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1. 发明授权

US08716663B2 Device and method for particle therapy monitoring and verification 有权
标题翻译：用于粒子治疗监测和验证的装置和方法
公开(公告)号：US08716663B2
公开(公告)日：2014-05-06
申请号：US12991372
申请日：2009-05-06
申请人： Caterina Brusasco , Bruno Marchand
发明人： Caterina Brusasco , Bruno Marchand
IPC分类号： G01T1/00
CPC分类号： A61N5/1048 , A61N5/1071 , A61N2005/1087
摘要： The present invention relates to a device and method for monitoring and verification of the quality of a radiation treatment beam in conformal radiation therapy, and in particular for IMPT (Intensity Modulated Particle Therapy) applications. The device comprises a 2D electronic detector measuring 2D responses to the delivered treatment beam. These 2D responses are compared with predicted 2D responses and differences in responses are signalled. Based on the measured 2D responses the effectively delivered 3D dose distribution in the target can be reconstructed.
摘要翻译：本发明涉及用于在适形辐射治疗中特别是用于IMPT（强度调制粒子治疗）应用的用于监测和验证辐射治疗束的质量的装置和方法。该装置包括测量对输送的治疗束的2D响应的2D电子检测器。将这些2D反应与预测的2D反应进行比较，并且发出响应的差异。基于测量的2D响应，可以重建目标中有效递送的3D剂量分布。

2. 发明申请

US20110248188A1 Device And Method For Particle Therapy Monitoring And Verification 有权
标题翻译：粒子治疗监测与验证装置与方法
公开(公告)号：US20110248188A1
公开(公告)日：2011-10-13
申请号：US12991372
申请日：2009-05-06
申请人： Caterina Brusasco , Bruno Marchand
发明人： Caterina Brusasco , Bruno Marchand
IPC分类号： A61N5/10
CPC分类号： A61N5/1048 , A61N5/1071 , A61N2005/1087
摘要： The present invention relates to a device and method for monitoring and verification of the quality of a radiation treatment beam in conformal radiation therapy, and in particular for IMPT (Intensity Modulated Particle Therapy) applications. The device comprises a 2D electronic detector measuring 2D responses to the delivered treatment beam. These 2D responses are compared with predicted 2D responses and differences in responses are signalled. Based on the measured 2D responses the effectively delivered 3D dose distribution in the target can be reconstructed.
摘要翻译：本发明涉及用于在适形辐射治疗中特别是用于IMPT（强度调制粒子治疗）应用的用于监测和验证辐射治疗束的质量的装置和方法。该装置包括测量对输送的治疗束的2D响应的2D电子检测器。将这些2D反应与预测的2D反应进行比较，并且发出响应的差异。基于测量的2D响应，可以重建目标中有效递送的3D剂量分布。

3. 发明授权

US08779375B2 Device and method for monitoring a hadron beam 有权
标题翻译：用于监测强子束的装置和方法
公开(公告)号：US08779375B2
公开(公告)日：2014-07-15
申请号：US13257882
申请日：2010-03-22
申请人： Bruno Marchand , Caterina Brusasco , Sébastien De Neuter , Friedrich Friedl
发明人： Bruno Marchand , Caterina Brusasco , Sébastien De Neuter , Friedrich Friedl
IPC分类号： G01T1/185
CPC分类号： G01T1/2935
摘要： The present invention relates to a device for dosimetry monitoring of a hadron beam, comprising successive ionization chambers obtained by a series of parallel detector plates separated from each other by a gas filled gap, each detector plate having a collecting part comprising a collecting side insulated from a bias voltage part comprising a bias voltage side and arranged in such a way that the collecting side is facing the bias voltage side of a subsequent detector plate, the resulting assembly of these detector plates forming a plurality of ionization chamber cells, the thicknesses and the choice of the materials of each layer constituting each detector plate as well as the gap of an ionization chamber cell have been selected in order to satisfy the condition that the water equivalent thickness of cell is equal to the length of said cell.
摘要翻译：本发明涉及一种用于剂量测量监测强子束的装置，包括由一系列平行的检测器板获得的连续电离室，该平行检测器板通过气体填充的间隙彼此分开，每个检测器板具有收集部分，偏置电压部分包括偏置电压侧并且以使得集电侧面向后续检测器板的偏置电压侧的方式布置，所得到的这些检测器板的组件形成多个电离室电池，其厚度和选择构成每个检测器板的每个层的材料的选择以及电离室电池的间隙，以满足电池的水当量厚度等于所述电池的长度的条件。

4. 发明申请

US20120104270A1 Device And Method For Monitoring A Hadron Beam 有权
标题翻译：用于监测强子束的装置和方法
公开(公告)号：US20120104270A1
公开(公告)日：2012-05-03
申请号：US13257882
申请日：2010-03-22
申请人： Bruno Marchand , Caterina Brusasco , Sébastien De Neuter , Friedrich Friedl
发明人： Bruno Marchand , Caterina Brusasco , Sébastien De Neuter , Friedrich Friedl
IPC分类号： G01T1/02
CPC分类号： G01T1/2935
摘要： The present invention relates to a device for dosimetry monitoring of a hadron beam, comprising n successive ionization chambers i obtained by a serie or stack of n+1 parallel detector plates separated from each other by a gas filled gap, each detector plates having a collecting part comprising a collecting side insulated from a bias voltage part comprising a bias voltage side and ranged in a such way that the said collecting side is facing the said bias voltage side of a subsequent detector plate or inversely, each detector plate comprising m layers Lk of materials, the resulting assembly of these detector plates forming a plurality of ionization chamber cells, characterised in that: the thicknesses Ik and the choice of the materials of each layer Lk constituting each detector plate as well as the gap of an ionization chamber cell i have been selected in order to satisfy the equation (I) for each ionization chamber i, where lgi is the gas filled gap distance between two detector plates; Ik is the thickness of the corresponding layer Lk of a detector plate and; WETk is the water equivalent thickness (WET) of the corresponding layer Lk of a detector plate.
摘要翻译：本发明涉及一种用于剂量测量监测强子束的装置，其包括由通过气体填充间隙彼此分开的n + 1个平行检测器板的系列或堆叠获得的n个连续电离室，每个检测器板具有收集部分包括与包括偏置电压侧的偏置电压部分绝缘的集电端，并且以使得所述集电侧面向随后的检测器板的所述偏置电压侧或相反的方式，每个检测器板包括m层Lk 材料，形成多个电离室电池的这些检测器板的所得组件，其特征在于：厚度Ik和构成每个检测器板的每个层Lk的材料的选择以及电离室电池的间隙具有被选择以满足每个电离室i的等式（I），其中lgi是两个检测器板之间的气体填充的间隙距离 s; Ik是检测器板的相应层Lk的厚度; WETk是检测器板的相应层Lk的水当量厚度（WET）。

5. 发明申请

US20120310030A1 Device And Method For Line Control Of An Energy Beam 审中-公开
标题翻译：能量束线控制的装置和方法
公开(公告)号：US20120310030A1
公开(公告)日：2012-12-06
申请号：US13499634
申请日：2010-09-30
申请人： Jean-Marc Fontbonne , Jérôme Perronnel , Bruno Marchand , Caterina Brusasco
发明人： Jean-Marc Fontbonne , Jérôme Perronnel , Bruno Marchand , Caterina Brusasco
IPC分类号： A61N5/10 , G01T1/16
CPC分类号： H01J47/02
摘要： The invention relates to the field of line control of a beam, and especially to a device comprising a plurality of ionisation chambers, enabling the measurement of the dose deposited by an ionising beam and the field of said beam. At least one ionisation chamber is formed from support films having a thickness less than or equal to 100 nm.
摘要翻译：本发明涉及光束的线控制领域，特别涉及包括多个电离室的装置，其能够测量由电离束沉积的剂量和所述光束的场。至少一个电离室由厚度小于或等于100nm的支撑膜形成。

6. 发明授权

US07307264B2 Apparatus for irradiating a target volume 失效
标题翻译：用于照射目标体积的装置
公开(公告)号：US07307264B2
公开(公告)日：2007-12-11
申请号：US10513544
申请日：2002-11-29
申请人： Caterina Brusasco , Bruno Marchand , Jean-François De Le Hoye , Damien Prieels
发明人： Caterina Brusasco , Bruno Marchand , Jean-François De Le Hoye , Damien Prieels
IPC分类号： H01J33/02
CPC分类号： G21K1/087 , A61N5/10 , A61N5/1043 , A61N5/1048 , A61N2005/1087
摘要： An irradiation apparatus for irradiating by scanning a target volume according to a predetermined dose profile with a scanning beam of charged particles forming an irradiation spot on said target volume, said apparatus comprising: a beam generating device, a reference generator for computing, from said predetermined dose profile, through a dynamic inverse control strategy, the time evolution of commanded variables, these variables being the beam current I(t), the spot position settings x(t),y(t) and the scanning speed settings vx(t), vy(t), a monitor device having means for detecting at each time (t), the actual spot position as a measured position defined by the values xm(t),ym(t) on the target volume, characterised in that said irradiation apparatus further comprises means for determining the differences ex(t), ey(t) between the measured values xm(t), ym(t) and the spot position settings x(t) and y(t), and means for applying a correction to the scanning speed settings vx(t) and vy(t) depending on said differences ex(t), ey(t). The present invention is also related to a monitor for determining beam position in real-time.
摘要翻译：一种照射装置，用于通过用在所述目标体积上形成照射点的带电粒子的扫描光束根据预定剂量分布进行扫描来照射目标体积，所述装置包括：光束产生装置，用于从所述预定的剂量曲线，通过动态反向控制策略，指令变量的时间演化，这些变量是光束电流I（t），光点位置设置x（t），y（t）和扫描速度设置v < （t），具有用于在每个时间（t）检测的装置的实际光斑位置作为由值x（t）定义的测量位置的监视装置，（t），y（m）（t），其特征在于，所述照射装置还包括用于确定差异的装置，（t），测量值x m（t），y（m）之间的距离（t）和点位置设置 x（t）和 y（t），以及用于对扫描速度设置v x（t）和v Y（t）进行校正的装置，其取决于所述差异e x （t），e（y）（t）。本发明还涉及实时确定波束位置的监视器。

7. 发明申请

US20050238134A1 Apparatus for irradiating a target volume 失效
标题翻译：用于照射目标体积的装置
公开(公告)号：US20050238134A1
公开(公告)日：2005-10-27
申请号：US10513544
申请日：2002-11-29
申请人： Caterina Brusasco , Bruno Marchand , Jean-Francois De Le Hoye , Damien Prieels
发明人： Caterina Brusasco , Bruno Marchand , Jean-Francois De Le Hoye , Damien Prieels
IPC分类号： A61N5/10 , G21K1/087 , H01J47/06 , G21K1/12 , H05G1/60
CPC分类号： G21K1/087 , A61N5/10 , A61N5/1043 , A61N5/1048 , A61N2005/1087
摘要： An irradiation apparatus for irradiating by scanning a target volume according to a predetermined dose profile with a scanning beam of charged particles forming an irradiation spot on said target volume, said apparatus comprising: a beam generating device, a reference generator for computing, from said predetermined dose profile, through a dynamic inverse control strategy, the time evolution of commanded variables, these variables being the beam current I(t), the spot position settings x(t),y(t) and the scanning speed settings vx(t), vy(t), a monitor device having means for detecting at each time (t), the actual spot position as a measured position defined by the values xm(t),ym(t) on the target volume, characterised in that said irradiation apparatus further comprises means for determining the differences ex(t), ey(t) between the measured values xm(t), ym(t) and the spot position settings x(t) and y(t), and means for applying a correction to the scanning speed settings vx(t) and vy(t) depending on said differences ex(t), ey(t). The present invention is also related to a monitor for determining beam position in real-time.
摘要翻译：一种照射装置，用于通过用在所述目标体积上形成照射点的带电粒子的扫描光束根据预定剂量分布进行扫描来照射目标体积，所述装置包括：光束产生装置，用于从所述预定的剂量曲线，通过动态反向控制策略，指令变量的时间演化，这些变量是光束电流I（t），光点位置设置x（t），y（t）和扫描速度设置v < （t），具有用于在每个时间（t）检测的装置的实际光斑位置作为由值x（t）定义的测量位置的监视装置，（t），y（m）（t），其特征在于，所述照射装置还包括用于确定差异的装置，（t），测量值x m（t），y（m）之间的距离（t）和点位置设置 x（t）和 y（t），以及用于对扫描速度设置v x（t）和v Y（t）进行校正的装置，其取决于所述差异e x （t），e（y）（t）。本发明还涉及实时确定波束位置的监视器。

8. 发明授权

US06873123B2 Device and method for regulating intensity of beam extracted from a particle accelerator 失效
标题翻译：用于调节从粒子加速器提取的光束的强度的装置和方法
公开(公告)号：US06873123B2
公开(公告)日：2005-03-29
申请号：US10479380
申请日：2002-06-03
申请人： Bruno Marchand , Bertrand Bauvir
发明人： Bruno Marchand , Bertrand Bauvir
IPC分类号： A61N5/10 , H05H7/00 , H05H13/00 , H05H13/04 , A61N5/01
CPC分类号： H05H13/00 , H05H7/00
摘要： The invention concerns a device (10) for regulating the intensity of a beam extracted from a particle accelerator, such as a cyclotron, used for example for protontherapy, said particles being generated from an ion source. The invention is characterized in that it comprises at least: a comparator (90) determining a difference ε between a digital signal IR representing the intensity of the beam measured at the output of the accelerator and a setpoint value IC of the beam intensity: a Smith predictor (80) which determines on the basis of the difference ε, a correct value of the intensity of the beam IP; an inverted correspondence table (40) supplying, on the basis of the corrected value of the intensity of the beam IP, a setpoint value IA for supply arc current from the ion source (20).
摘要翻译：本发明涉及一种用于调节从例如用于质子疗法的回旋加速器的粒子加速器提取的束的强度的装置（10），所述颗粒是由离子源产生的。本发明的特征在于至少包括：比较器（90），其确定表示在加速器的输出处测量的光束的强度的数字信号IR与光束强度的设定值IC之间的差异ε：史密斯预测器（80），其基于差异ε确定光束IP的强度的正确值; 反向对应表（40），其根据光束IP的强度的校正值提供用于从离子源（20）供应电弧电流的设定值IA。

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