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1. 发明授权

US08896842B2 Compact multimodality optical coherence tomography imaging systems 有权
标题翻译：紧凑型多模光学相干断层成像系统
公开(公告)号：US08896842B2
公开(公告)日：2014-11-25
申请号：US13198117
申请日：2011-08-04
申请人： Bradley A. Bower , Robert H. Hart , Pete Huening , Eric L. Buckland
发明人： Bradley A. Bower , Robert H. Hart , Pete Huening , Eric L. Buckland
IPC分类号： G01B9/02 , A61B3/10 , A61B3/14
CPC分类号： A61B3/102 , A61B3/14 , G01B9/0203 , G01B9/02091
摘要： Systems for imaging a sample are provided. The system includes an optical coherence tomography (OCT) imaging portion having an associated OCT path defined by one set of optical elements between an OCT signal delivery optical fiber and the sample; an image capture portion having an associated image capture path defined by a second set of optical elements between an image capture device and the sample, different from the OCT path; and an illuminator portion having an associated illumination path defined by a third set of optical elements between an illumination source and the sample. The OCT path, the image capture path, and the illuminator path have at least one optical element in common, and the respective paths differ from each other by at least one optical element. The OCT path and the image capture path share a common intermediate conjugate image plane. Focal control is achieved for the OCT path and the image capture path concurrently through adjustment of one or more common optical elements distal to the common intermediate conjugate plane, such that focal control requires no differential adjustment between optical elements not in common to both paths.
摘要翻译：提供了用于成像样本的系统。该系统包括光学相干断层摄影（OCT）成像部分，其具有由OCT信号传送光纤和样本之间的一组光学元件限定的相关OCT路径; 图像捕获部分，具有由图像捕获装置和样本之间的不同于OCT路径的第二组光学元件定义的相关联的图像捕获路径; 以及具有由照明源和样品之间的第三组光学元件限定的相关联的照明路径的照明器部分。 OCT路径，图像捕获路径和照明器路径具有共同的至少一个光学元件，并且相应的路径由至少一个光学元件彼此不同。 OCT路径和图像捕获路径共享一个共同的中间共轭图像平面。通过调整远离公共中间共轭平面的一个或多个共同的光学元件，通过同时进行OCT路径和图像捕获路径的焦点控制，使得焦点控制不需要在两个路径不共同的光学元件之间进行差分调整。

2. 发明授权

US08687856B2 Methods, systems and computer program products for biometric identification by tissue imaging using optical coherence tomography (OCT) 有权
标题翻译：使用光学相干断层扫描（OCT）进行组织成像生物识别的方法，系统和计算机程序产品
公开(公告)号：US08687856B2
公开(公告)日：2014-04-01
申请号：US12624937
申请日：2009-11-24
申请人： Bradley A. Bower , Eric L. Buckland
发明人： Bradley A. Bower , Eric L. Buckland
IPC分类号： G06K9/00
CPC分类号： G06K9/00006 , G06K9/00087 , G06K9/00362
摘要： Optical coherence tomography (OCT) imaging systems for imaging uniquely identifiable structure are provided including a source having an associated source arm path and having an associated reference arm path coupled to the source path, the reference arm path having an associated reference arm path length. A sample having an associated sample arm path coupled to the source arm and reference arm paths is provided. Processing methods to convert the depth-dependent image data to a uniquely identifiable code are provided. Related methods and computer program products are also provided.
摘要翻译：提供用于成像唯一可识别结构的光学相干断层摄影（OCT）成像系统，包括具有相关联的源臂路径并具有耦合到源路径的相关联的参考臂路径的源，参考臂路径具有相关联的参考臂路径长度。提供具有耦合到源臂和参考臂路径的相关联的样本臂路径的样本。提供了将深度相关图像数据转换为唯一可识别代码的处理方法。还提供了相关方法和计算机程序产品。

3. 发明授权

US08348427B2 Systems for extended depth fourier domain optical coherence tomography (FDOCT) and related methods 有权
标题翻译：扩展深度傅立叶变换光学相干断层扫描系统（FDOCT）及相关方法
公开(公告)号：US08348427B2
公开(公告)日：2013-01-08
申请号：US12887891
申请日：2010-09-22
申请人： Eric L. Buckland , Joseph A. Izatt , Bradley A. Bower , Robert H. Hart
发明人： Eric L. Buckland , Joseph A. Izatt , Bradley A. Bower , Robert H. Hart
IPC分类号： A61B3/14 , A61B3/00 , G01B11/02
CPC分类号： A61B3/102 , G01B9/0201 , G01B9/02078 , G01B9/02091
摘要： Systems for extended depth frequency domain optical coherence tomography are provided including a detection system configured to sample spectral elements at substantially equal frequency intervals, wherein a spectral width associated with the sampled spectral elements is not greater than one-half of the frequency interval. Related methods are also provided herein.
摘要翻译：提供了用于扩展深度频域光学相干断层摄影的系统，其包括被配置为以基本相等的频率间隔对频谱元素进行采样的检测系统，其中与采样的频谱元素相关联的频谱宽度不大于频率间隔的一半。本文还提供了相关方法。

4. 发明申请

US20120033227A1 Compact Multimodality Optical Coherence Tomography Imaging Systems and Related Methods and Computer Program Products 有权
标题翻译：紧凑多模光学相干断层扫描成像系统及相关方法和计算机程序产品
公开(公告)号：US20120033227A1
公开(公告)日：2012-02-09
申请号：US13198117
申请日：2011-08-04
申请人： Bradley A. Bower , Robert H. Hart , Pete Huening , Eric L. Buckland
发明人： Bradley A. Bower , Robert H. Hart , Pete Huening , Eric L. Buckland
IPC分类号： G01B9/02
CPC分类号： A61B3/102 , A61B3/14 , G01B9/0203 , G01B9/02091
摘要： Systems for imaging a sample are provided. The system includes an optical coherence tomography (OCT) imaging portion having an associated OCT path defined by one set of optical elements between an OCT signal delivery optical fiber and the sample; an image capture portion having an associated image capture path defined by a second set of optical elements between an image capture device and the sample, different from the OCT path; and an illuminator portion having an associated illumination path defined by a third set of optical elements between an illumination source and the sample. The OCT path, the image capture path, and the illuminator path have at least one optical element in common, and the respective paths differ from each other by at least one optical element. The OCT path and the image capture path share a common intermediate conjugate image plane. Focal control is achieved for the OCT path and the image capture path concurrently through adjustment of one or more common optical elements distal to the common intermediate conjugate plane, such that focal control requires no differential adjustment between optical elements not in common to both paths.
摘要翻译：提供了用于成像样本的系统。该系统包括光学相干断层摄影（OCT）成像部分，其具有由OCT信号传送光纤和样本之间的一组光学元件限定的相关OCT路径; 图像捕获部分，具有由图像捕获装置和样本之间的不同于OCT路径的第二组光学元件定义的相关联的图像捕获路径; 以及具有由照明源和样品之间的第三组光学元件限定的相关联的照明路径的照明器部分。 OCT路径，图像捕获路径和照明器路径具有共同的至少一个光学元件，并且相应的路径由至少一个光学元件彼此不同。 OCT路径和图像捕获路径共享一个共同的中间共轭图像平面。通过调整远离公共中间共轭平面的一个或多个共同的光学元件，通过同时进行OCT路径和图像捕获路径的焦点控制，使得焦点控制不需要在两个路径不共同的光学元件之间进行差分调整。

5. 发明申请

US20110160576A1 Methods, Systems and Computer Program Products for Diagnosing Conditions Using Unique Codes Generated from a Multidimensional Image of a Sample 有权
标题翻译：方法，系统和计算机程序产品，用于使用从样本的多维图像生成的唯一代码来诊断条件
公开(公告)号：US20110160576A1
公开(公告)日：2011-06-30
申请号：US12953868
申请日：2010-11-24
申请人： Bradley A. Bower , Eric L. Buckland
发明人： Bradley A. Bower , Eric L. Buckland
IPC分类号： A61B6/00
CPC分类号： G06K9/00604 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/117 , A61B5/1171 , A61B5/6821 , A61B5/6826 , G06K7/1413 , G06K7/1417 , G06K7/1447 , G06K9/00033 , G06K9/0008 , G06K9/00892 , G06T11/006
摘要： Methods of providing a diagnosis using a digital code associated with an image are provided including collecting a multidimensional image, the multidimensional image having at least two dimensions; extracting a two dimensional subset of the multidimensional image; reducing the multidimensional image to a first code that is unique to the multidimensional image based on the extracted two dimensional image; comparing the first unique code associated with the subject to a library of reference codes, each of the reference codes in the library of reference codes being indicative of a class of objects; determining if the subject associated with the first unique code falls into at least one of the classes of objects associated with the reference codes based on a result of the comparison; and formulating a diagnostic decision based on the whether the first unique code associated with the subject falls into at least one of the classes associated with the reference code. Related systems and computer program products are also provided herein.
摘要翻译：提供使用与图像相关联的数字代码提供诊断的方法，包括收集多维图像，所述多维图像具有至少两个维度; 提取多维图像的二维子集; 将所述多维图像减少为基于所提取的二维图像对于所述多维图像是唯一的第一代码; 将与主题相关联的第一唯一代码与参考代码库进行比较，参考代码库中的每个参考代码指示一类对象; 基于比较的结果，确定与第一唯一码相关联的被摄体是否落入与参考码相关联的对象类别中的至少一个中; 以及基于与所述对象相关联的所述第一唯一代码是否落入与所述参考代码相关联的类别中的至少一个中来制定诊断决策。本文还提供了相关系统和计算机程序产品。

6. 发明申请

US20110102802A1 Systems for Comprehensive Fourier Domain Optical Coherence Tomography (FDOCT) and Related Methods 有权
标题翻译：综合傅里叶域光学相干断层扫描系统（FDOCT）及相关方法
公开(公告)号：US20110102802A1
公开(公告)日：2011-05-05
申请号：US12910184
申请日：2010-10-22
申请人： Joseph A. Izatt , Eric L. Buckland , Bradley A. Bower , Robert H. Hart
发明人： Joseph A. Izatt , Eric L. Buckland , Bradley A. Bower , Robert H. Hart
IPC分类号： G01B9/02
CPC分类号： A61B3/102 , A61B3/117 , A61B3/1225 , G01B9/0201 , G01B9/02078 , G01B9/02091
摘要： Optical coherence tomography systems for imaging a whole eye are provided including a sample arm including focal optics that are configured to rapidly switch between at least two scanning modes in less than about 1.0 second.
摘要翻译：提供了用于对整个眼睛进行成像的光学相干断层摄影系统，包括包括焦点光学元件的样本臂，其配置为在小于约1.0秒内在至少两个扫描模式之间快速切换。

7. 发明授权

US07593559B2 Method and system of coregistrating optical coherence tomography (OCT) with other clinical tests 有权
标题翻译：光学相干断层扫描（OCT）与其他临床试验的方法和系统
公开(公告)号：US07593559B2
公开(公告)日：2009-09-22
申请号：US11600913
申请日：2006-11-17
申请人： Cynthia A. Toth , Marcin Stopa , Bradley A. Bower
发明人： Cynthia A. Toth , Marcin Stopa , Bradley A. Bower
IPC分类号： G06K9/00
CPC分类号： A61B3/0025 , G01N21/4795 , G01N21/6456 , G01N2021/1787 , G01N2021/8887 , Y10S128/922
摘要： A method/system preserves annotations of different pathological conditions or changes that are recognized on cross-sections within a three dimensional volume of a patient's eye so that the annotations are maintained in a visible state in an en face projection produced with a SVP technique. it is thus possible to coregister the annotated conditions or changes with other types of two dimensional en face images such as images from other ophthalmic devices (e.g., angiography device, microperimetry device, autofluorescence device, fundal photography device.). The annotations are also maintained in a visible state in the coregistered image.
摘要翻译：方法/系统保留在患者眼睛的三维体积内的横截面上识别的不同病理状况或变化的注释，使得注释在由SVP技术产生的面部投影中保持在可见状态。因此，可以利用来自其他眼科装置（例如，血管造影装置，微量测定装置，自动荧光装置，基金摄影装置）的其他类型的二维面部图像来集中注释的条件或变化。注释也保持在核心映像中的可见状态。

8. 发明授权

US08797530B2 Linearized variable-dispersion spectrometers and related assemblies 有权
标题翻译：线性化可变色散光谱仪及相关组件
公开(公告)号：US08797530B2
公开(公告)日：2014-08-05
申请号：US13428247
申请日：2012-03-23
申请人： Christopher Saxer , Robert H. Hart , Eric L. Buckland , Pete Huening , Bradley A. Bower
发明人： Christopher Saxer , Robert H. Hart , Eric L. Buckland , Pete Huening , Bradley A. Bower
IPC分类号： G01J3/28
CPC分类号： G01J3/0208 , A61B3/1005 , A61B5/0066 , G01J3/14 , G01J3/1804 , G01J3/28 , G01J2003/1208
摘要： Wavenumber linear spectrometers are provided including an input configured to receive electromagnetic radiation from an external source; collimating optics configured to collimate the received electromagnetic radiation; a dispersive assembly including first and second diffractive gratings, wherein the first diffraction grating is configured in a first dispersive stage to receive the collimated electromagnetic radiation and wherein the dispersive assembly includes at least two dispersive stages configured to disperse the collimated input; and an imaging lens assembly configured to image the electromagnetic radiation dispersed by the at least two dispersive stages onto a linear detection array such that the variation in frequency spacing along the linear detection array is no greater than about 10%.
摘要翻译：提供波数线性光谱仪，其包括被配置为从外部源接收电磁辐射的输入; 准直光学器件，被配置成准直所接收的电磁辐射; 包括第一和第二衍射光栅的分散组件，其中所述第一衍射光栅被配置在第一色散级中以接收所述准直电磁辐射，并且其中所述色散组件包括被配置为分散所述准直输入的至少两个色散级; 以及成像透镜组件，被配置为将由至少两个色散级分散的电磁辐射成像到线性检测阵列上，使得沿着线性检测阵列的频率间隔的变化不大于约10％。

9. 发明申请

US20110216956A1 Methods, Systems and Computer Program Products for Collapsing Volume Data to Lower Dimensional Representations Thereof 有权
标题翻译：方法，系统和计算机程序产品用于缩小体积数据以降低其尺寸表示
公开(公告)号：US20110216956A1
公开(公告)日：2011-09-08
申请号：US13040923
申请日：2011-03-04
申请人： Bradley A. Bower , Eric L. Buckland , Igor Touzov
发明人： Bradley A. Bower , Eric L. Buckland , Igor Touzov
IPC分类号： G06K9/00
CPC分类号： G06K9/00
摘要： Methods of collapsing volume data to a lower dimensional representation of the volume data are provided. The methods include collapsing volume data to a lower dimensional representation of the volume data using histogram projection. Related systems and computer program products are also provided.
摘要翻译：提供了将体数据折叠成体数据的较低维度表示的方法。这些方法包括使用直方图投影将体数据折叠到体数据的较低维度表示。还提供了相关系统和计算机程序产品。

10. 发明申请

US20080181477A1 Methods, systems and computer program products for processing images generated using fourier domain optical coherence tomography (FDOCT) 有权
标题翻译：用于处理使用傅立叶变换光学相干断层扫描（FDOCT）生成的图像的方法，系统和计算机程序产品
公开(公告)号：US20080181477A1
公开(公告)日：2008-07-31
申请号：US12016352
申请日：2008-01-18
申请人： Joseph A. Izatt , Eric L. Buckland , Bennett R. Groshong , Bradley A. Bower
发明人： Joseph A. Izatt , Eric L. Buckland , Bennett R. Groshong , Bradley A. Bower
IPC分类号： G06K9/00
CPC分类号： G01B9/02091 , A61B3/102 , A61B3/117 , A61B5/0066 , A61B5/7207 , A61B5/7257 , G01N21/4795 , G01P3/36 , G06T11/003
摘要： Methods, systems and computer program products for managing frequency domain optical coherence tomography (FDOCT) image resolution. A spectrum used to acquire an image of a subject is calibrated and default dispersion correction parameters are set. Default dispersion management parameters associated with a region of the image of the subject are also set. The image of the subject is acquires after setting the default dispersion correction parameters and the default dispersion management parameters. A quality of the acquired image is compared to a quality metric for the acquired image. The dispersion correction parameters are adjusted if the quality of the acquired image does not meet or exceed the quality metric for the acquired image. The acquired image is reprocesses based on the adjusted dispersion correction parameters. The steps of comparing, adjusting and reprocessing are repeated until the acquired image meets or exceeds the quality metric for the acquired image
摘要翻译：用于管理频域光学相干断层扫描（FDOCT）图像分辨率的方法，系统和计算机程序产品。用于获取被摄体图像的光谱被校准，并且设置默认色散校正参数。还设置与被摄体的图像的区域相关联的默认色散管理参数。在设置默认色散校正参数和默认色散管理参数后，获取被摄体的图像。将所获取的图像的质量与所获取的图像的质量度量进行比较。如果所获取的图像的质量不满足或超过所获取的图像的质量度量，则调整色散校正参数。所获取的图像基于经调整的色散校正参数进行再处理。重复比较，调整和重新处理的步骤，直到所获取的图像满足或超过所获取的图像的质量度量

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