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1. 发明申请

US20070120281A1 Manufacture of fine particles and nano particles and coating thereof 审中-公开
标题翻译：制造细颗粒和纳米颗粒及其涂层
公开(公告)号：US20070120281A1
公开(公告)日：2007-05-31
申请号：US11594411
申请日：2006-11-08
申请人： Boris Khusid , Abhijit Gokhale , Rajesh Dave , Robert Pfeffer
发明人： Boris Khusid , Abhijit Gokhale , Rajesh Dave , Robert Pfeffer
IPC分类号： B29B9/00
CPC分类号： B01J2/04 , B01J2/006 , B01J3/008
摘要： An anti-solvent fluid technique is provided that assists in the formation, production and manufacture of fine particles including micro-sized and nanometer-sized particles for a wide variety of bio-medical and pharmaceutical applications. This technique is particularly effective for the manufacturing of polymers/biopolymers/drugs of micron, submicron or nano size as well as particle coating/encapsulation. Co-solvents are used to dissolve the polymer or mixture of polymers to make a solution. The method facilitates rapid drying of precipitated particles with reduced size and agglomerations. The method includes: (1) providing: an anti-solvent fluid; both organic solvents are soluble in the anti-solvent fluid; a second solvent that is at least partially soluble in or miscible with the first solvent; and a solute that is soluble in the first solvent and is substantially insoluble in the second solvent and the anti-solvent fluid; (2) capillary nozzle(s) are used to inject the solution into anti-solvent; (3) contacting the first solvent, the second solvent and the solute together to form a solution; (4) contacting the solution with the anti-solvent fluid to extract both solvents from the solution and precipitate the solute in the form of particles; and (5) contacting the solution with the anti-solvent fluids to extract both solvents from solution and precipitate the solute(s).
摘要翻译：提供了一种抗溶剂流体技术，其有助于形成，生产和制造包括用于各种生物医学和药物应用的微尺寸和纳米尺寸颗粒的细颗粒。该技术对于制备微米，亚微米或纳米尺寸以及颗粒涂层/包封的聚合物/生物聚合物/药物是特别有效的。共溶剂用于溶解聚合物或聚合物混合物以制成溶液。该方法有助于快速干燥具有减小的尺寸和聚集的沉淀颗粒。该方法包括：（1）提供：反溶剂流体; 两种有机溶剂均溶于反溶剂液体; 至少部分可溶于第一溶剂或与第一溶剂混溶的第二溶剂; 以及可溶于第一溶剂且基本上不溶于第二溶剂和反溶剂流体的溶质; （2）毛细喷嘴用于将溶液注入反溶剂中; （3）将第一溶剂，第二溶剂和溶质接触在一起形成溶液; （4）使溶液与反溶剂流体接触，从溶液中提取两种溶剂，并以颗粒形式沉淀溶质; 和（5）使溶液与反溶剂流体接触以从溶液中萃取两种溶剂并沉淀溶质。

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