权

US08012679B1 Papillomavirus vaccines 失效
标题翻译：乳头瘤病毒疫苗
公开(公告)号：US08012679B1
公开(公告)日：2011-09-06
申请号：US08764926
申请日：1996-12-16
申请人： C. Richard Schlegel , A. Bennett Jenson
发明人： C. Richard Schlegel , A. Bennett Jenson
IPC分类号： C12Q1/70
CPC分类号： C07K14/005 , A61K39/00 , C12N2710/20022 , C12N2710/20034
摘要： Seven polyclonal and monoclonal antibodies were characterized for their ability to react specifically with either conformational or non-conformational epitopes of the HPV-1 virion. Using these antibodies, it was shown that the HPV-1 L1 protein (when expressed by an SV40 vector in cos cells) displayed conformational epitopes characteristic of intact viral particles. In addition, the L1 capsid protein was translocated normally into cell nuclei, was of appropriate size (57kD), and could be isolated in native form by immunoprecipitation techniques. Most importantly, the screening of expressed papillomavirus capsid proteins for reactivity with conformation-dependent antibodies represents a new, general methodology for ensuring that such proteins will be suitable for use in vaccine development or in the serologic detection/typing of human papillomavirus infections.
摘要翻译：表征了七种多克隆和单克隆抗体与HPV-1病毒体的构象或非构象表位特异性反应的能力。使用这些抗体，显示HPV-1 L1蛋白质（当在COS细胞中由SV40载体表达时）显示完整病毒颗粒特征的构象表位。此外，L1衣壳蛋白通常转位到细胞核中，具有适当的大小（57kD），并且可以通过免疫沉淀技术以天然形式分离。最重要的是，筛选表达的乳头状瘤病毒衣壳蛋白与构象依赖性抗体的反应性代表了一种新的通用方法，用于确保这些蛋白质适用于疫苗开发或人乳头状瘤病毒感染的血清学检测/分型。

2. 发明授权

US07279306B2 Stable (fixed) forms of viral capsid proteins, and viral capsid protein fusions, preferably papillomavirus L1 proteins, and uses thereof 有权
标题翻译：病毒衣壳蛋白的稳定（固定）形式和病毒衣壳蛋白融合，优选乳头瘤病毒L1蛋白，及其用途
公开(公告)号：US07279306B2
公开(公告)日：2007-10-09
申请号：US10332037
申请日：2001-06-11
申请人： C Richard Schlegel , Robert Garcea
发明人： C Richard Schlegel , Robert Garcea
IPC分类号： C12P21/06
CPC分类号： C12P21/02 , A61K39/00 , C07K14/005 , C07K2319/00 , C07K2319/23 , C07K2319/735 , C12N7/00 , C12N15/62 , C12N15/86 , C12N2710/20022 , C12N2710/20023 , Y02A50/464 , Y02A50/466 , Y02A50/467
摘要： Novel acetone- or alcohol-fixed viral capsid proteins, bacteria-containing, and papillomavirus L1-GST fusion proteins are described. These proteins are useful in vaccine preparation and as diagnostics.
摘要翻译：描述了新的丙酮或醇固定的病毒衣壳蛋白，含细菌和乳头瘤病毒L1-GST融合蛋白。这些蛋白质可用于疫苗制备和诊断。

3. 发明授权

US06485728B2 Formalin-Inactivated human papillomavirus L1 protein vaccine 失效
标题翻译：福尔马林灭活人乳头瘤病毒L1蛋白疫苗
公开(公告)号：US06485728B2
公开(公告)日：2002-11-26
申请号：US09134377
申请日：1998-08-14
申请人： C. Richard Schlegel , A. Bennett Jenson , Shin-je Ghim
发明人： C. Richard Schlegel , A. Bennett Jenson , Shin-je Ghim
IPC分类号： A61K3912
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/5252 , A61K2039/552 , C12N2710/14143 , C12N2710/20022 , C12N2710/20034 , G01N2333/025 , Y10S977/802 , Y10S977/918
摘要： Recombinantly produced L1 major capsid proteins which mimic conformational naturalizing epitopes on human and animal papilloma virions including canine and equine papilloma virions are provided. These recombinant proteins are useful as vaccines for conferring protection against papillomavirus infection. Antibodies to the recombinant protein are also provided. such antibodies are useful in the diagnosis and treatment of viral infection.
摘要翻译：提供了重组产生的L1主要衣壳蛋白，其模拟人和动物乳头瘤病毒粒子上的构象归化表位，包括犬和马乳头瘤病毒粒子。这些重组蛋白质可用作赋予乳头瘤病毒感染保护的疫苗。还提供了重组蛋白的抗体。这样的抗体可用于诊断和治疗病毒感染。

4. 发明授权

US5874089A Protecting against canine oral papillomavirus (copy) 失效
标题翻译：防止犬口腔乳头瘤病毒（复制）
公开(公告)号：US5874089A
公开(公告)日：1999-02-23
申请号：US724281
申请日：1996-10-01
申请人： C. Richard Schlegel , A. Bennett Jenson , Shin-je Ghim
发明人： C. Richard Schlegel , A. Bennett Jenson , Shin-je Ghim
IPC分类号： A61K39/00 , A61K39/12 , A61P31/12 , C07K14/025 , C12N7/01
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5252 , A61K2039/552 , A61K39/00 , C12N2710/14143 , C12N2710/20022 , C12N2710/20034 , G01N2333/025 , Y10S977/802 , Y10S977/918
摘要： Recombinantly produced L1 major capsid proteins which mimic conformational naturalizing epitopes on human and animal papilloma virions including canine and equine papilloma virions are provided. These recombinant proteins are useful as vaccines for conferring protection against papillomavirus infection. Antibodies to the recombinant protein are also provided. Such antibodies are useful in the diagnosis and treatment of viral infection.
摘要翻译：提供了重组产生的L1主要衣壳蛋白，其模拟人和动物乳头瘤病毒粒子上的构象归化表位，包括犬和马乳头瘤病毒粒子。这些重组蛋白质可用作赋予乳头瘤病毒感染保护的疫苗。还提供了重组蛋白的抗体。这些抗体可用于病毒感染的诊断和治疗。

5. 发明授权

US06887478B2 Formalin-treated human papillomavirus L1 protein vaccine 有权
标题翻译：福尔马林处理的人乳头瘤病毒L1蛋白疫苗
公开(公告)号：US06887478B2
公开(公告)日：2005-05-03
申请号：US10665537
申请日：2003-09-22
申请人： C. Richard Schlegel , A. Bennett Jenson , Shin-je Ghim
发明人： C. Richard Schlegel , A. Bennett Jenson , Shin-je Ghim
IPC分类号： A61K39/00 , A61K39/12 , A61P31/12 , C07K14/025 , C12N7/01
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/5252 , A61K2039/552 , C12N2710/14143 , C12N2710/20022 , C12N2710/20034 , G01N2333/025 , Y10S977/802 , Y10S977/918
摘要： Recombinantly produced L1 major capsid proteins which mimic conformational naturalizing epitopes on human and animal papilloma virions including canine and equine papilloma virions are provided. These recombinant proteins are useful as vaccines for conferring protection against papillomavirus infection. Antibodies to the recombinant protein are also provided. Such antibodies are useful in the diagnosis and treatment of viral infection.
摘要翻译：提供了重组产生的L1主要衣壳蛋白，其模拟人和动物乳头瘤病毒粒子上的构象归化表位，包括犬和马乳头瘤病毒粒子。这些重组蛋白质可用作赋予乳头瘤病毒感染保护的疫苗。还提供了重组蛋白的抗体。这些抗体可用于病毒感染的诊断和治疗。

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